Anti aging Antioxidant rich foods and Exercise, two Most effective factors of anti-aging lifestyle

Anti aging Antioxidant rich foods and Exercise

Two Most effective factors of anti-aging lifestyle

lose-weight anti aging antioxidants

What is aging and what is anti-aging?

You know aging is happening when you see the traces of it in your skin, joints and face. But have ever gone a bit deeper to know Why do we age? Is it normal? What makes aging an acceptable norm? Can it change?
Many say you cannot really stop body from aging and its fate and the nature of how it behaves. And some others say aging is a disease and can be cured. But to be honest the truth is somewhere between those lines. It happens because our DNA is designed to be destructed in some certain situations. Free radicals in our cells and outside our cells are always destructing other molecules, basically because they are unstable forms of molecules. Free radicals interact with other molecules in the body as they are in blood and metabolism, they cause Oxidative Damage. Sources of oxidative damage can be inflammations inside our body or sources from outside like:

• Smoking (first or second hand)
• Excessive exposure to UV rays
• Air Pollution
• Eating an unhealthy diet
• Certain medications and/or treatments
• Excessive exercise or physical activities

 

Antioxidants Counteract Oxidative Stress and Free Radicals

Antioxidants that you have probably heard of them are important players in this game. Antioxidant foods or some may say Anti-aging foods are the one that are rich in anti-oxygen agents which we call antioxidant agents. The main thing that antioxidants do that help us with an anti-aging lifestyle is that they fight against the free radicals. Usually when free radicals quantity is more that antioxidants the aging goes faster and faster.
Our body knows what the main molecules are that it is in war with, the free radicals. And the strongest and the best antioxidants are made inside our body that are hundreds of times more effective than foods. Foods are mostly effective in the inside cell fight and the antioxidants from foods are mostly effective and working on outside cell fights against free radicals.

 

lose-weight anti aging antioxidants

So the main two ways and factors to have a healthy anti-aging lifestyle is
1. To activate and trigger the antioxidants made by our body
2. To eat best antioxidant foods and (also skip the sugar…)

Activating the antioxidants within you

For triggering the intra antioxidants made in our body like glutathione which is the strongest antioxidant, exercise has been proven over and over that is the main thing that increase both brain BDNF and glutathione levels in our body. But not any sort of exercise. The most effective type that can actually make your body increase intra-antioxidants is intense exercise or HIIT: High intensity interval training. HIT intense interval training can increase bdnf. Yes, Intense Exercise is number 1. If you don’t exercise much, your brain may not be producing sufficient BDNF. To increase it, you’ll want to engage in an intense exercise; the greater the intensity, the more likely BDNF production will increase.

Both are some of the most important aging factors. Exercise Increases Brain plasticity and memory that leads to better learning. Brain plasticity is the main factor of brain aging. Basically plasticity means your brain has the capability of learning or not. Glutathione is also triggered by some foods like ginger and turmeric root but.

 

lose-weight anti aging antioxidants

Antioxidant foods in your diet

For The healthy foods and a diet full of antioxidant foods you should include some spices and foods in your diet like ginger, turmeric, clove and also eat some fruits daily like blueberries, cranberries, and acai berries.  Many other activities and strategies are associated with anti-aging lifestyle but the main two ones that can really lift up your mood and prevent fast aging and even stop it to some degrees are as mentioned Exercise and Antioxidant rich foods.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

MORINGA, antioxidant benefits, Uses, Side Effects & Interactions

Other Names of  MORINGA: Arango, Árbol de las Perlas, Behen, Ben Ailé, Ben Nut Tree, Ben Oléifère, Benzolive, Canéficier de l’Inde, Chinto Borrego, Clarifier Tree, Drumstick Tree,…

Research in progress 

 

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant

Moringa Oleifera has been hailed since time immemorial for its immense health benefits. The plant is native to Africa and many consider it the tree of life. It is also very common in Asia as it is widely used in Ayurvedic medicine. It contains a significant number of proteins, essential vitamins, and minerals making it common not only from a nutritional point of view but also in the cosmetics industry due to its powerful antioxidants.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Although Moringa has several benefits, we are going to narrow in on its antioxidant and anti-ageing properties.

Antioxidant effects of Moringa

Moringa has been found to contain about 47 antioxidants including phenolic acid, flavonoid/bioflavonoids, and tannic acid. Experiments have been carried out on different parts of the Moringa tree to identify what parts have more Polyphenol antioxidant benefits. In one study, It was found that all extracts acted as radical scavengers due to the presence of the polyphenolic compound. It was also found that the flowers possessed the highest antioxidant properties, followed closely by the leaf, root, gum bark and finally the seed.
What these strong antioxidants do is they help neutralize free radicals(oxidative damage). Free radicals are produced as by-products of normal body processes, medicine break-down after consumption and as a result of exposure to pollutants. Moringa is known as one of the most effective of antioxidant foods.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Anti-aging properties of Moringa

The cosmetics industry heavily relies on Moringa as a natural supplement to try and slow down the aging process. Moringa contains a plant hormone called zeatin, which affects the process of cell division, influencing aging. Moringa is the only known plant to contain such high levels of Zeatin.

APPLIED TO THE SKIN for:
Athlete’s foot.
Dandruff.
Warts.
Skin infections.
Snakebites.
Gum disease (gingivitis).
Other conditions.
Progeria is a disease in which a person ages rapidly at a much faster rate than normal. It afflicts people whose bodies cannot manufacture and/or utilize antioxidants. Moringa contains high levels of vitamin C, which helps with the synthesis of collagen. When the level of collagen is low, the skin collapses to take up the free space, causing wrinkles, which are a tell-tale sign of aging.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

The anti-aging properties of Moringa do not only apply to the skin. It has been known to decrease brain aging and cognition decline. The plant is a memory booster, helping with concentration, focus, and clarity. This is by virtue of its B vitamins, but also notably, the high concentration of Iron which allows for more oxygenated blood flow to the brain.

All this information should be enough to convince you to include Moringa, in your diet. You may either take it in its natural form or as a Moringa supplement. Moringa’s antioxidant properties can also help prevent and manage certain diseases such as cancer and cardiovascular disease which stem from the overproduction of free radicals in the body. In a world where pollution is rampant, intake of antioxidant super foods is a safe bet to prevent diseases.

Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant, Uses, Side Effects & Interactions

Moringa is your best choice as it is effective, safe, naturally occurring and affordable.

 

Moringa is used to improve “tired blood” (anemia); arthritis and other joint pain (rheumatism); asthma; cancer; constipation; diabetes; diarrhea; epilepsy; stomach pain; stomach and intestinal ulcers; intestinal spasms; headache; heart problems; high blood pressure; kidney stones; fluid retention; thyroid disorders; and bacterial, fungal, viral, and parasitic infections. Moringa is also used to reduce swelling, increase sex drive (as an aphrodisiac), prevent pregnancy, boost the immune system, and increase breast milk production.

So get Moringa for :

 

 

 

 

 

Reference and resources:

sources link , Reference for more research on MORINGA:

draxe.com
webmd.com
drweil.com
examine.com
ods.od.nih.gov

http://www.webmd.com/vitamins-supplements/ingredientmono-1242-moringa.aspx?activeingredientid=1242

 

Antioxidants Benefits & Effects of Polyphenols, Phenolic Acid

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

Flavones Flavonols Flavanones Isoflavones Anthocyanidins Chalcones, Catechins,Stilbenes

Research in progress

 

About Polyphenol, Phenolic acids:

A phenolic acid is a sort of phytochemical known as a polyphenol. Phenolic acids are found in an assortment of plant-based nourishments such as the seeds and skins of products of the soil leaves of vegetables contain the most noteworthy concentration. Phenolic acids are promptly consumed through the dividers of your intestinal tract, and they might be valuable to your wellbeing since they fill in as cancer prevention agents that counteract cell harm because of free-radical oxidation responses. The Polyphenol phenolic acid supplements may likewise work as anti inflammatory in the human body. It strongly supports a role for polyphenols in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanisms of action of polyphenols go beyond the modulation of oxidative stress. Polyphenols are the most abundant antioxidants in the diet. Their total dietary intake could be as high as 1 g/d, which is much higher than that of all other classes of phytochemicals and known dietary antioxidants.

 

 

 

 

 

Ranking list of top foods list with Polyphenols (Phenolic Acid)

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

Top foods list with Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects

Different Types of Polyphenols

Polyphenols are four main categories, with additional sub-groupings. based on the number of phenol rings they contain, and on the basis of structural elements in their construction.

As a general rule, foods contain complex mixtures of polyphenols, with higher levels found in the outer layers of the plants than the inner parts.

