MORINGA, antioxidant benefits, Uses, Side Effects & Interactions
Other Names of MORINGA: Arango, Árbol de las Perlas, Behen, Ben Ailé, Ben Nut Tree, Ben Oléifère, Benzolive, Canéficier de l’Inde, Chinto Borrego, Clarifier Tree, Drumstick Tree,…
Research in progress
Moringa Strong Antioxidant Benefits | A Polyphenol Antioxidant
Moringa Oleifera has been hailed since time immemorial for its immense health benefits. The plant is native to Africa and many consider it the tree of life. It is also very common in Asia as it is widely used in Ayurvedic medicine. It contains a significant number of proteins, essential vitamins, and minerals making it common not only from a nutritional point of view but also in the cosmetics industry due to its powerful antioxidants.
Although Moringa has several benefits, we are going to narrow in on its antioxidant and anti-ageing properties.
Antioxidant effects of Moringa
Moringa has been found to contain about 47 antioxidants including phenolic acid, flavonoid/bioflavonoids, and tannic acid. Experiments have been carried out on different parts of the Moringa tree to identify what parts have more Polyphenol antioxidant benefits. In one study, It was found that all extracts acted as radical scavengers due to the presence of the polyphenolic compound. It was also found that the flowers possessed the highest antioxidant properties, followed closely by the leaf, root, gum bark and finally the seed.
What these strong antioxidants do is they help neutralize free radicals(oxidative damage). Free radicals are produced as by-products of normal body processes, medicine break-down after consumption and as a result of exposure to pollutants. Moringa is known as one of the most effective of antioxidant foods.
Anti-aging properties of Moringa
The cosmetics industry heavily relies on Moringa as a natural supplement to try and slow down the aging process. Moringa contains a plant hormone called zeatin, which affects the process of cell division, influencing aging. Moringa is the only known plant to contain such high levels of Zeatin.
APPLIED TO THE SKIN for:
Gum disease (gingivitis).
Progeria is a disease in which a person ages rapidly at a much faster rate than normal. It afflicts people whose bodies cannot manufacture and/or utilize antioxidants. Moringa contains high levels of vitamin C, which helps with the synthesis of collagen. When the level of collagen is low, the skin collapses to take up the free space, causing wrinkles, which are a tell-tale sign of aging.
The anti-aging properties of Moringa do not only apply to the skin. It has been known to decrease brain aging and cognition decline. The plant is a memory booster, helping with concentration, focus, and clarity. This is by virtue of its B vitamins, but also notably, the high concentration of Iron which allows for more oxygenated blood flow to the brain.
All this information should be enough to convince you to include Moringa, in your diet. You may either take it in its natural form or as a Moringa supplement. Moringa’s antioxidant properties can also help prevent and manage certain diseases such as cancer and cardiovascular disease which stem from the overproduction of free radicals in the body. In a world where pollution is rampant, intake of antioxidant super foods is a safe bet to prevent diseases.
Moringa is your best choice as it is effective, safe, naturally occurring and affordable.
Moringa is used to improve “tired blood” (anemia); arthritis and other joint pain (rheumatism); asthma; cancer; constipation; diabetes; diarrhea; epilepsy; stomach pain; stomach and intestinal ulcers; intestinal spasms; headache; heart problems; high blood pressure; kidney stones; fluid retention; thyroid disorders; and bacterial, fungal, viral, and parasitic infections. Moringa is also used to reduce swelling, increase sex drive (as an aphrodisiac), prevent pregnancy, boost the immune system, and increase breast milk production.
So get Moringa for :
Inflammatory and pain
High cholesterol (LDL bad cholesterol)
Reference and resources:
sources link , Reference for more research on MORINGA:
Polyphenols (Phenolic Acid) | Antioxidant Benefits & Effects on our body
Research in progress
About Polyphenol, Phenolic acids:
A phenolic acid is a sort of phytochemical known as a polyphenol. Phenolic acids are found in an assortment of plant-based nourishments such as the seeds and skins of products of the soil leaves of vegetables contain the most noteworthy concentration. Phenolic acids are promptly consumed through the dividers of your intestinal tract, and they might be valuable to your wellbeing since they fill in as cancer prevention agents that counteract cell harm because of free-radical oxidation responses. The Polyphenol phenolic acid supplements may likewise work as anti inflammatory in the human body. It strongly supports a role for polyphenols in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanisms of action of polyphenols go beyond the modulation of oxidative stress. Polyphenols are the most abundant antioxidants in the diet. Their total dietary intake could be as high as 1 g/d, which is much higher than that of all other classes of phytochemicals and known dietary antioxidants.
Ranking list of top foods list with Polyphenols (Phenolic Acid)
Different Types of Polyphenols
Polyphenols are four main categories, with additional sub-groupings. based on the number of phenol rings they contain, and on the basis of structural elements in their construction.
As a general rule, foods contain complex mixtures of polyphenols, with higher levels found in the outer layers of the plants than the inner parts.
