Anti aging Antioxidant rich foods and Exercise, two Most effective factors of anti-aging lifestyle

Anti aging Antioxidant rich foods and Exercise

Two Most effective factors of anti-aging lifestyle

lose-weight anti aging antioxidants

What is aging and what is anti-aging?

You know aging is happening when you see the traces of it in your skin, joints and face. But have ever gone a bit deeper to know Why do we age? Is it normal? What makes aging an acceptable norm? Can it change?
Many say you cannot really stop body from aging and its fate and the nature of how it behaves. And some others say aging is a disease and can be cured. But to be honest the truth is somewhere between those lines. It happens because our DNA is designed to be destructed in some certain situations. Free radicals in our cells and outside our cells are always destructing other molecules, basically because they are unstable forms of molecules. Free radicals interact with other molecules in the body as they are in blood and metabolism, they cause Oxidative Damage. Sources of oxidative damage can be inflammations inside our body or sources from outside like:

• Smoking (first or second hand)
• Excessive exposure to UV rays
• Air Pollution
• Eating an unhealthy diet
• Certain medications and/or treatments
• Excessive exercise or physical activities

 

Antioxidants Counteract Oxidative Stress and Free Radicals

Antioxidants that you have probably heard of them are important players in this game. Antioxidant foods or some may say Anti-aging foods are the one that are rich in anti-oxygen agents which we call antioxidant agents. The main thing that antioxidants do that help us with an anti-aging lifestyle is that they fight against the free radicals. Usually when free radicals quantity is more that antioxidants the aging goes faster and faster.
Our body knows what the main molecules are that it is in war with, the free radicals. And the strongest and the best antioxidants are made inside our body that are hundreds of times more effective than foods. Foods are mostly effective in the inside cell fight and the antioxidants from foods are mostly effective and working on outside cell fights against free radicals.

 

lose-weight anti aging antioxidants

So the main two ways and factors to have a healthy anti-aging lifestyle is
1. To activate and trigger the antioxidants made by our body
2. To eat best antioxidant foods and (also skip the sugar…)

Activating the antioxidants within you

For triggering the intra antioxidants made in our body like glutathione which is the strongest antioxidant, exercise has been proven over and over that is the main thing that increase both brain BDNF and glutathione levels in our body. But not any sort of exercise. The most effective type that can actually make your body increase intra-antioxidants is intense exercise or HIIT: High intensity interval training. HIT intense interval training can increase bdnf. Yes, Intense Exercise is number 1. If you don’t exercise much, your brain may not be producing sufficient BDNF. To increase it, you’ll want to engage in an intense exercise; the greater the intensity, the more likely BDNF production will increase.

Both are some of the most important aging factors. Exercise Increases Brain plasticity and memory that leads to better learning. Brain plasticity is the main factor of brain aging. Basically plasticity means your brain has the capability of learning or not. Glutathione is also triggered by some foods like ginger and turmeric root but.

 

lose-weight anti aging antioxidants

Antioxidant foods in your diet

For The healthy foods and a diet full of antioxidant foods you should include some spices and foods in your diet like ginger, turmeric, clove and also eat some fruits daily like blueberries, cranberries, and acai berries.  Many other activities and strategies are associated with anti-aging lifestyle but the main two ones that can really lift up your mood and prevent fast aging and even stop it to some degrees are as mentioned Exercise and Antioxidant rich foods.

How antioxidants like HCA & CGA & POLYPHENOLS help burn more fat

Some antioxidants (foods) helps you lose weight | How antioxidants like HCA & CGA & POLYPHENOLS help burn more fat

 

 

Which antioxidant can help you lose weight:

  1. HCA hydroxycitric acid (found in garcinia cambogia)
  2. CGA Chlorogenic Acid (found in green coffee extract) (is of course a form of polyphenol antioxidant)
  3. POLYPHENOLS (PHENOLIC ACID) (found in green tea, berries, and…)

 

HCA hydroxycitric acid CGA Chlorogenic Acid POLYPHENOLS (PHENOLIC ACID)

HCA hydroxycitric acid,  CGA Chlorogenic Acid,  POLYPHENOLS (PHENOLIC ACID)

 

1. HCA hydroxycitric acid (antioxidant) in garcinia cambogia can help you lose weight:

  • hydroxycitric acid Helps your storage of body fats come into action and be used in long term
  • Blocks storage of the extra calories you do not use as fat in your body
  • hydroxycitric acid Increase lipid oxidation there by help to breakdown and remove fatty acids from your body
  • It may also help to decrease appetite to some degree
  • hydroxycitric acid may also help to lower triglyceride and low-density lipoprotein, or “LDL,” levels
  • Hydroxycitric acid is used to improve exercise performance too by limiting the use of stored energy in the muscles, which seems to prevent fatigue.

 

2. Chlorogenic Acid (found in green coffee extract) can help you lose weight:

  • Reduce the absorption of carbohydrates from the digestive tract
  • lowers blood sugar and insulin spikes
  • reduce fat absorbed from the diet
  • reduce fat stored in the liver
  • improve the function of the fat burning hormone adiponectin

 

3. POLYPHENOLS (PHENOLIC ACID) (found in green tea, berries, and…)

  • POLYPHENOLS (PHENOLIC ACID) in green tea are believed to block fat from being absorbed
  • POLYPHENOLS (PHENOLIC ACID) compounds in Green tea extract decreases starch digestion and absorption, Green tea extract blocks an enzyme that breaks down carbs
  • Green Tea May Prevent Weight Gain by Inhibiting Fat Absorption and Promoting Fat Use.

 

 

Main factor in losing weight

Losing weight is not a “one factor problem” that gets solved with one solution. many factors are involved in a healthy weight loss. Exercise is very important as diet is. What you eat generally determines how your body works. If you eat a hot spicy food you will expect your appropriate body reaction. As explained in earlier post about how sugar can contribute to agingour body fuel system is very complex and complicated. You can not just eat what ever randomly and assume it has no effect on you and how you perceive and how your body acts. We basically get energy from 4 different category of foods: Fat, carbohydrates, sugar, protein. our body has different hormones and enzymes to make every one of these into energy and use them. Sugar is very tasty right? thats because it burns fast and is vital so has almost the first priority for our body to be used. The extras always go to storage for later use. So when you have sugar you dont burn fat and also the extra sugar and all go to be stored as fat in your storage areas. this metabolism is critically dependent on what you eat. What you eat determines what your body does and feel. for more detailes on this read sugar and aging.

But how some antioxidants can actually help you lose weight and play a role in the complicated system of our body metabolism. hydroxycitric acid or HCA is know to be able to in some way help you lose weight. but let talk about how hydroxycitric acid (HCA) actually does it as an antioxidant agent found in some foods like garcinia cambogia. Hydroxycitric acid is derived from the dried rind of the fruit that grows on the Garcinia cambogia tree, which it is native to India, Malaysia and Africa. Hydroxycitric acid contains numerous phytochemicals including xanthones, flavanoids and benzophenones. Phytochemicals are antioxidant compounds found in plants that help to prevent free radical induced damage.

 

 

Hydroxycitric acid has become popular as a weight loss aid. It has been found to increase lipid oxidation and thereby help to breakdown and remove fatty acids from your body. It may also help to decrease appetite, and a six-week, placebo controlled study cited in the June 2002 edition of “International Journal of Obesity-Related Metabolic Disorders” examined the effectiveness of hydroxycitric acid as an appetite suppressant. The study found that hydroxycitric acid supplementation decreased the daily caloric intake in overweight individuals by 15 to 30 percent. The participants experienced weight loss, whilst also reporting feelings of satiety. HCA Hydroxycitric acid has also anti-inflammatory properties and is used to help treat inflammatory bowel disorders. More research needs to be done to confirm the efficacy of hydroxycitric acid for these uses however.

A lot of research has been done on the effects of a high antioxidant diet, they have been inconclusive on their direct effect on weight loss. As mentioned before many thing play important roles in healthy weight loss and antioxidants like HCA can help you a lot in how your metabolism works. 

Antioxidants are known to turn toxins in the body into harmless elements. Toxins are readily stored in fat cells. Therefore the more toxins we have in our body, the more our bodies will willingly ‘hold on’ to these fat cells in order to prevent toxins from freely roaming in our bodies. This is usually noticed by people who exercise and reach a plateau in their weight loss curve and in those who have slow metabolism rates. In order to reverse this, a diet rich in antioxidants has been shown to have numerous benefits.

While green tea can increase energy and enhance physical performance, there are no clear studies that indicate that the weight loss supplement boosts metabolism. The HCA in Garcinia Cambogia, however, jumpstarts the metabolism so that the body will burn fat at a faster rate. This makes for more permanent weight loss and can help dieters to avoid the yo-yo effect that sometimes comes with taking a weight loss product. Garcinia Cambogia is also high in fiber, which is a quality green tea doesn’t possess. Fiber helps to balance the blood sugar and moves food along the digestive tract speedily.

 

 

Although antioxidants have not been directly linked to fat burning, it is a wonder that people who consume foods rich in antioxidants tend to lose weight. In a study done with overweight participants, those who included green tea in their diet lost more weight compared to the control group. The same has been noted with the intake of water infused with lemon rinds. Lemons and green tea are both very good sources of antioxidants.

For fat loss to occur, the body has to convert stored fat into glucose to provide it with energy. Although no conclusive evidence has been found, research suggests that a diet rich in antioxidants can convert your body from a sugar burning to a fat burning machine. This means that instead of using up the sugars you ingest to produce energy, the body will use stored fats. Antioxidants found in green tea have been found to possibly cut through fat stored in the body.

More research is yet to be done on the benefits of increasing your intake of antioxidant. However, what is clear is that it is better to take them in their natural form rather than in supplements because foods containing antioxidants have other benefits too.

 

 

There have been several human studies on Green Coffee Bean Extract. These studies are so-called randomized controlled trials, which are the gold standard of scientific experiments in humans. One of them included 30 overweight individuals and went on for 12 weeks. There were two groups… one consumed regular Instant coffee, while the other consumed Instant coffee enriched with 200 mg of Green Coffee Bean Extract. Neither group was instructed to change their diet or exercise habits. This graph shows the weight changes in the two groups, from 0-12 weeks:

As you can see, the group taking the instant coffee with green coffee bean extract lost 11.9 pounds (5.4 kg), while the group taking plain instant coffee lost only 3.7 pounds (1.7 kg).

Body fat percentage also went down by 3.6% in the green coffee extract group, compared to 0.7% in the other group.

 

White kidney beans extracts and storage of energy as body fat

There are different ideas about White kidney beans extracts so we did not include them in the antioxidants that helps you lose weight.

White beans and other foods with a low glycemic score also offer extraordinary weight loss benefits. When the carbohydrates in our food cause our blood sugar levels to rise, a polypeptide hormone called insulin is produced by the pancreas (a large gland organ located behind the stomach). The purpose of insulin is to bring the elevated blood sugar levels back down by stimulating the uptake of glucose (sugar) by the body’s cells which can then use the glucose for energy. However, if the blood sugar levels are very high (e.g. after a high GI meal), insulin will cause some of the blood sugar to be stored as fat (for later use as energy). Low GI foods like beans have the opposite effect. Great news for those who are following a fat loss diet plan! In addition to their gentle effect on blood sugar levels, white beans may provide weight loss benefits due their ability to produce alpha-amylase inhibitors. Alpha-amylase inhibitors are known to slow the absorption of carbohydrates (and thus the storage of energy as body fat) by inhibiting enzymes responsible for cutting starches into simpler sugars.

Antioxidants in white kidney beans promote good health and wrinkle-free skin: White beans deliver a hefty supply of antioxidants, substances that fight off disease and help maintain optimum health. Antioxidants are believed to protect the cells in your body from free radicals, unstable molecules that damage cells. Ultimately, the damage caused by free radicals can result in many chronic conditions and degenerative diseases including certain types of cancer, atherosclerosis, thrombosis, arthritis, heart disease, immune system problems, Alzheimer’s disease, and dementia. source

What Are Starch Blockers like White kidney beans extracts?

Starches are complex carbohydrates that cannot be absorbed unless they are first broken down by the digestive enzyme amylase. Amylase inhibitors, also called starch blockers, prevent starches from being absorbed by the body. When amylase is blocked, those carbs pass through the body undigested, so you don’t absorb the calories.

Prescription drugs have to prove to the FDA that they are safe and effective. Supplements don’t. You also can’t be sure of what’s in a supplement.

Some supplements may have unlisted ingredients, maybe stimulants, that could be dangerous for people with diabetes, says Kathleen Dungan, MD, an endocrinologist at Ohio State University.

Prescription versions won’t have those extra ingredients, so they tend to be safer.

The FDA has sent warning letters to makers of no-prescription starch blockers in the past, saying their marketing claims are misleading.

If you’re considering using any product marketed for weight loss, talk to your doctor or a dietitian first. Ask yourself if it sounds too good to be true, and be skeptical.

Source

 

 

 

Sources and online websites about losing weight and antioxidants:

 

http://www.livestrong.com/article/429560-hydroxycitric-acid-information/

https://www.ncbi.nlm.nih.gov/pubmed/21401105

https://www.ncbi.nlm.nih.gov/pubmed/20933071

https://www.drugs.com/npp/garcinia-hydroxycitric-acid.html

 

 

 

Papers and references about losing weight and antioxidants:

 

1. Abraham Z, Malik SK, Rao GE, Narayanan SL, Biju S. Collection and characterization of Malabar tamarind [ Garcinia cambogia (Gaertn.) Desr.]. Genet Resour Crop Evol . 2006;53(2):401-406.
2. Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol . 2004;42(9):1513-1529.
3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.
4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.
5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.
6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.
7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.
8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.
9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.
10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.
11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.
12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.
13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.
14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.
15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.
16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.
17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.
18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.
19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.
20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.
21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.
22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.
23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.
24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.
25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.
26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.
27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.
28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.
29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.
30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.
31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.
32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.
33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.
34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.
35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.
36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.
37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.
38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.
39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.
40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci . 2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.
41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.
42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.
43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.
44. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol . 2009;15(14):1786-1787.
45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.
46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem . 2003;254(1-2):339-346.
47. Burdock G, Soni M, Bagchi M, Bagchi D. Garcinia cambogia toxicity is misleading. [Published correction appears in: Food Chem Toxicol . 2007;45(3):515.] Food Chem Toxicol . 2005;43(11):1683-1684; author reply 1685-1686.
48. Min B, McBride BF, Kardas MJ, et al. Electrocardiographic effects of an ephedra-free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy . 2005;25(5):654-659.
49. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia . 2008;79(4):255-261.

 

Exercise and Aging | Intense exercise can stop or slow down Aging

Exercise and Aging | Intense exercise can stop or slow down Aging

Before we start….. Exercise is the Most important thing we can do against aging. read more.

How exercise slows down aging?

