Sage, just a mint or strong antioxidants and Anti-Inflammatory

Introduction to SAGE


SAGE

Other Names: Common Sage, Dalmatian Sage, Feuille de la Bergère, Garden Sage, Herbe Sacré, Meadow Sage, Salvia lavandulaefolia, Salvia officinalis, Sauge, Sauge Ananas, 

Sage is an herb, a mint. The leaf is used to make medicine. Sage contains rosmarinic acid, rosmarinic acid is a potent antioxidant and an anti-inflammatory agent. Rosmarinic acid reduces harmful inflammation. Sage, just a mint or strong antioxidants and Anti-Inflammatory

Research confirms what herbalists have long known: sage is an outstanding memory enhancer and fights cognitive decline. Sage helps provide better brain function and more brain plasticity and has been used in the treatment of cerebrovascular disease for a long time. Alzheimer`s disease has always been at the top of our researches on brain deficits and for sage as well Research has suggested that it may be an effective option to help treat Alzheimer`s disease and increase BDNF and lower/slower brain aging.


Sage, just a mint or strong antioxidants and Anti-Inflammatory



Known for

Generally sage is known for gas (flatulence), loss of appetite, stomach pain (gastritis), diarrhea, bloating, and heartburn. It is also used for reducing overproduction of perspiration and saliva; and for depression, memory loss, and Alzheimer’s disease. These are all very different and very vast verity of diseases. 
The reson is that sage has both mints benefits + rosmarinic acid benefits that adds up antioxidant and an anti-inflammatory features to sage. Also if you look at some other features it has you see that sage actually is very good for High cholesterol. Taking common sage (Salvia officinalis) seems to reduce “bad” low-density lipoprotein (LDL) cholesterol and blood fats called triglycerides, and increase “good” high-density lipoprotein (HDL) cholesterol, in people with high cholesterol. Having all these together makes sage a worth attention mint/supplement.



Get Sage for

 


Sage, just a mint or strong antioxidants and Anti-Inflammatory




Get Sage naturally


You can easily get sage in your closest grocery store near you. 
Check out here for sage delicious recipes  


Sage, just a mint or strong antioxidants and Anti-Inflammatory

Nutrition Facts
Sage, ground

Amount Per 1 tbsp (2 g)

Calories 6
% Daily Value*
Total Fat 0.3 g 0%
Saturated fat 0.1 g 0%
Polyunsaturated fat 0 g
Monounsaturated fat 0 g
Cholesterol 0 mg 0%
Sodium 0 mg 0%
Potassium 21 mg 0%
Total Carbohydrate 1.2 g 0%
Dietary fiber 0.8 g 3%
Sugar 0 g
Protein 0.2 g 0%
Vitamin A 2% Vitamin C 1%
Calcium 3% Iron 3%
Vitamin D 0% Vitamin B-6 5%
Vitamin B-12 0% Magnesium 2%

Side effects of Sage


Sage is LIKELY SAFE in foods and in amounts typically used in foods.
However Some species of sage, such as common sage (Salvia officinalis), contain a chemical called thujone which can be poisonous if you get enough. so  keep it in normal plants doses. like when you cook a meal and use it as an ingredient. 
for special persecutions read here

Sage, just a mint or strong antioxidants and Anti-Inflammatory

Dosing of Sage

 
As mentioned keep it natural for your normal life, maybe a 2 meals a week as food ingredient or if you take it by pills For treating Alzheimer’s disease: 1 gram of sage per day. the dosing for Alzheimer’s disease can be increased through time to 2 and 2.5 grams. 
 
 
 
 
 
 
 
Web site sources For sage:
Articles and researches that can be useful on sage:
Articles and researches that can be useful on sage:

al-Sereiti MR, Abu-Amer KM, Sen P. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol 1999 Feb;37(2):124-30. 1999.
Calucci L, Pinzino C, Zandomeneghi M et al. Effects of gamma-irradiation on the free radical and antioxidant contents in nine aromatic herbs and spices. J Agric Food Chem 2003 Feb 12; 51(4):927-34. 2003.
Ensminger AH, Esminger M. K. J. e. al. Food for Health: A Nutrition Encyclopedia. Clovis, California: Pegus Press; 1986. 1986. PMID:15210.
Fortin, Francois, Editorial Director. The Visual Foods Encyclopedia. Macmillan, New York. 1996.
Grieve M. A Modern Herbal. Dover Publications, New York. 1971.
Houghton P. Sage, alternative treatment to Alzheimer’s drug. Research presented at the British Pharmaceutical Conference in Harrogate, September 15-17, 2003. 2003.
Kelm MA, Nair MG, Strasburg GM, DeWitt DL. Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine 2000 Mar;7(1):7-13. 2000. PMID:12240.
Malencic D, Gasic O, Popovic M, Boza P. Screening for antioxidant properties of Salvia reflexa hornem. Phytother Res 2000 Nov;14(7):546-8. 2000. PMID:12230.
Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes KA, Scholey AB. Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav. 2003 Jun;75(3):669-74. 2003.
Wood, Rebecca. The Whole Foods Encyclopedia. New York, NY: Prentice-Hall Press; 1988. 1988. PMID:15220.
1. Nikavar B, Abolhasani L, Izadpanah H. Alpha-amylase inhibitory activities of six salvia species. Iran J Pharm Res. 2008;7:297–303.
2. Itani WS, El-Banna SH, Hassan SB, Larsson RL, Bazarbachi A, Gali-Mutasib HU. Anti colon cancer components from Lebanese sage (Salvia Libanotica) essential oil. Cancer Biol Ther. 2008;7:1765–73. [PubMed]
3. Ayatollahi A, Shojaii A, Kobarfard F, Mohammadzadeh M, Choudhary M. Two flavones from Salvia leriaefolia. Iran J Pharm Res. 2009;8:179–84.
4. Smidling D, Mitic-Culafic D, Vukovic-Gacic B, Simic D, Knezevic-Vukcevic J. Evaluation of antiviral activity of fractionated extracts of Sage Salvia officinalis L (Lamiaceae) Arch Biol Sci Belgrade. 2008;60:421–9.
5. Rami K, Li Z. Antimicrobial activity of essential oil of Salvia officinalis L. collected in Syria. Afr J Biotech. 2011;10:8397–402.
6. Walch S, Tinzoh L, Zimmerman B, Stuhlinger W, Lachenmeier D. Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. Front Pharmacol. 2011;2:29. [PMC free article] [PubMed]
7. Khan A, Najeeb-ur- Rahman, Alkharfy K, Gilani A. Antidiarrheal andantispasmodic activities of Salvia officinalis are mediated through activation of K + channels. J Bangladesh Pharmacol Soc. 2011;6:111–6.
8. Loizzo MR, Tundis R, Menichini F, Saab AM, Statti GA, Menichini F. Cytotoxic activity of essential oils from Labiatae and Lauraceae families against in vitro human tumor models. Anticancer Res. 2007;27:3293–9. [PubMed]
9. Radulescu V, Chiliment S, Oprea E. Capillary gas chromatography-mass spectrometry of volatile and semi-volatile compounds of Salvia officinalis. J Chromatogr. 2004;1027:121–6. [PubMed]
10. Hadri A, Gomez Del Rio M, Sanz J, Coloma A, Idaomar M, Ozanas B, et al. Cytotoxic activity of α-humulene and transcaryo-phyllene from Salvia officinalis in animal and human tumor cells. An R Acad Nac Farm. 2010;76:343–56.
11. Hussain A, Anwar F, Iqbal T, Bhatti I. Antioxidant attributes of four Lamiaceae essential oils. Pak J Bot. 2011;43:1315–21.
12. Croteau R, Felton M, Karp F, Kjonaas R. Relationship of camphor biosynthesis to leaf development in sage (Salvia officinalis) Plant Physiol. 1981;67:820–4. [PMC free article] [PubMed]
13. Avato P, Fortunato I, Ruta C, D’ Elia R. Glandular hairs and essential oils in micro propagated plants of Salvia officinalis L. Plant Sci. 2005;169:29–36.
14. Baranauskiene R, Dambrauskiene E, Venskutonis P. Influence of harvesting time on the yield and chemical composition of sage (Salvia officinalis L.) Foodbalt. 2011:105–9.
15. Kamatou P, Viljoen A, Steenkamp P. Antioxidant, anti-inflammatory activities and HPLC analysis of South African Salvia species. Food Chem. 2010;119:684–8.
16. Yurtseven S, Cetin M, Sengiil T, Sogut B. Effect of sage extract (Salvia officinalis) on growth performance, blood parameters, oxidative stress and DNA damage in partridges. S Afr J Anim Sci. 2008;38:145–52.
17. Baricevic D, Sosa S, Loggia R, Tubaro A, Simonovska B, Krasna A, et al. Topical anti-inflammatory activity of Salvia officinalis L. leaves: The relevance of ursolic acid. J Ethnopharmacol. 2001;75:125–32. [PubMed]
18. Yadav S, Mukundan U. In vitro antioxidant properties of Salvia coccinea Buc’hoz ex etl. and Salvia officinalis L. Indian J Fundam Appl Life Sci. 2011;1:232–8.