1- Flavonoids, have Strong both antioxidant and anti-inflammatory properties, found in fruits, vegetables, legumes, red wine, and green tea
2- Stilbenes, found in red wine and peanuts (resveratrol is the most well known)
3- Lignans, found in seeds like flax, legumes, cereals, grains, fruits, algae, and certain vegetables
4- Phenolic acids
Hydroxybenzoic acids, found in tea
Hydroxycinnamic acids found in cinnamon of course but also in coffee, blueberries, kiwis, plums, apples, and cherries
Polyphenols are usually associated with/ improving:
- Fighting cancer cells and inhibiting angiogenesis (the growth of blood vessels that feed a tumor)
- Protecting your skin against ultraviolet radiation
- Fighting free radicals
- reducing the appearance of aging
- Promoting brain health
- protecting against dementia
- Reducing inflammation
- Supporting normal blood sugar levels
- Protecting your cardiovascular system
- Promoting normal blood pressure
Polyphenols work effective for :
Symptoms of ADHD (Attention Deficit Hyperactivity Disorder)
Eye Disorders AMD
Inflammatory and pain
Autoimmune diseases (rheumatoid arthritis)
High cholesterol (LDL bad cholesterol)
Antioxidants effects & Benefits of Phenolic acids:
• Anti-Diabetic Effects of Polyphenols
Numerous studies report the antidiabetic effects of polyphenols. Tea catechins have been investigated for their anti-diabetic potential.63,64 Polyphenols may affect glycemia through different mechanisms, including the inhibition of glucose absorption in the gut or of its uptake by peripheral tissues.Onion polyphenols, especially quercetin is known to possess strong anti diabetic activity. A recent study shows that quercetin has ability to protect the alterations in diabetic patients during oxidative stress. Quercetin significantly protected the lipid peroxidation and inhibition antioxidant system in diabetics. (source)
• Used as Anti bacterial:
Bacteria are collection of single cell microorganisms. Most microorganisms are innocuous in people because of the defensive impacts of the immune framework. Notwithstanding, a few microscopic organisms are perilous and can bring about irresistible maladies. Luckily, phenol acids are effective antibacterials and can help guard you from perilous microorganisms. Temporary reviews recommend that phenolic acid may likewise have antibacterial properties however additional confirmation is required before this can be affirmed. (source)
• Anti-Aging Effect
Aging is the accumulation process of diverse detrimental changes in the cells and tissues with advancing age, resulting in an increase in the risks of disease and death. Among many theories purposed for the explaining the mechanism of aging, free radical/oxidative stress theory is one of the most accepted one. Antioxidant capacity of the plasma is related to dietary intake of antioxidants; it has been found that the intake of antioxidant rich diet is effective in reducing the deleterious effects of aging and behavior. Several researches suggest that the combination of antioxidant/anti-inflammatory polyphenolic compounds found in fruits and vegetables may show efficacy as anti-aging compounds. Subset of the flavonoids known as anthocyanins, are particularly abundant in brightly colored fruits such as berry fruits and concord grapes and grape seeds. (source)
• Reduces inflammation:
Inflammation is the body’s method for managing disease, harm, aggravation or stress. It prompts warm, torment, redness or swelling around the influenced body part. Most inflammation is sure as it demonstrates that the body has recognized a risk and is endeavoring to manage the issue. In any case, some inflammation is superfluous and harms the body’s cells when there is no contamination, damage, bothering or worry to manage. Luckily, the phenolic acids can help monitor pointless inflammation. The strong antioxidants of phenolic acids are powerful against inflammation. (source)
• Antioxidant effects of Polyphenol, phenolic acid on cancer:
Antioxidants are substances that protect a human body’s cells from free radicals. Free radicals are destructive substances that are discharged into the body amid oxygen based responses. They have been connected with serious disease such as cancer, diabetes, a weak invulnerable system along with noticeable indications of maturing. Luckily, the greater parts of the phenolic acids aside from “capsaicin” are intense cancer prevention agents that can guard you from the antagonistic impacts related with free radicals. Several mechanisms of action have been identified for chemoprevention effect of polyphenols, these include estrogenic/antiestrogenic activity, antiproliferation, induction of cell cycle arrest or apoptosis, prevention of oxidation, induction of detoxification enzymes, regulation of the host immune system, anti-inflammatory activity and changes in cellular signaling
• Neuro-Protective Effects and Mental health boosters:
The phenolic acids have a considerable measure of potential with regards to boosting the emotional wellbeing. Early research proposes that phenolic acids may go about as an energizer and furthermore it prevents the Alzheimer’s disease. What’s more, they may likewise ensure against Alzheimer’s malady while vanillin may shield the cerebrum cells from harm, prevents Alzheimer’s infection and Parkinson’s ailment. In any case, additionally studies are required before the impacts of the phenolic acids on brain health are affirmed. Oxidative stress and damage to brain macromolecules is an important process in neurodegenerative diseases. Alzheimer’s disease is one of the most common occurring neurodisorder affecting up to 18 million people worldwide. Because polyphenols are highly antioxidative in nature, their consumption may provide protection in neurological diseases. It was observed that the people drinking three to four glasses of wine (vines that have Polyphenol contents) per day had 80% decreased incidence of dementia and Alzheimer’s disease compared to those who drank less or did not drink at all. (source)
Polyphenol Supplements interactions
These mostly happen with supplements not the foods containing Polyphenol
- Iron depletion in populations of people who have marginal iron stores
- Interference with thyroid hormone metabolism
- Interactions with pharmaceutical drugs, enhancing their biologic effects
References and sources for Polyphenols online:
Published papers and articles and References for Polyphenols
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Antioxidant Effects & Benefits of N-Acetyl cysteine (NAC)
Other Names: Acetyl Cysteine, Acétyl Cystéine, Acetylcysteine, Acétylcystéine, Chlorhydrate de Cystéine, Cysteine, Cystéine, Cysteine Hydrochloride, Cystine,
About N- Acetyl Cysteine (NAC):
For over thirty years, a protected, minimal effort compound known as N-acetyl cysreine (NAC) has given help to many individuals from the wheezing, thick mucus related to flu or cold and wheezing. Obviously, pharmaceutical organizations co-selected it for benefit by joining it into different licensed medications. The pitiful outcome is that most specialists or health experts have never known about it. Indeed, even many specialists stay uninformed of its potential part as an amazing guard against some of today’s most general health threats. Below are some amazing benefits NAC can provide a human body. N-acetyl cysteine comes from the amino acid L-cysteine. Amino acids are the building blocks of proteins. N-acetyl cysteine has many uses as medicine.