  • Exercise Increases Brain plasticity and memory that leads to better learning
  • Exercise Increases brain BDNF
  • Exercise Boosts and improves cardiovascular system 
  • Exercise creates inflammations that makes body boost immune system
  • Exercise triggers body production of growth Hormone
  • Exercise triggers body sweat system 
  • Exercise fights obesity 
  • Triggers production of new brain cells

 

Research in progress

 

Main question on exercise-aging relation:

Before going into details of how exercise can actually improve your body we should have  and understand some questions:

 

  • Why do we HAVE TO exercise?
  • Do you know what it means that cells in our body and specially our brain Age?
  • Does our body make new cells everywhere? even in brain?
  • When does aging stats?
  • Do you know Why our body operates the way it does and how can it affect our modern lifestyle?
  • Does aging happen in brain or skin or all of our body?
  • If we are perceiving the world in our brain shouldn’t we really care about protecting it from getting old?

 

First Aging starts From 15 to 20 so take this seriously. If you are in your 20s, you are already there.

We are based on our needs. All body structure and how it functions is designed or evolved based on its needs. if we did not need a hand we would not have one or hair or nose. The structure of our body is designed to get stronger and grow under pressure of need. fear is one of the strongest tools in nature that makes animals shape the way they are.

Telomeres that are the tiny caps found on the end of DNA strands, like plastic aglets on shoelaces. They are believed to protect the DNA from damage during cell division and replication. As a cell ages, its telomeres naturally shorten and fray. our modern lifestyle expedites that things like smoking or bad foods or obesity all contribute hugely to expediting that process.

In our original lifestyle we used to run to hunt or escape, for food and staying alive and keep living. our cells and DNA knows why they are shaped the way they are. Actually exercise and intense physical activity has been an integral part of our lives in the past. and our structure is shaped based on that.

If we dont use part of our body it starts weakening to its minimum. Imaging your muscles if you dont use a specific muscle it weakens even if you are an athlete if you stop the pressure after a while you see that because your muscle is not under pressure it loosens up and weakens. after one or two years you are nothing like your old body  and that strong part is the weakest. you did nothing and that is the exact problem. doing nothing with your body for your DNA means you dont need it. so it gets rid of it. It can not get rid of it in one generation but weakens it as its possible. and eventually gets rid of it if you pass enough generations.

Remember it should be intense and/or long. The high intensity and long time is what makes the difference and makes your body to fight aging.  

High intensity exercise is a strong signal to all cells involved specially your brain to work and grow and get stronger.Also long time can do it in another way for sure a 40 min session is much better and more effective than a 10 min session. you body feels like its running out of resources and power. They are all feeling fear and that is what is running them forward. Because that is how our body made to survive if it feels loos for a long time it means aging and slow death.

 

 

Aging In our brain and memory vs exercise | Can you grow new brain cells?

The science of neurogenesis suggests it’s possible to create neurons that improve your memory and thinking skills.(source)  For example in relation of AHN and exercise in a study Named: Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained  done by Miriam S. Nokia, Department of Psychology, University of Jyväskylä, Finland. On Exercise and AHN it was found that: Adult hippocampal neurogenesis is a continuous process that contributes to a variety of adaptive behaviours, such as learning (for review, see Aimone et al. 2014). A well-demonstrated means of promoting AHN in rodents is aerobic exercise, namely running (van Praag et al. 1999). High-intensity interval training had a smaller than expected effect on AHN. Resistance training does not promote AHN.

In accordance with several previous reports on the beneficial effects of running on AHN and cognition in rodents (for a review, see Vivar et al. 2013), in our present study forced endurance training on a treadmill as well as voluntary running in a running wheel led to a higher number of immature adult-born hippocampal neurons compared with that observed in animals not engaged in aerobic exercise. Furthermore, we found that daily voluntary running on a running wheel increased AHN considerably more than 30 min of forced endurance training on a treadmill three times a week. The correlation between running distance and AHN might be explained by considering the consequences of running (in a more naturalistic setting). The further an individual travels, the more likely it is to encounter new environments and stimuli from which it must make sense rapidly.

 

 

Finally in the  Conclusion it is mentioned that: Sustained aerobic exercise increases AHN and advances this field of study in several ways. First, we tested several different forms of physical exercise to study their effects on AHN. We also took advantage of a newly developed genetically heterogeneous contrasting rat model system that we selectively bred for low and high response to aerobic training to take into account genetic variation in training responsiveness. According to our findings, anaerobic resistance training does not affect AHN in the studied animals, despite its overall positive effects on physical fitness. Second, the effects of exercise on AHN depend, at least to some extent, on sustained aerobic activity, as HIT did not have statistically significant effect on AHN. Third, the highest numbers of adult-born hippocampal neurons were observed in rats selectively bred for a high response to aerobic exercise that ran voluntarily on running wheels. Thus, for all reasons combined, AHN is highest in animals born with a tendency for a higher response to exercise training ,engaging in a large amount of voluntary aerobic activity. (source)

 

 

Why and how physical activity promotes experience-induced brain plasticity is also another important study done by  Gerd Kempermann , from Center for Regenerative Therapies Dresden, German Research Foundation, Dresden, Germany.

In animals, most if not all aspects of cognition are inseparable from locomotion and physical activity. Exploration, spatial navigation, and most types of learning accessible in a rodent are based on its movement in the outer world. Search for food, shelter, and mates are physical activities, requiring mental input to be successful on both a phylogenetic and ontogenetic scale. Consequently, the fact that running induces neurogenesis will be less counterintuitive if one appreciates physical activity as a basis for cognition. An important question is, whether this association is preserved in humans. Physical activity would be an intrinsic behavior-based signal to the brain (and hippocampus) implying that the likelihood of cognitive challenge is increased. In addition, one could speculate that running long distances increases the chance to encounter new environments increasing the need for spatial orientation and memory like wild animals that need to find the way back to their safe shelter. (source)

 

 

 

Brain BDNF (Brain plasticity) and Exercise

What is brain plasticity? Neuroplasticity – or brain plasticity – is the ability of the brain to modify its connections or re-wire itself. Without this ability, any brain, not just the human brain, would be unable to develop from infancy through to adulthood or recover from brain injury.

What is  BDNF?   The BDNF gene provides instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells. In the brain, the BDNF protein is active at the connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience, a characteristic called synaptic plasticity. The BDNF protein helps regulate synaptic plasticity, which is important for learning and memory.

The BDNF protein is found in regions of the brain that control eating, drinking, and body weight; the protein likely contributes to the management of these functions.

Pushup for both your muscles and your brain.

 

How To Increase BDNF (Brain-Derived Neutrophic Factor)

Increase your BDNF , there are some specific ways this can be done. It should also be noted that many methods that increase BDNF simultaneously increase neurogenesis.

 

 

1. Intense Exercise

Yes, Intense Exercise is number 1. If you don’t exercise much, your brain may not be producing sufficient BDNF. To increase it, you’ll want to engage in an intense exercise; the greater the intensity, the more likely BDNF production will increase. It has also been suggested that the more frequently you engage in high intensity exercise, the greater the production. Most specifically, aerobic exercise within the 60% to 75% of your max heart rate should be maintained for approximately 30 minutes. Don’t expect a huge boost in BDNF after just one gym session.

(Source: http://www.ncbi.nlm.nih.gov/pubmed/21282661  –  http://www.ncbi.nlm.nih.gov/pubmed/21722657)

 

2. Intermittent Fasting or Caloric Restriction

3. Dietary modifications

4. Sunlight (Vitamin D)

5. Supplements

6. Lose weight

7. Certain drugs

8. Social Enrichment

 

 

 

How exercise and aging muscles relations are?

Basically we have 4 main types of exercise:

1.Endurance

Endurance, or aerobic, activities increase your breathing and heart rate. They keep your heart, lungs, and circulatory system healthy and improve your overall fitness. Building your endurance makes it easier to carry out many of your everyday activities.

Brisk walking or jogging
Yard work (mowing, raking, digging)
Dancing
Strength

 

2. Strength exercises

Strength exercises make your muscles stronger. Even small increases in strength can make a big difference in your ability to stay independent and carry out everyday activities, such as climbing stairs and carrying groceries. These exercises also are called “strength training” or “resistance training.”

Lifting weights
Using a resistance band
Using your own body weight
Balance

 

3. Balance exercises

Balance exercises help prevent falls, a common problem in older adults. Many lower-body strength exercises also will improve your balance.

Standing on one foot
Heel-to-toe walk
Tai Chi
Flexibility

 

4. Flexibility exercises

Flexibility exercises stretch your muscles and can help your body stay limber. Being flexible gives you more freedom of movement for other exercises as well as for your everyday activities.

Shoulder and upper arm stretch
Calf stretch
Yoga

 

Almost any amount and type of physical activity may slow aging deep within our cells, a new study finds. And middle age may be a critical time to get the process rolling, at least by one common measure of cell aging. But a recent study from Cell Metabolism discovered that certain forms of exercise may increase muscle mass and mitochondrial density, particularly with people 64 and over.Not surprisingly, resistance training increased muscle mass and strength for all subjects. And cardio HIIT (high intensity interval training) improved the age-related decline in mitochondria.

For those of us who don’t know every portion of our cells’ interiors, telomeres are tiny caps found on the end of DNA strands, like plastic aglets on shoelaces. They are believed to protect the DNA from damage during cell division and replication. As a cell ages, its telomeres naturally shorten and fray. But the process can be accelerated by obesity, smoking, insomnia, diabetes and other aspects of health and lifestyle as we have talked about in all of our articles. In those cases, the affected cells age prematurely.

Exercise may slow the fraying of telomeres. Past studies have found, for instance, that master athletes typically have longer telomeres than sedentary people of the same age, as do older women who frequently walk or engage in other fairly moderate exercise.

But those studies were relatively narrow, focusing mostly on elderly people who ran or walked. It remained unclear whether people of different ages who engaged in a variety of exercises would likewise show effects on their telomeres.

So for the new study, which was published this month in Medicine & Science in Sports & Exercise, researchers from the University of Mississippi and University of California, San Francisco, decided to look more broadly at the interactions of exercise and telomeres among a wide swath of Americans.

 

 

Exercise And Ageing, Exercise Is The Key To Keep Your Body Young

Ageing is a natural part of life. Face it. As soon as you hit your twenties, you notice changes in your body that are clear signs of ageing. However, people age differently and you want to be one of those people who looks and feels younger than they actually are. You want to be as healthy and strong as you possibly can be so you can still enjoy life even in your later years.

Let’s take a look at how exercise can help you keep your body young.

As you get older, your heart muscle becomes less efficient. It works harder to pump the same amount of blood to your organs. Blood vessels also tend to lose their elasticity and hardened fatty deposits may make the supply of blood even harder. This can be avoided by eating a healthy diet with limited saturated fats, a lot of lean protein and vegetables. Consistent daily exercise will also go a long way in delaying the onset of such problems.

 

Exercise and Aging

 

One of the features of a young body is its ability to move fluidly. As you age, your bones decrease in size and density. It is even said that you lose a total of 2 inches as you grow older. Less dense bones make them prone to fracture. Muscles, joints and tendons also generally lose strength and flexibility as you get older. When you regularly exercise, your body gets used to physical activity and tries to keep up. Include weight training in your exercise regiment to keep your bones strong and your joints fluid. Proper diet will also go a long way to helping with this.

 

Exercise and Aging

 

 

Exercise the release of brain-derived neurotrophic factor (BDNF). Exercise causes a beneficial response in the brain and an increase of BDFN, which is a trophic factor which is linked to cognitive improvement and the alleviation of anxiety and depression. The levels of this protein have been found to increase after exercise. You may already have experienced this before when in an anxious state. Exercise seems to alleviate the anxiety and make you have clearer thoughts. As you get older, your mental sharpness decreases slowly. You can delay this through regular exercise from a young age.

As you get older, maintaining a healthy weight or losing weight becomes even more difficult. Given that most people tend to go into a sedentary lifestyle as they age, it may seem almost impossible. Your metabolism also slows down, meaning that you burn fewer calories. The best remedy for this is maintaining a consistent workout schedule consisting of strength and cardio workouts at least 3 times a week. This ill help you increase your ratio of lean muscle to fat. Being overweight naturally, makes you look and feel older than you actually are. You may feel like you are hurling around a heavy body everywhere you go.

Exercise and nutrition go hand in hand when considering slowing down the ageing process. One cannot do without the other.

 

 

 

Online Sources for exercise and aging:

http://onlinelibrary.wiley.com/doi/10.1113/JP271552/full

https://well.blogs.nytimes.com/2015/10/28/does-exercise-slow-the-aging-process/

mentalhealthdaily.com/2015/03/30/8-ways-to-increase-bdnf-levels-brain-derived-neurotrophic-factor/

……………………………………………………………………………………………………………………..

 

Papers and references for exercise and aging:

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Aimone JB, Li Y, Lee SW, Clemenson GD, Deng W & Gage FH (2014). Regulation and function of adult neurogenesis: from genes to cognition. Physiol Rev 94, 991–1026.

Allen DM, van Praag H, Ray J, Weaver Z, Winrow CJ, Carter TA, Braquet R, Harrington E, Ried T, Brown KD, Gage FH & Barlow C (2001). Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev 15, 554–566.

Bednarczyk MR, Aumont A, Decary S, Bergeron R & Fernandes KJ (2009). Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain of adult CD1 mice. Hippocampus 19, 913–927.

Biedermann SV, Fuss J, Steinle J, Auer MK, Dormann C, Falfán-Melgoza C, Ende G, Gass P & Weber-Fahr W (2014). The hippocampus and exercise: histological correlates of MR-detected volume changes. Brain Struct Funct doi: 10.1007/s00429-014-0976-5

Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Hakkinen K, Jenkins NT, Karavirta L, Kraus WE, Leon AS, Rao DC, Sarzynski MA, Skinner JS, Slentz CA & Rankinen T (2012). Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS One 7, e37887.

Bouchard C & Rankinen T (2001). Individual differences in response to regular physical activity. Med Sci Sports Exerc 33, S446–S451; discussion S452–S453.

Cameron HA & McKay RD (2001). Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 435, 406–417.

Carro E, Nuñez A, Busiguina S & Torres-Aleman I (2000). Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci 20, 2926–2933.

Cassilhas RC, Lee KS, Fernandes J, Oliveira MG, Tufik S, Meeusen R & de Mello MT (2012a). Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms. Neuroscience 202, 309–317.

Cassilhas RC, Lee KS, Venancio DP, Oliveira MG, Tufik S & de Mello MT (2012b). Resistance exercise improves hippocampus-dependent memory. Braz J Med Biol Res 45, 1215–1220.

Castilla-Ortega E, Rosell-Valle C, Pedraza C, Rodríguez de Fonseca F, Estivill-Torrús G & Santin LJ (2014). Voluntary exercise followed by chronic stress strikingly increases mature adult-born hippocampal neurons and prevents stress-induced deficits in ‘what–when–where’ memory. Neurobiol Learn Mem 109, 62–73.

Chae CH, Jung SL, An SH, Park BY, Kim TW, Wang SW, Kim JH, Lee HC & Kim HT (2014). Swimming exercise stimulates neuro-genesis in the subventricular zone via increase in synapsin I and nerve growth factor levels. Biol Sport 31, 309–314.

Clelland CD, Choi M, Romberg C, Clemenson GD Jr, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH & Bussey TJ (2009). A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325, 210–213.