 

1- Flavonoids,  have Strong both antioxidant and anti-inflammatory properties, found in fruits, vegetables, legumes, red wine, and green tea
      Flavones
      Flavonols
      Flavanones
      Isoflavones
      Anthocyanidins
      Chalcones
      Catechins
2- Stilbenes, found in red wine and peanuts (resveratrol is the most well known)
3- Lignans, found in seeds like flax, legumes, cereals, grains, fruits, algae, and certain vegetables
4- Phenolic acids
Hydroxybenzoic acids, found in tea
Hydroxycinnamic acids found in cinnamon of course but also in coffee, blueberries, kiwis, plums, apples, and cherries

 

Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body

 

Polyphenols are usually associated with/ improving:

  • Fighting cancer cells and inhibiting angiogenesis (the growth of blood vessels that feed a tumor)
  • Protecting your skin against ultraviolet radiation
  • Fighting free radicals
  • reducing the appearance of aging
  • Promoting brain health
  • protecting against dementia
  • Reducing inflammation
  • Supporting normal blood sugar levels
  • Protecting your cardiovascular system
  • Promoting normal blood pressure

 

Polyphenols work effective for :

 

 

 

Antioxidants effects & Benefits of Phenolic acids:

• Anti-Diabetic Effects of  Polyphenols

Numerous studies report the antidiabetic effects of polyphenols. Tea catechins have been investigated for their anti-diabetic potential.63,64 Polyphenols may affect glycemia through different mechanisms, including the inhibition of glucose absorption in the gut or of its uptake by peripheral tissues.Onion polyphenols, especially quercetin is known to possess strong anti diabetic activity. A recent study shows that quercetin has ability to protect the alterations in diabetic patients during oxidative stress. Quercetin significantly protected the lipid peroxidation and inhibition antioxidant system in diabetics. (source)

Cranberry Strong Antioxidant Effects

 

• Used as Anti bacterial:

Bacteria are collection of single cell microorganisms. Most microorganisms are innocuous in people because of the defensive impacts of the immune framework. Notwithstanding, a few microscopic organisms are perilous and can bring about irresistible maladies. Luckily, phenol acids are effective antibacterials and can help guard you from perilous microorganisms. Temporary reviews recommend that phenolic acid may likewise have antibacterial properties however additional confirmation is required before this can be affirmed. (source)

 Sage, just a mint or strong antioxidants and Anti-Inflammatory

• Anti-Aging Effect

Aging is the accumulation process of diverse detrimental changes in the cells and tissues with advancing age, resulting in an increase in the risks of disease and death. Among many theories purposed for the explaining the mechanism of aging, free radical/oxidative stress theory is one of the most accepted one. Antioxidant capacity of the plasma is related to dietary intake of antioxidants; it has been found that the intake of antioxidant rich diet is effective in reducing the deleterious effects of aging and behavior. Several researches suggest that the combination of antioxidant/anti-inflammatory polyphenolic compounds found in fruits and vegetables may show efficacy as anti-aging compounds. Subset of the flavonoids known as anthocyanins, are particularly abundant in brightly colored fruits such as berry fruits and concord grapes and grape seeds.  (source)

• Reduces inflammation:

Inflammation is the body’s method for managing disease, harm, aggravation or stress. It prompts warm, torment, redness or swelling around the influenced body part. Most inflammation is sure as it demonstrates that the body has recognized a risk and is endeavoring to manage the issue. In any case, some inflammation is superfluous and harms the body’s cells when there is no contamination, damage, bothering or worry to manage. Luckily, the phenolic acids can help monitor pointless inflammation. The strong antioxidants of phenolic acids are powerful against inflammation. (source)

Ranking list of top foods list with Polyphenols (Phenolic Acid)

• Antioxidant effects of Polyphenol, phenolic acid on cancer:

Antioxidants are substances that protect a human body’s cells from free radicals. Free radicals are destructive substances that are discharged into the body amid oxygen based responses. They have been connected with serious disease such as cancer, diabetes, a weak invulnerable system along with noticeable indications of maturing. Luckily, the greater parts of the phenolic acids aside from “capsaicin” are intense cancer prevention agents that can guard you from the antagonistic impacts related with free radicals. Several mechanisms of action have been identified for chemoprevention effect of polyphenols, these include estrogenic/antiestrogenic activity, antiproliferation, induction of cell cycle arrest or apoptosis, prevention of oxidation, induction of detoxification enzymes, regulation of the host immune system, anti-inflammatory activity and changes in cellular signaling

Ranking list of top foods list with Polyphenols (Phenolic Acid)

 

• Neuro-Protective Effects and Mental health boosters:

The phenolic acids have a considerable measure of potential with regards to boosting the emotional wellbeing. Early research proposes that phenolic acids may go about as an energizer and furthermore it prevents the Alzheimer’s disease. What’s more, they may likewise ensure against Alzheimer’s malady while vanillin may shield the cerebrum cells from harm, prevents Alzheimer’s infection and Parkinson’s ailment. In any case, additionally studies are required before the impacts of the phenolic acids on brain health are affirmed. Oxidative stress and damage to brain macromolecules is an important process in neurodegenerative diseases. Alzheimer’s disease is one of the most common occurring neurodisorder affecting up to 18 million people worldwide. Because polyphenols are highly antioxidative in nature, their consumption may provide protection in neurological diseases. It was observed that the people drinking three to four glasses of wine (vines that have Polyphenol contents) per day had 80% decreased incidence of dementia and Alzheimer’s disease compared to those who drank less or did not drink at all. (source)

 

Green Tea, Antioxidant effects and benefits

Polyphenol Supplements interactions

These mostly happen with supplements not the foods containing Polyphenol

  • Iron depletion in populations of people who have marginal iron stores
  • Interference with thyroid hormone metabolism
  • Interactions with pharmaceutical drugs, enhancing their biologic effects

 

 

 

 

 

 

 

 

 

References and sources for Polyphenols online:

http://www.nature.com/ejcn/journal/v64/n3s/fig_tab/ejcn2010221t1.html

http://articles.mercola.com/sites/articles/archive/2015/12/14/polyphenols-benefits.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/

https://en.wikipedia.org/wiki/Antioxidant_effect_of_polyphenols_and_natural_phenols

http://ajcn.nutrition.org/content/81/1/215S.full

 

 

Published papers and articles  and References for Polyphenols

1. Scalbert A, Manach C, Morand C, Remesy C. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005;45:287–306. [PubMed]
2. Spencer JP, Abd El Mohsen MM, Minihane AM, Mathers JC. Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr. 2008;99:12–22. [PubMed]
3. Beckman CH. Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants? Physiol. Mol. Plant Pathol. 2000;57:101–110.
4. Graf BA, Milbury PE, Blumberg JB. Flavonols, flavonones, flavanones and human health: Epidemological evidence. J Med Food. 2005;8:281–290. [PubMed]
5. Arts ICW, Hollman PCH. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005;81:317–325. [PubMed]
6. Kondratyuk TP, Pezzuto JM. Natural Product Polyphenols of Relevance to Human Health. Pharm Biol. 2004;42:46–63.
7. Shahidi F, Naczk M. Food phenolics, sources, chemistry, effects, applications. Lancaster, PA: Technomic Publishing Co Inc; 1995.
8. de Groot H, Rauen U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharmacol. 1998;12:249–255. [PubMed]
9. Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med. 1997;29:95–120. [PubMed]
10. Wink M. Compartmentation of secondary metabolites and xenobiotics in plant vacuoles. Adv Bot Res. 1997;25:141–169.
11. Simon BF, Perez-Ilzarbe J, Hernandez T, Gomez-Cordoves C, Estrella I. Importance of phenolic compounds for the characterization of fruit juices. J Agric Food Sci. 1992;40:1531–1535.
12. Manach C, Scalbert A, Morand C, Rémésy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79:727–747. [PubMed]
13. Parr AJ, Bolwell GP. Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenol content or profile. J Agric Food Chem. 2000;80:985–1012.
14. Sosulski FW, Krygier K, Hogge L. Importance of phenolic compounds for the characterization of fruit juices. J Agric Food Chem. 1982;30:337–340.
15. Price KR, Bacon JR, Rhodes MJC. Effect of storage and domestic processing on the content and composition of flavonol glucosides in onion (Allium cepa) J Agric Food Chem. 1997;45:938–942.
16. Crozier A, Lean MEJ, McDonald MS, Black C. Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. J Agric Food Chem. 1997;45:590–595.
17. D’Archivio M, Filesi C, Benedetto RD, Gargiulo R, Giovannini C, Masella R. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanità 2007;43:348–361. [PubMed]
18. Day AJ, Williamson G. Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma. Br J Nutr. 2001;86:S105–S110. [PubMed]
19. Setchell KD, Faughnan MS, Avades T, Zimmer-Nechemias L, Brown NM, et al. Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. Am J Clin Nutr. 2003;77:411–419. [PubMed]
20. Duthie GG, Pedersen MW, Gardner PT, Morrice PC, Jenkinson AM, McPhail DB, Steele GM. The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur J Clin Nutr. 1998;52:733–736. [PubMed]
21. Young JF, Nielsen SE, Haraldsdóttir J, Daneshvar B, Lauridsen ST, Knuthsen P, Crozier A, Sandström B, Dragsted LO. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr. 1999;69:87–94. [PubMed]
22. Gee JM, DuPont MS, Rhodes MJ, Johnson IT. Quercetin glucosides interact with the intestinal glucose transport pathway. Free Radic Biol Med. 1998;25:19–25. [PubMed]
23. Crespy V, Morand C, Besson C, Manach C, Demigne C, Remesy C. Quercetin, but not its glycosides, is absorbed from the rat stomach. J Agric Food Chem. 2002;50:618–621. [PubMed]
24. Passamonti S, Vrhovsek U, Vanzo A, Mattivi F. Fast access of some grape pigments to the brain. J Agric Food Chem. 2005;53:7029–7034. [PubMed]
25. Halliwell B, Zhao K, Whiteman M. The gastrointestinal tract: a major site of antioxidant action? Free Radic Res. 2000;33:819–830. [PubMed]
26. Clifford MN. Chlorogenic acids and other cinnamates. Nature, occurence, dietary burden, absorption and metabolism. J Sci Food Agric. 2000;80:1033–1043.
27. Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr. 2001;131:66–71. [PubMed]
28. Kuhnau J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet. 1976;24:117–191. [PubMed]
29. Lee MJ, Maliakal P, Chen L, Meng X, Bondoc FY, et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev. 2002;11:1025–1032. [PubMed]
30. Falany CN. Enzymology of human cytosolic sulfotransferases. Faseb J. 1997;11:206–216. [PubMed]
31. Spencer JP, Chowrimootoo G, Choudhury R, Debnam ES, Srai SK, Rice-Evans C. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett. 1999;458:224–230. [PubMed]
32. Hollman PC, Tijburg LB, Yang CS. Bioavailability of flavonoids from tea. Crit Rev Food Sci Nutr. 1997;37:719–738. [PubMed]
33. Dangles O, Dufour C, Manach C, Morand C, Remesy C. Binding of flavonoids to plasma proteins. Methods Enzymol. 2001;335:319–333. [PubMed]
34. Dufour C, Loonis M, Dangles O. Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin. Free Radic Biol Med. 2007;43:241–252. [PubMed]
35. Vitrac X, Moni JP, Vercauteren J, Deffieux G, Mérillon JM. Direct liquid chromatography analysis of resveratrol derivatives and flavanonols in wines with absorbance and fluorescence detection. Anal Chim Acta. 2002;458:103–110.
36. Luqman S, Rizvi SI. Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res. 2006;20:303–306. [PubMed]
37. Pandey KB, Mishra N, Rizvi SI. Protective role of myricetin on markers of oxidative stress in human erythrocytes subjected to oxidative stress. Nat Prod Commun. 2009;4:221–226. [PubMed]
38. Pandey KB, Rizvi SI. Protective effect of resveratrol on markers of oxidative stress in human erythrocytes subjected to in vitro oxidative insult. Phytother Res. 2009. In press. [PubMed]
39. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992;339:1523–1526. [PubMed]