N-acetyl cysteine is used to counteract acetaminophen (Tylenol) and carbon monoxide poisoning. It is also used for chest pain (unstable angina), bile duct blockage in infants, amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), Alzheimer’s disease, allergic reactions to the anti-seizure drug phenytoin (Dilantin), and an eye infection called keratoconjunctivitis. It is also used for reducing levels of a type of cholesterol called lipoprotein (a), homocysteine levels (a possible risk factor for heart disease) and the risk of heart attack and stroke in patients with serious kidney disease. (source)
N-acetyl-cysteine is an effective scavenger of free radicals as well as a major contributor to maintenance of the cellular glutathione status in muscle cells. Studies have demonstrated some possible roles for NAC to minimize fatigue or extend the time it takes for it to accumulate as well as prevent the onset of apoptosis secondary to exhaustive exercise. It is still not known if the combination of vitamin C and NAC may be detrimental after damaging exercise as well as NAC’s other possible roles during muscle damage and extensive muscle proteolysis.
Benefits of NAC:
• Fights liver disease:
A lot of people, ordinarily utilized pharmaceuticals for killing pain, for example, Tylenol and Vicodin contain a substance called Acetaminophen. On the off chance that taken in high amounts, Acetaminophen can be harmful to the liver and can bring about liver disappointment. NAC is ordinarily used to treat liver disappointment because of Acetaminophen and enormously expands the patient’s odds of survival. NAC has likewise been appeared to viably treat liver diseases brought on by different variables, for example by liquor utilization or ecological poisons.
• Great to fight with Cellular Oxidative Damage:
Oxygen radicals will bring about oxidative harm that is hindering to cells and their DNA By recharging Glutathione where it is required in the body, NAC battles against oxygen radicals and thusly averts cell harm. This can be particularly useful if cells have been presented to lead.
• Treats HIV:
HIV is an ailment that causes the disappointment of the bodies’ immune reaction. It has been demonstrated that large amounts of NAC in the body can help keep the proliferation of one strain of HIV, HIV-1. This proposes that the cells with high NAC levels might have the capacity to oppose HIV disease. NAC might be a decent supplement to take for subjects who are HIV+ and are taking different prescriptions.
• Helps decreasing tissues’ inflammation:
long with reducing oxidative harm in tissues, NAC can work to lessen the aggravation in tissues. NAC diminishes the measure of various provocative particles introduce in the body. Reduction of irritation can diminish side effects of various illnesses or reduce danger of creating diverse infections. Strong antioxidants in NAC additionally help in reducing aggravation after lively exercise, which considers individuals to play out these activities without an excessive amount of soreness.
• Used to prevent addictive behaviors in human:
Addictive behaviors incorporate voraciously consuming food, medicate addictions, and other habitual practices. NAC is able to reduce or dispose of these practices in rat models. An efficient survey found that NAC helps people a lot that are addicted particularly with cocaine and cannabis. Some other addictions, for example, pulling the hairs or biting nails can likewise be averted utilizing NAC.
• Great for decreasing Insulin resistance in bodies:
High glucose and heftiness can bring about irritation in fat tissue. This aggravation starts a flagging pathway that at last prompts to the decimation of insulin receptors. The decimation prompts diabetes 2 in human body. The strong antioxidants of NAC have been appeared to reduce aggravation in fat cells.
Get NAC for:
(Antioxidant effects of NAC is indirectly applied to body basically by improving and playing a role as trigger for GLUTATHIONE)
Inflammatory and pain
High cholesterol (LDL bad cholesterol)
The following doses have been studied in scientific research:
For chest pain that is not relieved by rest (unstable angina): 600 mg of N-acetyl cysteine three times daily with a nitroglycerin patch.
For preventing sudden worsening of chronic bronchitis: doses of 200 mg twice daily, 200 mg three times daily, 300 mg slow-release twice daily, and 600 mg controlled-release twice daily have been used.
For treating chronic obstructive pulmonary disease (COPD): 600 mg of N-acetyl cysteine once daily, in addition to standard care, has been used for up to 6 months.
For more details (source)
Do not take this combination
Nitroglycerin interacts with N-ACETYL CYSTEINE
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Cognitive decline and the best foods used to stop it!
Antioxidant compounds, contained in fruit, vegetables and tea, have been postulated to have a protective effect against age-related cognitive decline by combating oxidative stress. However, recent research on this subject has been conflicting. here are some basic point about CD and Aging and the main focus of this Article is on foods that Helps us fight CD.
About Cognitive Decline (What is Cognitive Decline?):
If you have Cognitive Decline or cognitive impairment, you may be aware that your memory or mental function has “slipped.” Your family and close friends also may notice a change. But generally these changes aren’t severe enough to significantly interfere with your day-to-day life and usual activities.
When anyone makes some tea or use computer or even read a book, that person it utilizing the cognitive capacities. Cognitive capacities are the mental aptitudes that you have to carry from the easiest to the most perplexing task. These mental abilities incorporate mindfulness, memory, information handling and thinking. As our age increases, the cognitive abilities continuously break down. A specific sum of cognitive decrease is a typical thing in maturing. A few people may encounter an extreme crumbling in psychological abilities, prompting dementia. This can make it difficult to adapt to customary everyday tasks. In order to get rid or avoid such problems, below are some foods that can be utilized.
Mild cognitive impairment may increase your risk of later progressing to dementia, caused by Alzheimer’s disease or other neurological conditions. But some people with mild cognitive impairment never get worse, and a few eventually get better.