Creer DJ, Romberg C, Saksida LM, van Praag H & Bussey TJ (2010). Running enhances spatial pattern separation in mice. Proc Natl Acad Sci USA 107, 2367–2372.

Dalla C, Papachristos EB, Whetstone AS & Shors TJ (2009). Female rats learn trace memories better than male rats and consequently retain a greater proportion of new neurons in their hippocampi. Proc Natl Acad Sci USA 106, 2927–2932.

Erickson KI, Prakash RS, Voss MW, Chaddock L, Hu L, Morris KS, White SM, Wójcicki TR, McAuley E & Kramer AF (2009). Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 19, 1030–1039.

Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E & Kramer AF (2011). Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA 108, 3017–3022.

Fardell JE, Vardy J, Shah JD & Johnston IN (2012). Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity. Psychopharmacology (Berl) 220, 183–193.

Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH & Christie BR (2004). Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague–Dawley rats in vivo. Neuroscience 124, 71–79.

Fischer TJ, Walker TL, Overall RW, Brandt MD & Kempermann G (2014). Acute effects of wheel running on adult hippocampal precursor cells in mice are not caused by changes in cell cycle length or S phase length. Front Neurosci 8, 314.

Gibala MJ, Little JP, Macdonald MJ & Hawley JA (2012). Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol 590, 1077–1084.

Gould E, Beylin A, Tanapat P, Reeves A & Shors TJ (1999). Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 2, 260–265.

Haram PM, Kemi OJ, Lee SJ, Bendheim MØ, Al-Share QY, Waldum HL, Gilligan LJ, Koch LG, Britton SL, Najjar SM & Wisløff U (2009). Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovasc Res 81, 723–732.

Hauser T, Klaus F, Lipp HP & Amrein I (2009). No effect of running and laboratory housing on adult hippocampal neurogenesis in wild caught long-tailed wood mouse. BMC Neurosci 10, 43.

Hornberger TA Jr & Farrar RP (2004). Physiological hypertrophy of the FHL muscle following 8 weeks of progressive resistance exercise in the rat. Can J Appl Physiol 29, 16–31.

Inoue K, Okamoto M, Shibato J, Lee MC, Matsui T, Rakwal R & Soya H (2015). Long-term mild, rather than intense, exercise enhances adult hippocampal neurogenesis and greatly changes the transcriptomic profile of the hippocampus. PLoS One 10, e0128720.

Johnson RA, Rhodes JS, Jeffrey SL, Garland T Jr & Mitchell GS (2003). Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running. Neuroscience 121, 1–7.

Koch LG & Britton SL (2008). Aerobic metabolism underlies complexity and capacity. J Physiol 586, 83–95.

Koch LG & Britton SL (2001). Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol Genomics 5, 45–52.
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Koch LG, Pollott GE & Britton SL (2013). Selectively bred rat model system for low and high response to exercise training. Physiol Genomics 45, 606–614.

Lee MC, Inoue K, Okamoto M, Liu YF, Matsui T, Yook JS & Soya H (2013). Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running. Neurosci Lett 537, 6–10.

Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG & Goodyear LJ (2013). Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes 62, 2717–2727.

Leuner B, Glasper ER & Gould E (2010). Sexual experience promotes adult neurogenesis in the hippocampus despite an initial elevation in stress hormones. PLoS One 5, e11597.

Li Y, Luikart BW, Birnbaum S, Chen J, Kwon CH, Kernie SG, Bassel-Duby R & Parada LF (2008). TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron 59, 399–412.

Lucassen PJ, Oomen CA, Naninck EF, Fitzsimons CP, van Dam AM, Czeh B & Korosi A (2015). Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation. Cold Spring Harb Perspect Biol 7, a021303.

Marlatt MW, Potter MC, Lucassen PJ & van Praag H (2012). Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice. Dev Neurobiol 72, 943–952.

Marton O, Koltai E, Takeda M, Koch LG, Britton SL, Davies KJ, Boldogh I & Radak Z (2015). Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. Pflugers Arch 467, 779–788.

Niwa A, Nishibori M, Hamasaki S, Kobori T, Liu K, Wake H, Mori S, Yoshino T & Takahashi H (2015). Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle. Brain Struct Funct doi: 10.1007/s00429-015-0995-x

Nokia MS, Anderson ML & Shors TJ (2012). Chemotherapy disrupts learning, neurogenesis and theta activity in the adult brain. Eur J Neurosci 36, 3521–3530.

Novaes Gomes FG, Fernandes J, Vannucci Campos D, Cassilhas RC, Viana GM, D’Almeida V, de Moraes Rêgo MK, Buainain PI, Cavalheiro EA & Arida RM (2014). The beneficial effects of strength exercise on hippocampal cell proliferation and apoptotic signaling is impaired by anabolic androgenic steroids. Psychoneuroendocrinology 50, 106–117.

Okamoto M, Hojo Y, Inoue K, Matsui T, Kawato S, McEwen BS & Soya H (2012). Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis. Proc Natl Acad Sci USA 109, 13100–13105.

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Rothman SM & Mattson MP (2013). Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience 239, 228–240.

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Winocur G, Wojtowicz JM, Huang J & Tannock IF (2014). Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats. Psychopharmacology (Berl) 231, 2311–2320.

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Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

MORINGA, antioxidant benefits, Uses, Side Effects & Interactions

Other Names of  MORINGA: Arango, Árbol de las Perlas, Behen, Ben Ailé, Ben Nut Tree, Ben Oléifère, Benzolive, Canéficier de l’Inde, Chinto Borrego, Clarifier Tree, Drumstick Tree,…

Research in progress 

 

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant

Moringa Oleifera has been hailed since time immemorial for its immense health benefits. The plant is native to Africa and many consider it the tree of life. It is also very common in Asia as it is widely used in Ayurvedic medicine. It contains a significant number of proteins, essential vitamins, and minerals making it common not only from a nutritional point of view but also in the cosmetics industry due to its powerful antioxidants.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Although Moringa has several benefits, we are going to narrow in on its antioxidant and anti-ageing properties.

Antioxidant effects of Moringa

Moringa has been found to contain about 47 antioxidants including phenolic acid, flavonoid/bioflavonoids, and tannic acid. Experiments have been carried out on different parts of the Moringa tree to identify what parts have more Polyphenol antioxidant benefits. In one study, It was found that all extracts acted as radical scavengers due to the presence of the polyphenolic compound. It was also found that the flowers possessed the highest antioxidant properties, followed closely by the leaf, root, gum bark and finally the seed.
What these strong antioxidants do is they help neutralize free radicals(oxidative damage). Free radicals are produced as by-products of normal body processes, medicine break-down after consumption and as a result of exposure to pollutants. Moringa is known as one of the most effective of antioxidant foods.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Anti-aging properties of Moringa

The cosmetics industry heavily relies on Moringa as a natural supplement to try and slow down the aging process. Moringa contains a plant hormone called zeatin, which affects the process of cell division, influencing aging. Moringa is the only known plant to contain such high levels of Zeatin.

APPLIED TO THE SKIN for:
Athlete’s foot.
Dandruff.
Warts.
Skin infections.
Snakebites.
Gum disease (gingivitis).
Other conditions.
Progeria is a disease in which a person ages rapidly at a much faster rate than normal. It afflicts people whose bodies cannot manufacture and/or utilize antioxidants. Moringa contains high levels of vitamin C, which helps with the synthesis of collagen. When the level of collagen is low, the skin collapses to take up the free space, causing wrinkles, which are a tell-tale sign of aging.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

The anti-aging properties of Moringa do not only apply to the skin. It has been known to decrease brain aging and cognition decline. The plant is a memory booster, helping with concentration, focus, and clarity. This is by virtue of its B vitamins, but also notably, the high concentration of Iron which allows for more oxygenated blood flow to the brain.

All this information should be enough to convince you to include Moringa, in your diet. You may either take it in its natural form or as a Moringa supplement. Moringa’s antioxidant properties can also help prevent and manage certain diseases such as cancer and cardiovascular disease which stem from the overproduction of free radicals in the body. In a world where pollution is rampant, intake of antioxidant super foods is a safe bet to prevent diseases.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Moringa is your best choice as it is effective, safe, naturally occurring and affordable.

 

Moringa is used to improve “tired blood” (anemia); arthritis and other joint pain (rheumatism); asthma; cancer; constipation; diabetes; diarrhea; epilepsy; stomach pain; stomach and intestinal ulcers; intestinal spasms; headache; heart problems; high blood pressure; kidney stones; fluid retention; thyroid disorders; and bacterial, fungal, viral, and parasitic infections. Moringa is also used to reduce swelling, increase sex drive (as an aphrodisiac), prevent pregnancy, boost the immune system, and increase breast milk production.

So get Moringa for :

 

 

 

 

 

Reference and resources:

sources link , Reference for more research on MORINGA:

draxe.com
webmd.com
drweil.com
examine.com
ods.od.nih.gov

http://www.webmd.com/vitamins-supplements/ingredientmono-1242-moringa.aspx?activeingredientid=1242

 

Antioxidants Benefits & Effects of Polyphenols, Phenolic Acid

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

Flavones Flavonols Flavanones Isoflavones Anthocyanidins Chalcones, Catechins,Stilbenes

Research in progress

 

About Polyphenol, Phenolic acids:

A phenolic acid is a sort of phytochemical known as a polyphenol. Phenolic acids are found in an assortment of plant-based nourishments such as the seeds and skins of products of the soil leaves of vegetables contain the most noteworthy concentration. Phenolic acids are promptly consumed through the dividers of your intestinal tract, and they might be valuable to your wellbeing since they fill in as cancer prevention agents that counteract cell harm because of free-radical oxidation responses. The Polyphenol phenolic acid supplements may likewise work as anti inflammatory in the human body. It strongly supports a role for polyphenols in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanisms of action of polyphenols go beyond the modulation of oxidative stress. Polyphenols are the most abundant antioxidants in the diet. Their total dietary intake could be as high as 1 g/d, which is much higher than that of all other classes of phytochemicals and known dietary antioxidants.

 

 

 

 

 

Ranking list of top foods list with Polyphenols (Phenolic Acid)

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

Top foods list with Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects

Different Types of Polyphenols

Polyphenols are four main categories, with additional sub-groupings. based on the number of phenol rings they contain, and on the basis of structural elements in their construction.

As a general rule, foods contain complex mixtures of polyphenols, with higher levels found in the outer layers of the plants than the inner parts.

 

1- Flavonoids,  have Strong both antioxidant and anti-inflammatory properties, found in fruits, vegetables, legumes, red wine, and green tea
      Flavones
      Flavonols
      Flavanones
      Isoflavones
      Anthocyanidins
      Chalcones
      Catechins
2- Stilbenes, found in red wine and peanuts (resveratrol is the most well known)
3- Lignans, found in seeds like flax, legumes, cereals, grains, fruits, algae, and certain vegetables
4- Phenolic acids
Hydroxybenzoic acids, found in tea
Hydroxycinnamic acids found in cinnamon of course but also in coffee, blueberries, kiwis, plums, apples, and cherries

 

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

 

Polyphenols are usually associated with/ improving:

  • Fighting cancer cells and inhibiting angiogenesis (the growth of blood vessels that feed a tumor)
  • Protecting your skin against ultraviolet radiation
  • Fighting free radicals
  • reducing the appearance of aging
  • Promoting brain health
  • protecting against dementia
  • Reducing inflammation
  • Supporting normal blood sugar levels
  • Protecting your cardiovascular system
  • Promoting normal blood pressure

 

Polyphenols work effective for :

 

 

 

Antioxidants effects & Benefits of Phenolic acids:

• Anti-Diabetic Effects of  Polyphenols

Numerous studies report the antidiabetic effects of polyphenols. Tea catechins have been investigated for their anti-diabetic potential.63,64 Polyphenols may affect glycemia through different mechanisms, including the inhibition of glucose absorption in the gut or of its uptake by peripheral tissues.Onion polyphenols, especially quercetin is known to possess strong anti diabetic activity. A recent study shows that quercetin has ability to protect the alterations in diabetic patients during oxidative stress. Quercetin significantly protected the lipid peroxidation and inhibition antioxidant system in diabetics. (source)

Cranberry Strong Antioxidant Effects

 

• Used as Anti bacterial:

Bacteria are collection of single cell microorganisms. Most microorganisms are innocuous in people because of the defensive impacts of the immune framework. Notwithstanding, a few microscopic organisms are perilous and can bring about irresistible maladies. Luckily, phenol acids are effective antibacterials and can help guard you from perilous microorganisms. Temporary reviews recommend that phenolic acid may likewise have antibacterial properties however additional confirmation is required before this can be affirmed. (source)

 Sage, just a mint or strong antioxidants and Anti-Inflammatory

• Anti-Aging Effect

Aging is the accumulation process of diverse detrimental changes in the cells and tissues with advancing age, resulting in an increase in the risks of disease and death. Among many theories purposed for the explaining the mechanism of aging, free radical/oxidative stress theory is one of the most accepted one. Antioxidant capacity of the plasma is related to dietary intake of antioxidants; it has been found that the intake of antioxidant rich diet is effective in reducing the deleterious effects of aging and behavior. Several researches suggest that the combination of antioxidant/anti-inflammatory polyphenolic compounds found in fruits and vegetables may show efficacy as anti-aging compounds. Subset of the flavonoids known as anthocyanins, are particularly abundant in brightly colored fruits such as berry fruits and concord grapes and grape seeds.  (source)

• Reduces inflammation:

Inflammation is the body’s method for managing disease, harm, aggravation or stress. It prompts warm, torment, redness or swelling around the influenced body part. Most inflammation is sure as it demonstrates that the body has recognized a risk and is endeavoring to manage the issue. In any case, some inflammation is superfluous and harms the body’s cells when there is no contamination, damage, bothering or worry to manage. Luckily, the phenolic acids can help monitor pointless inflammation. The strong antioxidants of phenolic acids are powerful against inflammation. (source)

Ranking list of top foods list with Polyphenols (Phenolic Acid)

• Antioxidant effects of Polyphenol, phenolic acid on cancer:

Antioxidants are substances that protect a human body’s cells from free radicals. Free radicals are destructive substances that are discharged into the body amid oxygen based responses. They have been connected with serious disease such as cancer, diabetes, a weak invulnerable system along with noticeable indications of maturing. Luckily, the greater parts of the phenolic acids aside from “capsaicin” are intense cancer prevention agents that can guard you from the antagonistic impacts related with free radicals. Several mechanisms of action have been identified for chemoprevention effect of polyphenols, these include estrogenic/antiestrogenic activity, antiproliferation, induction of cell cycle arrest or apoptosis, prevention of oxidation, induction of detoxification enzymes, regulation of the host immune system, anti-inflammatory activity and changes in cellular signaling

Ranking list of top foods list with Polyphenols (Phenolic Acid)

 

• Neuro-Protective Effects and Mental health boosters:

The phenolic acids have a considerable measure of potential with regards to boosting the emotional wellbeing. Early research proposes that phenolic acids may go about as an energizer and furthermore it prevents the Alzheimer’s disease. What’s more, they may likewise ensure against Alzheimer’s malady while vanillin may shield the cerebrum cells from harm, prevents Alzheimer’s infection and Parkinson’s ailment. In any case, additionally studies are required before the impacts of the phenolic acids on brain health are affirmed. Oxidative stress and damage to brain macromolecules is an important process in neurodegenerative diseases. Alzheimer’s disease is one of the most common occurring neurodisorder affecting up to 18 million people worldwide. Because polyphenols are highly antioxidative in nature, their consumption may provide protection in neurological diseases. It was observed that the people drinking three to four glasses of wine (vines that have Polyphenol contents) per day had 80% decreased incidence of dementia and Alzheimer’s disease compared to those who drank less or did not drink at all. (source)

 

Green Tea, Antioxidant effects and benefits

Polyphenol Supplements interactions

These mostly happen with supplements not the foods containing Polyphenol

  • Iron depletion in populations of people who have marginal iron stores
  • Interference with thyroid hormone metabolism
  • Interactions with pharmaceutical drugs, enhancing their biologic effects

 

 

 

 

 

 

 

 

 

References and sources for Polyphenols online:

http://www.nature.com/ejcn/journal/v64/n3s/fig_tab/ejcn2010221t1.html

http://articles.mercola.com/sites/articles/archive/2015/12/14/polyphenols-benefits.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/

https://en.wikipedia.org/wiki/Antioxidant_effect_of_polyphenols_and_natural_phenols

http://ajcn.nutrition.org/content/81/1/215S.full

 

 

Published papers and articles  and References for Polyphenols

1. Scalbert A, Manach C, Morand C, Remesy C. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005;45:287–306. [PubMed]
2. Spencer JP, Abd El Mohsen MM, Minihane AM, Mathers JC. Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr. 2008;99:12–22. [PubMed]
3. Beckman CH. Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants? Physiol. Mol. Plant Pathol. 2000;57:101–110.
4. Graf BA, Milbury PE, Blumberg JB. Flavonols, flavonones, flavanones and human health: Epidemological evidence. J Med Food. 2005;8:281–290. [PubMed]
5. Arts ICW, Hollman PCH. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005;81:317–325. [PubMed]
6. Kondratyuk TP, Pezzuto JM. Natural Product Polyphenols of Relevance to Human Health. Pharm Biol. 2004;42:46–63.
7. Shahidi F, Naczk M. Food phenolics, sources, chemistry, effects, applications. Lancaster, PA: Technomic Publishing Co Inc; 1995.
8. de Groot H, Rauen U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharmacol. 1998;12:249–255. [PubMed]
9. Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med. 1997;29:95–120. [PubMed]
10. Wink M. Compartmentation of secondary metabolites and xenobiotics in plant vacuoles. Adv Bot Res. 1997;25:141–169.
11. Simon BF, Perez-Ilzarbe J, Hernandez T, Gomez-Cordoves C, Estrella I. Importance of phenolic compounds for the characterization of fruit juices. J Agric Food Sci. 1992;40:1531–1535.
12. Manach C, Scalbert A, Morand C, Rémésy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79:727–747. [PubMed]
13. Parr AJ, Bolwell GP. Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenol content or profile. J Agric Food Chem. 2000;80:985–1012.
14. Sosulski FW, Krygier K, Hogge L. Importance of phenolic compounds for the characterization of fruit juices. J Agric Food Chem. 1982;30:337–340.
15. Price KR, Bacon JR, Rhodes MJC. Effect of storage and domestic processing on the content and composition of flavonol glucosides in onion (Allium cepa) J Agric Food Chem. 1997;45:938–942.
16. Crozier A, Lean MEJ, McDonald MS, Black C. Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. J Agric Food Chem. 1997;45:590–595.
17. D’Archivio M, Filesi C, Benedetto RD, Gargiulo R, Giovannini C, Masella R. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanità 2007;43:348–361. [PubMed]
18. Day AJ, Williamson G. Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma. Br J Nutr. 2001;86:S105–S110. [PubMed]
19. Setchell KD, Faughnan MS, Avades T, Zimmer-Nechemias L, Brown NM, et al. Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. Am J Clin Nutr. 2003;77:411–419. [PubMed]
20. Duthie GG, Pedersen MW, Gardner PT, Morrice PC, Jenkinson AM, McPhail DB, Steele GM. The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur J Clin Nutr. 1998;52:733–736. [PubMed]
21. Young JF, Nielsen SE, Haraldsdóttir J, Daneshvar B, Lauridsen ST, Knuthsen P, Crozier A, Sandström B, Dragsted LO. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr. 1999;69:87–94. [PubMed]
22. Gee JM, DuPont MS, Rhodes MJ, Johnson IT. Quercetin glucosides interact with the intestinal glucose transport pathway. Free Radic Biol Med. 1998;25:19–25. [PubMed]
23. Crespy V, Morand C, Besson C, Manach C, Demigne C, Remesy C. Quercetin, but not its glycosides, is absorbed from the rat stomach. J Agric Food Chem. 2002;50:618–621. [PubMed]
24. Passamonti S, Vrhovsek U, Vanzo A, Mattivi F. Fast access of some grape pigments to the brain. J Agric Food Chem. 2005;53:7029–7034. [PubMed]
25. Halliwell B, Zhao K, Whiteman M. The gastrointestinal tract: a major site of antioxidant action? Free Radic Res. 2000;33:819–830. [PubMed]
26. Clifford MN. Chlorogenic acids and other cinnamates. Nature, occurence, dietary burden, absorption and metabolism. J Sci Food Agric. 2000;80:1033–1043.
27. Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr. 2001;131:66–71. [PubMed]
28. Kuhnau J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet. 1976;24:117–191. [PubMed]
29. Lee MJ, Maliakal P, Chen L, Meng X, Bondoc FY, et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev. 2002;11:1025–1032. [PubMed]
30. Falany CN. Enzymology of human cytosolic sulfotransferases. Faseb J. 1997;11:206–216. [PubMed]
31. Spencer JP, Chowrimootoo G, Choudhury R, Debnam ES, Srai SK, Rice-Evans C. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett. 1999;458:224–230. [PubMed]
32. Hollman PC, Tijburg LB, Yang CS. Bioavailability of flavonoids from tea. Crit Rev Food Sci Nutr. 1997;37:719–738. [PubMed]
33. Dangles O, Dufour C, Manach C, Morand C, Remesy C. Binding of flavonoids to plasma proteins. Methods Enzymol. 2001;335:319–333. [PubMed]
34. Dufour C, Loonis M, Dangles O. Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin. Free Radic Biol Med. 2007;43:241–252. [PubMed]
35. Vitrac X, Moni JP, Vercauteren J, Deffieux G, Mérillon JM. Direct liquid chromatography analysis of resveratrol derivatives and flavanonols in wines with absorbance and fluorescence detection. Anal Chim Acta. 2002;458:103–110.
36. Luqman S, Rizvi SI. Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res. 2006;20:303–306. [PubMed]
37. Pandey KB, Mishra N, Rizvi SI. Protective role of myricetin on markers of oxidative stress in human erythrocytes subjected to oxidative stress. Nat Prod Commun. 2009;4:221–226. [PubMed]
38. Pandey KB, Rizvi SI. Protective effect of resveratrol on markers of oxidative stress in human erythrocytes subjected to in vitro oxidative insult. Phytother Res. 2009. In press. [PubMed]
39. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992;339:1523–1526. [PubMed]

 

How Skin Aging Happens And How You Can Keep Your Skin Young? remedies & antioxidants to go wrinkles free!

NAC, Antioxidant Effects & Benefits of N-Acetyl cysteine (NAC) a trigger for GLUTATHIONE

Antioxidant Effects & Benefits of N-Acetyl cysteine (NAC)

Other Names: Acetyl Cysteine, Acétyl Cystéine, Acetylcysteine, Acétylcystéine, Chlorhydrate de Cystéine, Cysteine, Cystéine, Cysteine Hydrochloride, Cystine,

About N- Acetyl Cysteine (NAC):

For over thirty years, a protected, minimal effort compound known as N-acetyl cysreine (NAC) has given help to many individuals from the wheezing, thick mucus related to flu or cold and wheezing. Obviously, pharmaceutical organizations co-selected it for benefit by joining it into different licensed medications. The pitiful outcome is that most specialists or health experts have never known about it. Indeed, even many specialists stay uninformed of its potential part as an amazing guard against some of today’s most general health threats. Below are some amazing benefits NAC can provide a human body. N-acetyl cysteine comes from the amino acid L-cysteine. Amino acids are the building blocks of proteins. N-acetyl cysteine has many uses as medicine.

N-acetyl cysteine is used to counteract acetaminophen (Tylenol) and carbon monoxide poisoning. It is also used for chest pain (unstable angina), bile duct blockage in infants, amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), Alzheimer’s disease, allergic reactions to the anti-seizure drug phenytoin (Dilantin), and an eye infection called keratoconjunctivitis. It is also used for reducing levels of a type of cholesterol called lipoprotein (a), homocysteine levels (a possible risk factor for heart disease) and the risk of heart attack and stroke in patients with serious kidney disease. (source)

N-acetyl-cysteine is an effective scavenger of free radicals as well as a major contributor to maintenance of the cellular glutathione status in muscle cells. Studies have demonstrated some possible roles for NAC to minimize fatigue or extend the time it takes for it to accumulate as well as prevent the onset of apoptosis secondary to exhaustive exercise. It is still not known if the combination of vitamin C and NAC may be detrimental after damaging exercise as well as NAC’s other possible roles during muscle damage and extensive muscle proteolysis.

Benefits of NAC:

• Fights liver disease:

A lot of people, ordinarily utilized pharmaceuticals for killing pain, for example, Tylenol and Vicodin contain a substance called Acetaminophen. On the off chance that taken in high amounts, Acetaminophen can be harmful to the liver and can bring about liver disappointment. NAC is ordinarily used to treat liver disappointment because of Acetaminophen and enormously expands the patient’s odds of survival. NAC has likewise been appeared to viably treat liver diseases brought on by different variables, for example by liquor utilization or ecological poisons.

• Great to fight with Cellular Oxidative Damage:

Oxygen radicals will bring about oxidative harm that is hindering to cells and their DNA By recharging Glutathione where it is required in the body, NAC battles against oxygen radicals and thusly averts cell harm. This can be particularly useful if cells have been presented to lead.

• Treats HIV:

HIV is an ailment that causes the disappointment of the bodies’ immune reaction. It has been demonstrated that large amounts of NAC in the body can help keep the proliferation of one strain of HIV, HIV-1. This proposes that the cells with high NAC levels might have the capacity to oppose HIV disease. NAC might be a decent supplement to take for subjects who are HIV+ and are taking different prescriptions.

• Helps decreasing tissues’ inflammation:

long with reducing oxidative harm in tissues, NAC can work to lessen the aggravation in tissues. NAC diminishes the measure of various provocative particles introduce in the body. Reduction of irritation can diminish side effects of various illnesses or reduce danger of creating diverse infections. Strong antioxidants in NAC additionally help in reducing aggravation after lively exercise, which considers individuals to play out these activities without an excessive amount of soreness.

• Used to prevent addictive behaviors in human:

Addictive behaviors incorporate voraciously consuming food, medicate addictions, and other habitual practices. NAC is able to reduce or dispose of these practices in rat models. An efficient survey found that NAC helps people a lot that are addicted particularly with cocaine and cannabis. Some other addictions, for example, pulling the hairs or biting nails can likewise be averted utilizing NAC.

• Great for decreasing Insulin resistance in bodies:

High glucose and heftiness can bring about irritation in fat tissue. This aggravation starts a flagging pathway that at last prompts to the decimation of insulin receptors. The decimation prompts diabetes 2 in human body. The strong antioxidants of NAC have been appeared to reduce aggravation in fat cells.

Get NAC for:

(Antioxidant effects of NAC is indirectly applied to body basically by improving and playing a role as trigger for GLUTATHIONE)

The following doses have been studied in scientific research:

BY MOUTH:

For chest pain that is not relieved by rest (unstable angina): 600 mg of N-acetyl cysteine three times daily with a nitroglycerin patch.
For preventing sudden worsening of chronic bronchitis: doses of 200 mg twice daily, 200 mg three times daily, 300 mg slow-release twice daily, and 600 mg controlled-release twice daily have been used.
For treating chronic obstructive pulmonary disease (COPD): 600 mg of N-acetyl cysteine once daily, in addition to standard care, has been used for up to 6 months.

For more details (source)

 

Major Interaction

Do not take this combination
Nitroglycerin interacts with N-ACETYL CYSTEINE

 

 

 

 

Good resources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129149/

http://www.webmd.com/vitamins-supplements/ingredientmono-1018-n-acetyl%20cysteine.aspx?activeingredientid=1018

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685276/

 

 

References
Evans WJ. Vitamin E, vitamin C, and exercise. Am J Clin Nutr. 2000;72:647S–652S. [PubMed]
Stipanuk MH. Biochemical and Physiological Aspects of Human Nutrition. Philadelphia, PA: SAUNDERS; 2000.
Sen CK. Antioxidant and redox regulation of cellular signaling: introduction. Med Sci Sports Exerc. 2001;33:368–370. doi: 10.1097/00005768-200103000-00005. [PubMed] [Cross Ref]
Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr. 2000;72:637S–646S. [PubMed]
Van Remmen H, Hamilton ML, Richardson A. Oxidative Damage to DNA and Aging. Exerc Sport Sci Rev. 2003;31:149–153. doi: 10.1097/00003677-200307000-00009. [PubMed] [Cross Ref]
Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol. 2000;279:L1005–L1028. [PubMed]
Bryant RJ, Ryder J, Martino P, et al. Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. J Strength Cond Res. 2003;17:792–800. doi: 10.1519/1533-4287(2003)017<0792:EOVEAC>2.0.CO;2. [PubMed] [Cross Ref]
Ramel A, Wagner KH, Elmadfa I. Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men. Eur J Nutr. 2004;43:2–6. doi: 10.1007/s00394-004-0432-z. [PubMed] [Cross Ref]
Rodriguez MC, Rosenfeld J, Tarnopolsky MA. Plasma malondialdehyde increases transiently after ischemic forearm exercise. Med Sci Sports Exerc. 2003;35:1859–1865. doi: 10.1249/01.MSS.0000093609.75937.70. [PubMed] [Cross Ref]
Chan KM, Decker EA. Endogenous skeletal muscle antioxidants. Critical Reviews in Food Science and Nutrition. 1994;34:403–426. [PubMed]
Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr. 2000;72:653S–669S. [PubMed]
Davison GW, Hughes CM, Bell RA. Exercise and mononuclear cell DNA damage: The effects of antioxidant supplementation. Int J Sport Nutr Exerc Metab. 2005;15:480–492. [PubMed]
Sen CK. Glutathione homeostasis in response to exercise training and nutritional supplements. Molecular and Cellular Biochemistry. 1999;196:31–42. doi: 10.1023/A:1006910011048. [PubMed] [Cross Ref]
Viguie CA, Frei B, Shigenaga MK, et al. Antioxidant status and indexes of oxidative stress during consecutive days of exercise. J Appl Physiol. 1993;75:566–572. [PubMed]
Laires MJ, Madeira F, Sergio J. Preliminary study of the relationship between plasma and erythrocyte magnesium variations and some circulating pro-oxidant and antioxidant indices in a standardized physical effort. Magnesium Research. 1993;6:233–238. [PubMed]
Lee J, Clarkson PM. Plasma creatine kinase activity and glutathione after eccentric exercise. Med Sci Sports Exerc. 2003;35:930–936. doi: 10.1249/01.MSS.0000069553.47739.36. [PubMed] [Cross Ref]
Laaksonen DE, Atalay M, Niskanen L, et al. Blood glutathione homeostasis as a determinant of resting and exercise-induced oxidative stress in young men. Redox Rep. 1999;4:53–59. doi: 10.1179/135100099101534648. [PubMed] [Cross Ref]
Meister A. Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol Ther. 1991;51:155–194. doi: 10.1016/0163-7258(91)90076-X. [PubMed] [Cross Ref]
Sen CK. Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochemical Pharmacology. 1998;55:1747–1758. doi: 10.1016/S0006-2952(97)00672-2. [PubMed] [Cross Ref]
Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J. 1996;10 [PubMed]
Sen CK, Khanna S, Reznick AZ, et al. Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa-B activation in skeletal muscle-derived L6 cells. Biochem Biophys Res Commun. 1997;237:645–649. doi: 10.1006/bbrc.1997.7206. [PubMed] [Cross Ref]
Reid MB, Stokic DS, Koch SM, et al. N-Acetylcysteine inhibits muscle fatigue in humans. J Clin Invest. 1994;94:2468–2474. [PMC free article] [PubMed]
Supinski GS, Stofan D, Ciufo R, et al. N-acetylcysteine administration alters the response to inspiratory loading in oxygen-supplemented rats. J Appl Physiol. 1997;82:1119–1125. [PubMed]
Matuszczak Y, Farid M, Jones J, et al. Effect of n-acetylcysteine on glutathione oxidation and fatigue during handgrip exercise. Muscle Nerve. 2005;32:633–638. doi: 10.1002/mus.20385. [PubMed]

Cognitive decline and the best foods used to stop it!

