MORINGA, antioxidant benefits, Uses, Side Effects & Interactions
Other Names of MORINGA: Arango, Árbol de las Perlas, Behen, Ben Ailé, Ben Nut Tree, Ben Oléifère, Benzolive, Canéficier de l’Inde, Chinto Borrego, Clarifier Tree, Drumstick Tree,…
Research in progress
Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant
Moringa Oleifera has been hailed since time immemorial for its immense health benefits. The plant is native to Africa and many consider it the tree of life. It is also very common in Asia as it is widely used in Ayurvedic medicine. It contains a significant number of proteins, essential vitamins, and minerals making it common not only from a nutritional point of view but also in the cosmetics industry due to its powerful antioxidants.
Although Moringa has several benefits, we are going to narrow in on its antioxidant and anti-ageing properties.
Antioxidant effects of Moringa
Moringa has been found to contain about 47 antioxidants including phenolic acid, flavonoid/bioflavonoids, and tannic acid. Experiments have been carried out on different parts of the Moringa tree to identify what parts have more Polyphenol antioxidant benefits. In one study, It was found that all extracts acted as radical scavengers due to the presence of the polyphenolic compound. It was also found that the flowers possessed the highest antioxidant properties, followed closely by the leaf, root, gum bark and finally the seed.
What these strong antioxidants do is they help neutralize free radicals(oxidative damage). Free radicals are produced as by-products of normal body processes, medicine break-down after consumption and as a result of exposure to pollutants. Moringa is known as one of the most effective of antioxidant foods.
Anti-aging properties of Moringa
The cosmetics industry heavily relies on Moringa as a natural supplement to try and slow down the aging process. Moringa contains a plant hormone called zeatin, which affects the process of cell division, influencing aging. Moringa is the only known plant to contain such high levels of Zeatin.
APPLIED TO THE SKIN for:
Gum disease (gingivitis).
Progeria is a disease in which a person ages rapidly at a much faster rate than normal. It afflicts people whose bodies cannot manufacture and/or utilize antioxidants. Moringa contains high levels of vitamin C, which helps with the synthesis of collagen. When the level of collagen is low, the skin collapses to take up the free space, causing wrinkles, which are a tell-tale sign of aging.
The anti-aging properties of Moringa do not only apply to the skin. It has been known to decrease brain aging and cognition decline. The plant is a memory booster, helping with concentration, focus, and clarity. This is by virtue of its B vitamins, but also notably, the high concentration of Iron which allows for more oxygenated blood flow to the brain.
All this information should be enough to convince you to include Moringa, in your diet. You may either take it in its natural form or as a Moringa supplement. Moringa’s antioxidant properties can also help prevent and manage certain diseases such as cancer and cardiovascular disease which stem from the overproduction of free radicals in the body. In a world where pollution is rampant, intake of antioxidant super foods is a safe bet to prevent diseases.
Moringa is your best choice as it is effective, safe, naturally occurring and affordable.
Moringa is used to improve “tired blood” (anemia); arthritis and other joint pain (rheumatism); asthma; cancer; constipation; diabetes; diarrhea; epilepsy; stomach pain; stomach and intestinal ulcers; intestinal spasms; headache; heart problems; high blood pressure; kidney stones; fluid retention; thyroid disorders; and bacterial, fungal, viral, and parasitic infections. Moringa is also used to reduce swelling, increase sex drive (as an aphrodisiac), prevent pregnancy, boost the immune system, and increase breast milk production.
So get Moringa for :
Inflammatory and pain
High cholesterol (LDL bad cholesterol)
Reference and resources:
sources link , Reference for more research on MORINGA:
Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body
Research in progress
About Polyphenol, Phenolic acids:
A phenolic acid is a sort of phytochemical known as a polyphenol. Phenolic acids are found in an assortment of plant-based nourishments such as the seeds and skins of products of the soil leaves of vegetables contain the most noteworthy concentration. Phenolic acids are promptly consumed through the dividers of your intestinal tract, and they might be valuable to your wellbeing since they fill in as cancer prevention agents that counteract cell harm because of free-radical oxidation responses. The Polyphenol phenolic acid supplements may likewise work as anti inflammatory in the human body. It strongly supports a role for polyphenols in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanisms of action of polyphenols go beyond the modulation of oxidative stress. Polyphenols are the most abundant antioxidants in the diet. Their total dietary intake could be as high as 1 g/d, which is much higher than that of all other classes of phytochemicals and known dietary antioxidants.
Ranking list of top foods list with Polyphenols (Phenolic Acid)
Different Types of Polyphenols
Polyphenols are four main categories, with additional sub-groupings. based on the number of phenol rings they contain, and on the basis of structural elements in their construction.
As a general rule, foods contain complex mixtures of polyphenols, with higher levels found in the outer layers of the plants than the inner parts.
