Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

MORINGA, antioxidant benefits, Uses, Side Effects & Interactions

Other Names of  MORINGA: Arango, Árbol de las Perlas, Behen, Ben Ailé, Ben Nut Tree, Ben Oléifère, Benzolive, Canéficier de l’Inde, Chinto Borrego, Clarifier Tree, Drumstick Tree,…

Research in progress 

 

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant

Moringa Oleifera has been hailed since time immemorial for its immense health benefits. The plant is native to Africa and many consider it the tree of life. It is also very common in Asia as it is widely used in Ayurvedic medicine. It contains a significant number of proteins, essential vitamins, and minerals making it common not only from a nutritional point of view but also in the cosmetics industry due to its powerful antioxidants.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Although Moringa has several benefits, we are going to narrow in on its antioxidant and anti-ageing properties.

Antioxidant effects of Moringa

Moringa has been found to contain about 47 antioxidants including phenolic acid, flavonoid/bioflavonoids, and tannic acid. Experiments have been carried out on different parts of the Moringa tree to identify what parts have more Polyphenol antioxidant benefits. In one study, It was found that all extracts acted as radical scavengers due to the presence of the polyphenolic compound. It was also found that the flowers possessed the highest antioxidant properties, followed closely by the leaf, root, gum bark and finally the seed.
What these strong antioxidants do is they help neutralize free radicals(oxidative damage). Free radicals are produced as by-products of normal body processes, medicine break-down after consumption and as a result of exposure to pollutants. Moringa is known as one of the most effective of antioxidant foods.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Anti-aging properties of Moringa

The cosmetics industry heavily relies on Moringa as a natural supplement to try and slow down the aging process. Moringa contains a plant hormone called zeatin, which affects the process of cell division, influencing aging. Moringa is the only known plant to contain such high levels of Zeatin.

APPLIED TO THE SKIN for:
Athlete’s foot.
Dandruff.
Warts.
Skin infections.
Snakebites.
Gum disease (gingivitis).
Other conditions.
Progeria is a disease in which a person ages rapidly at a much faster rate than normal. It afflicts people whose bodies cannot manufacture and/or utilize antioxidants. Moringa contains high levels of vitamin C, which helps with the synthesis of collagen. When the level of collagen is low, the skin collapses to take up the free space, causing wrinkles, which are a tell-tale sign of aging.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

The anti-aging properties of Moringa do not only apply to the skin. It has been known to decrease brain aging and cognition decline. The plant is a memory booster, helping with concentration, focus, and clarity. This is by virtue of its B vitamins, but also notably, the high concentration of Iron which allows for more oxygenated blood flow to the brain.

All this information should be enough to convince you to include Moringa, in your diet. You may either take it in its natural form or as a Moringa supplement. Moringa’s antioxidant properties can also help prevent and manage certain diseases such as cancer and cardiovascular disease which stem from the overproduction of free radicals in the body. In a world where pollution is rampant, intake of antioxidant super foods is a safe bet to prevent diseases.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Moringa is your best choice as it is effective, safe, naturally occurring and affordable.

 

Moringa is used to improve “tired blood” (anemia); arthritis and other joint pain (rheumatism); asthma; cancer; constipation; diabetes; diarrhea; epilepsy; stomach pain; stomach and intestinal ulcers; intestinal spasms; headache; heart problems; high blood pressure; kidney stones; fluid retention; thyroid disorders; and bacterial, fungal, viral, and parasitic infections. Moringa is also used to reduce swelling, increase sex drive (as an aphrodisiac), prevent pregnancy, boost the immune system, and increase breast milk production.

So get Moringa for :

 

 

 

 

 

Reference and resources:

sources link , Reference for more research on MORINGA:

draxe.com
webmd.com
drweil.com
examine.com
ods.od.nih.gov

http://www.webmd.com/vitamins-supplements/ingredientmono-1242-moringa.aspx?activeingredientid=1242

 

Antioxidants Benefits & Effects of Polyphenols, Phenolic Acid

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

Flavones Flavonols Flavanones Isoflavones Anthocyanidins Chalcones, Catechins,Stilbenes

Research in progress

 

About Polyphenol, Phenolic acids:

A phenolic acid is a sort of phytochemical known as a polyphenol. Phenolic acids are found in an assortment of plant-based nourishments such as the seeds and skins of products of the soil leaves of vegetables contain the most noteworthy concentration. Phenolic acids are promptly consumed through the dividers of your intestinal tract, and they might be valuable to your wellbeing since they fill in as cancer prevention agents that counteract cell harm because of free-radical oxidation responses. The Polyphenol phenolic acid supplements may likewise work as anti inflammatory in the human body. It strongly supports a role for polyphenols in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanisms of action of polyphenols go beyond the modulation of oxidative stress. Polyphenols are the most abundant antioxidants in the diet. Their total dietary intake could be as high as 1 g/d, which is much higher than that of all other classes of phytochemicals and known dietary antioxidants.

 

 

 

 

 

Ranking list of top foods list with Polyphenols (Phenolic Acid)

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

Top foods list with Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects

Different Types of Polyphenols

Polyphenols are four main categories, with additional sub-groupings. based on the number of phenol rings they contain, and on the basis of structural elements in their construction.

As a general rule, foods contain complex mixtures of polyphenols, with higher levels found in the outer layers of the plants than the inner parts.