 

NAC, Antioxidant Effects & Benefits of N-Acetyl cysteine (NAC) a trigger for GLUTATHIONE

Antioxidant Effects & Benefits of N-Acetyl cysteine (NAC)

Other Names: Acetyl Cysteine, Acétyl Cystéine, Acetylcysteine, Acétylcystéine, Chlorhydrate de Cystéine, Cysteine, Cystéine, Cysteine Hydrochloride, Cystine,

About N- Acetyl Cysteine (NAC):

For over thirty years, a protected, minimal effort compound known as N-acetyl cysreine (NAC) has given help to many individuals from the wheezing, thick mucus related to flu or cold and wheezing. Obviously, pharmaceutical organizations co-selected it for benefit by joining it into different licensed medications. The pitiful outcome is that most specialists or health experts have never known about it. Indeed, even many specialists stay uninformed of its potential part as an amazing guard against some of today’s most general health threats. Below are some amazing benefits NAC can provide a human body. N-acetyl cysteine comes from the amino acid L-cysteine. Amino acids are the building blocks of proteins. N-acetyl cysteine has many uses as medicine.

N-acetyl cysteine is used to counteract acetaminophen (Tylenol) and carbon monoxide poisoning. It is also used for chest pain (unstable angina), bile duct blockage in infants, amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), Alzheimer’s disease, allergic reactions to the anti-seizure drug phenytoin (Dilantin), and an eye infection called keratoconjunctivitis. It is also used for reducing levels of a type of cholesterol called lipoprotein (a), homocysteine levels (a possible risk factor for heart disease) and the risk of heart attack and stroke in patients with serious kidney disease. (source)

N-acetyl-cysteine is an effective scavenger of free radicals as well as a major contributor to maintenance of the cellular glutathione status in muscle cells. Studies have demonstrated some possible roles for NAC to minimize fatigue or extend the time it takes for it to accumulate as well as prevent the onset of apoptosis secondary to exhaustive exercise. It is still not known if the combination of vitamin C and NAC may be detrimental after damaging exercise as well as NAC’s other possible roles during muscle damage and extensive muscle proteolysis.

Benefits of NAC:

• Fights liver disease:

A lot of people, ordinarily utilized pharmaceuticals for killing pain, for example, Tylenol and Vicodin contain a substance called Acetaminophen. On the off chance that taken in high amounts, Acetaminophen can be harmful to the liver and can bring about liver disappointment. NAC is ordinarily used to treat liver disappointment because of Acetaminophen and enormously expands the patient’s odds of survival. NAC has likewise been appeared to viably treat liver diseases brought on by different variables, for example by liquor utilization or ecological poisons.

• Great to fight with Cellular Oxidative Damage:

Oxygen radicals will bring about oxidative harm that is hindering to cells and their DNA By recharging Glutathione where it is required in the body, NAC battles against oxygen radicals and thusly averts cell harm. This can be particularly useful if cells have been presented to lead.

• Treats HIV:

HIV is an ailment that causes the disappointment of the bodies’ immune reaction. It has been demonstrated that large amounts of NAC in the body can help keep the proliferation of one strain of HIV, HIV-1. This proposes that the cells with high NAC levels might have the capacity to oppose HIV disease. NAC might be a decent supplement to take for subjects who are HIV+ and are taking different prescriptions.

• Helps decreasing tissues’ inflammation:

long with reducing oxidative harm in tissues, NAC can work to lessen the aggravation in tissues. NAC diminishes the measure of various provocative particles introduce in the body. Reduction of irritation can diminish side effects of various illnesses or reduce danger of creating diverse infections. Strong antioxidants in NAC additionally help in reducing aggravation after lively exercise, which considers individuals to play out these activities without an excessive amount of soreness.

• Used to prevent addictive behaviors in human:

Addictive behaviors incorporate voraciously consuming food, medicate addictions, and other habitual practices. NAC is able to reduce or dispose of these practices in rat models. An efficient survey found that NAC helps people a lot that are addicted particularly with cocaine and cannabis. Some other addictions, for example, pulling the hairs or biting nails can likewise be averted utilizing NAC.

• Great for decreasing Insulin resistance in bodies:

High glucose and heftiness can bring about irritation in fat tissue. This aggravation starts a flagging pathway that at last prompts to the decimation of insulin receptors. The decimation prompts diabetes 2 in human body. The strong antioxidants of NAC have been appeared to reduce aggravation in fat cells.

Get NAC for:

(Antioxidant effects of NAC is indirectly applied to body basically by improving and playing a role as trigger for GLUTATHIONE)

The following doses have been studied in scientific research:

BY MOUTH:

For chest pain that is not relieved by rest (unstable angina): 600 mg of N-acetyl cysteine three times daily with a nitroglycerin patch.
For preventing sudden worsening of chronic bronchitis: doses of 200 mg twice daily, 200 mg three times daily, 300 mg slow-release twice daily, and 600 mg controlled-release twice daily have been used.
For treating chronic obstructive pulmonary disease (COPD): 600 mg of N-acetyl cysteine once daily, in addition to standard care, has been used for up to 6 months.

For more details (source)

 

Major Interaction

Do not take this combination
Nitroglycerin interacts with N-ACETYL CYSTEINE

 

 

 

 

Good resources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129149/

http://www.webmd.com/vitamins-supplements/ingredientmono-1018-n-acetyl%20cysteine.aspx?activeingredientid=1018

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685276/

 

 