1- Flavonoids, have Strong both antioxidant and anti-inflammatory properties, found in fruits, vegetables, legumes, red wine, and green tea
2- Stilbenes, found in red wine and peanuts (resveratrol is the most well known)
3- Lignans, found in seeds like flax, legumes, cereals, grains, fruits, algae, and certain vegetables
4- Phenolic acids
Hydroxybenzoic acids, found in tea
Hydroxycinnamic acids found in cinnamon of course but also in coffee, blueberries, kiwis, plums, apples, and cherries
Polyphenols are usually associated with/ improving:
- Fighting cancer cells and inhibiting angiogenesis (the growth of blood vessels that feed a tumor)
- Protecting your skin against ultraviolet radiation
- Fighting free radicals
- reducing the appearance of aging
- Promoting brain health
- protecting against dementia
- Reducing inflammation
- Supporting normal blood sugar levels
- Protecting your cardiovascular system
- Promoting normal blood pressure
Polyphenols work effective for :
Symptoms of ADHD (Attention Deficit Hyperactivity Disorder)
Eye Disorders AMD
Inflammatory and pain
Autoimmune diseases (rheumatoid arthritis)
High cholesterol (LDL bad cholesterol)
Antioxidants effects & Benefits of Phenolic acids:
• Anti-Diabetic Effects of Polyphenols
Numerous studies report the antidiabetic effects of polyphenols. Tea catechins have been investigated for their anti-diabetic potential.63,64 Polyphenols may affect glycemia through different mechanisms, including the inhibition of glucose absorption in the gut or of its uptake by peripheral tissues.Onion polyphenols, especially quercetin is known to possess strong anti diabetic activity. A recent study shows that quercetin has ability to protect the alterations in diabetic patients during oxidative stress. Quercetin significantly protected the lipid peroxidation and inhibition antioxidant system in diabetics. (source)
• Used as Anti bacterial:
Bacteria are collection of single cell microorganisms. Most microorganisms are innocuous in people because of the defensive impacts of the immune framework. Notwithstanding, a few microscopic organisms are perilous and can bring about irresistible maladies. Luckily, phenol acids are effective antibacterials and can help guard you from perilous microorganisms. Temporary reviews recommend that phenolic acid may likewise have antibacterial properties however additional confirmation is required before this can be affirmed. (source)
• Anti-Aging Effect
Aging is the accumulation process of diverse detrimental changes in the cells and tissues with advancing age, resulting in an increase in the risks of disease and death. Among many theories purposed for the explaining the mechanism of aging, free radical/oxidative stress theory is one of the most accepted one. Antioxidant capacity of the plasma is related to dietary intake of antioxidants; it has been found that the intake of antioxidant rich diet is effective in reducing the deleterious effects of aging and behavior. Several researches suggest that the combination of antioxidant/anti-inflammatory polyphenolic compounds found in fruits and vegetables may show efficacy as anti-aging compounds. Subset of the flavonoids known as anthocyanins, are particularly abundant in brightly colored fruits such as berry fruits and concord grapes and grape seeds. (source)
• Reduces inflammation:
Inflammation is the body’s method for managing disease, harm, aggravation or stress. It prompts warm, torment, redness or swelling around the influenced body part. Most inflammation is sure as it demonstrates that the body has recognized a risk and is endeavoring to manage the issue. In any case, some inflammation is superfluous and harms the body’s cells when there is no contamination, damage, bothering or worry to manage. Luckily, the phenolic acids can help monitor pointless inflammation. The strong antioxidants of phenolic acids are powerful against inflammation. (source)
• Antioxidant effects of Polyphenol, phenolic acid on cancer:
Antioxidants are substances that protect a human body’s cells from free radicals. Free radicals are destructive substances that are discharged into the body amid oxygen based responses. They have been connected with serious disease such as cancer, diabetes, a weak invulnerable system along with noticeable indications of maturing. Luckily, the greater parts of the phenolic acids aside from “capsaicin” are intense cancer prevention agents that can guard you from the antagonistic impacts related with free radicals. Several mechanisms of action have been identified for chemoprevention effect of polyphenols, these include estrogenic/antiestrogenic activity, antiproliferation, induction of cell cycle arrest or apoptosis, prevention of oxidation, induction of detoxification enzymes, regulation of the host immune system, anti-inflammatory activity and changes in cellular signaling
• Neuro-Protective Effects and Mental health boosters:
The phenolic acids have a considerable measure of potential with regards to boosting the emotional wellbeing. Early research proposes that phenolic acids may go about as an energizer and furthermore it prevents the Alzheimer’s disease. What’s more, they may likewise ensure against Alzheimer’s malady while vanillin may shield the cerebrum cells from harm, prevents Alzheimer’s infection and Parkinson’s ailment. In any case, additionally studies are required before the impacts of the phenolic acids on brain health are affirmed. Oxidative stress and damage to brain macromolecules is an important process in neurodegenerative diseases. Alzheimer’s disease is one of the most common occurring neurodisorder affecting up to 18 million people worldwide. Because polyphenols are highly antioxidative in nature, their consumption may provide protection in neurological diseases. It was observed that the people drinking three to four glasses of wine (vines that have Polyphenol contents) per day had 80% decreased incidence of dementia and Alzheimer’s disease compared to those who drank less or did not drink at all. (source)
Polyphenol Supplements interactions
These mostly happen with supplements not the foods containing Polyphenol
- Iron depletion in populations of people who have marginal iron stores
- Interference with thyroid hormone metabolism
- Interactions with pharmaceutical drugs, enhancing their biologic effects
References and sources for Polyphenols online:
Published papers and articles and References for Polyphenols
1. Scalbert A, Manach C, Morand C, Remesy C. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005;45:287–306. [PubMed]
2. Spencer JP, Abd El Mohsen MM, Minihane AM, Mathers JC. Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr. 2008;99:12–22. [PubMed]
3. Beckman CH. Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants? Physiol. Mol. Plant Pathol. 2000;57:101–110.
4. Graf BA, Milbury PE, Blumberg JB. Flavonols, flavonones, flavanones and human health: Epidemological evidence. J Med Food. 2005;8:281–290. [PubMed]
5. Arts ICW, Hollman PCH. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005;81:317–325. [PubMed]
6. Kondratyuk TP, Pezzuto JM. Natural Product Polyphenols of Relevance to Human Health. Pharm Biol. 2004;42:46–63.
7. Shahidi F, Naczk M. Food phenolics, sources, chemistry, effects, applications. Lancaster, PA: Technomic Publishing Co Inc; 1995.