 

1- Flavonoids,  have Strong both antioxidant and anti-inflammatory properties, found in fruits, vegetables, legumes, red wine, and green tea
      Flavones
      Flavonols
      Flavanones
      Isoflavones
      Anthocyanidins
      Chalcones
      Catechins
2- Stilbenes, found in red wine and peanuts (resveratrol is the most well known)
3- Lignans, found in seeds like flax, legumes, cereals, grains, fruits, algae, and certain vegetables
4- Phenolic acids
Hydroxybenzoic acids, found in tea
Hydroxycinnamic acids found in cinnamon of course but also in coffee, blueberries, kiwis, plums, apples, and cherries

 

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

 

Polyphenols are usually associated with/ improving:

  • Fighting cancer cells and inhibiting angiogenesis (the growth of blood vessels that feed a tumor)
  • Protecting your skin against ultraviolet radiation
  • Fighting free radicals
  • reducing the appearance of aging
  • Promoting brain health
  • protecting against dementia
  • Reducing inflammation
  • Supporting normal blood sugar levels
  • Protecting your cardiovascular system
  • Promoting normal blood pressure

 

Polyphenols work effective for :

 

 

 

Antioxidants effects & Benefits of Phenolic acids:

• Anti-Diabetic Effects of  Polyphenols

Numerous studies report the antidiabetic effects of polyphenols. Tea catechins have been investigated for their anti-diabetic potential.63,64 Polyphenols may affect glycemia through different mechanisms, including the inhibition of glucose absorption in the gut or of its uptake by peripheral tissues.Onion polyphenols, especially quercetin is known to possess strong anti diabetic activity. A recent study shows that quercetin has ability to protect the alterations in diabetic patients during oxidative stress. Quercetin significantly protected the lipid peroxidation and inhibition antioxidant system in diabetics. (source)

Cranberry Strong Antioxidant Effects

 

• Used as Anti bacterial:

Bacteria are collection of single cell microorganisms. Most microorganisms are innocuous in people because of the defensive impacts of the immune framework. Notwithstanding, a few microscopic organisms are perilous and can bring about irresistible maladies. Luckily, phenol acids are effective antibacterials and can help guard you from perilous microorganisms. Temporary reviews recommend that phenolic acid may likewise have antibacterial properties however additional confirmation is required before this can be affirmed. (source)

 Sage, just a mint or strong antioxidants and Anti-Inflammatory

• Anti-Aging Effect

Aging is the accumulation process of diverse detrimental changes in the cells and tissues with advancing age, resulting in an increase in the risks of disease and death. Among many theories purposed for the explaining the mechanism of aging, free radical/oxidative stress theory is one of the most accepted one. Antioxidant capacity of the plasma is related to dietary intake of antioxidants; it has been found that the intake of antioxidant rich diet is effective in reducing the deleterious effects of aging and behavior. Several researches suggest that the combination of antioxidant/anti-inflammatory polyphenolic compounds found in fruits and vegetables may show efficacy as anti-aging compounds. Subset of the flavonoids known as anthocyanins, are particularly abundant in brightly colored fruits such as berry fruits and concord grapes and grape seeds.  (source)

• Reduces inflammation:

Inflammation is the body’s method for managing disease, harm, aggravation or stress. It prompts warm, torment, redness or swelling around the influenced body part. Most inflammation is sure as it demonstrates that the body has recognized a risk and is endeavoring to manage the issue. In any case, some inflammation is superfluous and harms the body’s cells when there is no contamination, damage, bothering or worry to manage. Luckily, the phenolic acids can help monitor pointless inflammation. The strong antioxidants of phenolic acids are powerful against inflammation. (source)

Ranking list of top foods list with Polyphenols (Phenolic Acid)

• Antioxidant effects of Polyphenol, phenolic acid on cancer:

Antioxidants are substances that protect a human body’s cells from free radicals. Free radicals are destructive substances that are discharged into the body amid oxygen based responses. They have been connected with serious disease such as cancer, diabetes, a weak invulnerable system along with noticeable indications of maturing. Luckily, the greater parts of the phenolic acids aside from “capsaicin” are intense cancer prevention agents that can guard you from the antagonistic impacts related with free radicals. Several mechanisms of action have been identified for chemoprevention effect of polyphenols, these include estrogenic/antiestrogenic activity, antiproliferation, induction of cell cycle arrest or apoptosis, prevention of oxidation, induction of detoxification enzymes, regulation of the host immune system, anti-inflammatory activity and changes in cellular signaling

Ranking list of top foods list with Polyphenols (Phenolic Acid)

 

• Neuro-Protective Effects and Mental health boosters:

The phenolic acids have a considerable measure of potential with regards to boosting the emotional wellbeing. Early research proposes that phenolic acids may go about as an energizer and furthermore it prevents the Alzheimer’s disease. What’s more, they may likewise ensure against Alzheimer’s malady while vanillin may shield the cerebrum cells from harm, prevents Alzheimer’s infection and Parkinson’s ailment. In any case, additionally studies are required before the impacts of the phenolic acids on brain health are affirmed. Oxidative stress and damage to brain macromolecules is an important process in neurodegenerative diseases. Alzheimer’s disease is one of the most common occurring neurodisorder affecting up to 18 million people worldwide. Because polyphenols are highly antioxidative in nature, their consumption may provide protection in neurological diseases. It was observed that the people drinking three to four glasses of wine (vines that have Polyphenol contents) per day had 80% decreased incidence of dementia and Alzheimer’s disease compared to those who drank less or did not drink at all. (source)

 

Green Tea, Antioxidant effects and benefits

Polyphenol Supplements interactions

These mostly happen with supplements not the foods containing Polyphenol

  • Iron depletion in populations of people who have marginal iron stores
  • Interference with thyroid hormone metabolism
  • Interactions with pharmaceutical drugs, enhancing their biologic effects

 

 

 

 

 

 

 

 

 

References and sources for Polyphenols online:

http://www.nature.com/ejcn/journal/v64/n3s/fig_tab/ejcn2010221t1.html

http://articles.mercola.com/sites/articles/archive/2015/12/14/polyphenols-benefits.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/

https://en.wikipedia.org/wiki/Antioxidant_effect_of_polyphenols_and_natural_phenols

http://ajcn.nutrition.org/content/81/1/215S.full

 

 