References
Evans WJ. Vitamin E, vitamin C, and exercise. Am J Clin Nutr. 2000;72:647S–652S. [PubMed]
Stipanuk MH. Biochemical and Physiological Aspects of Human Nutrition. Philadelphia, PA: SAUNDERS; 2000.
Sen CK. Antioxidant and redox regulation of cellular signaling: introduction. Med Sci Sports Exerc. 2001;33:368–370. doi: 10.1097/00005768-200103000-00005. [PubMed] [Cross Ref]
Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr. 2000;72:637S–646S. [PubMed]
Van Remmen H, Hamilton ML, Richardson A. Oxidative Damage to DNA and Aging. Exerc Sport Sci Rev. 2003;31:149–153. doi: 10.1097/00003677-200307000-00009. [PubMed] [Cross Ref]
Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol. 2000;279:L1005–L1028. [PubMed]
Bryant RJ, Ryder J, Martino P, et al. Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. J Strength Cond Res. 2003;17:792–800. doi: 10.1519/1533-4287(2003)017<0792:EOVEAC>2.0.CO;2. [PubMed] [Cross Ref]
Ramel A, Wagner KH, Elmadfa I. Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men. Eur J Nutr. 2004;43:2–6. doi: 10.1007/s00394-004-0432-z. [PubMed] [Cross Ref]
Rodriguez MC, Rosenfeld J, Tarnopolsky MA. Plasma malondialdehyde increases transiently after ischemic forearm exercise. Med Sci Sports Exerc. 2003;35:1859–1865. doi: 10.1249/01.MSS.0000093609.75937.70. [PubMed] [Cross Ref]
Chan KM, Decker EA. Endogenous skeletal muscle antioxidants. Critical Reviews in Food Science and Nutrition. 1994;34:403–426. [PubMed]
Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr. 2000;72:653S–669S. [PubMed]
Davison GW, Hughes CM, Bell RA. Exercise and mononuclear cell DNA damage: The effects of antioxidant supplementation. Int J Sport Nutr Exerc Metab. 2005;15:480–492. [PubMed]
Sen CK. Glutathione homeostasis in response to exercise training and nutritional supplements. Molecular and Cellular Biochemistry. 1999;196:31–42. doi: 10.1023/A:1006910011048. [PubMed] [Cross Ref]
Viguie CA, Frei B, Shigenaga MK, et al. Antioxidant status and indexes of oxidative stress during consecutive days of exercise. J Appl Physiol. 1993;75:566–572. [PubMed]
Laires MJ, Madeira F, Sergio J. Preliminary study of the relationship between plasma and erythrocyte magnesium variations and some circulating pro-oxidant and antioxidant indices in a standardized physical effort. Magnesium Research. 1993;6:233–238. [PubMed]
Lee J, Clarkson PM. Plasma creatine kinase activity and glutathione after eccentric exercise. Med Sci Sports Exerc. 2003;35:930–936. doi: 10.1249/01.MSS.0000069553.47739.36. [PubMed] [Cross Ref]
Laaksonen DE, Atalay M, Niskanen L, et al. Blood glutathione homeostasis as a determinant of resting and exercise-induced oxidative stress in young men. Redox Rep. 1999;4:53–59. doi: 10.1179/135100099101534648. [PubMed] [Cross Ref]
Meister A. Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol Ther. 1991;51:155–194. doi: 10.1016/0163-7258(91)90076-X. [PubMed] [Cross Ref]
Sen CK. Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochemical Pharmacology. 1998;55:1747–1758. doi: 10.1016/S0006-2952(97)00672-2. [PubMed] [Cross Ref]
Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J. 1996;10 [PubMed]
Sen CK, Khanna S, Reznick AZ, et al. Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa-B activation in skeletal muscle-derived L6 cells. Biochem Biophys Res Commun. 1997;237:645–649. doi: 10.1006/bbrc.1997.7206. [PubMed] [Cross Ref]
Reid MB, Stokic DS, Koch SM, et al. N-Acetylcysteine inhibits muscle fatigue in humans. J Clin Invest. 1994;94:2468–2474. [PMC free article] [PubMed]
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Matuszczak Y, Farid M, Jones J, et al. Effect of n-acetylcysteine on glutathione oxidation and fatigue during handgrip exercise. Muscle Nerve. 2005;32:633–638. doi: 10.1002/mus.20385. [PubMed]

Pycnogenol strong antioxidant benefits and effects

Pycnogenol strong antioxidant benefits and effects

Research in progress

 

pycnogenol

Pycnogenol is the trademark name given to a product derived from the pine bark of the Pinus pinaster tree that contains numerous unique health benefits. It has been used since the 1500s for the treatment of scurvy caused by a lack of vitamin C during the French sailing voyages from France to the New World. Even today, it is known that the best source of pine bark comes from the south-west forest of France.

 

Pycnogenol is one of the most researched natural ingredients currently in the market. It is a great source of vitamin C as well as a host of phytochemicals – natural compounds from plants that have many health benefits. The powerful ingredient contained in Pycnogenol is known as oligomeric proanthocyanidin compounds (OPCs). This active ingredient of pycnogenol can also be obtained from peanut skin, witch hazel bark and grape seed. However, that from the French pine bark is preferred.

 

Important effects of Pycnogenol

Pycnogenol is uniquely known for its antioxidant properties. During the normal cellular process, your body produces free radicals as a by-product. These, if left to accumulate in your body can lead to serious health problems such as neurodegenerative diseases and cancers. Antioxidants freely and safely interact with these free radicals to destroy the chain reaction they cause in advance before they damage essential molecules. Pycnogenol works both to prevent and minimise the oxidation damage from free radicals. Antioxidants are naturally found in fruits and vegetables and diets that are rich in these are encouraged. Green tea and coffee are also great sources of antioxidants.

pycnogenol

Other than its antioxidant properties, Pycnogenol has several other benefits to the human body. These are:

  1. Lowers levels of glucose – A study conducted with 77 diabetic patients that added Pycnogenol to their prescription drugs found greater improvement in blood sugar control and cardiovascular health also.
  2. Prevents hearing loss and imbalance – Ear poisoning (Ototoxicity) is a condition that occurs when certain drugs or chemicals damage the vestibulocochlear nerve in the inner ear. This nerve affects both hearing and balance. Pycnogenol has been found to alleviate symptoms of this condition due to its antioxidant properties.
  3. Protects the skin from UV radiation – Pycnogenol has been found to offer photoprotection. When studies were conducted on its effect on the skin, it was found that not only does it protect against the harmful rays of the sun but it also reduces hyperpigmentation of the skin.
  4. For erectile dysfunction – Pycnogenol has been found to have a significant impact on nitric oxide(NO) levels in the body. NO is responsible for the vasodilation of blood vessels and improving blood flow. Research shows that a combination of Pycnogenol and arginine were effective in improving moderate erectile dysfunction.
  5. Boosts brain function – Sometimes, a decline in cognitive activity and alertness may be the cause of accumulation of free radicals in the brain. Pycnogenol, containing antioxidant properties has been found to alleviate degeneration of brain cells by reducing oxidative stress.

Pycnogenol has been found to have other numerous benefits like reducing inflammation and would make a great addition to your nutrition to fight off diseases and infections.

 

cranberry strong antioxidant effects, benefits and sideffects

DHA & EPA Antioxidant and anti-aging benefits

DHA & EPA effects and antioxidant benefits!

 

Introducing DHA & EPA:

Omega-3 fatty acids are connected to healthy aging in humans. The omega-3 unsaturated fats derived from fishes, EPA and DHA, have been related with fetal improvement, cardiovascular activities, and Alzheimer’s sickness. Nonetheless, in light of the fact that our bodies don’t proficiently deliver some omega-3 unsaturated fats from marine sources, it is important to get satisfactory sums through fish and fish oil items. The effective and strong antioxidants of EPA and DHA help improving health. They are imperative for appropriate fetal improvement, including neuronal, retinal, and invulnerable function positively and have been connected to provide great outcomes in anticipation, management of weight as well as intellectual capacity in those with exceptionally mellow Alzheimer’s sickness.

Antioxidant Effects of DHA & EPA:

The DHA & EPA supplements have numerous effects on heart. They fight against arrhythmias, heart assault and stroke. They likewise moderate plaque develops, lessen triglycerides, circulatory strain, irritation and thickening, and enhance lipid proportions. Because of their mitigating impacts and strong antioxidants, they might be helpful in treating rheumatoid joint inflammation, asthma and Crohn’s illness. The potential part of DHA & EPA in counteracting and treating osteoporosis, renal disease, cataracts, Alzheimer’s illness, depression and different conditions is as yet being examined.

 

 

Get DHA & EPA for:

For the highest amount of EPA and DHA here is the list of high omega foods by draxe:

  • Mackerel: 6,982 milligrams in 1 cup cooked (174 precent DV)
  • Salmon Fish Oil: 4,767 milligrams in 1 tablespoon (119 percent DV)
  • Cod Liver Oil: 2.664 milligrams in 1 tablespoon (66 percent DV)
  • Walnuts: 2,664 milligrams in 1/4 cup (66 percent DV)
  • Chia Seeds: 2,457 milligrams in 1 tablespoon (61 percent DV)
  • Herring: 1,885 milligrams in 3 ounces (47 percent DV)
  • Salmon (wild-caught): 1,716 milligrams in 3 ounces (42 percent DV)
  • Flaxseeds (ground): 1,597 milligrams in 1 tablespoon (39 percent DV)
  • Tuna: 1,414 milligrams in 3 ounces (35 percent DV)
  • White Fish: 1,363 milligrams in 3 ounces (34 percent DV)
  • Sardines: 1,363 milligrams in 1 can/3.75 ounces (34 percent DV)
  • Hemp Seeds: 1,000 milligrams  in 1 tablespoon (25 percent DV)
  • Anchovies: 951 milligrams in 1 can/2 ounces (23 percent DV)
  • Natto: 428 milligrams in 1/4 cup (10 percent DV)
  • Egg Yolks: 240 milligrams in 1/2 cup (6 percent DV)

 

Antioxidant benefits of DHA & EPA:

 

  • Decrease brain aging and keeps brain healthy: The EPA & DHA supplements are important and might be taken to keep up solid capacity of the mind and retina due to their strong antioxidants. DHA is a building square of tissue in the cerebrum and retina of the eye. It assists in shaping neural transmitters, for example, phosphatidylserine, which is vital for the working of brain. DHA is found in the retina of the eye and taking DHA might be fundamental for keeping the working of eye great.