8. de Groot H, Rauen U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharmacol. 1998;12:249–255. [PubMed]
9. Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med. 1997;29:95–120. [PubMed]
10. Wink M. Compartmentation of secondary metabolites and xenobiotics in plant vacuoles. Adv Bot Res. 1997;25:141–169.
11. Simon BF, Perez-Ilzarbe J, Hernandez T, Gomez-Cordoves C, Estrella I. Importance of phenolic compounds for the characterization of fruit juices. J Agric Food Sci. 1992;40:1531–1535.
12. Manach C, Scalbert A, Morand C, Rémésy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79:727–747. [PubMed]
13. Parr AJ, Bolwell GP. Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenol content or profile. J Agric Food Chem. 2000;80:985–1012.
14. Sosulski FW, Krygier K, Hogge L. Importance of phenolic compounds for the characterization of fruit juices. J Agric Food Chem. 1982;30:337–340.
15. Price KR, Bacon JR, Rhodes MJC. Effect of storage and domestic processing on the content and composition of flavonol glucosides in onion (Allium cepa) J Agric Food Chem. 1997;45:938–942.
16. Crozier A, Lean MEJ, McDonald MS, Black C. Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. J Agric Food Chem. 1997;45:590–595.
17. D’Archivio M, Filesi C, Benedetto RD, Gargiulo R, Giovannini C, Masella R. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanità 2007;43:348–361. [PubMed]
18. Day AJ, Williamson G. Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma. Br J Nutr. 2001;86:S105–S110. [PubMed]
19. Setchell KD, Faughnan MS, Avades T, Zimmer-Nechemias L, Brown NM, et al. Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. Am J Clin Nutr. 2003;77:411–419. [PubMed]
20. Duthie GG, Pedersen MW, Gardner PT, Morrice PC, Jenkinson AM, McPhail DB, Steele GM. The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur J Clin Nutr. 1998;52:733–736. [PubMed]
21. Young JF, Nielsen SE, Haraldsdóttir J, Daneshvar B, Lauridsen ST, Knuthsen P, Crozier A, Sandström B, Dragsted LO. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr. 1999;69:87–94. [PubMed]
22. Gee JM, DuPont MS, Rhodes MJ, Johnson IT. Quercetin glucosides interact with the intestinal glucose transport pathway. Free Radic Biol Med. 1998;25:19–25. [PubMed]
23. Crespy V, Morand C, Besson C, Manach C, Demigne C, Remesy C. Quercetin, but not its glycosides, is absorbed from the rat stomach. J Agric Food Chem. 2002;50:618–621. [PubMed]
24. Passamonti S, Vrhovsek U, Vanzo A, Mattivi F. Fast access of some grape pigments to the brain. J Agric Food Chem. 2005;53:7029–7034. [PubMed]
25. Halliwell B, Zhao K, Whiteman M. The gastrointestinal tract: a major site of antioxidant action? Free Radic Res. 2000;33:819–830. [PubMed]
26. Clifford MN. Chlorogenic acids and other cinnamates. Nature, occurence, dietary burden, absorption and metabolism. J Sci Food Agric. 2000;80:1033–1043.
27. Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr. 2001;131:66–71. [PubMed]
28. Kuhnau J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet. 1976;24:117–191. [PubMed]
29. Lee MJ, Maliakal P, Chen L, Meng X, Bondoc FY, et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev. 2002;11:1025–1032. [PubMed]
30. Falany CN. Enzymology of human cytosolic sulfotransferases. Faseb J. 1997;11:206–216. [PubMed]
31. Spencer JP, Chowrimootoo G, Choudhury R, Debnam ES, Srai SK, Rice-Evans C. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett. 1999;458:224–230. [PubMed]
32. Hollman PC, Tijburg LB, Yang CS. Bioavailability of flavonoids from tea. Crit Rev Food Sci Nutr. 1997;37:719–738. [PubMed]
33. Dangles O, Dufour C, Manach C, Morand C, Remesy C. Binding of flavonoids to plasma proteins. Methods Enzymol. 2001;335:319–333. [PubMed]
34. Dufour C, Loonis M, Dangles O. Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin. Free Radic Biol Med. 2007;43:241–252. [PubMed]
35. Vitrac X, Moni JP, Vercauteren J, Deffieux G, Mérillon JM. Direct liquid chromatography analysis of resveratrol derivatives and flavanonols in wines with absorbance and fluorescence detection. Anal Chim Acta. 2002;458:103–110.