Cognitive decline and the best foods used to stop it!

Antioxidant compounds, contained in fruit, vegetables and tea, have been postulated to have a protective effect against age-related cognitive decline by combating oxidative stress. However, recent research on this subject has been conflicting. here are some basic point about CD and Aging and the main focus of this Article is on foods that Helps us fight CD.

About Cognitive Decline (What is Cognitive Decline?):

If you have Cognitive Decline or cognitive impairment, you may be aware that your memory or mental function has “slipped.” Your family and close friends also may notice a change. But generally these changes aren’t severe enough to significantly interfere with your day-to-day life and usual activities.

When anyone makes some tea or use computer or even read a book, that person it utilizing the cognitive capacities. Cognitive capacities are the mental aptitudes that you have to carry from the easiest to the most perplexing task. These mental abilities incorporate mindfulness, memory, information handling and thinking. As our age increases, the cognitive abilities continuously break down. A specific sum of cognitive decrease is a typical thing in maturing. A few people may encounter an extreme crumbling in psychological abilities, prompting dementia. This can make it difficult to adapt to customary everyday tasks. In order to get rid or avoid such problems, below are some foods that can be utilized.

Mild cognitive impairment may increase your risk of later progressing to dementia, caused by Alzheimer’s disease or other neurological conditions. But some people with mild cognitive impairment never get worse, and a few eventually get better.

 

About Cognitive Decline (What is Cognitive Decline?):

 

Cognitive disorders like CD are a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium. While anxiety disorders, mood disorders, and psychotic disorders can also have an effect on cognitive and memory functions. Cognitive Decline is generally happening to all while aging but we dont really notice that. we get old and our abilities and awareness reduces but we dont understand maybe others do.

Cognitive decline is categorized under dementia in Mental disorders. For dementia cases, studies suggest that diets with high Omega 3 content, low in saturated fats and sugars, along with regular exercise can increase the level of brain plasticity and BDNF. Other studies have shown that mental exercise such a newly developed “computerized brain training programs” can also help build and maintain targeted specific areas of the brain.

Findings from some studies suggest that intakes of vitamin C and E that significantly exceed adequate or recommended intakes (over 130 and 15 mg/day for vitamin C and E, respectively) may be beneficial . This is in slight contrast to a very thorough review of vitamin C, cognitive decline and AD by Harrison , who concluded that a healthy, long-term diet in which adequate vitamin C levels are maintained and vitamin deficiency is avoided may protect against age-related cognitive decline and AD, and be more beneficial than taking supplements. (source & source & Source )

 

About Cognitive Decline (What is Cognitive Decline?):

 

 

Foods that are best to Slow down & stop Cognitive Decline caused by aging:

Green Tea:

Green Tea, Antioxidant effects and benefits

Green tea is on the top of the list in the skin friendly drinks due to its noteworthy storage facility of polyphenols that can cause aging. Having four glasses each day can give amazing results by fighting against aging elements in human body.

 

• GINGER ROOT:

Ginger (root) Unique health benefits & Antioxidant effects

Grated and ground ginger in two wooden spoons ginger root green leaves on the wooden board

Ginger and turmeric are from the same basic family of plants. Health benefits of turmeric is largely mentioned in many articles. But now ginger. Ginger is a Southeast Asian plant. The spice ginger is the underground rhizome of the ginger plant, known botanically as Zingiber officinale. Ginger is used as a spice and medicine.

•  TURMERIC:

Turmeric (Curcumin) Anti-inflammatory & Antioxidant Keeps you young

different types of turmeric barks

Health benefits of turmeric is largely mentioned in many articles. Turmeric is known for improving conditions for arthritis, heartburn (dyspepsia), joint pain, stomach pain, Crohn’s disease and ulcerative colitis, bypass surgery, hemorrhage, diarrhea, intestinal gas, stomach bloating, loss of appetite, stomach ulcers an so on.

•  Sage:

Sage, just a mint or strong antioxidants and Anti-Inflammatory

Sage is an herb, a mint. The leaf is used to make medicine. Sage contains rosmarinic acid, rosmarinic acid is a potent antioxidant and an anti-inflammatory agent. Rosmarinic acid reduces harmful inflammation.

Salmon:

Fish oil, DHA & EPA & OMEGA 3-6-9 Antioxidants and benefits

Raw red fish

Salmon contains astaxanthin which works amazingly on skin and enhances the elasticity of skin by decrease the number of fine lines and wrinkles.  astaxanthin is by some researches considered as the strongest antioxidant ever found.

• Fish and fish oil:

Fish oil, DHA & EPA & OMEGA 3-6-9 Antioxidants and benefits

According to the researchers after several researches, the phenomenal measure of fish they take keeps that away from dangerous heart diseases and cancer. Fish is a copious wellspring of omega-3 fats, which help avert cholesterol development in the arteries and secure against irregular heart rhythms.

•  Olive Oil & Olive extracts:

vitamin-e Unique health benefits & Antioxidant effects

Forty years back, analysts from the Seven Countries Study revealed that the monounsaturated fats found in the olive oil were to a great extent, reason of the low rates of coronary illness and cancer. Presently, the studies  indicated that olive oil additionally contains poly-phenols, effective cancer prevention agents that may help forestall age-related infections.

•  Berries:

Cranberry Strong Antioxidant Effects

All Berries, especially members of some important families, like Rosaceae (strawberry, raspberry, blackberry), and Ericaceae (blueberry, cranberry), belong to the best dietary sources of bioactive compounds (BAC). Because of the antioxidant properties of BAC, they are of great interest also for nutritionists and food technologists due to the opportunity to use BAC as functional foods ingredients. The bioactive compounds in berries contain mainly phenolic compounds (phenolic acids, flavonoids, such as anthocyanins and flavonols, and tannins) and ascorbic acid.

•  MATCHA:

Green Tea, Antioxidant effects and benefits

Matcha is basically green tea leaves that have been stone ground and processed into a powder. The powder is then filtered and raced with boiling water. Due to the difficult procedure required to deliver matcha, the tea is for the most part expensive than others.

OLIVE LEAF

branch of green olives antioxidant benefits

branch of green olives

If you are going to consider getting Olive leaf (extracts) you should know based on the studies these are the situations that it has been proven that Olive leaf (extracts) can improve.
Lowers Blood Pressure, Improves Cardiovascular Health, Diabetes, Reduces the Risk of Cancer and so on.

 

• Eggs:

Protein (amino acids) repairs all those cells that have endured the damage from free radical. Eggs, an amazing source of protein, likewise contain biotin which is an essential vitamin that protect the body from free radicals.

• Pomegranate:

The antioxidant rich fruit may help skin to make more collagen and can also help in speeding healing. The essential nutrients in it help making the skin look fresh and glower and it works amazingly as an anti aging food.

• Beans:

Beans are another protein source. They help repair cells that have endured the free radical damage. During digestion, protein separates into amino acids, the building squares of cells which further help to speed as well as repair and regenerate the skin cells along with collagen.

• Chocolate coco powder:

If dietary phenolics are active in-vivo antioxidants, chocolate can contribute a significant portion of dietary antioxidants, and the pleasant pairing of red wine and dark chocolate could have synergistic advantages beyond their complementary tastes. According to a study, the people who live in Kuna in the San Blas islands near panama, have a rate of heart illness that is a great percent less than those of Panamanians. The Kuna people, in order to stay away from heart diseases, drink a lot of a refreshments made with liberal extents of chocolate, which is bizarrely rich in flavanols that help protect the sound capacity of veins. Keeping up young veins and fights aging.

•  Watermelon:

The reviving and sweet treat contains a definitive cancer prevention agent, vitamin C, in addition to lycopene as well as potassium, which controls the adjust of water and supplements in cells and makes individuals look healthy and young.

• Dark Chocolate:

The sweet chocolate is rich in cocoa flavanols, plant compounds as well as the effective & strong antioxidant properties, which help hydrate skin and enhance circulation.

• Walnuts:

It’s the only kind of nut that contains a significant amount of unsaturated fats, which is particularly important for vegetarians who are not able to eat fish. Walnuts pack an omega-3 called alpha-linolenic corrosive. Deficiency in this fat can bring about dermatitis, which is related with dry, flaky skin. So, having walnuts will make the skin fresh, and young.

• Citrus fruits peel:

Analysts from the University of Arizona took a gander at individuals who stated that they ate citrus fruits, squeezes, and peels each week. Individuals, who ate peels such as orange peel or lemon juice, had a 33% diminished hazard for “squamous cell carcinoma”. Juices and fruit didn’t have any impact. Limonene is a compound found in the oil in the peels that offers the UV-defensive benefits and makes the skin look great.

• Walnuts:

Walnuts are stuffed with healthy as well as anti inflammatory supplements, and are the main great nut source of alpha linolenic corrosive. They help advance blood stream, which thusly takes into consideration a great delivery of oxygen to the cerebrum. What’s more, a study found that mice with the infection that were routinely nourished walnuts had enhanced memory, learning and function ability coordination.

• Coffee:

Caffeine, the gentle stimulant found in coffee actually enhances mental acuity. Beside caffeine’s mind boosting impacts, caffeine’s cell reinforcement lavishness keeps up the mental health. Also, some exploration recommends that drinking coffee can really fight with depression and anxiety in ladies and can stop cognitive decline.

• Blueberries:

Incredible things do come in little bundles, blueberries are a natural product few attempt to eat each and every. That is on the grounds that they have such a variety of extraordinary medical advantage ­while having an aftertaste like a great treat. It’s one of the most astounding cell reinforcement rich sustenance known to man, including vitamin C and vitamin K and fiber. As a result of their elevated amounts of Gallic acid, blueberries are particularly great at shielding our brains from degeneration, stress and cognitive decline.

• Broccoli:

It’s one of the best foods to improve brain health. On account of its elevated amounts of vitamin K and choline, it will help keep your memory sharp.

• Coconut oil:

It is a standout among the most flexible and bravo nourishments for brains out there. With 77 coconut oil uses and cures, there’s nothing that coconut oil can’t help. What’s more, with regards to your mental health it’s loaded with other advantages, as well. Coconut oil functions as a characteristic calming, stifling cells in charge of aggravation. It can help with memory misfortune as a person becomes older and kills terrible microbes that hang out in the guts. Hence, it’s great to stop cognitive decline in human.

• Egg Yolks:

Egg yolks contain a lot of choline, which helps in fetal mental health for pregnant ladies. It additionally separates bethane, a synthetic that produces hormones identified with bliss and fight against cognitive decline. The eggs can really make an individual happy and keep the mental health great.

• Spinach:

Spinach is rich in antioxidants, which is thought to fight against cognitive decline. What’s more, a study found that ladies who revealed eating the most verdant green and cruciferous vegetables had an especially decreased rate of cognitive decline as contrasted with the individuals who ate the minimum.

• Tomatoes:

A study found that lycopene-rich tomato helped participants prevent sunburn when they combined it with olive oil and use it for ten weeks without missing any day. Other than being an extraordinary source of strong antioxidant lycopene, tomatoes are considered a high carotenoid fruit. These nutrients may help to get rid from free radicals that can cause many diseases including aging.

 

 

 

Some good sources for cognition Decline:

http://www.mayoclinic.org/diseases-conditions/mild-cognitive-impairment/home/ovc-20206082

https://link.springer.com/article/10.1007%2Fs11130-013-0370-0

https://en.wikipedia.org/wiki/Cognitive_disorder

 

Best Anti-aging Nutrition, foods, supplements and solutions

What happens in Neuro-degenerative diseases

What happens in Neuro-degenerative diseases

In progress

Neuro-degenerative diseases

Neuro-degenerative disease is a term that refers to a range of conditions that affect the neurones in the human brain. It is the progressive loss of structure or function of neurones or even their death. Neurones are the bricks of the nervous system, which includes the brain and spinal cord. Neurones are not like cells which reproduce and replace themselves. Once they are damaged or die, they cannot be replaced. This makes neuro-degenerative diseases incurable and debilitating resulting in the progressive degeneration and/ or death of nerve cells. The result of this is usually physically exhibited with problems in movement and mentally with cognitive ineptness (known as dementias).

 

Examples of neurodegenerative diseases include Parkinson’s, Alzheimer’s, Pick’s, Huntington’s disease, Amyotrophic lateral sclerosis (ALS) and dementia. Parkinson’s disease occurs when nerves in a central area of the brain slowly degenerate resulting in problems in coordination and movement. Huntington’s disease is an inherited nerve disorder that causes neural degeneration. Pick’s disease occurs when large portions of nerves at the front and sides of the brain are destroyed due to an accumulation of abnormal protein. ALS causes the rapid destruction of nerves and controlling muscle function.

 

Studies on the effects of antioxidants for the treatment of various diseases and the optimum functioning of the body have been conducted in the recent past to try and pinpoint all the benefits of an antioxidant-filled diet. A new review aimed to identify the potential of antioxidant methods for the treatment of degenerative diseases.