 

  • Cancer Treatment: Studies revealed that DHA & EPA supplements can avoid and kill different kind of cancers, including colon, breast as well as prostate. While being an effective supplement for cancer patients, at the same time it’s also an effective treatment in those cancer treatments that are done naturally.

 

  • Great for cardiovascular system: EPA and DHA supplements are changed over into substances like hormones known as prostaglandins, and they manage cell action and perfect cardiovascular capacity.

 

  • Diabetes: The strong antioxidants of DHA and EPA can also help in decreasing the danger of diabetic patients from resulting cognitive deficit since it shields the hippocampus cells from being pulverized. Furthermore, they could also help decrease oxidative anxiety, which assumes a great part in the advancement of both micro-vascular and cardiovascular diabetes difficulties.

 

  • Decrease Joint Pains: All the essential antioxidants found in EPA and DHA seem to decrease few joint pains. Human reviews have demonstrated the supplemental fish oil decreases fiery joint pain. They are also successful in diminishing such pain that is brought by joint pain.

 

  • Beneficiary for Human Development: Human development and scholarly advancement – DHA assumes an essential part during the development and improvement of fetal. DHA of the high concentrations are found in the mind and increment 300 to 500 percent in a newborn child’s cerebrum amid the last trimester of pregnancy. Adding DHA supplements in to the pregnant mother’s eating routine might be helpful for the embryo’s mental health. Elderly individuals ought to likewise take EPA DHA, on the grounds that as adults get more established, the bodies frame less EPA and DHA, which may bring about less mental concentration and psychological capacity. Taking some EPA DHA supplements likewise may help with mental variations.

 

  • Decrease muscle degeneration: The strong antioxidants of DHA and EPA diminish the rate of muscle degeneration. A few researches recommends that fit body mass is better held after surgery by expanding the intake of EPA in the eating routine. There are a lot of confirmations proposing that fish oil helps muscle development.

Omega 3 fatty acids, DHA & EPA are naturally found in fishes as well as fish oils. However, DHA & EPA Supplements can also be consumed few times in a week in order to get all the above mentioned benefits.

 

 

Reference Websites:
www.livestrong,com
www.mercola.com

Hydrogen Peroxide, antioxidant benefits and effects!

Some on Cellular Hydrogen Peroxide, antioxidant benefits and effects!

First some on how antioxidants work with free radicals and where is Hydrogen Peroxide:

Free radicals can be broken down into five types. The first four types come from oxygen atoms and are called Reactive Oxygen Species (ROS), but the fifth type derives from nitrogen:

Superoxide ion (O): An oxygen molecule with an extra electron that can damage mitochondria, DNA and other molecules.
Hydroxyl radical (OH): A highly reactive molecule formed by the reduction of an oxygen molecule, capable of damaging almost any organic molecule in its vicinity, including carbohydrates, lipids, proteins, and DNA. OH cannot be eliminated by an enzymatic reaction.
Singlet oxygen: Formed by your immune system, singlet oxygen causes oxidation of your LDL.
Hydrogen peroxide (H2O2): Not a free radical itself, but easily converts to free radicals like OH, which then do the damage. Hydrogen peroxide is neutralized by peroxidase (an enzymatic antioxidant).
Reactive Nitrogen Species (RNS) (NO): Nitric acid is the most important RNS.
These various free radical species can damage DNA in different ways.

They can disrupt duplication of DNA, interfere with DNA maintenance, break open the molecule or alter the structure by reacting with the DNA bases. Cancer, atherosclerosis, Parkinson’s, Alzheimer’s disease, and cataracts are examples of diseases thought to result from free radical damage.

In fact, free radicals are implicated in more than 60 different diseases.

Lipids in cell membranes are quite prone to oxidative damage because free radicals tend to collect in cell membranes, known as “lipid peroxidation.” (The lipid peroxide radical is sometimes abbreviated as LOO.) When a cell membrane becomes oxidized by an ROS, it becomes brittle and leaky. Eventually, the cell falls apart and dies.

This is akin to what happens when butter, vegetable oils or meat becomes rancid—and why manufacturers sometimes add agents to prevent that. How can this free radical pillage be stopped?

This is where antioxidants come in. (sources)

Antioxidants can be categorized in multiple ways. Based on their activity, they can be categorized as enzymatic and non-enzymatic antioxidants. Enzymatic antioxidants work by breaking down and removing free radicals. The antioxidant enzymes convert dangerous oxidative products to hydrogen peroxide (H2O2) and then to water, in a multi-step process in presence of cofactors such as copper, zinc, manganese, and iron. Non-enzymatic antioxidants work by interrupting free radical chain reactions. Few examples of the non-enzymatic antioxidants are vitamin C, vitamin E, plant polyphenol, carotenoids, and glutathione.7 (source)

Free radicals are atoms, molecules or ions with unpaired electrons, which are highly active to chemical reactions with other molecules. In the biology system, the free radicals are often derived from oxygen, nitrogen and sulphur molecules. These free radicals are parts of groups of molecules called reactive oxygen species (ROS), reactive nitrogen species (RNS) and reactive sulphur species (RSS). For example, ROS includes free radicals such as superoxide anion (O2−•), perhydroxyl radical (HO2•), hydroxyl radical (▪OH), nitric oxide and other species such as hydrogen peroxide (H2O2), (source)

About Cellular Hydrogen Peroxide:

Using hydrogen peroxide on cuts and scratches truly isn’t just the most ideal approach to use it due to the fact that there are a lot more benefits of it. Hydrogen peroxide has various awesome uses outside of medical aid. Hydrogen peroxide is the main germicidal agent made just out of water and oxygen. Similar to ozone, it executes the organisms of illness formed by oxidation. Hydrogen peroxide is viewed as the most secure and natural effective sanitizer. It executes microorganisms by oxidizing them, which can be best depicted as a controlled consuming procedure. At the point when Hydrogen peroxide responds with natural material it separates into oxygen and water. As an extreme, nontoxic compound, the hydrogen peroxide works amazingly in some other ways too and it is affordable, as well. Below are some antioxidant benefits of hydrogen peroxide.

The results of some researches obtained show that the antioxidant and anti-radical activity of phenolic acids correlated positively with the number of hydroxyl groups bonded to the aromatic ring. The model of an ortho substitution of hydroxyl groups to the aromatic ring seems to be adequate for antioxidant and H2O2 or DPPH• scavenging activity of phenolic acids. (source)

Antioxidant & other benefits of Hydrogen Peroxide:

  • Cancer Treatment with strong Hydrogen Peroxide antioxidants: The cancer is spreading a lot in people and there are several characteristic drugs that must be utilized to stop the spreading and dispose of the cancer cells either by executing the cancer cells or by killing the organisms inside the cancer cells and turning around the cancer cells into ordinary cells. The antioxidants generally found in Hydrogen peroxide are useful in killing such organisms and can decrease the risk of cancer.

 

  • Maintain common health: The human body makes hydrogen peroxide and its strong antioxidants are able to battle such diseases which must be removed to make our immune framework work accurately. The White platelets are known as Leukocytes. A sub-class of Leukocytes called Neutrophils delivers hydrogen peroxide as the main line of barrier against poisons, parasites, microorganisms as well as infections and yeast.

 

  • Infection treatment: By soaking he infected area of body in 3% of hydrogen peroxide for few minutes a few times each day can help getting rid of that infection. Indeed, even gangrene that would not heal with any solution has been recuperated by absorbing Hydrogen peroxide due to its strong antioxidant reactions on wounds.

 

  • Help removing parasites: As in a lot of other treatments, when taken inside, the effective and strong antioxidants of hydrogen peroxide adds oxygen to the body’s inward condition. This oxidized condition is one in which parasites can’t exist and all of them are normally wiped out from the body.

 

  • Treatment for foot fungus: The researches still can’t seem to have been done to demonstrate this works for everybody that it is a fast home cure for foot fungus. In order to help treating the foot fungus, the use of the spray containing 3% hydrogen peroxide and water on them (particularly the toes) and letting them dry can heal it if done regularly. The strong antioxidants of hydrogen peroxide help a lot to treat the disease.

 

  • Best for mouth and teeth: Many individuals don’t understand that hydrogen peroxide makes an extremely viable and economical mouthwash. Utilize 3% of hydrogen peroxide and include a dash of fluid chlorophyll for enhancing if you want. On the other side, taking one capful of hydrogen peroxide and holding in your mouth for 10 minutes and then spit it out will never cause ulcer and your teeth will be more white. On the off chance that you have a frightful toothache and can’t get to a dental practitioner immediately, put a capful of 3% Hydrogen peroxide into your mouth and hold it for 10 minutes a few times each day. The torment will decrease significantly.

 

  • Treats the birds Mites Infections: Patients contaminated by minor vermin stated that hydrogen peroxide successfully removes the parasites on their skins. They shower it on their skin two or three times with a couple of minutes between the applications and get stunning outcomes. The antioxidants available in hydrogen peroxide help fighting the disease and provide great results at the end.

 

  • Best for Wound care: The antioxidants available in Hydrogen Peroxide help in healing wounds and stop the bleeding from little wounds. A few sources prescribed to soak wounds for five or more minutes a few times each day in order to heal the wound.