36. Luqman S, Rizvi SI. Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res. 2006;20:303–306. [PubMed]
37. Pandey KB, Mishra N, Rizvi SI. Protective role of myricetin on markers of oxidative stress in human erythrocytes subjected to oxidative stress. Nat Prod Commun. 2009;4:221–226. [PubMed]
38. Pandey KB, Rizvi SI. Protective effect of resveratrol on markers of oxidative stress in human erythrocytes subjected to in vitro oxidative insult. Phytother Res. 2009. In press. [PubMed]
39. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992;339:1523–1526. [PubMed]
Antioxidant Effects & Benefits of N-Acetyl cysteine (NAC)
Other Names: Acetyl Cysteine, Acétyl Cystéine, Acetylcysteine, Acétylcystéine, Chlorhydrate de Cystéine, Cysteine, Cystéine, Cysteine Hydrochloride, Cystine,
About N- Acetyl Cysteine (NAC):
For over thirty years, a protected, minimal effort compound known as N-acetyl cysreine (NAC) has given help to many individuals from the wheezing, thick mucus related to flu or cold and wheezing. Obviously, pharmaceutical organizations co-selected it for benefit by joining it into different licensed medications. The pitiful outcome is that most specialists or health experts have never known about it. Indeed, even many specialists stay uninformed of its potential part as an amazing guard against some of today’s most general health threats. Below are some amazing benefits NAC can provide a human body. N-acetyl cysteine comes from the amino acid L-cysteine. Amino acids are the building blocks of proteins. N-acetyl cysteine has many uses as medicine.
N-acetyl cysteine is used to counteract acetaminophen (Tylenol) and carbon monoxide poisoning. It is also used for chest pain (unstable angina), bile duct blockage in infants, amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), Alzheimer’s disease, allergic reactions to the anti-seizure drug phenytoin (Dilantin), and an eye infection called keratoconjunctivitis. It is also used for reducing levels of a type of cholesterol called lipoprotein (a), homocysteine levels (a possible risk factor for heart disease) and the risk of heart attack and stroke in patients with serious kidney disease. (source)
N-acetyl-cysteine is an effective scavenger of free radicals as well as a major contributor to maintenance of the cellular glutathione status in muscle cells. Studies have demonstrated some possible roles for NAC to minimize fatigue or extend the time it takes for it to accumulate as well as prevent the onset of apoptosis secondary to exhaustive exercise. It is still not known if the combination of vitamin C and NAC may be detrimental after damaging exercise as well as NAC’s other possible roles during muscle damage and extensive muscle proteolysis.
Benefits of NAC:
• Fights liver disease:
A lot of people, ordinarily utilized pharmaceuticals for killing pain, for example, Tylenol and Vicodin contain a substance called Acetaminophen. On the off chance that taken in high amounts, Acetaminophen can be harmful to the liver and can bring about liver disappointment. NAC is ordinarily used to treat liver disappointment because of Acetaminophen and enormously expands the patient’s odds of survival. NAC has likewise been appeared to viably treat liver diseases brought on by different variables, for example by liquor utilization or ecological poisons.
• Great to fight with Cellular Oxidative Damage:
Oxygen radicals will bring about oxidative harm that is hindering to cells and their DNA By recharging Glutathione where it is required in the body, NAC battles against oxygen radicals and thusly averts cell harm. This can be particularly useful if cells have been presented to lead.
• Treats HIV:
HIV is an ailment that causes the disappointment of the bodies’ immune reaction. It has been demonstrated that large amounts of NAC in the body can help keep the proliferation of one strain of HIV, HIV-1. This proposes that the cells with high NAC levels might have the capacity to oppose HIV disease. NAC might be a decent supplement to take for subjects who are HIV+ and are taking different prescriptions.
• Helps decreasing tissues’ inflammation:
long with reducing oxidative harm in tissues, NAC can work to lessen the aggravation in tissues. NAC diminishes the measure of various provocative particles introduce in the body. Reduction of irritation can diminish side effects of various illnesses or reduce danger of creating diverse infections. Strong antioxidants in NAC additionally help in reducing aggravation after lively exercise, which considers individuals to play out these activities without an excessive amount of soreness.
• Used to prevent addictive behaviors in human:
Addictive behaviors incorporate voraciously consuming food, medicate addictions, and other habitual practices. NAC is able to reduce or dispose of these practices in rat models. An efficient survey found that NAC helps people a lot that are addicted particularly with cocaine and cannabis. Some other addictions, for example, pulling the hairs or biting nails can likewise be averted utilizing NAC.
• Great for decreasing Insulin resistance in bodies:
High glucose and heftiness can bring about irritation in fat tissue. This aggravation starts a flagging pathway that at last prompts to the decimation of insulin receptors. The decimation prompts diabetes 2 in human body. The strong antioxidants of NAC have been appeared to reduce aggravation in fat cells.
Get NAC for:
(Antioxidant effects of NAC is indirectly applied to body basically by improving and playing a role as trigger for GLUTATHIONE)
Inflammatory and pain
High cholesterol (LDL bad cholesterol)
The following doses have been studied in scientific research:
For chest pain that is not relieved by rest (unstable angina): 600 mg of N-acetyl cysteine three times daily with a nitroglycerin patch.
For preventing sudden worsening of chronic bronchitis: doses of 200 mg twice daily, 200 mg three times daily, 300 mg slow-release twice daily, and 600 mg controlled-release twice daily have been used.
For treating chronic obstructive pulmonary disease (COPD): 600 mg of N-acetyl cysteine once daily, in addition to standard care, has been used for up to 6 months.
For more details (source)
Do not take this combination
Nitroglycerin interacts with N-ACETYL CYSTEINE
Evans WJ. Vitamin E, vitamin C, and exercise. Am J Clin Nutr. 2000;72:647S–652S. [PubMed]
Stipanuk MH. Biochemical and Physiological Aspects of Human Nutrition. Philadelphia, PA: SAUNDERS; 2000.