Cognitive disorders like CD are a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium. While anxiety disorders, mood disorders, and psychotic disorders can also have an effect on cognitive and memory functions. Cognitive Decline is generally happening to all while aging but we dont really notice that. we get old and our abilities and awareness reduces but we dont understand maybe others do.
Cognitive decline is categorized under dementia in Mental disorders. For dementia cases, studies suggest that diets with high Omega 3 content, low in saturated fats and sugars, along with regular exercise can increase the level of brain plasticity and BDNF. Other studies have shown that mental exercise such a newly developed “computerized brain training programs” can also help build and maintain targeted specific areas of the brain.
Findings from some studies suggest that intakes of vitamin C and E that significantly exceed adequate or recommended intakes (over 130 and 15 mg/day for vitamin C and E, respectively) may be beneficial . This is in slight contrast to a very thorough review of vitamin C, cognitive decline and AD by Harrison , who concluded that a healthy, long-term diet in which adequate vitamin C levels are maintained and vitamin deficiency is avoided may protect against age-related cognitive decline and AD, and be more beneficial than taking supplements. (source & source & Source )
Foods that are best to Slow down & stop Cognitive Decline caused by aging:
• Green Tea:
Green tea is on the top of the list in the skin friendly drinks due to its noteworthy storage facility of polyphenols that can cause aging. Having four glasses each day can give amazing results by fighting against aging elements in human body.
• GINGER ROOT:
Ginger and turmeric are from the same basic family of plants. Health benefits of turmeric is largely mentioned in many articles. But now ginger. Ginger is a Southeast Asian plant. The spice ginger is the underground rhizome of the ginger plant, known botanically as Zingiber officinale. Ginger is used as a spice and medicine.
Health benefits of turmeric is largely mentioned in many articles. Turmeric is known for improving conditions for arthritis, heartburn (dyspepsia), joint pain, stomach pain, Crohn’s disease and ulcerative colitis, bypass surgery, hemorrhage, diarrhea, intestinal gas, stomach bloating, loss of appetite, stomach ulcers an so on.
Sage is an herb, a mint. The leaf is used to make medicine. Sage contains rosmarinic acid, rosmarinic acid is a potent antioxidant and an anti-inflammatory agent. Rosmarinic acid reduces harmful inflammation.
Salmon contains astaxanthin which works amazingly on skin and enhances the elasticity of skin by decrease the number of fine lines and wrinkles. astaxanthin is by some researches considered as the strongest antioxidant ever found.
According to the researchers after several researches, the phenomenal measure of fish they take keeps that away from dangerous heart diseases and cancer. Fish is a copious wellspring of omega-3 fats, which help avert cholesterol development in the arteries and secure against irregular heart rhythms.
Forty years back, analysts from the Seven Countries Study revealed that the monounsaturated fats found in the olive oil were to a great extent, reason of the low rates of coronary illness and cancer. Presently, the studies indicated that olive oil additionally contains poly-phenols, effective cancer prevention agents that may help forestall age-related infections.
All Berries, especially members of some important families, like Rosaceae (strawberry, raspberry, blackberry), and Ericaceae (blueberry, cranberry), belong to the best dietary sources of bioactive compounds (BAC). Because of the antioxidant properties of BAC, they are of great interest also for nutritionists and food technologists due to the opportunity to use BAC as functional foods ingredients. The bioactive compounds in berries contain mainly phenolic compounds (phenolic acids, flavonoids, such as anthocyanins and flavonols, and tannins) and ascorbic acid.
Matcha is basically green tea leaves that have been stone ground and processed into a powder. The powder is then filtered and raced with boiling water. Due to the difficult procedure required to deliver matcha, the tea is for the most part expensive than others.
If you are going to consider getting Olive leaf (extracts) you should know based on the studies these are the situations that it has been proven that Olive leaf (extracts) can improve.
Lowers Blood Pressure, Improves Cardiovascular Health, Diabetes, Reduces the Risk of Cancer and so on.
Protein (amino acids) repairs all those cells that have endured the damage from free radical. Eggs, an amazing source of protein, likewise contain biotin which is an essential vitamin that protect the body from free radicals.
The antioxidant rich fruit may help skin to make more collagen and can also help in speeding healing. The essential nutrients in it help making the skin look fresh and glower and it works amazingly as an anti aging food.
Beans are another protein source. They help repair cells that have endured the free radical damage. During digestion, protein separates into amino acids, the building squares of cells which further help to speed as well as repair and regenerate the skin cells along with collagen.
• Chocolate coco powder:
If dietary phenolics are active in-vivo antioxidants, chocolate can contribute a significant portion of dietary antioxidants, and the pleasant pairing of red wine and dark chocolate could have synergistic advantages beyond their complementary tastes. According to a study, the people who live in Kuna in the San Blas islands near panama, have a rate of heart illness that is a great percent less than those of Panamanians. The Kuna people, in order to stay away from heart diseases, drink a lot of a refreshments made with liberal extents of chocolate, which is bizarrely rich in flavanols that help protect the sound capacity of veins. Keeping up young veins and fights aging.
The reviving and sweet treat contains a definitive cancer prevention agent, vitamin C, in addition to lycopene as well as potassium, which controls the adjust of water and supplements in cells and makes individuals look healthy and young.
• Dark Chocolate:
The sweet chocolate is rich in cocoa flavanols, plant compounds as well as the effective & strong antioxidant properties, which help hydrate skin and enhance circulation.
It’s the only kind of nut that contains a significant amount of unsaturated fats, which is particularly important for vegetarians who are not able to eat fish. Walnuts pack an omega-3 called alpha-linolenic corrosive. Deficiency in this fat can bring about dermatitis, which is related with dry, flaky skin. So, having walnuts will make the skin fresh, and young.