Published papers and articles  and References for Polyphenols

1. Scalbert A, Manach C, Morand C, Remesy C. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005;45:287–306. [PubMed]
2. Spencer JP, Abd El Mohsen MM, Minihane AM, Mathers JC. Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr. 2008;99:12–22. [PubMed]
3. Beckman CH. Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants? Physiol. Mol. Plant Pathol. 2000;57:101–110.
4. Graf BA, Milbury PE, Blumberg JB. Flavonols, flavonones, flavanones and human health: Epidemological evidence. J Med Food. 2005;8:281–290. [PubMed]
5. Arts ICW, Hollman PCH. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005;81:317–325. [PubMed]
6. Kondratyuk TP, Pezzuto JM. Natural Product Polyphenols of Relevance to Human Health. Pharm Biol. 2004;42:46–63.
7. Shahidi F, Naczk M. Food phenolics, sources, chemistry, effects, applications. Lancaster, PA: Technomic Publishing Co Inc; 1995.
8. de Groot H, Rauen U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharmacol. 1998;12:249–255. [PubMed]
9. Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med. 1997;29:95–120. [PubMed]
10. Wink M. Compartmentation of secondary metabolites and xenobiotics in plant vacuoles. Adv Bot Res. 1997;25:141–169.
11. Simon BF, Perez-Ilzarbe J, Hernandez T, Gomez-Cordoves C, Estrella I. Importance of phenolic compounds for the characterization of fruit juices. J Agric Food Sci. 1992;40:1531–1535.
12. Manach C, Scalbert A, Morand C, Rémésy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79:727–747. [PubMed]
13. Parr AJ, Bolwell GP. Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenol content or profile. J Agric Food Chem. 2000;80:985–1012.
14. Sosulski FW, Krygier K, Hogge L. Importance of phenolic compounds for the characterization of fruit juices. J Agric Food Chem. 1982;30:337–340.
15. Price KR, Bacon JR, Rhodes MJC. Effect of storage and domestic processing on the content and composition of flavonol glucosides in onion (Allium cepa) J Agric Food Chem. 1997;45:938–942.
16. Crozier A, Lean MEJ, McDonald MS, Black C. Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. J Agric Food Chem. 1997;45:590–595.
17. D’Archivio M, Filesi C, Benedetto RD, Gargiulo R, Giovannini C, Masella R. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanità 2007;43:348–361. [PubMed]
18. Day AJ, Williamson G. Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma. Br J Nutr. 2001;86:S105–S110. [PubMed]
19. Setchell KD, Faughnan MS, Avades T, Zimmer-Nechemias L, Brown NM, et al. Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. Am J Clin Nutr. 2003;77:411–419. [PubMed]
20. Duthie GG, Pedersen MW, Gardner PT, Morrice PC, Jenkinson AM, McPhail DB, Steele GM. The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur J Clin Nutr. 1998;52:733–736. [PubMed]
21. Young JF, Nielsen SE, Haraldsdóttir J, Daneshvar B, Lauridsen ST, Knuthsen P, Crozier A, Sandström B, Dragsted LO. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr. 1999;69:87–94. [PubMed]
22. Gee JM, DuPont MS, Rhodes MJ, Johnson IT. Quercetin glucosides interact with the intestinal glucose transport pathway. Free Radic Biol Med. 1998;25:19–25. [PubMed]
23. Crespy V, Morand C, Besson C, Manach C, Demigne C, Remesy C. Quercetin, but not its glycosides, is absorbed from the rat stomach. J Agric Food Chem. 2002;50:618–621. [PubMed]
24. Passamonti S, Vrhovsek U, Vanzo A, Mattivi F. Fast access of some grape pigments to the brain. J Agric Food Chem. 2005;53:7029–7034. [PubMed]
25. Halliwell B, Zhao K, Whiteman M. The gastrointestinal tract: a major site of antioxidant action? Free Radic Res. 2000;33:819–830. [PubMed]
26. Clifford MN. Chlorogenic acids and other cinnamates. Nature, occurence, dietary burden, absorption and metabolism. J Sci Food Agric. 2000;80:1033–1043.
27. Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr. 2001;131:66–71. [PubMed]
28. Kuhnau J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet. 1976;24:117–191. [PubMed]
29. Lee MJ, Maliakal P, Chen L, Meng X, Bondoc FY, et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev. 2002;11:1025–1032. [PubMed]
30. Falany CN. Enzymology of human cytosolic sulfotransferases. Faseb J. 1997;11:206–216. [PubMed]
31. Spencer JP, Chowrimootoo G, Choudhury R, Debnam ES, Srai SK, Rice-Evans C. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett. 1999;458:224–230. [PubMed]
32. Hollman PC, Tijburg LB, Yang CS. Bioavailability of flavonoids from tea. Crit Rev Food Sci Nutr. 1997;37:719–738. [PubMed]
33. Dangles O, Dufour C, Manach C, Morand C, Remesy C. Binding of flavonoids to plasma proteins. Methods Enzymol. 2001;335:319–333. [PubMed]
34. Dufour C, Loonis M, Dangles O. Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin. Free Radic Biol Med. 2007;43:241–252. [PubMed]
35. Vitrac X, Moni JP, Vercauteren J, Deffieux G, Mérillon JM. Direct liquid chromatography analysis of resveratrol derivatives and flavanonols in wines with absorbance and fluorescence detection. Anal Chim Acta. 2002;458:103–110.
36. Luqman S, Rizvi SI. Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res. 2006;20:303–306. [PubMed]
37. Pandey KB, Mishra N, Rizvi SI. Protective role of myricetin on markers of oxidative stress in human erythrocytes subjected to oxidative stress. Nat Prod Commun. 2009;4:221–226. [PubMed]
38. Pandey KB, Rizvi SI. Protective effect of resveratrol on markers of oxidative stress in human erythrocytes subjected to in vitro oxidative insult. Phytother Res. 2009. In press. [PubMed]
39. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992;339:1523–1526. [PubMed]

 

Cognitive decline and the best foods used to stop it!

Cognitive decline and the best foods used to stop it!

