How antioxidants like HCA & CGA & POLYPHENOLS help burn more fat

Some antioxidants (foods) helps you lose weight | How antioxidants like HCA & CGA & POLYPHENOLS help burn more fat

 

 

Which antioxidant can help you lose weight:

  1. HCA hydroxycitric acid (found in garcinia cambogia)
  2. CGA Chlorogenic Acid (found in green coffee extract) (is of course a form of polyphenol antioxidant)
  3. POLYPHENOLS (PHENOLIC ACID) (found in green tea, berries, and…)

 

HCA hydroxycitric acid CGA Chlorogenic Acid POLYPHENOLS (PHENOLIC ACID)

HCA hydroxycitric acid,  CGA Chlorogenic Acid,  POLYPHENOLS (PHENOLIC ACID)

 

1. HCA hydroxycitric acid (antioxidant) in garcinia cambogia can help you lose weight:

  • hydroxycitric acid Helps your storage of body fats come into action and be used in long term
  • Blocks storage of the extra calories you do not use as fat in your body
  • hydroxycitric acid Increase lipid oxidation there by help to breakdown and remove fatty acids from your body
  • It may also help to decrease appetite to some degree
  • hydroxycitric acid may also help to lower triglyceride and low-density lipoprotein, or “LDL,” levels
  • Hydroxycitric acid is used to improve exercise performance too by limiting the use of stored energy in the muscles, which seems to prevent fatigue.

 

2. Chlorogenic Acid (found in green coffee extract) can help you lose weight:

  • Reduce the absorption of carbohydrates from the digestive tract
  • lowers blood sugar and insulin spikes
  • reduce fat absorbed from the diet
  • reduce fat stored in the liver
  • improve the function of the fat burning hormone adiponectin

 

3. POLYPHENOLS (PHENOLIC ACID) (found in green tea, berries, and…)

  • POLYPHENOLS (PHENOLIC ACID) in green tea are believed to block fat from being absorbed
  • POLYPHENOLS (PHENOLIC ACID) compounds in Green tea extract decreases starch digestion and absorption, Green tea extract blocks an enzyme that breaks down carbs
  • Green Tea May Prevent Weight Gain by Inhibiting Fat Absorption and Promoting Fat Use.

 

 

Main factor in losing weight

Losing weight is not a “one factor problem” that gets solved with one solution. many factors are involved in a healthy weight loss. Exercise is very important as diet is. What you eat generally determines how your body works. If you eat a hot spicy food you will expect your appropriate body reaction. As explained in earlier post about how sugar can contribute to agingour body fuel system is very complex and complicated. You can not just eat what ever randomly and assume it has no effect on you and how you perceive and how your body acts. We basically get energy from 4 different category of foods: Fat, carbohydrates, sugar, protein. our body has different hormones and enzymes to make every one of these into energy and use them. Sugar is very tasty right? thats because it burns fast and is vital so has almost the first priority for our body to be used. The extras always go to storage for later use. So when you have sugar you dont burn fat and also the extra sugar and all go to be stored as fat in your storage areas. this metabolism is critically dependent on what you eat. What you eat determines what your body does and feel. for more detailes on this read sugar and aging.

But how some antioxidants can actually help you lose weight and play a role in the complicated system of our body metabolism. hydroxycitric acid or HCA is know to be able to in some way help you lose weight. but let talk about how hydroxycitric acid (HCA) actually does it as an antioxidant agent found in some foods like garcinia cambogia. Hydroxycitric acid is derived from the dried rind of the fruit that grows on the Garcinia cambogia tree, which it is native to India, Malaysia and Africa. Hydroxycitric acid contains numerous phytochemicals including xanthones, flavanoids and benzophenones. Phytochemicals are antioxidant compounds found in plants that help to prevent free radical induced damage.

 

 

Hydroxycitric acid has become popular as a weight loss aid. It has been found to increase lipid oxidation and thereby help to breakdown and remove fatty acids from your body. It may also help to decrease appetite, and a six-week, placebo controlled study cited in the June 2002 edition of “International Journal of Obesity-Related Metabolic Disorders” examined the effectiveness of hydroxycitric acid as an appetite suppressant. The study found that hydroxycitric acid supplementation decreased the daily caloric intake in overweight individuals by 15 to 30 percent. The participants experienced weight loss, whilst also reporting feelings of satiety. HCA Hydroxycitric acid has also anti-inflammatory properties and is used to help treat inflammatory bowel disorders. More research needs to be done to confirm the efficacy of hydroxycitric acid for these uses however.

A lot of research has been done on the effects of a high antioxidant diet, they have been inconclusive on their direct effect on weight loss. As mentioned before many thing play important roles in healthy weight loss and antioxidants like HCA can help you a lot in how your metabolism works. 