Sen CK. Antioxidant and redox regulation of cellular signaling: introduction. Med Sci Sports Exerc. 2001;33:368–370. doi: 10.1097/00005768-200103000-00005. [PubMed] [Cross Ref]
Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr. 2000;72:637S–646S. [PubMed]
Van Remmen H, Hamilton ML, Richardson A. Oxidative Damage to DNA and Aging. Exerc Sport Sci Rev. 2003;31:149–153. doi: 10.1097/00003677-200307000-00009. [PubMed] [Cross Ref]
Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol. 2000;279:L1005–L1028. [PubMed]
Bryant RJ, Ryder J, Martino P, et al. Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. J Strength Cond Res. 2003;17:792–800. doi: 10.1519/1533-4287(2003)017<0792:EOVEAC>2.0.CO;2. [PubMed] [Cross Ref]
Ramel A, Wagner KH, Elmadfa I. Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men. Eur J Nutr. 2004;43:2–6. doi: 10.1007/s00394-004-0432-z. [PubMed] [Cross Ref]
Rodriguez MC, Rosenfeld J, Tarnopolsky MA. Plasma malondialdehyde increases transiently after ischemic forearm exercise. Med Sci Sports Exerc. 2003;35:1859–1865. doi: 10.1249/01.MSS.0000093609.75937.70. [PubMed] [Cross Ref]
Chan KM, Decker EA. Endogenous skeletal muscle antioxidants. Critical Reviews in Food Science and Nutrition. 1994;34:403–426. [PubMed]
Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr. 2000;72:653S–669S. [PubMed]
Davison GW, Hughes CM, Bell RA. Exercise and mononuclear cell DNA damage: The effects of antioxidant supplementation. Int J Sport Nutr Exerc Metab. 2005;15:480–492. [PubMed]
Sen CK. Glutathione homeostasis in response to exercise training and nutritional supplements. Molecular and Cellular Biochemistry. 1999;196:31–42. doi: 10.1023/A:1006910011048. [PubMed] [Cross Ref]
Viguie CA, Frei B, Shigenaga MK, et al. Antioxidant status and indexes of oxidative stress during consecutive days of exercise. J Appl Physiol. 1993;75:566–572. [PubMed]
Laires MJ, Madeira F, Sergio J. Preliminary study of the relationship between plasma and erythrocyte magnesium variations and some circulating pro-oxidant and antioxidant indices in a standardized physical effort. Magnesium Research. 1993;6:233–238. [PubMed]
Lee J, Clarkson PM. Plasma creatine kinase activity and glutathione after eccentric exercise. Med Sci Sports Exerc. 2003;35:930–936. doi: 10.1249/01.MSS.0000069553.47739.36. [PubMed] [Cross Ref]
Laaksonen DE, Atalay M, Niskanen L, et al. Blood glutathione homeostasis as a determinant of resting and exercise-induced oxidative stress in young men. Redox Rep. 1999;4:53–59. doi: 10.1179/135100099101534648. [PubMed] [Cross Ref]
Meister A. Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol Ther. 1991;51:155–194. doi: 10.1016/0163-7258(91)90076-X. [PubMed] [Cross Ref]
Sen CK. Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochemical Pharmacology. 1998;55:1747–1758. doi: 10.1016/S0006-2952(97)00672-2. [PubMed] [Cross Ref]
Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J. 1996;10 [PubMed]
Sen CK, Khanna S, Reznick AZ, et al. Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa-B activation in skeletal muscle-derived L6 cells. Biochem Biophys Res Commun. 1997;237:645–649. doi: 10.1006/bbrc.1997.7206. [PubMed] [Cross Ref]
Reid MB, Stokic DS, Koch SM, et al. N-Acetylcysteine inhibits muscle fatigue in humans. J Clin Invest. 1994;94:2468–2474. [PMC free article] [PubMed]
Supinski GS, Stofan D, Ciufo R, et al. N-acetylcysteine administration alters the response to inspiratory loading in oxygen-supplemented rats. J Appl Physiol. 1997;82:1119–1125. [PubMed]
Matuszczak Y, Farid M, Jones J, et al. Effect of n-acetylcysteine on glutathione oxidation and fatigue during handgrip exercise. Muscle Nerve. 2005;32:633–638. doi: 10.1002/mus.20385. [PubMed]
What is Cancer? Why cancer happens? how to stop it?
research in progress
Cancer has become a common word among people these days. The population suffering from cancer has largely increased. Even if you are cancer-free, chances are, you know someone who has the disease and it affects you in some way. This article aims to outline the causes of cancer, how it can be prevented or stopped and to expound the relationship between cancer and antioxidants. But first…
What is cancer?
Cancer, simply put is a disease caused by the uncontrolled division of abnormal cells in a concentrated part of the body, which later spread to surrounding tissues. Cancer is a name given to a collection of diseases with this similar characteristic.
The normal, healthy cycle of human cells happens such that when cells grow old or get damaged, they die and are replaced by others. When cancer develops, however, this system is not orderly anymore. As cells become damaged, instead of dying, they continue to survive and others are formed when they are not needed. These extra cells can continuously divide, causing tumours. These can either be malignant or benign. Malignant tumours spread into and invade nearby tissues. They also sometimes break off and travel to other parts of the body. Benign tumours, on the other hand, may be large but do not spread into or invade other issues.
When our bodies are exposed to carcinogens (Substances directly responsible for destroying DNA) free radicals form and damage other cells. Examples of carcinogens include tobacco, arsenic, asbestos, radiation and chemical compounds.
How can you stop cancer?