19. Nickavar B, Kamelinejad M, Izadpanah H. In vitro free radical scavenging activity of five Salvia species. Pak J Pharm Sci. 2007;20:291–4. [PubMed]
20. Aleksovski A, Sovova H. Supercritical Co2 extraction of Salvia officinalis L. J Supercrit Fluids. 2007;40:239–45.
21. Sa C, Ramos A, Azevedo M, Lima C, Fernandes-Ferreira M, Pereira-Wilson C. Sage tea drinking improves lipid profile and antioxidant defences in humans. Int J Mol Sci. 2009;10:3937–50. [PMC free article] [PubMed]
22. Lu Y, Yeap Foo L. Flavonoid and phenolic glycosides from Salvia officinalis. Phytochemistry. 2000;55:263–7. [PubMed]
23. Lu Y, Yeap Foo L. Salvianolic acid L, a potent phenolic antioxidant from Salvia officinalis. Tetrahedron Lett. 2001;42:8223–5.
24. Stanojevic D, Comic L, Stefanovic O, Solujic-Sukdolak S. In vitro synergistic antibacterial activity of Salvia officinalis and some preservatives. Arch Biol Sci Belgrade. 2010;62:175–83.
25. Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: Review of pharmacologyical activity and pilot tolerability clinical trial. Pharmacol Biochem Behav. 2003;75:651–9. [PubMed]
26. Imanshadi M, Hosseinzadeh H. The Pharmacological effects of Salvia species on the central nervous system. Phytother Res. 2006;20:427–37. [PubMed]
27. Eidi M, Eidi A, Bahar M. Effects of Salvia officinalis L. (sage) Leaves on memory retention and its interaction with cholinergic system. Nutrition. 2006;22:321–6. [PubMed]
28. Ferreira A, Proenca C, Serralheiro M, Araujo M. The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. J Ethnopharmacol. 2006;108:31–7. [PubMed]
29. Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Wesnes KA, Scholey AB. Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol Behav. 2005;83:699–709. [PubMed]
30. Akhondzadeh S, Noroozian M, Mohammadi M, Ohadina S, Jamshidi AH, Khani M. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: A double blind, randomized and placebo-controlled trial. J Clin Pharm Ther. 2003;28:53–9. [PubMed]
31. Iuvone T, De Filipis D, Esposito G, D’Amico A, Izzo AA. The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta Peptide-induced neurotoxicity. J Pharmacol Exp Ther. 2006;317:1143–9. [PubMed]
32. Moss L, Rouse M, Wesens K, Moss M. Differential effects of the aromas of Salvia species on memory and mood. Hum Psychopharmacol. 2010;25:388–96. [PubMed]
33. Christensen KB, Jorgenson M, Kotowska D, Peterson RK, Kristiansen K, Christensen LP. Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.) J Ethnopharmacol. 2010;132:127–33. [PubMed]
34. Eidi M, Eidi A, Zamanizadeh H. Effect of Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats. J Ethnopharmcol. 2005;100:310–3. [PubMed]
35. Keshavarz M, Bidmeshkipour A, Mostafavi A, Mansouri K, Mohamadi-Motlagh H. Anti tumor activity of Salvia officinalis is due to its anti-angiogenic, anti-migratory and anti-proliferative effects. Cell J. 2011;12:477–82.
36. Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003;9:653–60. [PubMed]
37. Jedinak A, Muckova M, Kost’alova D, Maliar T, Masterova I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch C. 2006;61:777–82. [PubMed]
38. Pedro DF, Ramos AA, Lima CF, Baltazar F, Pereira-Wilson C. Modulation of DNA damage prevention and signaling pathways in diet induced colon cancer prevention. BMC Proc. 2010;4(Suppl 2):P58.
39. Canale MP, Villahermos SM, Martino G, Rovella V, Noce A, De Lorenzo A, et al. Obesity-related metabolic syndrome: Mechanisms of sympathetic over activity. Int J Endocrinol 2013. 2013 865965. [PMC free article] [PubMed]
40. Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes KA, et al. “Salvia lavandulaefolia (Spanish sage) enhances memory in healthy young volunteers. Pharmacol Biochem and Behav. 2003;75:669–74. [PubMed]
41. Ninomiya K, Matsuda H, Shimoda H, Nishida N, Kasajima N, Youshino T, et al. Carnosic acid, a new class of lipid absorption inhibitor from sage. Bioorg Med Chem Lett. 2004;14:1943–6. [PubMed]
42. Bommer S, Klein P, Suter A. First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes. Adv Ther. 2011;28:490–500. [PubMed]
43. Kermanshah H, Kamangar SH, Arami S, Mirsalehian A, Kamalineghad M, Karimi M, et al. In vitro evaluation of antibacterial activity of hydroalcoholic extract of Salvia officinalis and Pimpinella anisum against cariogenic bacteria. J Dent Med. 2009;22:149–54.

Chemistry, Pharmacology, and Medicinal Property of Sage (Salvia) to Prevent and Cure Illnesses such as Obesity, Diabetes, Depression, Dementia, Lupus, Autism, Heart Disease, and Cancer
Mohsen Hamidpour,1 Rafie Hamidpour,2 Soheila Hamidpour,3 and Mina Shahlari4