Antioxidants are known to turn toxins in the body into harmless elements. Toxins are readily stored in fat cells. Therefore the more toxins we have in our body, the more our bodies will willingly ‘hold on’ to these fat cells in order to prevent toxins from freely roaming in our bodies. This is usually noticed by people who exercise and reach a plateau in their weight loss curve and in those who have slow metabolism rates. In order to reverse this, a diet rich in antioxidants has been shown to have numerous benefits.

While green tea can increase energy and enhance physical performance, there are no clear studies that indicate that the weight loss supplement boosts metabolism. The HCA in Garcinia Cambogia, however, jumpstarts the metabolism so that the body will burn fat at a faster rate. This makes for more permanent weight loss and can help dieters to avoid the yo-yo effect that sometimes comes with taking a weight loss product. Garcinia Cambogia is also high in fiber, which is a quality green tea doesn’t possess. Fiber helps to balance the blood sugar and moves food along the digestive tract speedily.

 

 

Although antioxidants have not been directly linked to fat burning, it is a wonder that people who consume foods rich in antioxidants tend to lose weight. In a study done with overweight participants, those who included green tea in their diet lost more weight compared to the control group. The same has been noted with the intake of water infused with lemon rinds. Lemons and green tea are both very good sources of antioxidants.

For fat loss to occur, the body has to convert stored fat into glucose to provide it with energy. Although no conclusive evidence has been found, research suggests that a diet rich in antioxidants can convert your body from a sugar burning to a fat burning machine. This means that instead of using up the sugars you ingest to produce energy, the body will use stored fats. Antioxidants found in green tea have been found to possibly cut through fat stored in the body.

More research is yet to be done on the benefits of increasing your intake of antioxidant. However, what is clear is that it is better to take them in their natural form rather than in supplements because foods containing antioxidants have other benefits too.

 

 

There have been several human studies on Green Coffee Bean Extract. These studies are so-called randomized controlled trials, which are the gold standard of scientific experiments in humans. One of them included 30 overweight individuals and went on for 12 weeks. There were two groups… one consumed regular Instant coffee, while the other consumed Instant coffee enriched with 200 mg of Green Coffee Bean Extract. Neither group was instructed to change their diet or exercise habits. This graph shows the weight changes in the two groups, from 0-12 weeks:

As you can see, the group taking the instant coffee with green coffee bean extract lost 11.9 pounds (5.4 kg), while the group taking plain instant coffee lost only 3.7 pounds (1.7 kg).

Body fat percentage also went down by 3.6% in the green coffee extract group, compared to 0.7% in the other group.

 

White kidney beans extracts and storage of energy as body fat

There are different ideas about White kidney beans extracts so we did not include them in the antioxidants that helps you lose weight.

White beans and other foods with a low glycemic score also offer extraordinary weight loss benefits. When the carbohydrates in our food cause our blood sugar levels to rise, a polypeptide hormone called insulin is produced by the pancreas (a large gland organ located behind the stomach). The purpose of insulin is to bring the elevated blood sugar levels back down by stimulating the uptake of glucose (sugar) by the body’s cells which can then use the glucose for energy. However, if the blood sugar levels are very high (e.g. after a high GI meal), insulin will cause some of the blood sugar to be stored as fat (for later use as energy). Low GI foods like beans have the opposite effect. Great news for those who are following a fat loss diet plan! In addition to their gentle effect on blood sugar levels, white beans may provide weight loss benefits due their ability to produce alpha-amylase inhibitors. Alpha-amylase inhibitors are known to slow the absorption of carbohydrates (and thus the storage of energy as body fat) by inhibiting enzymes responsible for cutting starches into simpler sugars.

Antioxidants in white kidney beans promote good health and wrinkle-free skin: White beans deliver a hefty supply of antioxidants, substances that fight off disease and help maintain optimum health. Antioxidants are believed to protect the cells in your body from free radicals, unstable molecules that damage cells. Ultimately, the damage caused by free radicals can result in many chronic conditions and degenerative diseases including certain types of cancer, atherosclerosis, thrombosis, arthritis, heart disease, immune system problems, Alzheimer’s disease, and dementia. source

What Are Starch Blockers like White kidney beans extracts?

Starches are complex carbohydrates that cannot be absorbed unless they are first broken down by the digestive enzyme amylase. Amylase inhibitors, also called starch blockers, prevent starches from being absorbed by the body. When amylase is blocked, those carbs pass through the body undigested, so you don’t absorb the calories.

Prescription drugs have to prove to the FDA that they are safe and effective. Supplements don’t. You also can’t be sure of what’s in a supplement.