Antioxidant compounds, contained in fruit, vegetables and tea, have been postulated to have a protective effect against age-related cognitive decline by combating oxidative stress. However, recent research on this subject has been conflicting. here are some basic point about CD and Aging and the main focus of this Article is on foods that Helps us fight CD.

About Cognitive Decline (What is Cognitive Decline?):

If you have Cognitive Decline or cognitive impairment, you may be aware that your memory or mental function has “slipped.” Your family and close friends also may notice a change. But generally these changes aren’t severe enough to significantly interfere with your day-to-day life and usual activities.

When anyone makes some tea or use computer or even read a book, that person it utilizing the cognitive capacities. Cognitive capacities are the mental aptitudes that you have to carry from the easiest to the most perplexing task. These mental abilities incorporate mindfulness, memory, information handling and thinking. As our age increases, the cognitive abilities continuously break down. A specific sum of cognitive decrease is a typical thing in maturing. A few people may encounter an extreme crumbling in psychological abilities, prompting dementia. This can make it difficult to adapt to customary everyday tasks. In order to get rid or avoid such problems, below are some foods that can be utilized.

Mild cognitive impairment may increase your risk of later progressing to dementia, caused by Alzheimer’s disease or other neurological conditions. But some people with mild cognitive impairment never get worse, and a few eventually get better.

 

About Cognitive Decline (What is Cognitive Decline?):

 

Cognitive disorders like CD are a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium. While anxiety disorders, mood disorders, and psychotic disorders can also have an effect on cognitive and memory functions. Cognitive Decline is generally happening to all while aging but we dont really notice that. we get old and our abilities and awareness reduces but we dont understand maybe others do.

Cognitive decline is categorized under dementia in Mental disorders. For dementia cases, studies suggest that diets with high Omega 3 content, low in saturated fats and sugars, along with regular exercise can increase the level of brain plasticity and BDNF. Other studies have shown that mental exercise such a newly developed “computerized brain training programs” can also help build and maintain targeted specific areas of the brain.

Findings from some studies suggest that intakes of vitamin C and E that significantly exceed adequate or recommended intakes (over 130 and 15 mg/day for vitamin C and E, respectively) may be beneficial . This is in slight contrast to a very thorough review of vitamin C, cognitive decline and AD by Harrison , who concluded that a healthy, long-term diet in which adequate vitamin C levels are maintained and vitamin deficiency is avoided may protect against age-related cognitive decline and AD, and be more beneficial than taking supplements. (source & source & Source )

 

About Cognitive Decline (What is Cognitive Decline?):

 

 

Foods that are best to Slow down & stop Cognitive Decline caused by aging:

Green Tea:

Green Tea, Antioxidant effects and benefits

Green tea is on the top of the list in the skin friendly drinks due to its noteworthy storage facility of polyphenols that can cause aging. Having four glasses each day can give amazing results by fighting against aging elements in human body.

 

• GINGER ROOT:

Ginger (root) Unique health benefits & Antioxidant effects

Grated and ground ginger in two wooden spoons ginger root green leaves on the wooden board

Ginger and turmeric are from the same basic family of plants. Health benefits of turmeric is largely mentioned in many articles. But now ginger. Ginger is a Southeast Asian plant. The spice ginger is the underground rhizome of the ginger plant, known botanically as Zingiber officinale. Ginger is used as a spice and medicine.

•  TURMERIC:

Turmeric (Curcumin) Anti-inflammatory & Antioxidant Keeps you young

different types of turmeric barks

Health benefits of turmeric is largely mentioned in many articles. Turmeric is known for improving conditions for arthritis, heartburn (dyspepsia), joint pain, stomach pain, Crohn’s disease and ulcerative colitis, bypass surgery, hemorrhage, diarrhea, intestinal gas, stomach bloating, loss of appetite, stomach ulcers an so on.

•  Sage:

Sage, just a mint or strong antioxidants and Anti-Inflammatory

Sage is an herb, a mint. The leaf is used to make medicine. Sage contains rosmarinic acid, rosmarinic acid is a potent antioxidant and an anti-inflammatory agent. Rosmarinic acid reduces harmful inflammation.

Salmon:

Fish oil, DHA & EPA & OMEGA 3-6-9 Antioxidants and benefits

Raw red fish

Salmon contains astaxanthin which works amazingly on skin and enhances the elasticity of skin by decrease the number of fine lines and wrinkles.  astaxanthin is by some researches considered as the strongest antioxidant ever found.

• Fish and fish oil:

Fish oil, DHA & EPA & OMEGA 3-6-9 Antioxidants and benefits

According to the researchers after several researches, the phenomenal measure of fish they take keeps that away from dangerous heart diseases and cancer. Fish is a copious wellspring of omega-3 fats, which help avert cholesterol development in the arteries and secure against irregular heart rhythms.

•  Olive Oil & Olive extracts:

vitamin-e Unique health benefits & Antioxidant effects

Forty years back, analysts from the Seven Countries Study revealed that the monounsaturated fats found in the olive oil were to a great extent, reason of the low rates of coronary illness and cancer. Presently, the studies  indicated that olive oil additionally contains poly-phenols, effective cancer prevention agents that may help forestall age-related infections.

•  Berries:

Cranberry Strong Antioxidant Effects

All Berries, especially members of some important families, like Rosaceae (strawberry, raspberry, blackberry), and Ericaceae (blueberry, cranberry), belong to the best dietary sources of bioactive compounds (BAC). Because of the antioxidant properties of BAC, they are of great interest also for nutritionists and food technologists due to the opportunity to use BAC as functional foods ingredients. The bioactive compounds in berries contain mainly phenolic compounds (phenolic acids, flavonoids, such as anthocyanins and flavonols, and tannins) and ascorbic acid.

•  MATCHA:

Green Tea, Antioxidant effects and benefits

Matcha is basically green tea leaves that have been stone ground and processed into a powder. The powder is then filtered and raced with boiling water. Due to the difficult procedure required to deliver matcha, the tea is for the most part expensive than others.