 

  • Treating Sinus Infection: A tablespoon of 3% Hydrogen peroxide added to some non-chlorinated water can be utilized as a nasal shower. Contingent upon the level of sinus contribution, one should alter the measure of peroxide utilized. It can be used as a treatment for sinus infection due to the strong antioxidants available in it.

 

 

Reference Websites:
www.wakeup-world.com
www.realfarmacy.com

Ginger (root) Unique health benefits & Antioxidant effects

Vitamin E, Strong everyday antioxidant we have to have in our diet

Vitamin C, An antioxidant our body needs to stay healthy & prevent cancer

Olive leaf (extracts) One of the strongest antioxidants found

Olive leaf Extract One of the strongest antioxidants found, about Olive leaf Extract antioxidant benefits

Research in progress                        

Other Names of olive tree:
Acide Gras Insaturé, Acide Gras Mono-Insaturé, Acide Gras n-9, Acide Gras Oméga 9, Common Olive, Extra Virgin Olive Oil, Feuille d’Olivier, Green Olive, Huile d’Assaisonnement, Huile d’Olive

Introduction to Olive leaf extract benefits

Olive oil is has been known and used to prevent heart attack and stroke (cardiovascular disease), breast cancer, colorectal cancer, rheumatoid arthritis, and migraine headache. But Olive leaf extract comes from the leaves of olive tree, and is much different from Olive Oil. the olive leaf contains phenolics such as oleuropein, It has shown that it has protective effects against LDL oxidation also  benefits glucose metabolism for diabetes and skin health. Olive leaf is used as immune system boost for treating viral, bacterial, and other infections including influenza, swine flu, herpes, shingles, HIV/ARC/AIDS, and hepatitis B, pneumonia; chronic fatigue: tuberculosis (TB); gonorrhea; fever; malaria; dengue and infections in the teeth, ears, and urinary tract, and infections following surgery. Some Other also use it for high blood pressure, diabetes, hay fever, improving kidney and digestive function. Olive leaf kills and /or resists the multiplication of viruses, bacteria, yeasts, fungi, and other parasites in body. The olive leaf extract differ from immune boosters in that immune boosters tha stimulate your immune system to destroy disease which still requires your own energy. Olive leaf extract mainly does the work for you. it is not a supplementary for immune system it is like a parallel procedure.

vitamin-e Unique health benefits & Antioxidant effects

Proven Olive Leaf Benefits

I you are going to consider getting Olive leaf (extracts) you should know based on the studies these are the situations that it has been proven that Olive leaf (extracts) can improve.
  • Lowers Blood Pressure
  • Improves Cardiovascular Health
  • Diabetes
  • Reduces the Risk of Cancer
  • Improves Brain Function
  • Treats Arthritis
  • Kills Bacteria and Fungi
  • Improves Immune System
  • Protects Skin
  • More energy
  • Toothache relief
  • Diminished food cravings
  • Joint pain relief
  • Heartbeat regulation
  • Improved wound healing

 

branch of green olives antioxidant benefits

branch of green olives

Cancer and Olive leaf (extracts)

The Mediterranean diet which includes olive is renowned for its ability to reduce the risk of cancer as some researches say.  While numerous aspects of the diet contribute to this risk reduction, there’s growing evidence that olive oil and leaf extract contains phenolics such as oleuropein that are key components of the diet’s anti-cancer effects. Oleuropein and olive leaf extracts have numerous other mechanisms of action against cancer: They can prevent inflammation,  inflammation is another major promoter of tumor growth and olive leaf extracts are strong in fighting  inflammations.
In breast cancer cells specifically, oleuropein reduces malignant cells’ ability to respond to estrogen, the female hormone that many breast cancer cells depend on for their survival. Oleuropein stops production growth factor and the “protein-melting” enzymes that cancer cells need in order to invade healthy tissues.

Neuroprotection of Olive leaf (extracts)

Olive extracts help protect the brain neural system from the destruction brought on by age-related degenerative conditions such as Alzheimer’s and Parkinson’s diseases.  Olive extracts suppress the inflammations and reduce the damage done by oxidative stress in body cells, we did mention what oxidative stress is and how antioxidants tend to stop it from damaging our body, read more about that in our full article about Antioxidants.
Researchers found that if  the possible stroke patients be pre-treated by olive  extracts they can greatly reduce the damage after stroke. cause basically after a normal blood flow comes back after the stroke the damage gets worse. But olive extracts has shown that they change the atmosphere of the system so the come back is not that dangerous. Microscopic examination of brain tissue showed up to a 55% decrease in the volume of dying brain tissue after strokes that were pre-treated by olive extracts. Brain damages and inflammations in brain all lead to more dying neurons and cells that will lead to creating more tangles. tangles are one of the two main reasons and causes in brain aging. so Olive extracts generally work as a nice anti-age supplement.

branch of green olives antioxidant benefits

POLYPHENOLIC ANTIOXIDANTS & Olive leaf (extracts)

Polyphenolic antioxidants can help to slow down ageing by reducing cell degradation and assist in the prevention of a number of degenerative diseases. Polyphenolic antioxidants are best known in the scientific and medical communities for their ability to neutralize free radicals. The most studied polyphenolic antioxidants in Olive Leaf.
OLIVE EXTRACTS INTERACTIONS 
Moderate Interaction Be cautious with this combination
  • Medications for diabetes (Antidiabetes drugs) interacts with OLIVE
  • Medications for high blood pressure (Antihypertensive drugs) interacts with OLIVE
 

Useful Website sources and articles on Vitamin E and its benefits:


 
 
 
 
 
Phenolic compounds and antioxidant activity of olive leaf extracts.
 
 
 
 
 
 
 
 
Papers and articles for reading and references about Olive leaf (extracts):
 
 
Available at: http://www.tesisenred.net/bitstream/handle/10803/7208/tvk.pdf?sequence=1#page=30. Accessed March 8, 2013.
 
Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010;78(2):133-54.
 
Wahle KW, Caruso D, Ochoa JJ, Quiles JL. Olive oil and modulation of cell signaling in disease prevention. Lipids.2004 Dec;39(12):1223-31.
 
Waterman E, Lockwood B. Active components and clinical applications of olive oil. Altern Med Rev. 2007 Dec;12(4):331-42.
 
Hamdi HK, Castellon R. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Biophys Res Commun.2005 Sep 2;334(3):769-78.
 
Ribeiro Rde A, Fiuza de Melo MM, De Barros F, Gomes C, Trolin G. Acute antihypertensive effect in conscious rats produced by some medicinal plants used in the state of Sao Paulo. J Ethnopharmacol.1986 Mar;15(3):261-9.
 
Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. J Ethnopharmacol.2003 Feb;84(2-3):299-305.
 
Khayyal MT, el-Ghazaly MA, Abdallah DM, Nassar NN, Okpanyi SN, Kreuter MH. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung.2002;52(11):797-802.
 
Cherif S, Rahal N, Haouala M, et al. A clinical trial of a titrated Olea extract in the treatment of essential arterial hypertension. J Pharm Belg. 1996 Mar-Apr;51(2):69-71.
 
Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, Aydogan C. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res. 2008 Sep;22(9):1239-42.
 
Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine.2011 Feb 15;18(4):251-8.
 
Available at: http://www.rxlist.com/capoten-drug.htm. Accessed March 11, 2013.
 
Scheffler A, Rauwald HW, Kampa B, Mann U, Mohr FW, Dhein S. Olea europaea leaf extract exerts L-type Ca(2+) channel antagonistic effects. J Ethnopharmacol.2008 Nov 20;120(2):233-40.
 
Gilani AH, Khan AU, Shah AJ, Connor J, Jabeen Q. Blood pressure lowering effect of olive is mediated through calcium channel blockade. Int J Food Sci Nutr.2005 Dec;56(8):613-20.
 
Zare L, Esmaeili-Mahani S, Abbasnejad M, et al. Oleuropein, chief constituent of olive leaf extract, prevents the development of morphine antinociceptive tolerance through inhibition of morphine-induced L-type calcium channel overexpression. Phytother Res. 2012 Nov;26(11):1731-7.
 
Visioli F, Bellosta S, Galli C. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci. 1998;62(6):541-6.
 
Rocha BS, Gago B, Barbosa RM, Laranjinha J. Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology.2009 Nov 9;265(1-2):41-8.
 
Palmieri D, Aliakbarian B, Casazza AA, et al. Effects of polyphenol extract from olive pomace on anoxia-induced endothelial dysfunction. Microvasc Res. 2012 May;83(3):281-9.
 
Scoditti E, Calabriso N, Massaro M, et al. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys. 2012 Nov 15;527(2):81-9.
 
Dell’Agli M, Fagnani R, Galli GV, et al. Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling. J Agric Food Chem. 2010 Feb 24;58(4):2246-52.
 
Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem Biol Interact. 2008 Nov 25;176(2-3):88-98.
 
Visioli F, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sci. 1994;55(24):1965-71.
 
Masella R, Vari R, D’Archivio M, et al. Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J Nutr.2004 Apr;134(4):785-91.
 
Wang L, Geng C, Jiang L, et al. The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. Eur J Nutr. 2008 Aug;47(5):235-43.
 