Some supplements may have unlisted ingredients, maybe stimulants, that could be dangerous for people with diabetes, says Kathleen Dungan, MD, an endocrinologist at Ohio State University.

Prescription versions won’t have those extra ingredients, so they tend to be safer.

The FDA has sent warning letters to makers of no-prescription starch blockers in the past, saying their marketing claims are misleading.

If you’re considering using any product marketed for weight loss, talk to your doctor or a dietitian first. Ask yourself if it sounds too good to be true, and be skeptical.

Source

 

 

 

Sources and online websites about losing weight and antioxidants:

 

http://www.livestrong.com/article/429560-hydroxycitric-acid-information/

https://www.ncbi.nlm.nih.gov/pubmed/21401105

https://www.ncbi.nlm.nih.gov/pubmed/20933071

https://www.drugs.com/npp/garcinia-hydroxycitric-acid.html

 

 

 

Papers and references about losing weight and antioxidants:

 

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9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.
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11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.
12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.
13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.
14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.
15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.
16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.
17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.
18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.
19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.
20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.
21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.
22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.
23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.
24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.
25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.
26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.
27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.
28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.
29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.
30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.
31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.
32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.
33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.
34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.
35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.
36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.
37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.
38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.
39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.
40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci . 2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.
41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.
42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.
43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.
44. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol . 2009;15(14):1786-1787.
45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.
46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem . 2003;254(1-2):339-346.
47. Burdock G, Soni M, Bagchi M, Bagchi D. Garcinia cambogia toxicity is misleading. [Published correction appears in: Food Chem Toxicol . 2007;45(3):515.] Food Chem Toxicol . 2005;43(11):1683-1684; author reply 1685-1686.
48. Min B, McBride BF, Kardas MJ, et al. Electrocardiographic effects of an ephedra-free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy . 2005;25(5):654-659.
49. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia . 2008;79(4):255-261.

 

Sugar stands accused | Author makes case for ‘uniquely toxic’ health effects in talk at HLS

Sugar stands accused | Author makes case for ‘uniquely toxic’ health effects in talk at HLS

read th full article about sugar and aging

Science journalist and author Gary Taubes ’77 made his case that sugar consumption — which has risen dramatically over the last century — drives metabolic dysfunction that makes people sick. The hourlong talk was sponsored by the Food Law and Policy Clinic and drawn from Taubes’ new book, “The Case Against Sugar.”

A reputation for “empty calories” — devoid of vitamins and nutrients but otherwise no different from other foods containing an equal number of calories — has allowed sugar to maintain a prominent place in the U.S. diet. Taubes is dubious. First, all calories are not equal because the body metabolizes different foods in different ways. More specifically, there may be something about eating too much sugar — in particular fructose, which is metabolized in the liver — that implicates it in metabolic disease.

“I’m making an argument that sugar is uniquely toxic,” said Taubes. “It has deleterious effects on the human body that lead to obesity and diabetes.”

 

sources

Cocoa for pleasure, being young and healthy | Study on benefits of savory powder

Cocoa for pleasure, being young and healthy | Massive study will try to determine benefits of much-loved, savory powder

 

“Cocoa flavanols appear to be very promising for reducing the risk of cardiovascular disease and memory loss, cognitive decline,” said JoAnn Manson, co-principal investigator of the study, Michael and Lee Bell Professor of Women’s Health at Harvard Medical School, and chief of the Division of Preventive Medicine at Brigham and Women’s Hospital (BWH). “But the evidence to date has been inconclusive. Most of the randomized trials previously done have been smaller in size, suggesting there may be favorable effects on cardiovascular disease risk factors, including lowering blood pressure, improving blood flow and dilation of blood vessels, decreasing inflammation, and maybe improving insulin sensitivity and the ability to metabolize glucose.”

 

 

The bad news for chocoholics, however, is that though cocoa is a key ingredient, variations in processing methods make chocolate an unreliable source of flavanols, Manson said. Chocolate also typically contains enough fat, sugar, and calories that, however the trial turns out, it’s unlikely to result in prescriptions to eat more chocolate, though capsules or beverages high in cocoa flavanols are possible, Manson said.

“The results of the COSMOS trial would not lead to a clinical recommendation to eat more chocolate, though it might provide more incentive for people to enjoy chocolate as a treat,” Manson said.