• Citrus fruits peel:
Analysts from the University of Arizona took a gander at individuals who stated that they ate citrus fruits, squeezes, and peels each week. Individuals, who ate peels such as orange peel or lemon juice, had a 33% diminished hazard for “squamous cell carcinoma”. Juices and fruit didn’t have any impact. Limonene is a compound found in the oil in the peels that offers the UV-defensive benefits and makes the skin look great.
Walnuts are stuffed with healthy as well as anti inflammatory supplements, and are the main great nut source of alpha linolenic corrosive. They help advance blood stream, which thusly takes into consideration a great delivery of oxygen to the cerebrum. What’s more, a study found that mice with the infection that were routinely nourished walnuts had enhanced memory, learning and function ability coordination.
Caffeine, the gentle stimulant found in coffee actually enhances mental acuity. Beside caffeine’s mind boosting impacts, caffeine’s cell reinforcement lavishness keeps up the mental health. Also, some exploration recommends that drinking coffee can really fight with depression and anxiety in ladies and can stop cognitive decline.
Incredible things do come in little bundles, blueberries are a natural product few attempt to eat each and every. That is on the grounds that they have such a variety of extraordinary medical advantage while having an aftertaste like a great treat. It’s one of the most astounding cell reinforcement rich sustenance known to man, including vitamin C and vitamin K and fiber. As a result of their elevated amounts of Gallic acid, blueberries are particularly great at shielding our brains from degeneration, stress and cognitive decline.
It’s one of the best foods to improve brain health. On account of its elevated amounts of vitamin K and choline, it will help keep your memory sharp.
• Coconut oil:
It is a standout among the most flexible and bravo nourishments for brains out there. With 77 coconut oil uses and cures, there’s nothing that coconut oil can’t help. What’s more, with regards to your mental health it’s loaded with other advantages, as well. Coconut oil functions as a characteristic calming, stifling cells in charge of aggravation. It can help with memory misfortune as a person becomes older and kills terrible microbes that hang out in the guts. Hence, it’s great to stop cognitive decline in human.
• Egg Yolks:
Egg yolks contain a lot of choline, which helps in fetal mental health for pregnant ladies. It additionally separates bethane, a synthetic that produces hormones identified with bliss and fight against cognitive decline. The eggs can really make an individual happy and keep the mental health great.
Spinach is rich in antioxidants, which is thought to fight against cognitive decline. What’s more, a study found that ladies who revealed eating the most verdant green and cruciferous vegetables had an especially decreased rate of cognitive decline as contrasted with the individuals who ate the minimum.
A study found that lycopene-rich tomato helped participants prevent sunburn when they combined it with olive oil and use it for ten weeks without missing any day. Other than being an extraordinary source of strong antioxidant lycopene, tomatoes are considered a high carotenoid fruit. These nutrients may help to get rid from free radicals that can cause many diseases including aging.
Some good sources for cognition Decline:
ALA, ALPHA – LIPOIC ACID Antioxidant & anti-Inflammatory
Other Names for ALPHA – LIPOIC ACID :
Acetate Replacing Factor, A-Lipoic Acid, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque, Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque
Introduction to ALPHA – LIPOIC ACID or ALA
Alpha-lipoic acid is a substance made by the body. It is found in every body cell, where it helps turn glucose into energy. Alpha-lipoic acid is a vitamin-like chemical and an antioxidant. ALPHA – LIPOIC ACID or ALA can be found in Yeast, liver, kidney, spinach, broccoli, and potatoes. It is also made in the laboratory for use as medicine.
Alpha-lipoic acid is used to break down carbohydrates in body and use the energy for organs in the body. Alpha-Lipoic Acid (ALA) is a mitochondrial fatty acid that is highly involved in energy metabolism as mentioned mostly for carbohydrates. ALA has shown benefit against various forms of oxidation and inflammation some part of this is because ALA resets the cycle of vitamin E & C.
ALA, ALPHA – LIPOIC ACID is Known for:
Alpha-lipoic acid helps prevent certain kinds of cell damage in the body. It also restores vitamin levels such as vitamin E and vitamin C in their cycles so they would work again as an antioxidant in their cycles and this reduces body need of antioxidants. There are some evidence that alpha-lipoic acid can improve the function and conduction of neuron cells in diabetes. ALA antioxidant benefits might also be helpful in liver diseases.
ALA is know to be used to improve these conditions:
- Coronary artery bypass graft (CABG) surgery.
- Diabetic nerve pain.
- Weight loss. 1800 mg of alpha-lipoic acid daily for 20 weeks.
- Wound healing.
- Alcoholic liver disease. 300 mg of alpha-lipoic acid daily for up to 6 months
- Alzheimer’s disease. 600-900 mg of alpha-lipoic acid daily for up to 2 years
- Heart-related nerve problems
- Damage to the retina caused by diabetes
- HIV-related brain problems.
- Rheumatoid arthritis. 300 mg of alpha-lipoic acid by mouth daily for 12 weeks
Get ALA for:
- Weight Loss
- EYE health
- Nerve Repair
- Blood Pressure
- liver disease
- Heart-related nerve problems
- Weight loss
- Immune system
- Inflammatory and pain
- Neuro-degenerative diseases
- Cognition decline
- Autoimmune diseases (rheumatoid arthritis)
- Joint health
- Motion Sickness
- Damaging nerves system
- Treatment of Dementia
- Alzheimer’s disease
- High cholesterol
- Healthier Arteries
Get ALA naturally:
Main natural sources of ALA ALPHA – LIPOIC ACID
- Red meat
- Organ meat (sch as liver, hearts, kidneys from beef or chicken)
- Brussel sprouts
- Brewer’s yeast
ALA ALPHA – LIPOIC ACID is Both water and fat soluble and found in many natural foods meats, and plants. It can be in a protein bound or in other forms.