Impellizzeri D, Esposito E, Mazzon E, et al. The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. Clin Nutr. 2011 Aug;30(4):533-40.
 
Carluccio MA, Siculella L, Ancora MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):622-9.
 
Turner R, Etienne N, Alonso MG, et al. Antioxidant and anti-atherogenic activities of olive oil phenolics. Int J Vitam Nutr Res. 2005 Jan;75(1):61-70.
 
Dell’Agli M, Fagnani R, Mitro N, et al. Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation. J Agric Food Chem. 2006 May 3;54(9):3259-64.
 
Singh I, Mok M, Christensen AM, Turner AH, Hawley JA. The effects of polyphenols in olive leaves on platelet function. Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):127-32.
 
Zbidi H, Salido S, Altarejos J, et al. Olive tree wood phenolic compounds with human platelet antiaggregant properties. Blood Cells Mol Dis. 2009 May-Jun;42(3):279-85.
 
Wainstein J, Ganz T, Boaz M, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food. 2012 Jul;15(7):605-10.
 
Gonzalez M, Zarzuelo A, Gamez MJ, Utrilla MP, Jimenez J, Osuna I. Hypoglycemic activity of olive leaf. Planta Med. 1992 Dec;58(6):513-5.
 
Al-Azzawie HF, Alhamdani MS. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci. 2006 Feb 16;78(12):1371-7.
 
Jemai H, El Feki A, Sayadi S. Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats. J Agric Food Chem. 2009 Oct 14;57(19):8798-804.
 
Eidi A, Eidi M, Darzi R. Antidiabetic effect of Olea europaea L. in normal and diabetic rats. Phytother Res. 2009 Mar;23(3):347-50.
 
Poudyal H, Campbell F, Brown L. Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J Nutr. 2010 May;140(5):946-53.
 
Simon D, Balkau B. Diabetes mellitus, hyperglycaemia and cancer. Diabetes Metab. 2010 Jun;36(3):182-91.
 
Kontou N, Psaltopoulou T, Soupos N, et al. Metabolic syndrome and colorectal cancer: the protective role of Mediterranean diet–a case-control study. Angiology. 2012 Jul;63(5):390-6.
 
Verberne L, Bach-Faig A, Buckland G, Serra-Majem L. Association between the Mediterranean diet and cancer risk: a review of observational studies. Nutr Cancer. 2010;62(7):860-70.
 
Anter J, Fernandez-Bedmar Z, Villatoro-Pulido M, et al. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutat Res. 2011 Aug 16;723(2):165-70.
 
Corona G, Deiana M, Incani A, Vauzour D, Dessi MA, Spencer JP. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem Biophys Res Commun. 2007 Oct 26;362(3):606-11.
 
Kimura Y, Sumiyoshi M. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. J Nutr. 2009 Nov;139(11):2079-86.
 
Sirianni R, Chimento A, De Luca A, et al. Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation. Mol Nutr Food Res. 2010 Jun;54(6):833-40.
 
Menendez JA, Vazquez-Martin A, Oliveras-Ferraros C, et al. Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. Int J Mol Med. 2008 Oct;22(4):433-9.
 
Goulas V, Exarchou V, Troganis AN, et al. Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res. 2009 May;53(5):600-8.
 
Abdel-Hamid NM, El-Moselhy MA, El-Baz A. Hepatocyte lysosomal membrane stabilization by olive leaves against chemically induced hepatocellular neoplasia in rats. Int J Hepatol. 2011;2011:736581.
 
Fares R, Bazzi S, Baydoun SE, Abdel-Massih RM. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract. Plant Foods Hum Nutr. 2011 Mar;66(1):58-63.
 
Grawish ME, Zyada MM, Zaher AR. Inhibition of 4-NQO-induced F433 rat tongue carcinogenesis by oleuropein-rich extract. Med Oncol. 2011 Dec;28(4):1163-8.
 
Acquaviva R, Di Giacomo C, Sorrenti V, et al. Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol. 2012 Jul;41(1):31-8.
 
Mohagheghi F, Bigdeli MR, Rasoulian B, Hashemi P, Pour MR. The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia. Phytomedicine. 2011 Jan 15;18(2-3):170-5.
 
Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J. Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. 2007 Feb;49(2):93-102. Epub 2006 Dec 20.
 
Dekanski D, Selakovic V, Piperski V, Radulovic Z, Korenic A, Radenovic L. Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils. Phytomedicine.2011 Oct 15;18(13):1137-43.
 
Khalatbary AR, Ahmadvand H. Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurol Res. 2012 Jan;34(1):44-51.
 
Bazoti FN, Bergquist J, Markides KE, Tsarbopoulos A. Noncovalent interaction between amyloid-beta-peptide (1-40) and oleuropein studied by electrospray ionization mass spectrometry. J Am Soc Mass Spectrom. 2006 Apr;17(4):568-75.
 
Daccache A, Lion C, Sibille N, et al. Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem Int. 2011 May;58(6):700-7.
 
Rigacci S, Guidotti V, Bucciantini M, et al. Abeta(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon. Curr Alzheimer Res. 2011 Dec;8(8):841-52.
 
Flemmig J, Kuchta K, Arnhold J, Rauwald HW. Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. Phytomedicine.2011 May 15;18(7):561-6.
 
Impellizzeri D, Esposito E, Mazzon E, et al. Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in mice. J Pharmacol Exp Ther.2011 Dec;339(3):859-69.
 
Gong D, Geng C, Jiang L, Wang L, Yoshimura H, Zhong L. Mechanisms of olive leaf extract-ameliorated rat arthritis caused by kaolin and carrageenan. Phytother Res. 2012 Mar;26(3):397-402.
 
Olive leaf. Monograph. Altern Med Rev. 2009 Mar;14(1):62-6.

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What are Ginkgo Biloba wonderful benefits as antioxidants and in memory and eye improvements

What are Ginkgo Biloba wonderful benefits as antioxidants and in memory and eye improvements

health benefits ginkgo tea natural-treatments-for-eye-BENEFITS & ANTIOXIDANT EFFECTS

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GINKGO
Other Names: Abricot Argenté Japonais, Adiantifolia, Arbre aux Écus, Arbre aux Quarante Écus, Arbre du Ciel, Arbre Fossile, Bai Guo Ye, Baiguo, Extrait de Feuille de Ginkgo, Extrait de Ginkgo
 Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer's disease.

Ginkgo Biloba Supplements and its Antioxidant benefits!

Ginkgo improves blood flow to the brain and acts as an antioxidant. These effects may translate into some benefits for certain medical problems, but the results have been mixed.

Some studies have found that in healthy people, ginkgo might modestly boost memory and cognitive speed. Other studies have not found a benefit. (source) Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer’s disease.

About Ginkgo Biloba:

The scientific name of Ginkgo Biloba is “Salisburia adiantifolia”. It is an extract got from the leaf of the Chinese ginkgo tree which is additionally known as the maidenhair tree. The known scientific terms for extract of the green ginkgo biloba tree are EGb761 and GBE, which is regularly noted for its cerebral improving impacts. As indicated by Traditional Chinese Medicine and current clinical reviews, Ginkgo Biloba is viable, safe and it also benefits the body from various perspectives since it applies defensive impacts against mitochondrial harm and oxidative anxiety.

Amount of Ginkgo Biloba Supplements to use:

The scientific name of Ginkgo Biloba is “Salisburia adiantifolia”. It is an extract got from the leaf of the Chinese ginkgo tree which is additionally known as the maidenhair tree. The known scientific terms for extract of the green ginkgo biloba tree are EGb761 and GBE, which is regularly noted for its cerebral improving impacts. As indicated by Traditional Chinese Medicine and current clinical reviews, Ginkgo Biloba is viable, safe and it also benefits the body from various perspectives since it applies defensive impacts against mitochondrial harm and oxidative anxiety.There is no standard measurements of Ginkgo Biloba supplements to use, but, in therapeutic reviews, every clinical trial have utilized an extract of ginkgo which is standardized to 24 percent flavones glycosides along with 6 percent of terpene lactones. A typical dosage in individuals with dementia is 40ml of that concentrate three times each day. There is no standard dose of ginkgo biloba supplements. However, in medical studies, almost all clinical trials have used a standardized extract of ginkgo, standardized to 24% flavone glycosides and 6% terpene lactones. A common dose in people with dementia is 40 milligrams of that extract three times daily. For improving cognitive function in healthy people, studies have used between 120 milligrams to 600 milligrams of the extract daily.

Ginkgo Biloba:

 

Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer's disease.

Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer’s disease.

Effects & Benefits of Ginkgo Biloba Antioxidants:

  • Decrease depression & anxiety: In the event that you experience the ill effects of constantly high anxiety that is executing your personal satisfaction, apprehension and despondency then ginkgo may have the capacity to offer assistance. A research revealed that Ginkgo biloba antioxidants improves the body’s capacity to deal with stressors and they also neutralizes the impacts of large amounts of stress hormones such as cortisol as well as adrenaline. It raises the body’s capacity to adapt to inconvenience and stress; it may be particularly useful for individuals with generalized anxiety disorder (GAD) and conceivably regular depression, panic assaults and social fears, as well.