Harvard Medical School researchers look at cocoa for health

harvard researchers plot early attack against alzheimers

harvard researchers plot early attack against alzheimers

Plotting the demise of Alzheimer’s
New study is major test for power of early action

The Harvard Aging Brain Study, a National Institute on Aging-backed project now in its seventh year, has shown that amyloid beta, the protein thought to cause Alzheimer’s, accumulates in the brain a decade or more before symptoms occur. That finding has given new hope to researchers struggling to move beyond a rash of high-profile Alzheimer’s failures in clinical drug trials. In February, just three months after Eli Lilly & Co. announced a trial failure, drug maker Merck & Co. halted a study. Several additional drugs are still in trials, but researchers are reconsidering their approach and wondering whether the problem is in trying to reverse, rather than prevent, dementia.

Now, the “catch it early” idea is being put to the test in a new study called A4, or Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease, led by Sperling and the University of Southern California’s Paul Aisen. Researchers will try an anti-amyloid drug on people who show no signs of cognitive decline, but who do have abnormally high levels of amyloid beta in their brains.

 

Read more on the source

 

 

Harvard scientists find Compound protects nerve cells targeted by diseases

Harvard scientists find Compound protects nerve cells targeted by diseases

Caption: SMN protein (red) is necessary for the survival of spinal cord neurons (motor neurons) responsible for breathing and all movement. Harvard researchers have found a compound that stabilized this protein in mouse and human motor neurons. This may lead to the development of new treatments for motor neuron diseases including Spinal Muscular Atrophy and Lou Gehrig’s disease.
Credit to Natalia Rodriguez- Muela.

Harvard scientists find evidence that ALS and SMA could be treated with a common drug

Harvard Stem Cell Institute (HSCI) researchers have identified a compound that helps protect the cells destroyed by spinal muscular atrophy (SMA), the most frequent fatal genetic disease in children under 2 years of age.

SMA is a neurodegenerative disease targeting motor neurons, the long nerve cells that relay messages from the brain to the muscles and that are, consequently, responsible for bodily movements, including walking, swallowing, and even breathing. Patients with milder forms of SMA experience muscle wasting that may confine them to a wheelchair, while the more severe forms cause paralysis and death before the second birthday.

The findings were published in the journal Cell Reports.

“This discovery opens up new lines of drug interrogation,” said Lee Rubin, HSCI principal faculty member and the senior author on the study. Rubin’s lab, which operates out of in Harvard’s Department of Stem Cell and Regenerative Biology, uses induced pluripotent stem cells (iPS cells) to make human models of neurological diseases.

This work was supported by the SMA Foundation, National Institute of Neurological Disorders and Stroke grant P01 NS066888, National Institutes of Health grants NS045523 and NS075672, Massachusetts Spinal Cord Injury Research Trust, and the Harvard Stem Cell Institute.

 

 

Read the full article on source

 

 

 

How old can we get? Does our cells know that? Harvard scientists

How old can we get? Does our cells know that?

 


Harvard scientists:

When it comes to aging, certain tissue types seem to lead the charge, according to Professor of Stem Cell and Regenerative Biology Lee Rubin, who directs the Harvard Stem Cell Institute’s Therapeutic Screening Center. Particular tissues — nerve cells appear to be one — somehow signal to others that it’s time to age. This raises the prospect, Rubin said, that aging might be reversed by treating these key tissue categories, rather than designing individual treatments for the myriad tissue types that make up the body.

In addition to key tissues, certain chemical pathways — like insulin signaling —seem to be able to control aging, said Rubin, whose work has received backing from the National Institute of Neurological Disorders and Stroke, as well as private foundations. The insulin signaling pathway is a chemical chain reaction in which the hormone insulin helps the body metabolize glucose. Reducing it has been shown to greatly extend life span in flies and worms, Rubin said. Also, signaling doesn’t have to be reduced in all tissues.

Researchers have identified but not yet confirmed candidate blood factors for the rejuvenating effects. What seems not in doubt is the overall effect of the young blood on the old mouse. Interest is intense enough that a California company, Alkahest, has begun experiments giving Alzheimer’s patients plasma from young blood in hopes of improving cognition and brain function.

Even if that approach works, Rubin said, there would be practical hurdles to the widespread administration of young people’s blood plasma to older patients. But with an active compound identified, a drug could be made available to restore at least some cognitive function in Alzheimer’s patients.

 

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Balance in aging | Tai chi can help

The balance in aging, how tai chi can be helping you stay healthier while aging

To grow old well requires minimizing accidents

“Tai chi calms me down and has lowered my blood pressure,”

 

Fourth in an occasional series on how Harvard researchers are tackling the problematic issues of aging.

The morning light is pouring into the senior living community in Canton, where six residents are performing an exquisite choreography of sweeping, lyrical movements, emulating their Tai chi instructor.

“Wave hands like clouds,” urges Kerry Paulhus, leading them in the classic low-impact and slow-motion exercises of the ancient Chinese martial art. With relaxing music playing in the background, the students shift their weight from one leg to the other, turn their waists, and rotate their arms as if they indeed were clouds.