If you research how to stop cancer, you will find a host of conflicting information. This is because new discoveries and possible treatments are constantly being made. The common fact that you will find, however, is that in order to prevent or treat cancer, it highly depends on the lifestyle choices you decide to take. This includes eating a healthy diet, maintaining a healthy weight, being physically active and letting go of habits that will put you in more risk.
What is the role of antioxidants in cancer treatment?
Antioxidants are natural chemicals that interact with and neutralise free radicals. Free radicals are chemicals that are given off in normal body processes that have the ability to harm cells. The body naturally releases antioxidants to fight these, but when in abundance, they can be hazardous. Free radicals that damage DNA, in particular, can play a role in cancer development.
Antioxidants, therefore, work by eliminating free radicals that potentially cause cancer. They are obtained from a diet rich in fruits and vegetables and include beta-carotene, lycopene and vitamins E, C, the spreadA. Antioxidants can also be found in wine, green tea and chocolate.
When it comes to cancer treatment using antioxidants, there are two camps. One says that antioxidants can alter the effects of chemo and radiation while another says that oxidation increases the spread of malignant tumours.
Generally, patients being treated for a possible cure or undergoing radiation therapy are asked not to take antioxidants supplements, while those with advanced cancer are allowed to take antioxidant supplements to try and treat the disease.
Some on Cellular Hydrogen Peroxide, antioxidant benefits and effects!
First some on how antioxidants work with free radicals and where is Hydrogen Peroxide:
Free radicals can be broken down into five types. The first four types come from oxygen atoms and are called Reactive Oxygen Species (ROS), but the fifth type derives from nitrogen:
Superoxide ion (O): An oxygen molecule with an extra electron that can damage mitochondria, DNA and other molecules.
Hydroxyl radical (OH): A highly reactive molecule formed by the reduction of an oxygen molecule, capable of damaging almost any organic molecule in its vicinity, including carbohydrates, lipids, proteins, and DNA. OH cannot be eliminated by an enzymatic reaction.
Singlet oxygen: Formed by your immune system, singlet oxygen causes oxidation of your LDL.
Hydrogen peroxide (H2O2): Not a free radical itself, but easily converts to free radicals like OH, which then do the damage. Hydrogen peroxide is neutralized by peroxidase (an enzymatic antioxidant).
Reactive Nitrogen Species (RNS) (NO): Nitric acid is the most important RNS.
These various free radical species can damage DNA in different ways.
They can disrupt duplication of DNA, interfere with DNA maintenance, break open the molecule or alter the structure by reacting with the DNA bases. Cancer, atherosclerosis, Parkinson’s, Alzheimer’s disease, and cataracts are examples of diseases thought to result from free radical damage.
In fact, free radicals are implicated in more than 60 different diseases.
Lipids in cell membranes are quite prone to oxidative damage because free radicals tend to collect in cell membranes, known as “lipid peroxidation.” (The lipid peroxide radical is sometimes abbreviated as LOO.) When a cell membrane becomes oxidized by an ROS, it becomes brittle and leaky. Eventually, the cell falls apart and dies.
This is akin to what happens when butter, vegetable oils or meat becomes rancid—and why manufacturers sometimes add agents to prevent that. How can this free radical pillage be stopped?
This is where antioxidants come in. (sources)
Antioxidants can be categorized in multiple ways. Based on their activity, they can be categorized as enzymatic and non-enzymatic antioxidants. Enzymatic antioxidants work by breaking down and removing free radicals. The antioxidant enzymes convert dangerous oxidative products to hydrogen peroxide (H2O2) and then to water, in a multi-step process in presence of cofactors such as copper, zinc, manganese, and iron. Non-enzymatic antioxidants work by interrupting free radical chain reactions. Few examples of the non-enzymatic antioxidants are vitamin C, vitamin E, plant polyphenol, carotenoids, and glutathione.7 (source)
Free radicals are atoms, molecules or ions with unpaired electrons, which are highly active to chemical reactions with other molecules. In the biology system, the free radicals are often derived from oxygen, nitrogen and sulphur molecules. These free radicals are parts of groups of molecules called reactive oxygen species (ROS), reactive nitrogen species (RNS) and reactive sulphur species (RSS). For example, ROS includes free radicals such as superoxide anion (O2−•), perhydroxyl radical (HO2•), hydroxyl radical (▪OH), nitric oxide and other species such as hydrogen peroxide (H2O2), (source)
About Cellular Hydrogen Peroxide:
Using hydrogen peroxide on cuts and scratches truly isn’t just the most ideal approach to use it due to the fact that there are a lot more benefits of it. Hydrogen peroxide has various awesome uses outside of medical aid. Hydrogen peroxide is the main germicidal agent made just out of water and oxygen. Similar to ozone, it executes the organisms of illness formed by oxidation. Hydrogen peroxide is viewed as the most secure and natural effective sanitizer. It executes microorganisms by oxidizing them, which can be best depicted as a controlled consuming procedure. At the point when Hydrogen peroxide responds with natural material it separates into oxygen and water. As an extreme, nontoxic compound, the hydrogen peroxide works amazingly in some other ways too and it is affordable, as well. Below are some antioxidant benefits of hydrogen peroxide.