This list is for lipoyllysinem, the protein-bound form.
|Food||Dry Weight (mg/g)||Protein (ng/g)|
|2. bovine (cow) kidney||2.64||50.57|
|3. bovine (cow) heart||1.51||41.42|
|6. green pea||0.39||17.13|
|7. brussel sprouts||0.39||18.39|
|8. bovine (cow) spleen||0.36||5.69|
|9. bovine (cow) brain||0.27||4.85|
|10. rice bran||0.16||4.44|
Side Effects of ALA:
- ALA, Alpha-lipoic acid is known as SAFE by mouth or when applied to the skin. the safe dosage is about the regular dose that can be found in natural sources like plants. 600 or 1200 mg daily.
- Negative effects could occur with long term high-dosage supplementation. High-dose ALA supplementation is therefore not recommended.
- People with diabetes should be careful to check their blood sugar levels because alpha-lipoic acid might lower blood sugar.
- People taking alpha-lipoic acid by mouth might get some rash.
Interactions of ALA:
- Medications for cancer (Chemotherapy) interacts with ALPHA-LIPOIC ACID.
- Medications for diabetes (Antidiabetes drugs) interacts with ALPHA-LIPOIC ACID
- Thyroid medications, Levothyroxine — Apha-lipoic acid may lower levels of thyroid hormone.
- Vitamin B1 (Thiamine) — Alpha lipoic acid can lower the level of vitamin B1 (Thiamine) in the body. This can be particularly dangerous in alcoholics.
Online sources for this article and good readings on ALA Alpha-lipoic acid:
List of references and papers:
Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo. 2000;14(2):327-330.
Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149:841-9.
Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin. 1999;94 Suppl 3:84-89.
Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke. 2001;32(4):1000-1004.
Faust A, Burkart V, Ulrich H, et al. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice. Int J Immunopharmacol. 1994;16:61-66.
Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. 2001;6(2):141-166.
Hruby K, Csomos G, Fuhrmann M, Thaler H. Chemotherapy of Amanita phalloides poisoning with intravenous silibinin. Hum Exp Toxicol. 1983;2(2):183-195.
Ibrahimpasic K. Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med Arh. 2013; 67(1):7-9.
Lynch MA. Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue. Nutr Neurosci. 2001;4(6):419-438.
Melhem MF, Craven PA, Derubertis FR. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol. 2001;12:124-133.
Melhem MF, Craven PA, Liachenko J, et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol. 2002;13:108-116.
Melmed: Williams Textbook of Endocrinology, 12th ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2011.
Mitkov MD, Aleksandrova IY, Orbetzova MM. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv). 2013; 55(1):55-63.
Monograph:Alpha-Lipoic Acid. Altern Med Rev. 1998;3(4):308-311.
Nagamatsu M, Nickander KK, Schmelzer JD,et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.
Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17(10):888-895.
Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-linoic acis. Free Radic Biol Med. 1997;22:359-378.
Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Rad Bio Med. 1995;19(2):227-250.
Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V. Alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996;717(1-2):184-188.
Rakel D. Rakel Integrative Medicine, 3rd ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2012.
Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung. 1991;41:1294-1298.
Xu J, Gao H, Song L, et al. Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. Lipids Health Dis. 2013; 12:58.
Yoo TH, Lee JH, Chun HS, Chi SG. a-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kB induction of RPS6KA4. Anticancer Drugs. 2013; 24(6):555-65.
Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care. 2006;29:2365-70.
Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997;46 (suppl 2):S62-66.
Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999; 107:421-430.
What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system
Introduction to Antioxidant
“a substance that inhibits oxidation, especially one used to counteract the deterioration of stored food products. a substance that removes potentially damaging oxidizing agents in a living organism.”
First thing that comes up in google search is what you see above. But what it really means that it removes potentially damaging oxidizing agents? what do the oxidizing agents do? what antioxidants do to them? how it helps our body with aging? how is it related to aging? Do antioxidants help your body in weight loss processes? How? Do they really keeps us young? are they same as anti-inflammatory substances?
It has been about 50 years only that even the word Antioxidant is being used.
The human body by its self naturally produces free radicals and the antioxidants to counteract their damaging effects, its something our body is aware of and has some solutions for it. However, in most cases, free radicals far outnumber the naturally occurring antioxidants and thats why we see that it could expedite aging and health issues. But what are free radicals? for a short answer:
Human body need oxygen for its chemical activities and in order to live. the simple act of breathing is the start of the formation of highly reactive molecules called free radicals. Free radicals interact with other molecules in the body as they are in blood and metabolism, they cause Oxidative Damage.
Oxidative damage can result the development of a wide range of illnesses and diseases or increasing the possibility of illness by effecting the immune system. Oxidative stress occurs when the production of reactive oxygen is greater than the body’s ability to detoxify and clean the reactive intermediates. This imbalance as mentioned before leads to oxidative damage to proteins, molecules, and genes within the body. when proteins start being damaged means now all your body is in danger cause not only your muscles but all of cell’s functions even DNA functions are done by different kinds of protein. But the free radical intensity does not only depend on the body it self it depends a lot on many factor and behaviors that we can control. Some external body causes could increase the free radicals and the damage they have on our body like:
- Smoking (first or second hand)
- Excessive exposure to UV rays
- Eating an unhealthy diet
- Certain medications and/or treatments
- Excessive exercise
- Breathing deep and enough
Normally, in our body bonds dont lag, they dont split in a way that leaves a molecule with an odd (unstable condition or harmful situation), unpaired electron. But when weak bonds split, free radicals are formed. Free radicals are very unstable it means they can react and bond quickly with many potentialities and affect quickly the other compounds, trying to capture the needed electron to gain stability.