OLIVE LEAF

branch of green olives antioxidant benefits

branch of green olives

If you are going to consider getting Olive leaf (extracts) you should know based on the studies these are the situations that it has been proven that Olive leaf (extracts) can improve.
Lowers Blood Pressure, Improves Cardiovascular Health, Diabetes, Reduces the Risk of Cancer and so on.

 

• Eggs:

Protein (amino acids) repairs all those cells that have endured the damage from free radical. Eggs, an amazing source of protein, likewise contain biotin which is an essential vitamin that protect the body from free radicals.

• Pomegranate:

The antioxidant rich fruit may help skin to make more collagen and can also help in speeding healing. The essential nutrients in it help making the skin look fresh and glower and it works amazingly as an anti aging food.

• Beans:

Beans are another protein source. They help repair cells that have endured the free radical damage. During digestion, protein separates into amino acids, the building squares of cells which further help to speed as well as repair and regenerate the skin cells along with collagen.

• Chocolate coco powder:

If dietary phenolics are active in-vivo antioxidants, chocolate can contribute a significant portion of dietary antioxidants, and the pleasant pairing of red wine and dark chocolate could have synergistic advantages beyond their complementary tastes. According to a study, the people who live in Kuna in the San Blas islands near panama, have a rate of heart illness that is a great percent less than those of Panamanians. The Kuna people, in order to stay away from heart diseases, drink a lot of a refreshments made with liberal extents of chocolate, which is bizarrely rich in flavanols that help protect the sound capacity of veins. Keeping up young veins and fights aging.

•  Watermelon:

The reviving and sweet treat contains a definitive cancer prevention agent, vitamin C, in addition to lycopene as well as potassium, which controls the adjust of water and supplements in cells and makes individuals look healthy and young.

• Dark Chocolate:

The sweet chocolate is rich in cocoa flavanols, plant compounds as well as the effective & strong antioxidant properties, which help hydrate skin and enhance circulation.

• Walnuts:

It’s the only kind of nut that contains a significant amount of unsaturated fats, which is particularly important for vegetarians who are not able to eat fish. Walnuts pack an omega-3 called alpha-linolenic corrosive. Deficiency in this fat can bring about dermatitis, which is related with dry, flaky skin. So, having walnuts will make the skin fresh, and young.

• Citrus fruits peel:

Analysts from the University of Arizona took a gander at individuals who stated that they ate citrus fruits, squeezes, and peels each week. Individuals, who ate peels such as orange peel or lemon juice, had a 33% diminished hazard for “squamous cell carcinoma”. Juices and fruit didn’t have any impact. Limonene is a compound found in the oil in the peels that offers the UV-defensive benefits and makes the skin look great.

• Walnuts:

Walnuts are stuffed with healthy as well as anti inflammatory supplements, and are the main great nut source of alpha linolenic corrosive. They help advance blood stream, which thusly takes into consideration a great delivery of oxygen to the cerebrum. What’s more, a study found that mice with the infection that were routinely nourished walnuts had enhanced memory, learning and function ability coordination.

• Coffee:

Caffeine, the gentle stimulant found in coffee actually enhances mental acuity. Beside caffeine’s mind boosting impacts, caffeine’s cell reinforcement lavishness keeps up the mental health. Also, some exploration recommends that drinking coffee can really fight with depression and anxiety in ladies and can stop cognitive decline.

• Blueberries:

Incredible things do come in little bundles, blueberries are a natural product few attempt to eat each and every. That is on the grounds that they have such a variety of extraordinary medical advantage ­while having an aftertaste like a great treat. It’s one of the most astounding cell reinforcement rich sustenance known to man, including vitamin C and vitamin K and fiber. As a result of their elevated amounts of Gallic acid, blueberries are particularly great at shielding our brains from degeneration, stress and cognitive decline.

• Broccoli:

It’s one of the best foods to improve brain health. On account of its elevated amounts of vitamin K and choline, it will help keep your memory sharp.

• Coconut oil:

It is a standout among the most flexible and bravo nourishments for brains out there. With 77 coconut oil uses and cures, there’s nothing that coconut oil can’t help. What’s more, with regards to your mental health it’s loaded with other advantages, as well. Coconut oil functions as a characteristic calming, stifling cells in charge of aggravation. It can help with memory misfortune as a person becomes older and kills terrible microbes that hang out in the guts. Hence, it’s great to stop cognitive decline in human.

• Egg Yolks:

Egg yolks contain a lot of choline, which helps in fetal mental health for pregnant ladies. It additionally separates bethane, a synthetic that produces hormones identified with bliss and fight against cognitive decline. The eggs can really make an individual happy and keep the mental health great.

• Spinach:

Spinach is rich in antioxidants, which is thought to fight against cognitive decline. What’s more, a study found that ladies who revealed eating the most verdant green and cruciferous vegetables had an especially decreased rate of cognitive decline as contrasted with the individuals who ate the minimum.

• Tomatoes:

A study found that lycopene-rich tomato helped participants prevent sunburn when they combined it with olive oil and use it for ten weeks without missing any day. Other than being an extraordinary source of strong antioxidant lycopene, tomatoes are considered a high carotenoid fruit. These nutrients may help to get rid from free radicals that can cause many diseases including aging.

 

 

 

Some good sources for cognition Decline:

http://www.mayoclinic.org/diseases-conditions/mild-cognitive-impairment/home/ovc-20206082

https://link.springer.com/article/10.1007%2Fs11130-013-0370-0

https://en.wikipedia.org/wiki/Cognitive_disorder

 

Alzheimer | What is Aging and is it the same as Alzheimer?

Alzheimer | What is Aging and is it the same as Alzheimer?

Alzheimer

As the years go by, you can expect gradual changes in your body. How your body ages depends partly on your genetics but your lifestyle choices have a greater effect on how well -or not- your body ages.  This brings the question: When does ageing begin? Well, over time, ageing affects the cells of every major organ of your body. In some people, changes can start early and are more visible.