The results of some researches obtained show that the antioxidant and anti-radical activity of phenolic acids correlated positively with the number of hydroxyl groups bonded to the aromatic ring. The model of an ortho substitution of hydroxyl groups to the aromatic ring seems to be adequate for antioxidant and H2O2 or DPPH• scavenging activity of phenolic acids. (source)
Antioxidant & other benefits of Hydrogen Peroxide:
- Cancer Treatment with strong Hydrogen Peroxide antioxidants: The cancer is spreading a lot in people and there are several characteristic drugs that must be utilized to stop the spreading and dispose of the cancer cells either by executing the cancer cells or by killing the organisms inside the cancer cells and turning around the cancer cells into ordinary cells. The antioxidants generally found in Hydrogen peroxide are useful in killing such organisms and can decrease the risk of cancer.
- Maintain common health: The human body makes hydrogen peroxide and its strong antioxidants are able to battle such diseases which must be removed to make our immune framework work accurately. The White platelets are known as Leukocytes. A sub-class of Leukocytes called Neutrophils delivers hydrogen peroxide as the main line of barrier against poisons, parasites, microorganisms as well as infections and yeast.
- Infection treatment: By soaking he infected area of body in 3% of hydrogen peroxide for few minutes a few times each day can help getting rid of that infection. Indeed, even gangrene that would not heal with any solution has been recuperated by absorbing Hydrogen peroxide due to its strong antioxidant reactions on wounds.
- Help removing parasites: As in a lot of other treatments, when taken inside, the effective and strong antioxidants of hydrogen peroxide adds oxygen to the body’s inward condition. This oxidized condition is one in which parasites can’t exist and all of them are normally wiped out from the body.
- Treatment for foot fungus: The researches still can’t seem to have been done to demonstrate this works for everybody that it is a fast home cure for foot fungus. In order to help treating the foot fungus, the use of the spray containing 3% hydrogen peroxide and water on them (particularly the toes) and letting them dry can heal it if done regularly. The strong antioxidants of hydrogen peroxide help a lot to treat the disease.
- Best for mouth and teeth: Many individuals don’t understand that hydrogen peroxide makes an extremely viable and economical mouthwash. Utilize 3% of hydrogen peroxide and include a dash of fluid chlorophyll for enhancing if you want. On the other side, taking one capful of hydrogen peroxide and holding in your mouth for 10 minutes and then spit it out will never cause ulcer and your teeth will be more white. On the off chance that you have a frightful toothache and can’t get to a dental practitioner immediately, put a capful of 3% Hydrogen peroxide into your mouth and hold it for 10 minutes a few times each day. The torment will decrease significantly.
- Treats the birds Mites Infections: Patients contaminated by minor vermin stated that hydrogen peroxide successfully removes the parasites on their skins. They shower it on their skin two or three times with a couple of minutes between the applications and get stunning outcomes. The antioxidants available in hydrogen peroxide help fighting the disease and provide great results at the end.
- Best for Wound care: The antioxidants available in Hydrogen Peroxide help in healing wounds and stop the bleeding from little wounds. A few sources prescribed to soak wounds for five or more minutes a few times each day in order to heal the wound.
- Treating Sinus Infection: A tablespoon of 3% Hydrogen peroxide added to some non-chlorinated water can be utilized as a nasal shower. Contingent upon the level of sinus contribution, one should alter the measure of peroxide utilized. It can be used as a treatment for sinus infection due to the strong antioxidants available in it.
Olive leaf Extract One of the strongest antioxidants found, about Olive leaf Extract antioxidant benefits
Research in progress
Other Names of olive tree:
Acide Gras Insaturé, Acide Gras Mono-Insaturé, Acide Gras n-9, Acide Gras Oméga 9, Common Olive, Extra Virgin Olive Oil, Feuille d’Olivier, Green Olive, Huile d’Assaisonnement, Huile d’Olive
Olive oil is has been known and used to prevent heart attack and stroke (cardiovascular disease), breast cancer, colorectal cancer, rheumatoid arthritis, and migraine headache. But Olive leaf extract comes from the leaves of olive tree, and is much different from Olive Oil. the olive leaf contains phenolics such as oleuropein, It has shown that it has protective effects against LDL oxidation also benefits glucose metabolism for diabetes and skin health. Olive leaf is used as immune system boost for treating viral, bacterial, and other infections including influenza, swine flu, herpes, shingles, HIV/ARC/AIDS, and hepatitis B, pneumonia; chronic fatigue: tuberculosis (TB); gonorrhea; fever; malaria; dengue and infections in the teeth, ears, and urinary tract, and infections following surgery. Some Other also use it for high blood pressure, diabetes, hay fever, improving kidney and digestive function. Olive leaf kills and /or resists the multiplication of viruses, bacteria, yeasts, fungi, and other parasites in body. The olive leaf extract differ from immune boosters in that immune boosters tha stimulate your immune system to destroy disease which still requires your own energy. Olive leaf extract mainly does the work for you. it is not a supplementary for immune system it is like a parallel procedure.
Proven Olive Leaf Benefits
- Lowers Blood Pressure
- Improves Cardiovascular Health
- Reduces the Risk of Cancer
- Improves Brain Function
- Treats Arthritis
- Kills Bacteria and Fungi
- Improves Immune System
- Protects Skin
- More energy
- Toothache relief
- Diminished food cravings
- Joint pain relief
- Heartbeat regulation
- Improved wound healing
Cancer and Olive leaf (extracts)
Neuroprotection of Olive leaf (extracts)
POLYPHENOLIC ANTIOXIDANTS & Olive leaf (extracts)
- Medications for diabetes (Antidiabetes drugs) interacts with OLIVE
- Medications for high blood pressure (Antihypertensive drugs) interacts with OLIVE
Useful Website sources and articles on Vitamin E and its benefits:
What are Ginkgo Biloba wonderful benefits as antioxidants and in memory and eye improvements
Other Names: Abricot Argenté Japonais, Adiantifolia, Arbre aux Écus, Arbre aux Quarante Écus, Arbre du Ciel, Arbre Fossile, Bai Guo Ye, Baiguo, Extrait de Feuille de Ginkgo, Extrait de Ginkgo
Ginkgo Biloba Supplements and its Antioxidant benefits!