 

Antioxidants work by eliminating the action of free radicals in the body. It has long been suspected that an accumulation of free radicals in the body can lead to neurodegenerative diseases through oxidative stress. Antioxidants are now being looked upon as possible remedies against solemn loss of neurones.

 

Polyphenols, in particular, have been linked to the prevention of neurodegenerative diseases. Polyphenols are secondary metabolites that have antioxidant properties. They can be found in most fruits and vegetables. These are able to protect cells found in the neural pathway by attenuating oxidative stress and damage. Oxidative stress is particularly prone to affect the brain as it requires high amounts of oxygen per unit weight and contains a high amount of oxidizable polyunsaturated fatty acids.

 

IN a study conducted in Chicago, it was found that the consumption of Vitamin E reduces the risk of Alzheimer’s if the condition is not caused by a genetic predisposition. Results were, however, inconclusive on patients who had inherited the disease.

 

More research is yet to be done on the effect of and antioxidant-rich diet on neuro-degenerative disorders. While some studies have been inconclusive, experts say that there is no harm in consuming antioxidants that are found naturally in our food. What would not be recommended is loading up on antioxidant supplements, which are sometimes not easily absorbed into the body. Treatment of neurodegenerative diseases using antioxidants has become an attractive alternative to prevent, delay or completely stop the effects of these diseases.

How weight loss can help you fight aging

How weight loss can help you fight aging

research in progress

weight loss

 

Obesity I the state of a person being very overweight with a lot of body fat. The common method to calculate obesity is using the Body Mass Index (BMI). It is a measure of how healthy you are given your height and weight. Obesity begins with a BMI score of 30 and above. This is not an absolute calculation and there are other ways of measuring.

 

Obesity, other than causing the obvious physical changes can lead to a several potentially life-threatening conditions. Short term or day-to-day symptoms associated with obesity include breathlessness, snoring, increased sweating, excessive exhaustion over menial tasks, low confidence and self-esteem, difficulty doing any physical activity and a general feeling of isolation. Psychological problems that are linked to obesity have been found to affect relationships with friends and family members. It may also lead to depression.

 

Obesity increases your risk of developing potentially fatal health conditions. These include type 2 diabetes, high blood pressure and cholesterol, asthma, cancer, gallstones, gastro-oesophageal reflux disease, reduced fertility, sleep apnea, liver disease and pregnancy complications. Research has found that obesity reduces your life expectancy by 3 to 10 years.

 

In this article, we will focus on the effect obesity has on ageing. Obesity, as we mentioned above comes with a host of other problems. When too much cholesterol is in the blood, plaque may form in the arteries causing cardiovascular disease such as heart attacks. This is because there is insufficient blood flow in the body. This contributes to ageing because, the skin, being the largest organ, requires adequate blood supply for it to function properly. Proteins responsible for skin elasticity and tautness are transported in the blood. If these are insufficient, the skin becomes saggy, wrinkled and greyish.

 

People suffering from obesity tend to lead fairly sedentary lifestyles. This means that they barely get any exercise done. Exercise helps reduce inflammation that comes with ageing. Inflammation is linked to many chronic illnesses and has been found to be the common factor in many of them. It is also common knowledge that people who are overweight or obese look and feel much older than they actually are. The worst thing about it is that obesity causes a decrease in energy levels in the body and the continued intake of unhealthy foods promotes the burning of sugar instead of fat. This means that people suffering from the disease only get bigger and weaker if they do not make significant lifestyle changes.

 

When a person is overweight or obese, their bones and joints experience a lot of pressure. This makes them brittle and decreases bone density. You can find fairly young people unable to do simple tasks like walking.

 

One of the biggest downfalls of obesity is its degeneration of brain cells. This is caused by a number of factors such as low levels of antioxidants in your diet, constricted blood vessels and a decrease in the production of BDNF. Exercise slows down brain ageing by producing higher BDNF which increases cognitive function.

 

Exercise and resultant weight loss is an inexpensive way to combat the degenerative features of ageing. If you are a beginner, start slow and work your way to higher intensity exercise.

cranberry strong antioxidant effects, benefits and sideffects

DHA & EPA Antioxidant and anti-aging benefits

DHA & EPA effects and antioxidant benefits!

 

Introducing DHA & EPA:

Omega-3 fatty acids are connected to healthy aging in humans. The omega-3 unsaturated fats derived from fishes, EPA and DHA, have been related with fetal improvement, cardiovascular activities, and Alzheimer’s sickness. Nonetheless, in light of the fact that our bodies don’t proficiently deliver some omega-3 unsaturated fats from marine sources, it is important to get satisfactory sums through fish and fish oil items. The effective and strong antioxidants of EPA and DHA help improving health. They are imperative for appropriate fetal improvement, including neuronal, retinal, and invulnerable function positively and have been connected to provide great outcomes in anticipation, management of weight as well as intellectual capacity in those with exceptionally mellow Alzheimer’s sickness.

Antioxidant Effects of DHA & EPA:

The DHA & EPA supplements have numerous effects on heart. They fight against arrhythmias, heart assault and stroke. They likewise moderate plaque develops, lessen triglycerides, circulatory strain, irritation and thickening, and enhance lipid proportions. Because of their mitigating impacts and strong antioxidants, they might be helpful in treating rheumatoid joint inflammation, asthma and Crohn’s illness. The potential part of DHA & EPA in counteracting and treating osteoporosis, renal disease, cataracts, Alzheimer’s illness, depression and different conditions is as yet being examined.

 

 

Get DHA & EPA for:

For the highest amount of EPA and DHA here is the list of high omega foods by draxe:

  • Mackerel: 6,982 milligrams in 1 cup cooked (174 precent DV)
  • Salmon Fish Oil: 4,767 milligrams in 1 tablespoon (119 percent DV)
  • Cod Liver Oil: 2.664 milligrams in 1 tablespoon (66 percent DV)
  • Walnuts: 2,664 milligrams in 1/4 cup (66 percent DV)
  • Chia Seeds: 2,457 milligrams in 1 tablespoon (61 percent DV)
  • Herring: 1,885 milligrams in 3 ounces (47 percent DV)
  • Salmon (wild-caught): 1,716 milligrams in 3 ounces (42 percent DV)
  • Flaxseeds (ground): 1,597 milligrams in 1 tablespoon (39 percent DV)
  • Tuna: 1,414 milligrams in 3 ounces (35 percent DV)
  • White Fish: 1,363 milligrams in 3 ounces (34 percent DV)
  • Sardines: 1,363 milligrams in 1 can/3.75 ounces (34 percent DV)
  • Hemp Seeds: 1,000 milligrams  in 1 tablespoon (25 percent DV)
  • Anchovies: 951 milligrams in 1 can/2 ounces (23 percent DV)
  • Natto: 428 milligrams in 1/4 cup (10 percent DV)
  • Egg Yolks: 240 milligrams in 1/2 cup (6 percent DV)

 

Antioxidant benefits of DHA & EPA:

 

  • Decrease brain aging and keeps brain healthy: The EPA & DHA supplements are important and might be taken to keep up solid capacity of the mind and retina due to their strong antioxidants. DHA is a building square of tissue in the cerebrum and retina of the eye. It assists in shaping neural transmitters, for example, phosphatidylserine, which is vital for the working of brain. DHA is found in the retina of the eye and taking DHA might be fundamental for keeping the working of eye great.

 

  • Cancer Treatment: Studies revealed that DHA & EPA supplements can avoid and kill different kind of cancers, including colon, breast as well as prostate. While being an effective supplement for cancer patients, at the same time it’s also an effective treatment in those cancer treatments that are done naturally.

 

  • Great for cardiovascular system: EPA and DHA supplements are changed over into substances like hormones known as prostaglandins, and they manage cell action and perfect cardiovascular capacity.

 

  • Diabetes: The strong antioxidants of DHA and EPA can also help in decreasing the danger of diabetic patients from resulting cognitive deficit since it shields the hippocampus cells from being pulverized. Furthermore, they could also help decrease oxidative anxiety, which assumes a great part in the advancement of both micro-vascular and cardiovascular diabetes difficulties.

 

  • Decrease Joint Pains: All the essential antioxidants found in EPA and DHA seem to decrease few joint pains. Human reviews have demonstrated the supplemental fish oil decreases fiery joint pain. They are also successful in diminishing such pain that is brought by joint pain.

 

  • Beneficiary for Human Development: Human development and scholarly advancement – DHA assumes an essential part during the development and improvement of fetal. DHA of the high concentrations are found in the mind and increment 300 to 500 percent in a newborn child’s cerebrum amid the last trimester of pregnancy. Adding DHA supplements in to the pregnant mother’s eating routine might be helpful for the embryo’s mental health. Elderly individuals ought to likewise take EPA DHA, on the grounds that as adults get more established, the bodies frame less EPA and DHA, which may bring about less mental concentration and psychological capacity. Taking some EPA DHA supplements likewise may help with mental variations.

 

  • Decrease muscle degeneration: The strong antioxidants of DHA and EPA diminish the rate of muscle degeneration. A few researches recommends that fit body mass is better held after surgery by expanding the intake of EPA in the eating routine. There are a lot of confirmations proposing that fish oil helps muscle development.

Omega 3 fatty acids, DHA & EPA are naturally found in fishes as well as fish oils. However, DHA & EPA Supplements can also be consumed few times in a week in order to get all the above mentioned benefits.

 

 

Reference Websites:
www.livestrong,com
www.mercola.com

Hydrogen Peroxide, antioxidant benefits and effects!

Some on Cellular Hydrogen Peroxide, antioxidant benefits and effects!

First some on how antioxidants work with free radicals and where is Hydrogen Peroxide:

Free radicals can be broken down into five types. The first four types come from oxygen atoms and are called Reactive Oxygen Species (ROS), but the fifth type derives from nitrogen:

Superoxide ion (O): An oxygen molecule with an extra electron that can damage mitochondria, DNA and other molecules.
Hydroxyl radical (OH): A highly reactive molecule formed by the reduction of an oxygen molecule, capable of damaging almost any organic molecule in its vicinity, including carbohydrates, lipids, proteins, and DNA. OH cannot be eliminated by an enzymatic reaction.
Singlet oxygen: Formed by your immune system, singlet oxygen causes oxidation of your LDL.
Hydrogen peroxide (H2O2): Not a free radical itself, but easily converts to free radicals like OH, which then do the damage. Hydrogen peroxide is neutralized by peroxidase (an enzymatic antioxidant).
Reactive Nitrogen Species (RNS) (NO): Nitric acid is the most important RNS.
These various free radical species can damage DNA in different ways.

They can disrupt duplication of DNA, interfere with DNA maintenance, break open the molecule or alter the structure by reacting with the DNA bases. Cancer, atherosclerosis, Parkinson’s, Alzheimer’s disease, and cataracts are examples of diseases thought to result from free radical damage.

In fact, free radicals are implicated in more than 60 different diseases.

Lipids in cell membranes are quite prone to oxidative damage because free radicals tend to collect in cell membranes, known as “lipid peroxidation.” (The lipid peroxide radical is sometimes abbreviated as LOO.) When a cell membrane becomes oxidized by an ROS, it becomes brittle and leaky. Eventually, the cell falls apart and dies.

This is akin to what happens when butter, vegetable oils or meat becomes rancid—and why manufacturers sometimes add agents to prevent that. How can this free radical pillage be stopped?

This is where antioxidants come in. (sources)

Antioxidants can be categorized in multiple ways. Based on their activity, they can be categorized as enzymatic and non-enzymatic antioxidants. Enzymatic antioxidants work by breaking down and removing free radicals. The antioxidant enzymes convert dangerous oxidative products to hydrogen peroxide (H2O2) and then to water, in a multi-step process in presence of cofactors such as copper, zinc, manganese, and iron. Non-enzymatic antioxidants work by interrupting free radical chain reactions. Few examples of the non-enzymatic antioxidants are vitamin C, vitamin E, plant polyphenol, carotenoids, and glutathione.7 (source)

Free radicals are atoms, molecules or ions with unpaired electrons, which are highly active to chemical reactions with other molecules. In the biology system, the free radicals are often derived from oxygen, nitrogen and sulphur molecules. These free radicals are parts of groups of molecules called reactive oxygen species (ROS), reactive nitrogen species (RNS) and reactive sulphur species (RSS). For example, ROS includes free radicals such as superoxide anion (O2−•), perhydroxyl radical (HO2•), hydroxyl radical (▪OH), nitric oxide and other species such as hydrogen peroxide (H2O2), (source)

About Cellular Hydrogen Peroxide:

Using hydrogen peroxide on cuts and scratches truly isn’t just the most ideal approach to use it due to the fact that there are a lot more benefits of it. Hydrogen peroxide has various awesome uses outside of medical aid. Hydrogen peroxide is the main germicidal agent made just out of water and oxygen. Similar to ozone, it executes the organisms of illness formed by oxidation. Hydrogen peroxide is viewed as the most secure and natural effective sanitizer. It executes microorganisms by oxidizing them, which can be best depicted as a controlled consuming procedure. At the point when Hydrogen peroxide responds with natural material it separates into oxygen and water. As an extreme, nontoxic compound, the hydrogen peroxide works amazingly in some other ways too and it is affordable, as well. Below are some antioxidant benefits of hydrogen peroxide.

The results of some researches obtained show that the antioxidant and anti-radical activity of phenolic acids correlated positively with the number of hydroxyl groups bonded to the aromatic ring. The model of an ortho substitution of hydroxyl groups to the aromatic ring seems to be adequate for antioxidant and H2O2 or DPPH• scavenging activity of phenolic acids. (source)

Antioxidant & other benefits of Hydrogen Peroxide:

  • Cancer Treatment with strong Hydrogen Peroxide antioxidants: The cancer is spreading a lot in people and there are several characteristic drugs that must be utilized to stop the spreading and dispose of the cancer cells either by executing the cancer cells or by killing the organisms inside the cancer cells and turning around the cancer cells into ordinary cells. The antioxidants generally found in Hydrogen peroxide are useful in killing such organisms and can decrease the risk of cancer.

 

  • Maintain common health: The human body makes hydrogen peroxide and its strong antioxidants are able to battle such diseases which must be removed to make our immune framework work accurately. The White platelets are known as Leukocytes. A sub-class of Leukocytes called Neutrophils delivers hydrogen peroxide as the main line of barrier against poisons, parasites, microorganisms as well as infections and yeast.

 

  • Infection treatment: By soaking he infected area of body in 3% of hydrogen peroxide for few minutes a few times each day can help getting rid of that infection. Indeed, even gangrene that would not heal with any solution has been recuperated by absorbing Hydrogen peroxide due to its strong antioxidant reactions on wounds.

 

  • Help removing parasites: As in a lot of other treatments, when taken inside, the effective and strong antioxidants of hydrogen peroxide adds oxygen to the body’s inward condition. This oxidized condition is one in which parasites can’t exist and all of them are normally wiped out from the body.

 

  • Treatment for foot fungus: The researches still can’t seem to have been done to demonstrate this works for everybody that it is a fast home cure for foot fungus. In order to help treating the foot fungus, the use of the spray containing 3% hydrogen peroxide and water on them (particularly the toes) and letting them dry can heal it if done regularly. The strong antioxidants of hydrogen peroxide help a lot to treat the disease.