Some internally generated sources of free radicals are:
- Xanthine oxidase
- Arachidonate pathways
- Ischemia/reperfusion injury
- Some externally generated sources of free radicals are:
- Cigarette smoke
- Environmental pollutants
- Certain drugs, pesticides
- Industrial solvents
Generally, free radicals attack (try to bond and become stable) the nearest stable molecule, “stealing” its electron. When the “attacked” molecule loses its electron, it becomes a free radical itself and causing this in a mass scale in body by beginning a chain reaction. Once the process is started, it can cascade, finally resulting in the disruption of a living cell. Cells are smallest stable and almost independent units in our body. every and each one of them are playing an important role in what an organ and bigger part does. It means they are independent but they also work as a team and they communicate, so if something goes wrong in one specially in RNA/DNA level it will spread. they communicate with substances and some other factors so many effects that free radicals have can be very local and at the same time in whole body.
Our body sometimes uses the free radicals. basically our body pretty much knows what they are and some free radicals arise normally during metabolism. Sometimes the body immune systems cells or white blood cells purposefully create them to neutralize viruses and bacteria, well that is as smart as it can get. However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also increase free radicals unnaturally. Usually The body handles free radicals, but if antioxidants are unavailable, or if the free-radical production becomes excessive, damage can occur.
Of particular importance is that free radical damage accumulates with age. Yes aging can be expedited by free radicals. they make your body an unsafe place to live for cells. they interfere with metabolism and damage the immune system and their number one scary result can be cancer.
Antioxidants Counteract Oxidative Stress and Free Radicals
The body is aware of its substances it naturally produces antioxidants like superoxide dismutase, catalase, or peroxidase enzymes, as a means of defending itself against free radicals. The antioxidants neutralize the free radicals, so makes them harmless to other cells. Antioxidants can repair damaged molecules in body by donating hydrogen atoms to them. Some antioxidants even have a chelating effect on free radical production that’s catalyzed by heavy metals. In this situation, the antioxidant contains the heavy metal molecules so strongly that the chemical reaction necessary to create a
free radical never occurs. When these kinds of antioxidants are water-soluble, it also causes the removal of the heavy metals from the body via the urine. for example Astaxanthin is in some cases considered nature’s most powerful antioxidant in foods and also available in pills and supplements now.
Different Types of Antioxidants
All the antioxidants are different and function different. Astaxanthin is actually a lipid-soluble antioxidant, while resveratrol is a water-soluble antioxidant And Each type of them function in its own way. antioxidants can be categorized in tow different ways, as a matter of fact three but molecular size is not an effective issue in terms of choosing what to take for you.
1. Antioxidants can be categorized basically in two categories:
Soluble in lipids/fat (hydrophobic) or water (hydrophilic). Both of them are neede in body in order to protect your cells. basically because body cells have both environments in them and as a matter of facts the interior of your cells and the fluid between them are composed of water, while the cell membranes themselves are mostly made of fat. The free radicals can strike both the watery cell contents or the fatty cellular membrane. Lipid-soluble antioxidants are the ones that protect your cell membranes from lipid peroxidation. Some examples of lipid-soluble antioxidants are vitamins A and E, carotenoids, and lipoic acid. Water-soluble antioxidants are found in aqueous fluids, like your blood and the fluids examples of water-soluble antioxidants are vitamin C, polyphenols, and glutathione.
2. They can also be categorized in another way as enzymatic and non-enzymatic antioxidants:
Enzymatic antioxidants benefit you by breaking down the structure of the free radicals and removing free radicals from your system. They can flush out dangerous oxidative products by converting them into hydrogen peroxide, then into water and gone you are free of free radicals.
Non-enzymatic antioxidants benefit you by interrupting free radical chain reactions that is another way to block them from damaging the whole environment. Some examples are carotenoids, vitamin C, vitamin E, plant polyphenols, and glutathione (GSH). Most antioxidants found in supplements and foods are non-enzymatic.
Why may Antioxidant Supplements do not work as well as foods Work?
Good natural sources for Vitemin C, vitamin A and vitamin E as the most popular antioxidants:
Good Food Sources of Vitamin C (mg/serving)
|Orange juice, fresh squeezed||
|Grapefruit juice, fresh squeezed||
|Green peppers, raw chopped||
|Broccoli, raw chopped||
Good Food Sources of Vitamin E (mg/serving)
9.3 (13.9 IU)
5.8 (8.7 IU)
4.7 (7.0 IU)
3.3 (4.9 IU)
3.2 (4.8 IU)
2.8 (4.2 IU)
Good Food Sources of Vitamin A
Food mcg RAE perserving IU per serving Percent DV*
Sweet potato, baked in skin, 1 whole 1,403 28,058 561
Beef liver, pan fried, 3 ounces 6,5822 2,175 444
Spinach, frozen, boiled, ½ cup 5731 1,458 229
Carrots, raw, ½ cup 459 9,189 184
Pumpkin pie, 1 piece 488 3,743 249
Cantaloupe, raw, ½ cup 135 2,706 54
Peppers, sweet, red, raw, ½ cup 117 2,332 47
Mangos, raw, 1 whole 112 2,240 45
Black-eyed peas (cowpeas),boiled, 1 cup 66 1,305 26
Apricots, dried, sulfured, 10 halves 63 1,261 25
Broccoli, boiled, ½ cup 60 1,208 24
Ice cream, French vanilla, soft serve, 1 cup 278 1,014 20
Cheese, ricotta, part skim, 1 cup 263 945 19
Tomato juice, canned, ¾ cup 42 821 16
Herring, Atlantic, pickled, 3 ounces 219 731 15
Some important questions about antioxidants:
Where are antioxidants?
How can we get them?