The impact of ageing on our health and function varies in severity. For example, lung tissue starts to lose elasticity around the age of 20 and the muscles of the rib cage slowly begin to shrink. This has led several researchers to say that ageing begins at around 20 years. Some, however, argue that the process begins after the onset of other changes in our bodies caused by puberty at around 12 years.

 

Some of the effects associated with ageing are loss of skin elasticity, thinning of hair, difficulty hearing and seeing, loss of sleep, loss of bone density, slowing down of metabolism, memory changes among others.

Alzheimer

Alzheimer’s disease is a general term for a type of dementia, a condition in which a person develops some cognitive problems resulting from changes in the brain. It is thought to be caused by the buildup of toxins in the brain. At the onset of the disease, people have a hard time remembering recent events, though they might remember past events clearly. With time, the condition deteriorates and other symptoms crop up such as difficulty completing tasks, trouble with words, misplacing things, trouble with visual perception, dramatic mood swings and physical problems.

 

When it comes to brain function, Alzheimer’s and normal ageing are quite similar, only that people with Alzheimer’s disease are just experiencing ageing faster than others. People with Alzheimer’s can forget their loved ones and even how to do simple tasks that they have been doing for years such as feeding themselves and using the toilet.

 

Alzheimer’s disease usually affects people over the age of 65. Someone suffering from the disease may live with it for a few years or even a few decades. While ageing affects both women and men equally – though the signs may show earlier in women, women are more likely to have Alzheimer’s than men. Research shows some evidence that people with high blood pressure and high cholesterol have a higher chance of getting Alzheimer’s. Head injuries, even early in life may also be a cause. However, the most common risks associated with Alzheimer’s are being older and if you have a history of the disease in your family.

 

While normal ageing may take several years for you to experience a noticeable decline in cognitive function, with Alzheimer’s, one you have the disease, people will be able to notice the signs within a couple of months and the curve only goes downward from there. Research shows that a good diet and regular exercise – both physical and mental can slow down the effects of ageing and delay the onset of Alzheimer’s.

Best Anti-aging Nutrition, foods, supplements and solutions

What happens in Neuro-degenerative diseases

What happens in Neuro-degenerative diseases

In progress

Neuro-degenerative diseases

Neuro-degenerative disease is a term that refers to a range of conditions that affect the neurones in the human brain. It is the progressive loss of structure or function of neurones or even their death. Neurones are the bricks of the nervous system, which includes the brain and spinal cord. Neurones are not like cells which reproduce and replace themselves. Once they are damaged or die, they cannot be replaced. This makes neuro-degenerative diseases incurable and debilitating resulting in the progressive degeneration and/ or death of nerve cells. The result of this is usually physically exhibited with problems in movement and mentally with cognitive ineptness (known as dementias).

 

Examples of neurodegenerative diseases include Parkinson’s, Alzheimer’s, Pick’s, Huntington’s disease, Amyotrophic lateral sclerosis (ALS) and dementia. Parkinson’s disease occurs when nerves in a central area of the brain slowly degenerate resulting in problems in coordination and movement. Huntington’s disease is an inherited nerve disorder that causes neural degeneration. Pick’s disease occurs when large portions of nerves at the front and sides of the brain are destroyed due to an accumulation of abnormal protein. ALS causes the rapid destruction of nerves and controlling muscle function.

 

Studies on the effects of antioxidants for the treatment of various diseases and the optimum functioning of the body have been conducted in the recent past to try and pinpoint all the benefits of an antioxidant-filled diet. A new review aimed to identify the potential of antioxidant methods for the treatment of degenerative diseases.

 

Antioxidants work by eliminating the action of free radicals in the body. It has long been suspected that an accumulation of free radicals in the body can lead to neurodegenerative diseases through oxidative stress. Antioxidants are now being looked upon as possible remedies against solemn loss of neurones.

 

Polyphenols, in particular, have been linked to the prevention of neurodegenerative diseases. Polyphenols are secondary metabolites that have antioxidant properties. They can be found in most fruits and vegetables. These are able to protect cells found in the neural pathway by attenuating oxidative stress and damage. Oxidative stress is particularly prone to affect the brain as it requires high amounts of oxygen per unit weight and contains a high amount of oxidizable polyunsaturated fatty acids.

 

IN a study conducted in Chicago, it was found that the consumption of Vitamin E reduces the risk of Alzheimer’s if the condition is not caused by a genetic predisposition. Results were, however, inconclusive on patients who had inherited the disease.

 

More research is yet to be done on the effect of and antioxidant-rich diet on neuro-degenerative disorders. While some studies have been inconclusive, experts say that there is no harm in consuming antioxidants that are found naturally in our food. What would not be recommended is loading up on antioxidant supplements, which are sometimes not easily absorbed into the body. Treatment of neurodegenerative diseases using antioxidants has become an attractive alternative to prevent, delay or completely stop the effects of these diseases.

cranberry strong antioxidant effects, benefits and sideffects

DHA & EPA Antioxidant and anti-aging benefits

DHA & EPA effects and antioxidant benefits!

 

Introducing DHA & EPA:

Omega-3 fatty acids are connected to healthy aging in humans. The omega-3 unsaturated fats derived from fishes, EPA and DHA, have been related with fetal improvement, cardiovascular activities, and Alzheimer’s sickness. Nonetheless, in light of the fact that our bodies don’t proficiently deliver some omega-3 unsaturated fats from marine sources, it is important to get satisfactory sums through fish and fish oil items. The effective and strong antioxidants of EPA and DHA help improving health. They are imperative for appropriate fetal improvement, including neuronal, retinal, and invulnerable function positively and have been connected to provide great outcomes in anticipation, management of weight as well as intellectual capacity in those with exceptionally mellow Alzheimer’s sickness.