 

  • Best for mouth and teeth: Many individuals don’t understand that hydrogen peroxide makes an extremely viable and economical mouthwash. Utilize 3% of hydrogen peroxide and include a dash of fluid chlorophyll for enhancing if you want. On the other side, taking one capful of hydrogen peroxide and holding in your mouth for 10 minutes and then spit it out will never cause ulcer and your teeth will be more white. On the off chance that you have a frightful toothache and can’t get to a dental practitioner immediately, put a capful of 3% Hydrogen peroxide into your mouth and hold it for 10 minutes a few times each day. The torment will decrease significantly.

 

  • Treats the birds Mites Infections: Patients contaminated by minor vermin stated that hydrogen peroxide successfully removes the parasites on their skins. They shower it on their skin two or three times with a couple of minutes between the applications and get stunning outcomes. The antioxidants available in hydrogen peroxide help fighting the disease and provide great results at the end.

 

  • Best for Wound care: The antioxidants available in Hydrogen Peroxide help in healing wounds and stop the bleeding from little wounds. A few sources prescribed to soak wounds for five or more minutes a few times each day in order to heal the wound.

 

  • Treating Sinus Infection: A tablespoon of 3% Hydrogen peroxide added to some non-chlorinated water can be utilized as a nasal shower. Contingent upon the level of sinus contribution, one should alter the measure of peroxide utilized. It can be used as a treatment for sinus infection due to the strong antioxidants available in it.

 

 

Reference Websites:
www.wakeup-world.com
www.realfarmacy.com

Vitamin E, Strong everyday antioxidant we have to have in our diet

Vitamin C, An antioxidant our body needs to stay healthy & prevent cancer

Olive leaf (extracts) One of the strongest antioxidants found

Olive leaf Extract One of the strongest antioxidants found, about Olive leaf Extract antioxidant benefits

Research in progress                        

Other Names of olive tree:
Acide Gras Insaturé, Acide Gras Mono-Insaturé, Acide Gras n-9, Acide Gras Oméga 9, Common Olive, Extra Virgin Olive Oil, Feuille d’Olivier, Green Olive, Huile d’Assaisonnement, Huile d’Olive

Introduction to Olive leaf extract benefits

Olive oil is has been known and used to prevent heart attack and stroke (cardiovascular disease), breast cancer, colorectal cancer, rheumatoid arthritis, and migraine headache. But Olive leaf extract comes from the leaves of olive tree, and is much different from Olive Oil. the olive leaf contains phenolics such as oleuropein, It has shown that it has protective effects against LDL oxidation also  benefits glucose metabolism for diabetes and skin health. Olive leaf is used as immune system boost for treating viral, bacterial, and other infections including influenza, swine flu, herpes, shingles, HIV/ARC/AIDS, and hepatitis B, pneumonia; chronic fatigue: tuberculosis (TB); gonorrhea; fever; malaria; dengue and infections in the teeth, ears, and urinary tract, and infections following surgery. Some Other also use it for high blood pressure, diabetes, hay fever, improving kidney and digestive function. Olive leaf kills and /or resists the multiplication of viruses, bacteria, yeasts, fungi, and other parasites in body. The olive leaf extract differ from immune boosters in that immune boosters tha stimulate your immune system to destroy disease which still requires your own energy. Olive leaf extract mainly does the work for you. it is not a supplementary for immune system it is like a parallel procedure.

vitamin-e Unique health benefits & Antioxidant effects

Proven Olive Leaf Benefits

I you are going to consider getting Olive leaf (extracts) you should know based on the studies these are the situations that it has been proven that Olive leaf (extracts) can improve.
  • Lowers Blood Pressure
  • Improves Cardiovascular Health
  • Diabetes
  • Reduces the Risk of Cancer
  • Improves Brain Function
  • Treats Arthritis
  • Kills Bacteria and Fungi
  • Improves Immune System
  • Protects Skin
  • More energy
  • Toothache relief
  • Diminished food cravings
  • Joint pain relief
  • Heartbeat regulation
  • Improved wound healing

 

branch of green olives antioxidant benefits

branch of green olives

Cancer and Olive leaf (extracts)

The Mediterranean diet which includes olive is renowned for its ability to reduce the risk of cancer as some researches say.  While numerous aspects of the diet contribute to this risk reduction, there’s growing evidence that olive oil and leaf extract contains phenolics such as oleuropein that are key components of the diet’s anti-cancer effects. Oleuropein and olive leaf extracts have numerous other mechanisms of action against cancer: They can prevent inflammation,  inflammation is another major promoter of tumor growth and olive leaf extracts are strong in fighting  inflammations.
In breast cancer cells specifically, oleuropein reduces malignant cells’ ability to respond to estrogen, the female hormone that many breast cancer cells depend on for their survival. Oleuropein stops production growth factor and the “protein-melting” enzymes that cancer cells need in order to invade healthy tissues.

Neuroprotection of Olive leaf (extracts)

Olive extracts help protect the brain neural system from the destruction brought on by age-related degenerative conditions such as Alzheimer’s and Parkinson’s diseases.  Olive extracts suppress the inflammations and reduce the damage done by oxidative stress in body cells, we did mention what oxidative stress is and how antioxidants tend to stop it from damaging our body, read more about that in our full article about Antioxidants.
Researchers found that if  the possible stroke patients be pre-treated by olive  extracts they can greatly reduce the damage after stroke. cause basically after a normal blood flow comes back after the stroke the damage gets worse. But olive extracts has shown that they change the atmosphere of the system so the come back is not that dangerous. Microscopic examination of brain tissue showed up to a 55% decrease in the volume of dying brain tissue after strokes that were pre-treated by olive extracts. Brain damages and inflammations in brain all lead to more dying neurons and cells that will lead to creating more tangles. tangles are one of the two main reasons and causes in brain aging. so Olive extracts generally work as a nice anti-age supplement.

branch of green olives antioxidant benefits

POLYPHENOLIC ANTIOXIDANTS & Olive leaf (extracts)

Polyphenolic antioxidants can help to slow down ageing by reducing cell degradation and assist in the prevention of a number of degenerative diseases. Polyphenolic antioxidants are best known in the scientific and medical communities for their ability to neutralize free radicals. The most studied polyphenolic antioxidants in Olive Leaf.
OLIVE EXTRACTS INTERACTIONS 
Moderate Interaction Be cautious with this combination
  • Medications for diabetes (Antidiabetes drugs) interacts with OLIVE
  • Medications for high blood pressure (Antihypertensive drugs) interacts with OLIVE
 

Useful Website sources and articles on Vitamin E and its benefits:


 
 
 
 
 
Phenolic compounds and antioxidant activity of olive leaf extracts.
 
 
 
 
 
 
 
 
Papers and articles for reading and references about Olive leaf (extracts):
 
 
Available at: http://www.tesisenred.net/bitstream/handle/10803/7208/tvk.pdf?sequence=1#page=30. Accessed March 8, 2013.
 
Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010;78(2):133-54.
 
Wahle KW, Caruso D, Ochoa JJ, Quiles JL. Olive oil and modulation of cell signaling in disease prevention. Lipids.2004 Dec;39(12):1223-31.
 
Waterman E, Lockwood B. Active components and clinical applications of olive oil. Altern Med Rev. 2007 Dec;12(4):331-42.
 
Hamdi HK, Castellon R. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Biophys Res Commun.2005 Sep 2;334(3):769-78.
 
Ribeiro Rde A, Fiuza de Melo MM, De Barros F, Gomes C, Trolin G. Acute antihypertensive effect in conscious rats produced by some medicinal plants used in the state of Sao Paulo. J Ethnopharmacol.1986 Mar;15(3):261-9.
 
Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. J Ethnopharmacol.2003 Feb;84(2-3):299-305.
 
Khayyal MT, el-Ghazaly MA, Abdallah DM, Nassar NN, Okpanyi SN, Kreuter MH. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung.2002;52(11):797-802.
 
Cherif S, Rahal N, Haouala M, et al. A clinical trial of a titrated Olea extract in the treatment of essential arterial hypertension. J Pharm Belg. 1996 Mar-Apr;51(2):69-71.
 
Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, Aydogan C. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res. 2008 Sep;22(9):1239-42.
 
Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine.2011 Feb 15;18(4):251-8.
 
Available at: http://www.rxlist.com/capoten-drug.htm. Accessed March 11, 2013.
 
Scheffler A, Rauwald HW, Kampa B, Mann U, Mohr FW, Dhein S. Olea europaea leaf extract exerts L-type Ca(2+) channel antagonistic effects. J Ethnopharmacol.2008 Nov 20;120(2):233-40.
 
Gilani AH, Khan AU, Shah AJ, Connor J, Jabeen Q. Blood pressure lowering effect of olive is mediated through calcium channel blockade. Int J Food Sci Nutr.2005 Dec;56(8):613-20.
 
Zare L, Esmaeili-Mahani S, Abbasnejad M, et al. Oleuropein, chief constituent of olive leaf extract, prevents the development of morphine antinociceptive tolerance through inhibition of morphine-induced L-type calcium channel overexpression. Phytother Res. 2012 Nov;26(11):1731-7.
 
Visioli F, Bellosta S, Galli C. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci. 1998;62(6):541-6.
 
Rocha BS, Gago B, Barbosa RM, Laranjinha J. Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology.2009 Nov 9;265(1-2):41-8.
 
Palmieri D, Aliakbarian B, Casazza AA, et al. Effects of polyphenol extract from olive pomace on anoxia-induced endothelial dysfunction. Microvasc Res. 2012 May;83(3):281-9.
 
Scoditti E, Calabriso N, Massaro M, et al. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys. 2012 Nov 15;527(2):81-9.
 
Dell’Agli M, Fagnani R, Galli GV, et al. Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling. J Agric Food Chem. 2010 Feb 24;58(4):2246-52.
 
Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem Biol Interact. 2008 Nov 25;176(2-3):88-98.
 
Visioli F, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sci. 1994;55(24):1965-71.
 
Masella R, Vari R, D’Archivio M, et al. Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J Nutr.2004 Apr;134(4):785-91.
 
Wang L, Geng C, Jiang L, et al. The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. Eur J Nutr. 2008 Aug;47(5):235-43.
 
Impellizzeri D, Esposito E, Mazzon E, et al. The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. Clin Nutr. 2011 Aug;30(4):533-40.
 
Carluccio MA, Siculella L, Ancora MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):622-9.
 
Turner R, Etienne N, Alonso MG, et al. Antioxidant and anti-atherogenic activities of olive oil phenolics. Int J Vitam Nutr Res. 2005 Jan;75(1):61-70.
 
Dell’Agli M, Fagnani R, Mitro N, et al. Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation. J Agric Food Chem. 2006 May 3;54(9):3259-64.
 
Singh I, Mok M, Christensen AM, Turner AH, Hawley JA. The effects of polyphenols in olive leaves on platelet function. Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):127-32.
 
Zbidi H, Salido S, Altarejos J, et al. Olive tree wood phenolic compounds with human platelet antiaggregant properties. Blood Cells Mol Dis. 2009 May-Jun;42(3):279-85.
 
Wainstein J, Ganz T, Boaz M, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food. 2012 Jul;15(7):605-10.
 
Gonzalez M, Zarzuelo A, Gamez MJ, Utrilla MP, Jimenez J, Osuna I. Hypoglycemic activity of olive leaf. Planta Med. 1992 Dec;58(6):513-5.
 
Al-Azzawie HF, Alhamdani MS. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci. 2006 Feb 16;78(12):1371-7.
 
Jemai H, El Feki A, Sayadi S. Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats. J Agric Food Chem. 2009 Oct 14;57(19):8798-804.
 
Eidi A, Eidi M, Darzi R. Antidiabetic effect of Olea europaea L. in normal and diabetic rats. Phytother Res. 2009 Mar;23(3):347-50.
 
Poudyal H, Campbell F, Brown L. Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J Nutr. 2010 May;140(5):946-53.
 
Simon D, Balkau B. Diabetes mellitus, hyperglycaemia and cancer. Diabetes Metab. 2010 Jun;36(3):182-91.
 
Kontou N, Psaltopoulou T, Soupos N, et al. Metabolic syndrome and colorectal cancer: the protective role of Mediterranean diet–a case-control study. Angiology. 2012 Jul;63(5):390-6.
 
Verberne L, Bach-Faig A, Buckland G, Serra-Majem L. Association between the Mediterranean diet and cancer risk: a review of observational studies. Nutr Cancer. 2010;62(7):860-70.
 
Anter J, Fernandez-Bedmar Z, Villatoro-Pulido M, et al. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutat Res. 2011 Aug 16;723(2):165-70.
 
Corona G, Deiana M, Incani A, Vauzour D, Dessi MA, Spencer JP. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem Biophys Res Commun. 2007 Oct 26;362(3):606-11.
 
Kimura Y, Sumiyoshi M. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. J Nutr. 2009 Nov;139(11):2079-86.
 
Sirianni R, Chimento A, De Luca A, et al. Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation. Mol Nutr Food Res. 2010 Jun;54(6):833-40.
 
Menendez JA, Vazquez-Martin A, Oliveras-Ferraros C, et al. Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. Int J Mol Med. 2008 Oct;22(4):433-9.
 
Goulas V, Exarchou V, Troganis AN, et al. Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res. 2009 May;53(5):600-8.
 
Abdel-Hamid NM, El-Moselhy MA, El-Baz A. Hepatocyte lysosomal membrane stabilization by olive leaves against chemically induced hepatocellular neoplasia in rats. Int J Hepatol. 2011;2011:736581.
 
Fares R, Bazzi S, Baydoun SE, Abdel-Massih RM. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract. Plant Foods Hum Nutr. 2011 Mar;66(1):58-63.
 
Grawish ME, Zyada MM, Zaher AR. Inhibition of 4-NQO-induced F433 rat tongue carcinogenesis by oleuropein-rich extract. Med Oncol. 2011 Dec;28(4):1163-8.
 
Acquaviva R, Di Giacomo C, Sorrenti V, et al. Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol. 2012 Jul;41(1):31-8.
 
Mohagheghi F, Bigdeli MR, Rasoulian B, Hashemi P, Pour MR. The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia. Phytomedicine. 2011 Jan 15;18(2-3):170-5.
 
Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J. Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. 2007 Feb;49(2):93-102. Epub 2006 Dec 20.
 
Dekanski D, Selakovic V, Piperski V, Radulovic Z, Korenic A, Radenovic L. Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils. Phytomedicine.2011 Oct 15;18(13):1137-43.
 
Khalatbary AR, Ahmadvand H. Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurol Res. 2012 Jan;34(1):44-51.
 
Bazoti FN, Bergquist J, Markides KE, Tsarbopoulos A. Noncovalent interaction between amyloid-beta-peptide (1-40) and oleuropein studied by electrospray ionization mass spectrometry. J Am Soc Mass Spectrom. 2006 Apr;17(4):568-75.
 
Daccache A, Lion C, Sibille N, et al. Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem Int. 2011 May;58(6):700-7.
 