Ginkgo improves blood flow to the brain and acts as an antioxidant. These effects may translate into some benefits for certain medical problems, but the results have been mixed.
Some studies have found that in healthy people, ginkgo might modestly boost memory and cognitive speed. Other studies have not found a benefit. (source) Ginkgo leaf is often taken by mouth for memory disorders including Alzheimer’s disease.
About Ginkgo Biloba:
The scientific name of Ginkgo Biloba is “Salisburia adiantifolia”. It is an extract got from the leaf of the Chinese ginkgo tree which is additionally known as the maidenhair tree. The known scientific terms for extract of the green ginkgo biloba tree are EGb761 and GBE, which is regularly noted for its cerebral improving impacts. As indicated by Traditional Chinese Medicine and current clinical reviews, Ginkgo Biloba is viable, safe and it also benefits the body from various perspectives since it applies defensive impacts against mitochondrial harm and oxidative anxiety.
Amount of Ginkgo Biloba Supplements to use:
The scientific name of Ginkgo Biloba is “Salisburia adiantifolia”. It is an extract got from the leaf of the Chinese ginkgo tree which is additionally known as the maidenhair tree. The known scientific terms for extract of the green ginkgo biloba tree are EGb761 and GBE, which is regularly noted for its cerebral improving impacts. As indicated by Traditional Chinese Medicine and current clinical reviews, Ginkgo Biloba is viable, safe and it also benefits the body from various perspectives since it applies defensive impacts against mitochondrial harm and oxidative anxiety.There is no standard measurements of Ginkgo Biloba supplements to use, but, in therapeutic reviews, every clinical trial have utilized an extract of ginkgo which is standardized to 24 percent flavones glycosides along with 6 percent of terpene lactones. A typical dosage in individuals with dementia is 40ml of that concentrate three times each day. There is no standard dose of ginkgo biloba supplements. However, in medical studies, almost all clinical trials have used a standardized extract of ginkgo, standardized to 24% flavone glycosides and 6% terpene lactones. A common dose in people with dementia is 40 milligrams of that extract three times daily. For improving cognitive function in healthy people, studies have used between 120 milligrams to 600 milligrams of the extract daily.
Symptoms of ADHD (Attention Deficit Hyperactivity Disorder)
Eye Disorders AMD
Inflammatory and pain
Autoimmune diseases (rheumatoid arthritis)
High cholesterol (LDL bad cholesterol)
Effects & Benefits of Ginkgo Biloba Antioxidants:
- Decrease depression & anxiety: In the event that you experience the ill effects of constantly high anxiety that is executing your personal satisfaction, apprehension and despondency then ginkgo may have the capacity to offer assistance. A research revealed that Ginkgo biloba antioxidants improves the body’s capacity to deal with stressors and they also neutralizes the impacts of large amounts of stress hormones such as cortisol as well as adrenaline. It raises the body’s capacity to adapt to inconvenience and stress; it may be particularly useful for individuals with generalized anxiety disorder (GAD) and conceivably regular depression, panic assaults and social fears, as well.
- Enhance Memory: The antioxidants in Ginkgo biloba are very beneficial for brain due to which Ginkgo Biloba supplements are known as “Brain herb”. Studies have demonstrated that it can enhance memory in individuals with dementia. Ginkgo biloba is usually added to some soft drinks, nutrition bars along with fruit smoothies in order to lift memory and upgrade cognitive execution.
- Improves the Vision and Eye health: While more confirmation is as yet required, ginkgo along with its strong antioxidants has all the earmarks of being a great supplement for eye health since it enhances blood stream to the eyes and battles free outspread harm that can hurt the cornea, macula as well as the retina. It may be particularly gainful for adults in protecting vision and bringing down UV harm or oxidative worry to eye tissue. A few reviews have observed that ginkgo biloba antioxidants are powerful at bringing down the hazard for age-related macular degeneration because of its platelet initiating variables and counteractive action of film harm created by free radicals.
- Kills Impotency: Ginkgo biloba can also be utilized in the treatment of impotency. The primary reason of male weakness is poor dissemination and weakened blood flow through the penis, which is frequently the consequence of atherosclerosis. Since ginkgo biloba builds blood stream, it’s been found to help up to 50% of patients following six months of utilization.
- Beneficial for Asthma: The antioxidants generally found in Ginko Biloba supplements helps and improve breathing. It is very beneficial for Asthma patients as it is likely to decrease the disease with the help of antioxidant reactions.
- Useful for Macular Degeneration: “Macular Degeneration” is a dynamic, degenerative eye ailment that hinders the retina. It is a standout among the most widely recognized reasons for visual impairment in the US. The strong and effective antioxidants found in ginkgo biloba may help cure or mitigate some retinal issues.
- Raynaud’s infection: Raynaud’s infection is actually caused by veins that over respond to the frosty and spasms, decreasing blood stream and there by denying limits of oxygen. The effective antioxidants in Ginkgo biloba may help this condition by enlarging the little veins, which would keep the spasms from totally hindering the blood stream.
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