Antioxidant Effects of DHA & EPA:

The DHA & EPA supplements have numerous effects on heart. They fight against arrhythmias, heart assault and stroke. They likewise moderate plaque develops, lessen triglycerides, circulatory strain, irritation and thickening, and enhance lipid proportions. Because of their mitigating impacts and strong antioxidants, they might be helpful in treating rheumatoid joint inflammation, asthma and Crohn’s illness. The potential part of DHA & EPA in counteracting and treating osteoporosis, renal disease, cataracts, Alzheimer’s illness, depression and different conditions is as yet being examined.

 

 

Get DHA & EPA for:

For the highest amount of EPA and DHA here is the list of high omega foods by draxe:

  • Mackerel: 6,982 milligrams in 1 cup cooked (174 precent DV)
  • Salmon Fish Oil: 4,767 milligrams in 1 tablespoon (119 percent DV)
  • Cod Liver Oil: 2.664 milligrams in 1 tablespoon (66 percent DV)
  • Walnuts: 2,664 milligrams in 1/4 cup (66 percent DV)
  • Chia Seeds: 2,457 milligrams in 1 tablespoon (61 percent DV)
  • Herring: 1,885 milligrams in 3 ounces (47 percent DV)
  • Salmon (wild-caught): 1,716 milligrams in 3 ounces (42 percent DV)
  • Flaxseeds (ground): 1,597 milligrams in 1 tablespoon (39 percent DV)
  • Tuna: 1,414 milligrams in 3 ounces (35 percent DV)
  • White Fish: 1,363 milligrams in 3 ounces (34 percent DV)
  • Sardines: 1,363 milligrams in 1 can/3.75 ounces (34 percent DV)
  • Hemp Seeds: 1,000 milligrams  in 1 tablespoon (25 percent DV)
  • Anchovies: 951 milligrams in 1 can/2 ounces (23 percent DV)
  • Natto: 428 milligrams in 1/4 cup (10 percent DV)
  • Egg Yolks: 240 milligrams in 1/2 cup (6 percent DV)

 

Antioxidant benefits of DHA & EPA:

 

  • Decrease brain aging and keeps brain healthy: The EPA & DHA supplements are important and might be taken to keep up solid capacity of the mind and retina due to their strong antioxidants. DHA is a building square of tissue in the cerebrum and retina of the eye. It assists in shaping neural transmitters, for example, phosphatidylserine, which is vital for the working of brain. DHA is found in the retina of the eye and taking DHA might be fundamental for keeping the working of eye great.

 

  • Cancer Treatment: Studies revealed that DHA & EPA supplements can avoid and kill different kind of cancers, including colon, breast as well as prostate. While being an effective supplement for cancer patients, at the same time it’s also an effective treatment in those cancer treatments that are done naturally.

 

  • Great for cardiovascular system: EPA and DHA supplements are changed over into substances like hormones known as prostaglandins, and they manage cell action and perfect cardiovascular capacity.

 

  • Diabetes: The strong antioxidants of DHA and EPA can also help in decreasing the danger of diabetic patients from resulting cognitive deficit since it shields the hippocampus cells from being pulverized. Furthermore, they could also help decrease oxidative anxiety, which assumes a great part in the advancement of both micro-vascular and cardiovascular diabetes difficulties.

 

  • Decrease Joint Pains: All the essential antioxidants found in EPA and DHA seem to decrease few joint pains. Human reviews have demonstrated the supplemental fish oil decreases fiery joint pain. They are also successful in diminishing such pain that is brought by joint pain.

 

  • Beneficiary for Human Development: Human development and scholarly advancement – DHA assumes an essential part during the development and improvement of fetal. DHA of the high concentrations are found in the mind and increment 300 to 500 percent in a newborn child’s cerebrum amid the last trimester of pregnancy. Adding DHA supplements in to the pregnant mother’s eating routine might be helpful for the embryo’s mental health. Elderly individuals ought to likewise take EPA DHA, on the grounds that as adults get more established, the bodies frame less EPA and DHA, which may bring about less mental concentration and psychological capacity. Taking some EPA DHA supplements likewise may help with mental variations.

 

  • Decrease muscle degeneration: The strong antioxidants of DHA and EPA diminish the rate of muscle degeneration. A few researches recommends that fit body mass is better held after surgery by expanding the intake of EPA in the eating routine. There are a lot of confirmations proposing that fish oil helps muscle development.

Omega 3 fatty acids, DHA & EPA are naturally found in fishes as well as fish oils. However, DHA & EPA Supplements can also be consumed few times in a week in order to get all the above mentioned benefits.

 

 

Reference Websites:
www.livestrong,com
www.mercola.com

Vitamin E, Strong everyday antioxidant we have to have in our diet

ALA, ALPHA – LIPOIC ACID, Antioxidant & anti-Inflammatory your body needs

ALA, ALPHA – LIPOIC ACID Antioxidant & anti-Inflammatory 



Other Names for ALPHA – LIPOIC ACID : 
Acetate Replacing Factor, A-Lipoic Acid, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque, Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque


 Introduction to ALPHA – LIPOIC ACID or ALA


Alpha-lipoic acid is a substance made by the body. It is found in every body cell, where it helps turn glucose into energy. Alpha-lipoic acid is a vitamin-like chemical and an antioxidant. ALPHA – LIPOIC ACID or ALA can be found in Yeast, liver, kidney, spinach, broccoli, and potatoes. It is also made in the laboratory for use as medicine.  
Alpha-lipoic acid is used to break down carbohydrates in body and use the energy for organs in the body. Alpha-Lipoic Acid (ALA) is a mitochondrial fatty acid that is highly involved in energy metabolism as mentioned mostly for carbohydrates. ALA has shown benefit against various forms of oxidation and inflammation some part of this is because ALA resets the cycle of vitamin E & C.


ALPHA - LIPOIC ACID

ALA, ALPHA – LIPOIC ACID is Known for:


Alpha-lipoic acid helps prevent certain kinds of cell damage in the body. It also restores vitamin levels such as vitamin E and vitamin C in their cycles so they would work again as an antioxidant in their cycles and this reduces body need of antioxidants. There are some evidence that alpha-lipoic acid can improve the function and conduction of neuron cells in diabetes. ALA antioxidant benefits might also be helpful in liver diseases. 