 

When class ended, Elaine Seidenberg and Fran Rogovin, both 84 and close friends for four years, were glowing.

“Tai chi calms me down and has lowered my blood pressure,” said Rogovin at Orchard Cove, a facility that is part of Hebrew SeniorLife. “It’s just amazing what Tai chi has done for me.”

 

read more on source

Grilled or microwaved mushrooms may be more healthier than eating it raw

Grilled or microwaved mushrooms may be more healthier than eating it raw

The results, published in the International Journal of Food Sciences and Nutrition, revealed that frying induced more severe losses in protein, ash, and carbohydrates content but increased the fat and energy.

Boiling improved the total glucans content by enhancing the betaglucans fraction.

A significant decrease was detected in the antioxidant activity especially after boiling and frying, while grilled and microwaved mushrooms reached higher values of antioxidant activity.

“Frying and boiling treatments produced more severe losses in proteins and antioxidants compounds, probably due to the leaching of soluble substances in the water or in the oil, which may significantly influence the nutritional value of the final product” said Irene Roncero from Mushroom Technological Research Center of La Rioja (CTICH) in Spain.

Conversely, when mushrooms were grilled or microwaved, “the content of polyphenol and antioxidant activity increased significantly, and there are no significant losses in nutritional value of the cooked mushrooms”, Roncero added.

Further, adding a little oil portion while grilling mushrooms is not a problem, the researchers observed.

“A minimal amount will not cause nutrient loses by leaching; in fact, the antioxidant capacity can be even improved. Moreover, if olive oil is used, the fatty acid profile of the final preparation is enhanced with barely increase in the calorie content,” Roncero said.

(source)

China’s demand for Antioxidants Market

China’s demand for Antioxidants Market

China’s demand for Antioxidants Market has grown at a fast pace in the past decade. In the next decade, both production and demand will continue to grow for this Antioxidants Market. The Chinese economy maintains a high speed growth which has been stimulated by the consecutive increases of industrial output, import & export, consumer consumption and capital investment for over two decades. This new study of Antioxidants market examines China’s economic trends, investment environment, industry development, supply and demand, industry capacity, industry structure, marketing channels and major industry participants. Historical data (2006, 2011 and 2016) and long-term forecasts through 2021 and 2026 are presented. (source)

Oolong, black or green | which tea is for what?

Oolong, black or green | which tea is for what?

1) Black tea: Black tea is rarely mentioned in the context of tea’s health benefits but it is rich in antioxidants, improves oral health, boosts weight loss and even brings down stress levels. Also being an oxidised tea, it is known for having anti-inflammatory, anti-oxidant properties that help control levels of bad cholesterol in the body, improve bone density, mitigate cardiovascular ailments and promote wellness.

2) Green tea: Being a storehouse of many antioxidant compounds, it’s easy to assume that green tea is one of the healthiest beverages. read all about green tea here.

3) Oolong tea:  Weight management: Oolong tea promotes fat metabolism (pushing the body to burn fat for energy), and blocks the absorption of excess fat and cholesterol. Regular consumption of oolong tea can actually boost your weight loss.

 

Is chocolate (cocoa) good or bad for health?

Is chocolate (cocoa) good or bad for health?

Research has even backed up some of the more bizarre health benefits that have been ascribed to cocoa. The Mayans used chocolate powder to relieve the runs, and in the last decade, researchers have identified possible diarrhea-blocking chemicals in chocolate. But as for prescribing cocoa to combat syphilis sores, Victorian-era doctors probably missed the mark.

(Chocolate) is a good antioxidant. It has a good effect on inflammation. We think most of the beneficial effects are because of this,” said Dr. Owais Khawaja, a cardiology fellow at St. Vincent Mercy Medical Center in Toledo, Ohio. These benefits might include reducing the risk of cancer and dementia, Khawaja said.

However, not all chocolate is created equal. The antioxidant and anti-inflammatory power of chocolate is thought to come from a class of plant nutrients found in cocoa beans called flavonoids. Dark chocolate has more of these than milk chocolate, and white chocolate — which does not actually contain chocolate — is not a good source of flavonoids.

Even a chocolate bar that is 70% cocoa, generally considered dark chocolate, can have varying levels of flavonoid compounds, depending on how it was processed. For example, chocolate that has gone through a chemical step known as dutching, also known as Dutch chocolate, has essentially lost all traces of these compounds.

(source)

Mushrooms should be microwaved to seal in goodness

Mushrooms should be microwaved to seal in goodness, scientists say

The study suggests that cooking the fungi that way enables them to maintain their high levels of essential amino acids and vitamins to keep blood cells healthy, produce energy and help metabolise fats and proteins.