Do natural sources work the same as supplements in terms of antioxidants?
What is the strongest antioxidant?
Is there a list of antioxidants?
Antioxidants are effective more in natural forms like food or pills/ tablets/ supplements?
What foods are high in antioxidants?
What do antioxidants do? or what are the benefits of antioxidants ?
Do antioxidants cure cancer?
Do antioxidants prevent cancer?
Are antioxidants the same as vitamins?
Which diseases can be healed and/or cured by antioxidants?
It is not limited to these diseases or body conditions but these are the most associated ones with antioxidants
SYMPTOMS OF ADHD (ATTENTION DEFICIT HYPERACTIVITY DISORDER)
Metabolic issues in obesity
EYE DISORDERS AMD
INFLAMMATORY AND PAIN
AUTOIMMUNE DISEASES (RHEUMATOID ARTHRITIS)
HIGH CHOLESTEROL (LDL BAD CHOLESTEROL)
This can be a very small and useful list of them but in fact as mentioned antioxidants are substances fighting Degenerative Diseases effecting both immune system and DNA in many levels this list of Degenerative Diseases can also be considered.
Categorization of Degenerative Diseases
- Neoplasms (divisions of mutated cells)
- Diseases of the Blood
- Endocrine Diseases
- Metabolic Syndrome (is a cluster of conditions – high blood pressure, high blood sugar, excess body fat (typically around the waist) and high level of bad cholesterol or low level of good cholesterol)
Hyperlipidemia (high level of fats in the blood)
Arteriosclerosis (thickening and hardening of artery walls)
Fatty Liver (build up of fats in the liver)
Hypertension (high blood pressure)
Obesity (being over weight)
- Diseases of the Nervous System
- Diseases of the Eye and Adnexa
- Diseases of the Ear and Mastoid Process
- Diseases of the Circulatory System
- Diseases of the Respiratory System
- Diseases of the Skin and Subcutaneous Tissue
- Diseases of the Musculoskeletal System and Connective Tissue
- Diseases of the Genitourinary System
- Ischemia (restriction or cut-off of blood supply)/reperfusion (restoration of blood supply) injuries
Cerebral Infraction (stroke caused by blockage)
Myocardial infraction (heart attack)
Post Cardiac Arrest (resuscitated heart after the heart stopped)
- Mitochondrial Diseases
- Medication Induced
- Stress Induced
Antioxidants Also Combat Infectious Diseases in basically two main ways:
1- Building or maintaining very healthy immune cells to fight the invasion
2- Countering the cell damages caused by the invasions/infections
- Bacteria Infections
- Virus Infections
- Fungi Infections
- Protozoa Infections
- Helminths Infections
Do antioxidants help in weight loss? or Do antioxidants help us lose weight?
Sources in web and scientific articles on antioxidants, free radicals and oxidation:
list of articles:
1. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. 4th. Oxford, UK: Clarendon Press; 2007.
2. Bahorun T, Soobrattee MA, Luximon-Ramma V, Aruoma OI. Free radicals and antioxidants in cardiovascular health and disease. Internet J. Med. Update. 2006;1:1–17.
3. Valko M, Izakovic M, Mazur M, Rhodes CJ, et al. Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell Biochem. 2004;266:37–56. [PubMed]
4. Valko M, Leibfritz D, Moncola J, Cronin MD, et al. Free radicals and antioxidants in normal physiological functions and human disease. Review. Int. J. Biochem. Cell Biol. 2007;39:44–84. [PubMed]
5. Droge W. Free radicals in the physiological control of cell function. Review. Physiol. Rev. 2002;82:47–95.[PubMed]
6. Willcox JK, Ash SL, Catignani GL. Antioxidants and prevention of chronic disease. Review. Crit. Rev. Food. Sci. Nutr. 2004;44:275–295. [PubMed]
8. Genestra M. Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Review. Cell Signal. 2007;19:1807–1819. [PubMed]
9. Halliwell B. Biochemistry of oxidative stress. Biochem. Soc. Trans. 2007;35:1147–1150. [PubMed]
11. Valko M, Rhodes CJ, Moncol J, Izakovic M, et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Mini-review. Chem. Biol. Interact. 2006;160:1–40. [PubMed]
12. Valko M, Morris H, Cronin MTD. Metals, toxicity and oxidative stress. Curr. Med. Chem. 2005;12:1161–1208. [PubMed]
13. Parthasarathy S, Santanam N, Ramachandran S, Meilhac O. Oxidants and antioxidants in atherogenesis: an appraisal. J. Lipid Res. 1999;40:2143–2157. [PubMed]
14. Frei B. Reactive oxygen species and antioxidant vitamins. Linus Pauling Institute. Oregon State University. 1997 http://lpi.oregonstate.edu/f-w97/reactive.html .
15. Chatterjee M, Saluja R, Kanneganti S, et al. Biochemical and molecular evaluation of neutrophil NOS in spontaneously hypertensive rats. Cell Mol. Biol. 2007;53:84–93. [PubMed]
16. Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Review. Diabetes Care. 2008;31(Suppl 2):S181–184. [PubMed]
17. Halliwell B. Role of free radicals in neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging. 2001;18:685–716. [PubMed]
18. Singh RP, Sharad S, Kapur S. Free radicals and oxidative stress in neurodegenerative diseases: Relevance of Dietary Antioxidants. JIACM. 2004;5:218–225.
19. Christen Y. Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 2000;71:621S–629S. [PubMed]
20. Butterfield DA. Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer’s disease brain. A review. Free Radic. Res. 2002;36:1307–1313. [PubMed]
22. Guo RF, Ward PA. Role of oxidants in lung injury during sepsis. Antioxid. Redox. Signal. 2007;9:1991–2002. [PubMed]
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