Rigacci S, Guidotti V, Bucciantini M, et al. Abeta(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon. Curr Alzheimer Res. 2011 Dec;8(8):841-52.
 
Flemmig J, Kuchta K, Arnhold J, Rauwald HW. Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. Phytomedicine.2011 May 15;18(7):561-6.
 
Impellizzeri D, Esposito E, Mazzon E, et al. Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in mice. J Pharmacol Exp Ther.2011 Dec;339(3):859-69.
 
Gong D, Geng C, Jiang L, Wang L, Yoshimura H, Zhong L. Mechanisms of olive leaf extract-ameliorated rat arthritis caused by kaolin and carrageenan. Phytother Res. 2012 Mar;26(3):397-402.
 
Olive leaf. Monograph. Altern Med Rev. 2009 Mar;14(1):62-6.

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What are Ginkgo Biloba wonderful benefits as antioxidants and in memory and eye improvements

What are Ginkgo Biloba wonderful benefits as antioxidants and in memory and eye improvements

health benefits ginkgo tea natural-treatments-for-eye-BENEFITS & ANTIOXIDANT EFFECTS

Research in progress
GINKGO
Other Names: Abricot Argenté Japonais, Adiantifolia, Arbre aux Écus, Arbre aux Quarante Écus, Arbre du Ciel, Arbre Fossile, Bai Guo Ye, Baiguo, Extrait de Feuille de Ginkgo, Extrait de Ginkgo
 Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer's disease.

Ginkgo Biloba Supplements and its Antioxidant benefits!

Ginkgo improves blood flow to the brain and acts as an antioxidant. These effects may translate into some benefits for certain medical problems, but the results have been mixed.

Some studies have found that in healthy people, ginkgo might modestly boost memory and cognitive speed. Other studies have not found a benefit. (source) Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer’s disease.

About Ginkgo Biloba:

The scientific name of Ginkgo Biloba is “Salisburia adiantifolia”. It is an extract got from the leaf of the Chinese ginkgo tree which is additionally known as the maidenhair tree. The known scientific terms for extract of the green ginkgo biloba tree are EGb761 and GBE, which is regularly noted for its cerebral improving impacts. As indicated by Traditional Chinese Medicine and current clinical reviews, Ginkgo Biloba is viable, safe and it also benefits the body from various perspectives since it applies defensive impacts against mitochondrial harm and oxidative anxiety.

Amount of Ginkgo Biloba Supplements to use:

The scientific name of Ginkgo Biloba is “Salisburia adiantifolia”. It is an extract got from the leaf of the Chinese ginkgo tree which is additionally known as the maidenhair tree. The known scientific terms for extract of the green ginkgo biloba tree are EGb761 and GBE, which is regularly noted for its cerebral improving impacts. As indicated by Traditional Chinese Medicine and current clinical reviews, Ginkgo Biloba is viable, safe and it also benefits the body from various perspectives since it applies defensive impacts against mitochondrial harm and oxidative anxiety.There is no standard measurements of Ginkgo Biloba supplements to use, but, in therapeutic reviews, every clinical trial have utilized an extract of ginkgo which is standardized to 24 percent flavones glycosides along with 6 percent of terpene lactones. A typical dosage in individuals with dementia is 40ml of that concentrate three times each day. There is no standard dose of ginkgo biloba supplements. However, in medical studies, almost all clinical trials have used a standardized extract of ginkgo, standardized to 24% flavone glycosides and 6% terpene lactones. A common dose in people with dementia is 40 milligrams of that extract three times daily. For improving cognitive function in healthy people, studies have used between 120 milligrams to 600 milligrams of the extract daily.

Ginkgo Biloba:

 

Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer's disease.

Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer’s disease.

Effects & Benefits of Ginkgo Biloba Antioxidants:

  • Decrease depression & anxiety: In the event that you experience the ill effects of constantly high anxiety that is executing your personal satisfaction, apprehension and despondency then ginkgo may have the capacity to offer assistance. A research revealed that Ginkgo biloba antioxidants improves the body’s capacity to deal with stressors and they also neutralizes the impacts of large amounts of stress hormones such as cortisol as well as adrenaline. It raises the body’s capacity to adapt to inconvenience and stress; it may be particularly useful for individuals with generalized anxiety disorder (GAD) and conceivably regular depression, panic assaults and social fears, as well.

 

  • Enhance Memory: The antioxidants in Ginkgo biloba are very beneficial for brain due to which Ginkgo Biloba supplements are known as “Brain herb”. Studies have demonstrated that it can enhance memory in individuals with dementia. Ginkgo biloba is usually added to some soft drinks, nutrition bars along with fruit smoothies in order to lift memory and upgrade cognitive execution.

 

  • Improves the Vision and Eye health: While more confirmation is as yet required, ginkgo along with its strong antioxidants has all the earmarks of being a great supplement for eye health since it enhances blood stream to the eyes and battles free outspread harm that can hurt the cornea, macula as well as the retina. It may be particularly gainful for adults in protecting vision and bringing down UV harm or oxidative worry to eye tissue. A few reviews have observed that ginkgo biloba antioxidants are powerful at bringing down the hazard for age-related macular degeneration because of its platelet initiating variables and counteractive action of film harm created by free radicals.

  • Kills Impotency: Ginkgo biloba can also be utilized in the treatment of impotency. The primary reason of male weakness is poor dissemination and weakened blood flow through the penis, which is frequently the consequence of atherosclerosis. Since ginkgo biloba builds blood stream, it’s been found to help up to 50% of patients following six months of utilization.

 

  • Beneficial for Asthma: The antioxidants generally found in Ginko Biloba supplements helps and improve breathing. It is very beneficial for Asthma patients as it is likely to decrease the disease with the help of antioxidant reactions.

 

  • Useful for Macular Degeneration: “Macular Degeneration” is a dynamic, degenerative eye ailment that hinders the retina. It is a standout among the most widely recognized reasons for visual impairment in the US. The strong and effective antioxidants found in ginkgo biloba may help cure or mitigate some retinal issues.

 

  • Raynaud’s infection: Raynaud’s infection is actually caused by veins that over respond to the frosty and spasms, decreasing blood stream and there by denying limits of oxygen. The effective antioxidants in Ginkgo biloba may help this condition by enlarging the little veins, which would keep the spasms from totally hindering the blood stream.
Source Websites:
www.draxe.com
www.greenmedinfo.com
www.mayoclinic.org

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Alpha-carotene benefits as an antioxidant

alpha-carotene natural-treatments-for-eye-BENEFITS & ANTIOXIDANT EFFECTS

Research in progress

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essential_carotenoids benefits as an antioxidant

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What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Introduction to Antioxidant

Antioxidant
an·ti·ox·i·dant
ˌan(t)ēˈäksədənt,ˌanˌtīˈäksədənt/

“a substance that inhibits oxidation, especially one used to counteract the deterioration of stored food products. a substance that removes potentially damaging oxidizing agents in a living organism.”
What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system
First thing that comes up in google search is what you see above. But what it really means that it removes potentially damaging oxidizing agents? what do the oxidizing agents do? what antioxidants do to them? how it helps our body with aging? how is it related to aging? Do antioxidants help your body in weight loss processes? How? Do they really keeps us young? are they same as anti-inflammatory substances? 



Lets take a closer look to the whole concept of Antioxidants.

It has been about 50 years only that even the word Antioxidant is being used. 

What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

The human body by its self naturally produces free radicals and the antioxidants to counteract their damaging effects, its something our body is aware of and has some solutions for it. However, in most cases, free radicals far outnumber the naturally occurring antioxidants and thats why we see that it could expedite aging and health issues. But what are free radicals? for a short answer: 

 What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Free Radicals and Oxidative Damage



Human body need oxygen for its chemical activities and in order to live. the simple act of breathing is the start of the formation of highly reactive molecules called free radicals. Free radicals interact with other molecules in the body as they are in blood and metabolism, they cause Oxidative Damage. 

What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system



Oxidative damage can result the development of a wide range of illnesses and diseases or increasing the possibility of illness by effecting the immune system. Oxidative stress occurs when the production of reactive oxygen is greater than the body’s ability to detoxify and clean the reactive intermediates. This imbalance as mentioned before leads to oxidative damage to proteins, molecules, and genes within the body. when proteins start being damaged means now all your body is in danger cause not only your muscles but all of cell’s functions even DNA functions are done by different kinds of protein. But the free radical intensity does not only depend on the body it self it depends a lot on many factor and behaviors that we  can control. Some external body causes could increase the free radicals and the damage they have on our body like:

  • Smoking (first or second hand)
  • Excessive exposure to UV rays
  • Pollution
  • Eating an unhealthy diet
  • Certain medications and/or treatments
  • Excessive exercise
  • Breathing deep and enough



What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system


How Free Radicals are Formed



Normally, in our body bonds dont lag, they dont split in a way that leaves a molecule with an odd (unstable condition or harmful situation), unpaired electron. But when weak bonds split, free radicals are formed. Free radicals are very unstable it means they can react and bond quickly with many potentialities and affect quickly the other compounds, trying to capture the needed electron to gain stability. 

Some internally generated sources of free radicals are:

  • Mitochondria
  • Xanthine oxidase
  • Peroxisomes
  • Inflammation
  • Phagocytosis
  • Arachidonate pathways
  • Exercise
  • Ischemia/reperfusion injury
  • Some externally generated sources of free radicals are:
  • Cigarette smoke
  • Environmental pollutants
  • Radiation
  • Certain drugs, pesticides
  • Industrial solvents
  • Ozone


Generally, free radicals attack (try to bond and become stable) the nearest stable molecule, “stealing” its electron. When the “attacked” molecule loses its electron, it becomes a free radical itself and causing this in a mass scale in body by beginning a chain reaction. Once the process is started, it can cascade, finally resulting in the disruption of a living cell. Cells are smallest stable and almost independent units in our body. every and each one of them are playing an important role in what an organ and bigger part does. It means they are independent but they also work as a team and they communicate, so if something goes wrong in one specially in RNA/DNA level it will spread. they communicate with substances and some other factors so many effects that free radicals have can be very local and at the same time in whole body.


What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Our body sometimes uses the free radicals. basically our body pretty much knows what they are and some free radicals arise normally during metabolism. Sometimes the body immune systems cells or white blood cells purposefully create them to neutralize viruses and bacteria, well that is as smart as it can get. However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also increase free radicals unnaturally. Usually The body handles free radicals, but if antioxidants are unavailable, or if the free-radical production becomes excessive, damage can occur. 


Of particular importance is that free radical damage accumulates with age. Yes aging can be expedited by free radicals. they make your body an unsafe place to live for cells. they interfere with metabolism and damage the immune system and their number one scary result can be cancer. 


Antioxidants Counteract Oxidative Stress and Free Radicals
The body is aware of its substances it naturally produces antioxidants like superoxide dismutase, catalase, or peroxidase enzymes, as a means of defending itself against free radicals. The antioxidants neutralize the free radicals, so makes them harmless to other cells. Antioxidants can repair damaged molecules in body by donating hydrogen atoms to them. Some antioxidants even have a chelating effect on free radical production that’s catalyzed by heavy metals. In this situation, the antioxidant contains the heavy metal molecules so strongly that the chemical reaction necessary to create a
free radical never occurs. When these kinds of antioxidants are water-soluble, it also causes the removal of the heavy metals from the body via the urine. for example Astaxanthin is in some cases considered nature’s most powerful antioxidant in foods and also available in pills and supplements now.



What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Different Types of Antioxidants

 

All the antioxidants are different and function different. Astaxanthin is actually a lipid-soluble antioxidant, while resveratrol is a water-soluble antioxidant And Each type of them function in its own way. antioxidants can be categorized in tow different ways, as a matter of fact three but molecular size is not an effective issue in terms of choosing what to take for you.


1. Antioxidants can be categorized basically in two categories:

 

Soluble in lipids/fat (hydrophobic) or water (hydrophilic). Both of them are neede in body in order to protect your cells. basically because body cells have both environments in them and as a matter of facts the interior of your cells and the fluid between them are composed of water, while the cell membranes themselves are mostly made of fat. The free radicals can strike both the watery cell contents or the fatty cellular membrane. Lipid-soluble antioxidants are the ones that protect your cell membranes from lipid peroxidation. Some examples of lipid-soluble antioxidants are vitamins A and E, carotenoids, and lipoic acid. Water-soluble antioxidants are found in aqueous fluids, like your blood and the fluids examples of water-soluble antioxidants are vitamin C, polyphenols, and glutathione.


2. They can also be categorized in another way as enzymatic and non-enzymatic antioxidants:


Enzymatic antioxidants benefit you by breaking down the structure of the free radicals and removing free radicals from your system. They can flush out dangerous oxidative products by converting them into hydrogen peroxide, then into water and gone you are free of free radicals.

Non-enzymatic antioxidants benefit you by interrupting free radical chain reactions that is another way to block them from damaging the whole environment. Some examples are carotenoids, vitamin C, vitamin E, plant polyphenols, and glutathione (GSH). Most antioxidants found in supplements and foods are non-enzymatic.



What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

 
What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune systemAstaxanthin has an especially high propensity for absorbing the excess energy from singlet oxygen, releasing it as heat, and returning the oxygen (and itself) back to its original state. This process is known as “quenching.”  Because of very different structures of all the molecules we call antioxidants the actual chemical procedure is different and the effectiveness and the way they can help the body is different. 

Why may Antioxidant Supplements do not work as well as foods Work?

Some Clinical and scientific studies of antioxidant supplements have not found them to be as effective as expected. Researchers have suggested several reasons:
 
> The Antioxidant beneficial health effects of a diet high in vegetables and fruits or other antioxidant-rich foods may actually be caused by other substances. that we dont know about them.
 
> Problem with doses. The effects of the large doses of antioxidants used in supplementation studies may be different from the smaller doses in natural foods.
 
> Differences in the chemical composition of antioxidants, For example, eight chemical forms of vitamin E are present in natural foods. but only two in Vitamin E supplements like alpha-tocopherol. Alpha-tocopherol also has been used in almost all research studies on vitamin E.


ALPHA - LIPOIC ACID What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Good natural sources for Vitemin C, vitamin A and vitamin E as the most popular antioxidants:


Good Food Sources of Vitamin C (mg/serving)

Food
Amount
Vitamin C
Orange juice, fresh squeezed
1 cup
124
Grapefruit juice, fresh squeezed
1 cup
94
Papaya
1/2 medium
94
Cantaloupe
1/4 melon
86
Orange
1 medium
80
Green peppers, raw chopped
1/2 cup
67
Tomato juice
1 cup
44
Strawberries
1/2 cup
43
Broccoli, raw chopped
1/2 cup
41
Grapefruit
1/2 medium
40
Source: USDA Nutrient Database for Standard Reference Release 13
 

Good Food Sources of Vitamin E (mg/serving)

Food
Amount
Vitamin E
Almonds
1/4 cup
9.3 (13.9 IU)
Sunflower seeds
1/4 cup
5.8 (8.7 IU)
Safflower oil
1 tbsp
4.7 (7.0 IU)
Peanuts
1/4 cup
3.3 (4.9 IU)