ALA, ALPHA – LIPOIC ACID Antioxidant & anti-Inflammatory
Other Names for ALPHA – LIPOIC ACID :
Acetate Replacing Factor, A-Lipoic Acid, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque, Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque
Introduction to ALPHA – LIPOIC ACID or ALA
Alpha-lipoic acid is a substance made by the body. It is found in every body cell, where it helps turn glucose into energy. Alpha-lipoic acid is a vitamin-like chemical and an antioxidant. ALPHA – LIPOIC ACID or ALA can be found in Yeast, liver, kidney, spinach, broccoli, and potatoes. It is also made in the laboratory for use as medicine.
Alpha-lipoic acid is used to break down carbohydrates in body and use the energy for organs in the body. Alpha-Lipoic Acid (ALA) is a mitochondrial fatty acid that is highly involved in energy metabolism as mentioned mostly for carbohydrates. ALA has shown benefit against various forms of oxidation and inflammation some part of this is because ALA resets the cycle of vitamin E & C.
ALA, ALPHA – LIPOIC ACID is Known for:
Alpha-lipoic acid helps prevent certain kinds of cell damage in the body. It also restores vitamin levels such as vitamin E and vitamin C in their cycles so they would work again as an antioxidant in their cycles and this reduces body need of antioxidants. There are some evidence that alpha-lipoic acid can improve the function and conduction of neuron cells in diabetes. ALA antioxidant benefits might also be helpful in liver diseases.
ALA is know to be used to improve these conditions:
- Coronary artery bypass graft (CABG) surgery.
- Diabetic nerve pain.
- Weight loss. 1800 mg of alpha-lipoic acid daily for 20 weeks.
- Wound healing.
- Alcoholic liver disease. 300 mg of alpha-lipoic acid daily for up to 6 months
- Alzheimer’s disease. 600-900 mg of alpha-lipoic acid daily for up to 2 years
- Heart-related nerve problems
- Damage to the retina caused by diabetes
- HIV-related brain problems.
- Rheumatoid arthritis. 300 mg of alpha-lipoic acid by mouth daily for 12 weeks
Get ALA for:
- Weight Loss
- EYE health
- Nerve Repair
- Blood Pressure
- liver disease
- Heart-related nerve problems
- Weight loss
- Immune system
- Inflammatory and pain
- Neuro-degenerative diseases
- Cognition decline
- Autoimmune diseases (rheumatoid arthritis)
- Joint health
- Motion Sickness
- Damaging nerves system
- Treatment of Dementia
- Alzheimer’s disease
- High cholesterol
- Healthier Arteries
Get ALA naturally:
Main natural sources of ALA ALPHA – LIPOIC ACID
- Red meat
- Organ meat (sch as liver, hearts, kidneys from beef or chicken)
- Brussel sprouts
- Brewer’s yeast
ALA ALPHA – LIPOIC ACID is Both water and fat soluble and found in many natural foods meats, and plants. It can be in a protein bound or in other forms.
This list is for lipoyllysinem, the protein-bound form.
|Food||Dry Weight (mg/g)||Protein (ng/g)|
|2. bovine (cow) kidney||2.64||50.57|
|3. bovine (cow) heart||1.51||41.42|
|6. green pea||0.39||17.13|
|7. brussel sprouts||0.39||18.39|
|8. bovine (cow) spleen||0.36||5.69|
|9. bovine (cow) brain||0.27||4.85|
|10. rice bran||0.16||4.44|
Side Effects of ALA:
- ALA, Alpha-lipoic acid is known as SAFE by mouth or when applied to the skin. the safe dosage is about the regular dose that can be found in natural sources like plants. 600 or 1200 mg daily.
- Negative effects could occur with long term high-dosage supplementation. High-dose ALA supplementation is therefore not recommended.
- People with diabetes should be careful to check their blood sugar levels because alpha-lipoic acid might lower blood sugar.
- People taking alpha-lipoic acid by mouth might get some rash.
Interactions of ALA:
- Medications for cancer (Chemotherapy) interacts with ALPHA-LIPOIC ACID.
- Medications for diabetes (Antidiabetes drugs) interacts with ALPHA-LIPOIC ACID
- Thyroid medications, Levothyroxine — Apha-lipoic acid may lower levels of thyroid hormone.
- Vitamin B1 (Thiamine) — Alpha lipoic acid can lower the level of vitamin B1 (Thiamine) in the body. This can be particularly dangerous in alcoholics.
Online sources for this article and good readings on ALA Alpha-lipoic acid:
List of references and papers:
Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo. 2000;14(2):327-330.
Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149:841-9.
Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin. 1999;94 Suppl 3:84-89.
Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke. 2001;32(4):1000-1004.
Faust A, Burkart V, Ulrich H, et al. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice. Int J Immunopharmacol. 1994;16:61-66.
Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. 2001;6(2):141-166.
Hruby K, Csomos G, Fuhrmann M, Thaler H. Chemotherapy of Amanita phalloides poisoning with intravenous silibinin. Hum Exp Toxicol. 1983;2(2):183-195.
Ibrahimpasic K. Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med Arh. 2013; 67(1):7-9.
Lynch MA. Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue. Nutr Neurosci. 2001;4(6):419-438.
Melhem MF, Craven PA, Derubertis FR. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol. 2001;12:124-133.
Melhem MF, Craven PA, Liachenko J, et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol. 2002;13:108-116.
Melmed: Williams Textbook of Endocrinology, 12th ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2011.
Mitkov MD, Aleksandrova IY, Orbetzova MM. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv). 2013; 55(1):55-63.
Monograph:Alpha-Lipoic Acid. Altern Med Rev. 1998;3(4):308-311.
Nagamatsu M, Nickander KK, Schmelzer JD,et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.
Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17(10):888-895.
Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-linoic acis. Free Radic Biol Med. 1997;22:359-378.
Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Rad Bio Med. 1995;19(2):227-250.
Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V. Alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996;717(1-2):184-188.
Rakel D. Rakel Integrative Medicine, 3rd ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2012.
Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung. 1991;41:1294-1298.
Xu J, Gao H, Song L, et al. Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. Lipids Health Dis. 2013; 12:58.
Yoo TH, Lee JH, Chun HS, Chi SG. a-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kB induction of RPS6KA4. Anticancer Drugs. 2013; 24(6):555-65.
Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care. 2006;29:2365-70.
Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997;46 (suppl 2):S62-66.
Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999; 107:421-430.