 

Microwaving increases the content of anti-inflamatory and antioxidants like polyphenol while other techniques like boiling or deep frying sees antioxidant levels plummet due to “leeching” from the liquid they are cooked in.  Mushrooms contain a high protein content and provides vitamins B1, B2, B12, C, D and E as well as minerals such as zinc and selenium. They are also an important source of biologically active compounds with potential medicinal value such as betaglucans, which reduces the risk of heart disease.  Ms Roncero and her team tested white button mushroom, shiitake, oyster and king oyster mushrooms harvested from onsite facilities in La Rioja, Spain.

(Source)

 

Exercise and Aging | Intense exercise can stop or slow down Aging

Exercise and Aging | Intense exercise can stop or slow down Aging

Before we start….. Exercise is the Most important thing we can do against aging. read more.

How exercise slows down aging?

  • Exercise Increases Brain plasticity and memory that leads to better learning
  • Exercise Increases brain BDNF
  • Exercise Boosts and improves cardiovascular system 
  • Exercise creates inflammations that makes body boost immune system
  • Exercise triggers body production of growth Hormone
  • Exercise triggers body sweat system 
  • Exercise fights obesity 
  • Triggers production of new brain cells

 

Research in progress

 

Main question on exercise-aging relation:

Before going into details of how exercise can actually improve your body we should have  and understand some questions:

 

  • Why do we HAVE TO exercise?
  • Do you know what it means that cells in our body and specially our brain Age?
  • Does our body make new cells everywhere? even in brain?
  • When does aging stats?
  • Do you know Why our body operates the way it does and how can it affect our modern lifestyle?
  • Does aging happen in brain or skin or all of our body?
  • If we are perceiving the world in our brain shouldn’t we really care about protecting it from getting old?

 

First Aging starts From 15 to 20 so take this seriously. If you are in your 20s, you are already there.

We are based on our needs. All body structure and how it functions is designed or evolved based on its needs. if we did not need a hand we would not have one or hair or nose. The structure of our body is designed to get stronger and grow under pressure of need. fear is one of the strongest tools in nature that makes animals shape the way they are.

Telomeres that are the tiny caps found on the end of DNA strands, like plastic aglets on shoelaces. They are believed to protect the DNA from damage during cell division and replication. As a cell ages, its telomeres naturally shorten and fray. our modern lifestyle expedites that things like smoking or bad foods or obesity all contribute hugely to expediting that process.

In our original lifestyle we used to run to hunt or escape, for food and staying alive and keep living. our cells and DNA knows why they are shaped the way they are. Actually exercise and intense physical activity has been an integral part of our lives in the past. and our structure is shaped based on that.

If we dont use part of our body it starts weakening to its minimum. Imaging your muscles if you dont use a specific muscle it weakens even if you are an athlete if you stop the pressure after a while you see that because your muscle is not under pressure it loosens up and weakens. after one or two years you are nothing like your old body  and that strong part is the weakest. you did nothing and that is the exact problem. doing nothing with your body for your DNA means you dont need it. so it gets rid of it. It can not get rid of it in one generation but weakens it as its possible. and eventually gets rid of it if you pass enough generations.

Remember it should be intense and/or long. The high intensity and long time is what makes the difference and makes your body to fight aging.  

High intensity exercise is a strong signal to all cells involved specially your brain to work and grow and get stronger.Also long time can do it in another way for sure a 40 min session is much better and more effective than a 10 min session. you body feels like its running out of resources and power. They are all feeling fear and that is what is running them forward. Because that is how our body made to survive if it feels loos for a long time it means aging and slow death.

 

 

Aging In our brain and memory vs exercise | Can you grow new brain cells?

The science of neurogenesis suggests it’s possible to create neurons that improve your memory and thinking skills.(source)  For example in relation of AHN and exercise in a study Named: Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained  done by Miriam S. Nokia, Department of Psychology, University of Jyväskylä, Finland. On Exercise and AHN it was found that: Adult hippocampal neurogenesis is a continuous process that contributes to a variety of adaptive behaviours, such as learning (for review, see Aimone et al. 2014). A well-demonstrated means of promoting AHN in rodents is aerobic exercise, namely running (van Praag et al. 1999). High-intensity interval training had a smaller than expected effect on AHN. Resistance training does not promote AHN.