 

  • Enhance Memory: The antioxidants in Ginkgo biloba are very beneficial for brain due to which Ginkgo Biloba supplements are known as “Brain herb”. Studies have demonstrated that it can enhance memory in individuals with dementia. Ginkgo biloba is usually added to some soft drinks, nutrition bars along with fruit smoothies in order to lift memory and upgrade cognitive execution.

 

  • Improves the Vision and Eye health: While more confirmation is as yet required, ginkgo along with its strong antioxidants has all the earmarks of being a great supplement for eye health since it enhances blood stream to the eyes and battles free outspread harm that can hurt the cornea, macula as well as the retina. It may be particularly gainful for adults in protecting vision and bringing down UV harm or oxidative worry to eye tissue. A few reviews have observed that ginkgo biloba antioxidants are powerful at bringing down the hazard for age-related macular degeneration because of its platelet initiating variables and counteractive action of film harm created by free radicals.

  • Kills Impotency: Ginkgo biloba can also be utilized in the treatment of impotency. The primary reason of male weakness is poor dissemination and weakened blood flow through the penis, which is frequently the consequence of atherosclerosis. Since ginkgo biloba builds blood stream, it’s been found to help up to 50% of patients following six months of utilization.

 

  • Beneficial for Asthma: The antioxidants generally found in Ginko Biloba supplements helps and improve breathing. It is very beneficial for Asthma patients as it is likely to decrease the disease with the help of antioxidant reactions.

 

  • Useful for Macular Degeneration: “Macular Degeneration” is a dynamic, degenerative eye ailment that hinders the retina. It is a standout among the most widely recognized reasons for visual impairment in the US. The strong and effective antioxidants found in ginkgo biloba may help cure or mitigate some retinal issues.

 

  • Raynaud’s infection: Raynaud’s infection is actually caused by veins that over respond to the frosty and spasms, decreasing blood stream and there by denying limits of oxygen. The effective antioxidants in Ginkgo biloba may help this condition by enlarging the little veins, which would keep the spasms from totally hindering the blood stream.
Source Websites:
www.draxe.com
www.greenmedinfo.com
www.mayoclinic.org

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ALA, ALPHA – LIPOIC ACID, Antioxidant & anti-Inflammatory your body needs

ALA, ALPHA – LIPOIC ACID Antioxidant & anti-Inflammatory 



Other Names for ALPHA – LIPOIC ACID : 
Acetate Replacing Factor, A-Lipoic Acid, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque, Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque


 Introduction to ALPHA – LIPOIC ACID or ALA


Alpha-lipoic acid is a substance made by the body. It is found in every body cell, where it helps turn glucose into energy. Alpha-lipoic acid is a vitamin-like chemical and an antioxidant. ALPHA – LIPOIC ACID or ALA can be found in Yeast, liver, kidney, spinach, broccoli, and potatoes. It is also made in the laboratory for use as medicine.  
Alpha-lipoic acid is used to break down carbohydrates in body and use the energy for organs in the body. Alpha-Lipoic Acid (ALA) is a mitochondrial fatty acid that is highly involved in energy metabolism as mentioned mostly for carbohydrates. ALA has shown benefit against various forms of oxidation and inflammation some part of this is because ALA resets the cycle of vitamin E & C.


ALPHA - LIPOIC ACID

ALA, ALPHA – LIPOIC ACID is Known for:


Alpha-lipoic acid helps prevent certain kinds of cell damage in the body. It also restores vitamin levels such as vitamin E and vitamin C in their cycles so they would work again as an antioxidant in their cycles and this reduces body need of antioxidants. There are some evidence that alpha-lipoic acid can improve the function and conduction of neuron cells in diabetes. ALA antioxidant benefits might also be helpful in liver diseases. 

ALA is know to be used to improve these conditions:

  • Coronary artery bypass graft (CABG) surgery.
  • Diabetes. 
  • Prediabetes. 
  • Diabetic nerve pain. 
  • Vitiligo. 
  • Weight loss. 1800 mg of alpha-lipoic acid daily for 20 weeks.
  • Wound healing. 
  • Alcoholic liver disease. 300 mg of alpha-lipoic acid daily for up to 6 months
  • Alzheimer’s disease. 600-900 mg of alpha-lipoic acid daily for up to 2 years
  • Heart-related nerve problems 
  • Damage to the retina caused by diabetes
  • HIV-related brain problems.
  • Rheumatoid arthritis.  300 mg of alpha-lipoic acid by mouth daily for 12 weeks 



Get ALA for: 


ALA is known to improve the following :

  • Diabetes
  • Cancer
  • Anti-Aging
  • Weight Loss
  • Pain
  • EYE health
  • Nerve Repair
  • Blood Pressure
  • liver disease
  • Heart-related nerve problems
  • Weight loss
  • Cardiovascular 
  • Immune system
  • HIV
  • Inflammatory and pain
  • Neuro-degenerative diseases
  • Cognition decline
  • Autoimmune diseases (rheumatoid arthritis)
  • Joint health
  • Motion Sickness
  • Arthritis
  • Damaging nerves system 
  • Treatment of Dementia
  • Alzheimer’s disease
  • High cholesterol
  • Healthier Arteries




Get ALA naturally:


Main natural sources of ALA ALPHA – LIPOIC ACID

  • Broccoli
  • Spinach
  • Red meat
  • Organ meat (sch as liver, hearts, kidneys from beef or chicken)
  • Brussel sprouts
  • Tomatoes
  • Peas
  • Brewer’s yeast
  • Beets
  • Carrots


ALPHA - LIPOIC ACID



ALA ALPHA – LIPOIC ACID is Both water and fat soluble and found in many natural foods meats, and plants. It can be in a protein bound or in other forms. 
This list is for  lipoyllysinem, the protein-bound form.

Food Dry Weight (mg/g) Protein (ng/g)
1. spinach 3.15 92.51
2. bovine (cow) kidney 2.64 50.57
3. bovine (cow) heart 1.51 41.42
4. broccoli 0.94 41.01
5. tomato 0.56 48.61
6. green pea 0.39 17.13
7. brussel sprouts 0.39 18.39
8. bovine (cow) spleen 0.36 5.69
9. bovine (cow) brain 0.27 4.85
10. rice bran 0.16 4.44






Side Effects of ALA:


  • ALA, Alpha-lipoic acid is known as SAFE by mouth or when applied to the skin. the safe dosage is about the regular dose that can be found in natural sources like plants. 600 or 1200 mg daily.
  • Negative effects could occur with long term high-dosage supplementation. High-dose ALA supplementation is therefore not recommended.
  • People with diabetes should be careful to check their blood sugar levels because alpha-lipoic acid might lower blood sugar.
  • People taking alpha-lipoic acid by mouth might get some rash.
 


Interactions of ALA:

  • Medications for cancer (Chemotherapy) interacts with ALPHA-LIPOIC ACID.
  • Medications for diabetes (Antidiabetes drugs) interacts with ALPHA-LIPOIC ACID
  • Thyroid medications, Levothyroxine — Apha-lipoic acid may lower levels of thyroid hormone. 
  • Vitamin B1 (Thiamine) — Alpha lipoic acid can lower the level of vitamin B1 (Thiamine) in the body. This can be particularly dangerous in alcoholics.












Online sources for this article and good readings on ALA Alpha-lipoic acid:


draxe.com

webmd.com

examine.com

superfoodly.com

umm.edu


List of references and papers:

Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo. 2000;14(2):327-330.

Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149:841-9.

Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin. 1999;94 Suppl 3:84-89.

Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke. 2001;32(4):1000-1004.

Faust A, Burkart V, Ulrich H, et al. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice. Int J Immunopharmacol. 1994;16:61-66.

Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. 2001;6(2):141-166.

Hruby K, Csomos G, Fuhrmann M, Thaler H. Chemotherapy of Amanita phalloides poisoning with intravenous silibinin. Hum Exp Toxicol. 1983;2(2):183-195.

Ibrahimpasic K. Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med Arh. 2013; 67(1):7-9.

Lynch MA. Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue. Nutr Neurosci. 2001;4(6):419-438.

Melhem MF, Craven PA, Derubertis FR. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol. 2001;12:124-133.

Melhem MF, Craven PA, Liachenko J, et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol. 2002;13:108-116.

Melmed: Williams Textbook of Endocrinology, 12th ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2011.

Mitkov MD, Aleksandrova IY, Orbetzova MM. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv). 2013; 55(1):55-63.

Monograph:Alpha-Lipoic Acid. Altern Med Rev. 1998;3(4):308-311.

Nagamatsu M, Nickander KK, Schmelzer JD,et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.

Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17(10):888-895.

Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-linoic acis. Free Radic Biol Med. 1997;22:359-378.

Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Rad Bio Med. 1995;19(2):227-250.

Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V. Alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996;717(1-2):184-188.

Rakel D. Rakel Integrative Medicine, 3rd ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2012.

Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung. 1991;41:1294-1298.

Xu J, Gao H, Song L, et al. Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. Lipids Health Dis. 2013; 12:58.

Yoo TH, Lee JH, Chun HS, Chi SG. a-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kB induction of RPS6KA4. Anticancer Drugs. 2013; 24(6):555-65.

Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care. 2006;29:2365-70.

Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997;46 (suppl 2):S62-66.

Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999; 107:421-430.


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