Co Q-10, Ubiquinol a strong antioxidant benefits


Research in progress                                   



Other Names for Co Q-10: 

Co Q10, Co Q-10, Coenzima Q-10, Co-Enzyme 10, Coenzyme Q 10, Coenzyme Q10, Co-Enzyme Q10, Co-Enzyme Q-10, Co-Q 10, CoQ10, Co-Q10, CoQ-10, Ubidcarenone, Ubidécarénone, Ubiquinone-10

Introduction to Co Q-10

 
Coenzyme Q₁₀,  which is also known as ubiquinone is a coenzyme that is ubiquitous in the bodies of most animals. Coenzyme Q-10 (CoQ-10) is a like a vitamin a substance found in all the body especially in the heart, liver, kidney, and pancreas. It can be eaten in small amounts in meats and seafood. 
 
Coenzyme Q10 is beneficial for many heart health issues in many ways. It assists in maintaining the healthy oxidative state of LDL cholesterol, helps with circulatory health, and supports optimal heart muscle health. CoQ10 may also help with the health of vessel walls. 

Also, Coenzyme Q10 may reduces the number and severity of migraine headaches, and improving sperm motility in men. 
Researcher in some cases has indicated therapeutic value in high doses to slow the progression of Parkinson’s disease, but a study by the National Institute for Neurological Disease and Stroke found no benefit in slowing symptoms or neural degeneration like many other antioxidants do.
 

Co Q-10 is known for:

Co Q-10 is in our blood and it is proven that it helps with many situations because of it antioxidant properties but it is also an issue and a question that does it really works if we take it orally and by supplements? here are some of the situations that Co q 10 is known to be used for  but not all of them are proven to be effective. In many cases coenzyme Q-10 has been used for treating heart and blood vessel conditions such as congestive heart failure, chest pain (angina), high blood pressure, and heart problems linked to certain cancer drugs, diabetes, gum disease (both taken by mouth and applied directly to the gums), breast cancer, Huntington’s disease, Parkinson’s disease, muscular dystrophy, increasing exercise tolerance, chronic fatigue syndrome (CFS), and Lyme disease. Coenzyme Q-10 is believed by some to treat hair loss related to taking warfarin (Coumadin), a medication used to slow blood clotting. 




Coenzyme Q-10 might help increase energy. This is because coenzyme Q-10 has a role in producing ATP, a molecule in body cells that functions like a rechargeable battery in the transfer of energy. Coenzyme Q-10 been tried for treating inherited or acquired disorders that limit energy production in the cells of the body (mitochondrial disorders), and for improving exercise performance. Some also used coenzyme Q-10 for strengthening the immune systems of people with HIV/AIDS, male infertility, migraine headache, and counteracting muscle pain sometimes caused by a group of cholesterol-lowering medications called “statins.”  COQ10 is also believed to enhance blood flow and protect the blood vessels, By nitric oxide preservation, like with Grape Seed Extract, Pycnogenol, and Resveratrol. COQ10 can reduce the damage of (LDL) in blood vessels. 

 

 

Foods with high Possible Co Q-10


Co Q-10, Ubiquinol I basically found more in fat and is fat soluble, so consider the list and also have in mind that having these in a meal can help in absorbing it in blood. 

  • Fatty Fish
  • Beef and Poultry
  • Nuts, Seeds and Oils
  • Fruits and Vegetables: strawberries & Broccoli


Possible Co Q-10, Ubiquinol Interactions 


You should not use CoQ10 without first talking to your health care provider. if you are using any of the following. Some of these are related to blood flow generally because Ubiquinol has been proven to have impact on blood pressure so it may interact with blood flow medicines. 

  • Chemotherapy medications
  • Daunorubicin and doxorubicin
  • Blood pressure medications
  • Blood-thinning medications
  • Betaxolol (Betoptic)
 
 
Useful Website sources and articles on Vitamin E and its benefits:

Useful Website sources and articles on Vitamin E and its benefits:

 
 
 
 
Papers and articles for reading and references :


Papers and articles for reading and references :

Aguilaniu H, Durieux J, Dillin A. Metabolism, ubiquinone synthesis, and longevity. Genes Dev. 2005;19(20):2399-406.

Al-Hasso. Coenzyme Q10: a review. Hosp Pharm. 2001;36(1):51-66.

Beal MF. Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. Methods Enzymol. 2004;382:473-87.

Belardinelli R, Mucaj A, Lacalaprice F, et al., Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J. 2006;27(22):2675-81.

Berthold HK, Naini A, Di Mauro S, Hallikainen M, Gylling H, Krone W, Gouni-Berthold I. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf. 2006;29(8):703-12.

Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on myopathyic symptoms in patients treated with statins. Am J Cardiol. 2007;99(10):1409-12.
Dhanasekaran M, Ren J. The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res. 2005;2(5):447-59.
de Bustos F, Molina JA, Jimenez-Jimenz FJ, Garcia-Redondo A, Gomez-Escalonilla C, Porta-Etessam J, et al. Serum levels of coenzyme Q10 in patients with Alzheimer’s disease. J Neural Transm. 2000;107(2):233-239.
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health-System Pharm. 2000;57(13):1221-1227.
Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q(10) improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002;56:1137-1142.
Khan M, Gross J, Haupt H, et al., A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg. 2007;136(1):72-7.
Khatta M, Alexander BS, Krichten CM, Fisher ML, Freudenberger R, Robinson SW et al. The effect of conenzyme Q10 in patients with congestive heart failure. Ann Int Med. 2000;132(8):636-640.
Kolahdouz Mohammadi R, Hosseinzadeh-Attar MJ, Eshraghian MR, Nakhjavani M, Khorami E, Esteghamati A. The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients. Minerva Gastroenterol Dietol. 2013;59(2):231-6.
Lafuente R, Gonzalez-Comadran M, Sola I, et al. Conezyme Q10 and male infertility: a meta-analysis. J Assist Reprod Genet. 2013;30(9):1147-56.
Langsjoen PH, Langsjoen JO, Langsjoen AM, Lucas LA. Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation. Biofactors. 2005;25(1-4):147-52.
Lee BJ, Tseng YF, Yen CH, Lin PT. Effects of coenzyme Q10 supplementation (300mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J. 2013;12(1):142.
Levy G, Kaufmann P, Buchsbaum R, et al., A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS. Neurology. 2006;66(5):660-3.
Madmani ME, Yusuf Solaiman A, Tamr Agha K, et al. Coenzyme Q10 for heart failure. Cochrane Database Syst Rev . 2014; 6:CD008684.
McCarty MF. Toward practical prevention of type 2 diabetes. Med Hypotheses. 2000;54(5):786-793.
Nahas R. Complementary and alternative medicine approaches to blood pressure reduction: An evidence-based review. Can Fam Physician. 2008 Nov;54(11):1529-33. Review.
Ochiai A, Itagaki S, Kurokawa T, Kobayashi M, Hirano T, Iseki K. Improvement in intestinal coenzyme q10 absorption by food intake. Yakugaku Zasshi. 2007;127(8):1251-4.
Ostrowski RP. Effect of coenzyme Q(10) on biochemical and morphological changes in experimental ischemia in the rat brain. Brain Res Bull. 2000;53(4):399-407.
Palan PR, Connell K, Ramirez E, Inegbenijie C, Gavara RY, Ouseph JA, Mikhail MS. Effects of menopause and hormone replacement therapy on serum levels of coenzyme Q10 and other lipid-soluble antioxidants. Biofactors. 2005;25(1-4):61-6.
Quinzii CM, Dimauro S, Hirano M. Human coenzyme q(10) deficiency. Neurochem Res. 2007;32(4-5):723-7.
Raitakari OT, McCredie RJ, Witting P, Griffiths KA, Letter J, Sullivan D, Stocker R, Celermajer DS. Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radic Biol Med. 2000;28(7):1100-1105.
Rakel D. Rakel: Integrative Medicine. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2007.
Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF. Conenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007;21(4):297-306.
Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors. 2003;18(1-4):91-100.
Salles JE, Moises VA, Almeida DR, Chacra AR, Moises RS. Myocardial dysfunction in mitochondrial diabetes treated with Coenzyme Q10. Diabetes Res Clin Pract. 2006;72(1):100-3.
Sander S, Coleman CI, Patel AA, Kluger J, White CM. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail. 2006;12(6):464-72.
Shults CW, Haas R. Clinical trials of coenzyme Q10 in neurological disorders. Biofactors. 2005;25(1-4):117-26.
Shults CW. Therapeutic role of coenzyme Q(10) in Parkinson’s disease. Pharmacol Ther. 2005;107(1):120-30.
Singh U, Devaraj S, Jialal I. Coenzyme Q10 supplementation and heart failure. Nutr Rev. 2007;65(6 Pt 1):286-93.
Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet. 1994;344:1372-1373.
Torkos S. Drug-nutrient interactions: A focus on cholesterol-lowering agents. Int J Integrative Med. 2000;2(3):9-13.
Watson PS, Scalia GM, Galbraith A, et al. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol. 1999;33:1549-1552.
Weant KA, Smith KM. The role of coenzyme Q10 in heart failure. Ann Pharmacother. 2005;39(9):1522-6.
Witte KK, Clark AL, Cleland JG. Chronic heart failure and micronutrients. J Am Coll Cardiol. 2001;37(7):1765-1774.