In accordance with several previous reports on the beneficial effects of running on AHN and cognition in rodents (for a review, see Vivar et al. 2013), in our present study forced endurance training on a treadmill as well as voluntary running in a running wheel led to a higher number of immature adult-born hippocampal neurons compared with that observed in animals not engaged in aerobic exercise. Furthermore, we found that daily voluntary running on a running wheel increased AHN considerably more than 30 min of forced endurance training on a treadmill three times a week. The correlation between running distance and AHN might be explained by considering the consequences of running (in a more naturalistic setting). The further an individual travels, the more likely it is to encounter new environments and stimuli from which it must make sense rapidly.

 

 

Finally in the  Conclusion it is mentioned that: Sustained aerobic exercise increases AHN and advances this field of study in several ways. First, we tested several different forms of physical exercise to study their effects on AHN. We also took advantage of a newly developed genetically heterogeneous contrasting rat model system that we selectively bred for low and high response to aerobic training to take into account genetic variation in training responsiveness. According to our findings, anaerobic resistance training does not affect AHN in the studied animals, despite its overall positive effects on physical fitness. Second, the effects of exercise on AHN depend, at least to some extent, on sustained aerobic activity, as HIT did not have statistically significant effect on AHN. Third, the highest numbers of adult-born hippocampal neurons were observed in rats selectively bred for a high response to aerobic exercise that ran voluntarily on running wheels. Thus, for all reasons combined, AHN is highest in animals born with a tendency for a higher response to exercise training ,engaging in a large amount of voluntary aerobic activity. (source)

 

 

Why and how physical activity promotes experience-induced brain plasticity is also another important study done by  Gerd Kempermann , from Center for Regenerative Therapies Dresden, German Research Foundation, Dresden, Germany.

In animals, most if not all aspects of cognition are inseparable from locomotion and physical activity. Exploration, spatial navigation, and most types of learning accessible in a rodent are based on its movement in the outer world. Search for food, shelter, and mates are physical activities, requiring mental input to be successful on both a phylogenetic and ontogenetic scale. Consequently, the fact that running induces neurogenesis will be less counterintuitive if one appreciates physical activity as a basis for cognition. An important question is, whether this association is preserved in humans. Physical activity would be an intrinsic behavior-based signal to the brain (and hippocampus) implying that the likelihood of cognitive challenge is increased. In addition, one could speculate that running long distances increases the chance to encounter new environments increasing the need for spatial orientation and memory like wild animals that need to find the way back to their safe shelter. (source)

 

 

 

Brain BDNF (Brain plasticity) and Exercise

What is brain plasticity? Neuroplasticity – or brain plasticity – is the ability of the brain to modify its connections or re-wire itself. Without this ability, any brain, not just the human brain, would be unable to develop from infancy through to adulthood or recover from brain injury.

What is  BDNF?   The BDNF gene provides instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells. In the brain, the BDNF protein is active at the connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience, a characteristic called synaptic plasticity. The BDNF protein helps regulate synaptic plasticity, which is important for learning and memory.

The BDNF protein is found in regions of the brain that control eating, drinking, and body weight; the protein likely contributes to the management of these functions.

Pushup for both your muscles and your brain.

 

How To Increase BDNF (Brain-Derived Neutrophic Factor)

Increase your BDNF , there are some specific ways this can be done. It should also be noted that many methods that increase BDNF simultaneously increase neurogenesis.

 

 

1. Intense Exercise

Yes, Intense Exercise is number 1. If you don’t exercise much, your brain may not be producing sufficient BDNF. To increase it, you’ll want to engage in an intense exercise; the greater the intensity, the more likely BDNF production will increase. It has also been suggested that the more frequently you engage in high intensity exercise, the greater the production. Most specifically, aerobic exercise within the 60% to 75% of your max heart rate should be maintained for approximately 30 minutes. Don’t expect a huge boost in BDNF after just one gym session.

(Source: http://www.ncbi.nlm.nih.gov/pubmed/21282661  –  http://www.ncbi.nlm.nih.gov/pubmed/21722657)

 

2. Intermittent Fasting or Caloric Restriction

3. Dietary modifications

4. Sunlight (Vitamin D)

5. Supplements

6. Lose weight

7. Certain drugs

8. Social Enrichment

 

 

 

How exercise and aging muscles relations are?

Basically we have 4 main types of exercise:

1.Endurance

Endurance, or aerobic, activities increase your breathing and heart rate. They keep your heart, lungs, and circulatory system healthy and improve your overall fitness. Building your endurance makes it easier to carry out many of your everyday activities.

Brisk walking or jogging
Yard work (mowing, raking, digging)
Dancing
Strength

 

2. Strength exercises

Strength exercises make your muscles stronger. Even small increases in strength can make a big difference in your ability to stay independent and carry out everyday activities, such as climbing stairs and carrying groceries. These exercises also are called “strength training” or “resistance training.”