ALA is know to be used to improve these conditions:

  • Coronary artery bypass graft (CABG) surgery.
  • Diabetes. 
  • Prediabetes. 
  • Diabetic nerve pain. 
  • Vitiligo. 
  • Weight loss. 1800 mg of alpha-lipoic acid daily for 20 weeks.
  • Wound healing. 
  • Alcoholic liver disease. 300 mg of alpha-lipoic acid daily for up to 6 months
  • Alzheimer’s disease. 600-900 mg of alpha-lipoic acid daily for up to 2 years
  • Heart-related nerve problems 
  • Damage to the retina caused by diabetes
  • HIV-related brain problems.
  • Rheumatoid arthritis.  300 mg of alpha-lipoic acid by mouth daily for 12 weeks 



Get ALA for: 


ALA is known to improve the following :

  • Diabetes
  • Cancer
  • Anti-Aging
  • Weight Loss
  • Pain
  • EYE health
  • Nerve Repair
  • Blood Pressure
  • liver disease
  • Heart-related nerve problems
  • Weight loss
  • Cardiovascular 
  • Immune system
  • HIV
  • Inflammatory and pain
  • Neuro-degenerative diseases
  • Cognition decline
  • Autoimmune diseases (rheumatoid arthritis)
  • Joint health
  • Motion Sickness
  • Arthritis
  • Damaging nerves system 
  • Treatment of Dementia
  • Alzheimer’s disease
  • High cholesterol
  • Healthier Arteries




Get ALA naturally:


Main natural sources of ALA ALPHA – LIPOIC ACID

  • Broccoli
  • Spinach
  • Red meat
  • Organ meat (sch as liver, hearts, kidneys from beef or chicken)
  • Brussel sprouts
  • Tomatoes
  • Peas
  • Brewer’s yeast
  • Beets
  • Carrots


ALPHA - LIPOIC ACID



ALA ALPHA – LIPOIC ACID is Both water and fat soluble and found in many natural foods meats, and plants. It can be in a protein bound or in other forms. 
This list is for  lipoyllysinem, the protein-bound form.

Food Dry Weight (mg/g) Protein (ng/g)
1. spinach 3.15 92.51
2. bovine (cow) kidney 2.64 50.57
3. bovine (cow) heart 1.51 41.42
4. broccoli 0.94 41.01
5. tomato 0.56 48.61
6. green pea 0.39 17.13
7. brussel sprouts 0.39 18.39
8. bovine (cow) spleen 0.36 5.69
9. bovine (cow) brain 0.27 4.85
10. rice bran 0.16 4.44






Side Effects of ALA:


  • ALA, Alpha-lipoic acid is known as SAFE by mouth or when applied to the skin. the safe dosage is about the regular dose that can be found in natural sources like plants. 600 or 1200 mg daily.
  • Negative effects could occur with long term high-dosage supplementation. High-dose ALA supplementation is therefore not recommended.
  • People with diabetes should be careful to check their blood sugar levels because alpha-lipoic acid might lower blood sugar.
  • People taking alpha-lipoic acid by mouth might get some rash.
 


Interactions of ALA:

  • Medications for cancer (Chemotherapy) interacts with ALPHA-LIPOIC ACID.
  • Medications for diabetes (Antidiabetes drugs) interacts with ALPHA-LIPOIC ACID
  • Thyroid medications, Levothyroxine — Apha-lipoic acid may lower levels of thyroid hormone. 
  • Vitamin B1 (Thiamine) — Alpha lipoic acid can lower the level of vitamin B1 (Thiamine) in the body. This can be particularly dangerous in alcoholics.












Online sources for this article and good readings on ALA Alpha-lipoic acid:


draxe.com

webmd.com

examine.com

superfoodly.com

umm.edu


List of references and papers:

Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo. 2000;14(2):327-330.

Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149:841-9.

Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin. 1999;94 Suppl 3:84-89.

Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke. 2001;32(4):1000-1004.

Faust A, Burkart V, Ulrich H, et al. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice. Int J Immunopharmacol. 1994;16:61-66.

Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. 2001;6(2):141-166.

Hruby K, Csomos G, Fuhrmann M, Thaler H. Chemotherapy of Amanita phalloides poisoning with intravenous silibinin. Hum Exp Toxicol. 1983;2(2):183-195.

Ibrahimpasic K. Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med Arh. 2013; 67(1):7-9.

Lynch MA. Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue. Nutr Neurosci. 2001;4(6):419-438.

Melhem MF, Craven PA, Derubertis FR. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol. 2001;12:124-133.

Melhem MF, Craven PA, Liachenko J, et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol. 2002;13:108-116.

Melmed: Williams Textbook of Endocrinology, 12th ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2011.

Mitkov MD, Aleksandrova IY, Orbetzova MM. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv). 2013; 55(1):55-63.

Monograph:Alpha-Lipoic Acid. Altern Med Rev. 1998;3(4):308-311.

Nagamatsu M, Nickander KK, Schmelzer JD,et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.

Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17(10):888-895.

Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-linoic acis. Free Radic Biol Med. 1997;22:359-378.

Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Rad Bio Med. 1995;19(2):227-250.

Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V. Alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996;717(1-2):184-188.

Rakel D. Rakel Integrative Medicine, 3rd ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2012.

Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung. 1991;41:1294-1298.

Xu J, Gao H, Song L, et al. Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. Lipids Health Dis. 2013; 12:58.

Yoo TH, Lee JH, Chun HS, Chi SG. a-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kB induction of RPS6KA4. Anticancer Drugs. 2013; 24(6):555-65.

Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care. 2006;29:2365-70.

Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997;46 (suppl 2):S62-66.

Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999; 107:421-430.


Turmeric (Curcumin) Anti-inflammatory & Antioxidant Keeps you young

Sage, just a mint or strong antioxidants and Anti-Inflammatory