Lifting weights
Using a resistance band
Using your own body weight
Balance

 

3. Balance exercises

Balance exercises help prevent falls, a common problem in older adults. Many lower-body strength exercises also will improve your balance.

Standing on one foot
Heel-to-toe walk
Tai Chi
Flexibility

 

4. Flexibility exercises

Flexibility exercises stretch your muscles and can help your body stay limber. Being flexible gives you more freedom of movement for other exercises as well as for your everyday activities.

Shoulder and upper arm stretch
Calf stretch
Yoga

 

Almost any amount and type of physical activity may slow aging deep within our cells, a new study finds. And middle age may be a critical time to get the process rolling, at least by one common measure of cell aging. But a recent study from Cell Metabolism discovered that certain forms of exercise may increase muscle mass and mitochondrial density, particularly with people 64 and over.Not surprisingly, resistance training increased muscle mass and strength for all subjects. And cardio HIIT (high intensity interval training) improved the age-related decline in mitochondria.

For those of us who don’t know every portion of our cells’ interiors, telomeres are tiny caps found on the end of DNA strands, like plastic aglets on shoelaces. They are believed to protect the DNA from damage during cell division and replication. As a cell ages, its telomeres naturally shorten and fray. But the process can be accelerated by obesity, smoking, insomnia, diabetes and other aspects of health and lifestyle as we have talked about in all of our articles. In those cases, the affected cells age prematurely.

Exercise may slow the fraying of telomeres. Past studies have found, for instance, that master athletes typically have longer telomeres than sedentary people of the same age, as do older women who frequently walk or engage in other fairly moderate exercise.

But those studies were relatively narrow, focusing mostly on elderly people who ran or walked. It remained unclear whether people of different ages who engaged in a variety of exercises would likewise show effects on their telomeres.

So for the new study, which was published this month in Medicine & Science in Sports & Exercise, researchers from the University of Mississippi and University of California, San Francisco, decided to look more broadly at the interactions of exercise and telomeres among a wide swath of Americans.

 

 

Exercise And Ageing, Exercise Is The Key To Keep Your Body Young

Ageing is a natural part of life. Face it. As soon as you hit your twenties, you notice changes in your body that are clear signs of ageing. However, people age differently and you want to be one of those people who looks and feels younger than they actually are. You want to be as healthy and strong as you possibly can be so you can still enjoy life even in your later years.

Let’s take a look at how exercise can help you keep your body young.

As you get older, your heart muscle becomes less efficient. It works harder to pump the same amount of blood to your organs. Blood vessels also tend to lose their elasticity and hardened fatty deposits may make the supply of blood even harder. This can be avoided by eating a healthy diet with limited saturated fats, a lot of lean protein and vegetables. Consistent daily exercise will also go a long way in delaying the onset of such problems.

 

Exercise and Aging

 

One of the features of a young body is its ability to move fluidly. As you age, your bones decrease in size and density. It is even said that you lose a total of 2 inches as you grow older. Less dense bones make them prone to fracture. Muscles, joints and tendons also generally lose strength and flexibility as you get older. When you regularly exercise, your body gets used to physical activity and tries to keep up. Include weight training in your exercise regiment to keep your bones strong and your joints fluid. Proper diet will also go a long way to helping with this.

 

Exercise and Aging

 

 

Exercise the release of brain-derived neurotrophic factor (BDNF). Exercise causes a beneficial response in the brain and an increase of BDFN, which is a trophic factor which is linked to cognitive improvement and the alleviation of anxiety and depression. The levels of this protein have been found to increase after exercise. You may already have experienced this before when in an anxious state. Exercise seems to alleviate the anxiety and make you have clearer thoughts. As you get older, your mental sharpness decreases slowly. You can delay this through regular exercise from a young age.

As you get older, maintaining a healthy weight or losing weight becomes even more difficult. Given that most people tend to go into a sedentary lifestyle as they age, it may seem almost impossible. Your metabolism also slows down, meaning that you burn fewer calories. The best remedy for this is maintaining a consistent workout schedule consisting of strength and cardio workouts at least 3 times a week. This ill help you increase your ratio of lean muscle to fat. Being overweight naturally, makes you look and feel older than you actually are. You may feel like you are hurling around a heavy body everywhere you go.

Exercise and nutrition go hand in hand when considering slowing down the ageing process. One cannot do without the other.

 

 

 

Online Sources for exercise and aging:

http://onlinelibrary.wiley.com/doi/10.1113/JP271552/full

https://well.blogs.nytimes.com/2015/10/28/does-exercise-slow-the-aging-process/

mentalhealthdaily.com/2015/03/30/8-ways-to-increase-bdnf-levels-brain-derived-neurotrophic-factor/

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