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What is brain plasticity? What is Brain BDNF?

What is brain plasticity? What is  BDNF?

BRAIN BDNF (BRAIN PLASTICITY) AND EXERCISE

 

What is brain plasticity? Neuroplasticity – or brain plasticity – is the ability of the brain to modify its connections or re-wire itself. Without this ability, any brain, not just the human brain, would be unable to develop from infancy through to adulthood or recover from brain injury.

What is  BDNF?   The BDNF gene provides instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells. In the brain, the BDNF protein is active at the connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience, a characteristic called synaptic plasticity. The BDNF protein helps regulate synaptic plasticity, which is important for learning and memory.

The BDNF protein is found in regions of the brain that control eating, drinking, and body weight; the protein likely contributes to the management of these functions. read more about exercise and brain bdnf

 

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What are antioxidants in green tea?

Green tea substance with antioxidant benefits?

Is all tea types the same in antioxidants?

The strongest tea in antioxidants?

Is green tea beneficial?

What are green tea health benefits?

 

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Keywords: Green tea catechins, dyslipidemia, oxidative stress, inflammation, endothelial cells, platelets, proliferation, cardiovascular disease

CAN YOU GROW NEW BRAIN CELLS?

CAN YOU GROW NEW BRAIN CELLS?

 

The science of neurogenesis suggests it’s possible to create neurons that improve your memory and thinking skills.(source)  For example in relation of AHN and exercise in a study Named: Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained  done by Miriam S. Nokia, Department of Psychology, University of Jyväskylä, Finland. On Exercise and AHN it was found that: Adult hippocampal neurogenesis is a continuous process that contributes to a variety of adaptive behaviours, such as learning (for review, see Aimone et al. 2014). A well-demonstrated means of promoting AHN in rodents is aerobic exercise, namely running (van Praag et al. 1999). High-intensity interval training had a smaller than expected effect on AHN. Resistance training does not promote AHN. read more

 

Read more about antioxidants

Read More about Cancer

 

 

Related questions:

What are antioxidants in green tea?

Green tea substance with antioxidant benefits?

Is all tea types the same in antioxidants?

The strongest tea in antioxidants?

Is green tea beneficial?

What are green tea health benefits?

 

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Read more about antioxidants

Read More about Anti aging

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Keywords: Green tea catechins, dyslipidemia, oxidative stress, inflammation, endothelial cells, platelets, proliferation, cardiovascular disease

Antioxidants and cancer | Do Antioxidants reduce the risk of cancer?

Antioxidants and cancer?

Do Antioxidants reduce the risk of cancer?

Can antioxidants prevent cancer or cure or stop or reduce the risk? which one is more accurate and basically how do they help our body?

Strong and Considerable laboratory evidence from chemical, cell culture, and animal studies indicates that antioxidants may slow or possibly prevent the development of cancer. Thats the answer you officially get for these questions and actually how we have been believing it is like for the last decades.

However, information from recent clinical trials is less clear. In recent years, large-scale, randomized clinical trials reached inconsistent conclusions. There is also some doubts on the fact that if the antioxidant supplements work the same as natural foods.

But we should be clear. Cancer cells when they are out there and being increased antioxidants do play important role as slowing down but main thing that is associated with antioxidant is prevention and not letting it happen in the first place. which means a healthy diet should be considered by every one before cancer actually happens.

Read more about antioxidants

Read More about Cancer

 

 

 

Related questions:

What are antioxidants in green tea?

Green tea substance with antioxidant benefits?

Is all tea types the same in antioxidants?

The strongest tea in antioxidants?

Is green tea beneficial?

What are green tea health benefits?

 

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Read more about antioxidants

Read More about Anti aging

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Keywords: Green tea catechins, dyslipidemia, oxidative stress, inflammation, endothelial cells, platelets, proliferation, cardiovascular disease

What is the Tea with the highest antioxidant benefits?

What is the Tea with the highest antioxidant benefits?

Black, green and white tea all originate from the Camellia senensis plant. There may be no actual ranking that levels these but here are the way each one effects your body:

Black Tea

Black tea is fully oxidized. During the process of oxidation, flavonoids called catechins are converted into tannins. The tannins are responsible for giving the tea its dark color. Even though black tea is more oxidized than other varieties, it still has a similar amount of antioxidants as it did before it was oxidized. Research suggests that drinking three or more cups a day may decrease the risk of heart attack, and drinking 4-5 cups may promote blood vessel relaxation.

Green Tea

Green tea is made from more mature leaves that are not fermented or oxidized. Most of the flavonoids in green tea are catechins, and one in particular is believed to be responsible for most of the health benefits in green tea. Green tea also contains a lot of polyphenols and has a lower caffeine content than black tea.

White Tea

White tea is very similar to green tea because it is made in the same way. The difference is that only the buds and young leaves of the plant are used. They are then dried in natural sunlight, which results in higher catechin levels but lower tannins levels. It’s believed that white tea has similar cardiovascular benefits as both black and green teas.

Oolong Tea

Oolong tea only goes through a short period of fermentation. These teas are said to have more polyphenols and a similar caffeine content to green and black teas, although slightly less.

Note: Black, green and white tea all originate from the Camellia senensis plant. Their differences come from the methods by which they are processed. The flavonoids found in tea, specifically catechins and tannins, have strong antioxidant properties.  you’re getting antioxidants like catechins and tannins that reduce the risk of cancer, improve the skin, enhance the immune system and promote good cardiovascular health. What you may want to consider instead is how much caffeine you want from the tea and your own personal taste preferences.

 

Related questions:

What are antioxidants in green tea?

Green tea substance with antioxidant benefits?

Is all tea types the same in antioxidants?

The strongest tea in antioxidants?

Is green tea beneficial?

What are green tea health benefits?

 

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Read more about antioxidants

Read More about Anti aging

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Keywords: Green tea catechins, dyslipidemia, oxidative stress, inflammation, endothelial cells, platelets, proliferation, cardiovascular disease

How much antioxidants in green tea???

How much antioxidants in green tea???

 

Green tea has Catechins. Catechins, the major polyphenolic compounds in green tea, exert vascular protective effects through multiple mechanisms, including antioxidative, anti-hypertensive, anti-inflammatory, anti-proliferative, anti-thrombogenic, and lipid lowering effects.   Tea catechins present antioxidant activity by scavenging free radicals, chelating redox active transition-metal ions, inhibiting redox active transcription factors, inhibiting pro-oxidant enzymes and inducing antioxidant enzymes. Green Tea catechins inhibit the key enzymes involved in lipid biosynthesis and reduce intestinal lipid absorption, thereby improving blood lipid profile. Catechins regulate vascular tone by activating endothelial nitric oxide. continue to green tea

 

Related questions:

What are antioxidants in green tea?

Green tea substance with antioxidant benefits?

Is green tea beneficial?

What are green tea health benefits?

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Read more about antioxidants

Read More about Cancer

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Keywords: Green tea catechins, dyslipidemia, oxidative stress, inflammation, endothelial cells, platelets, proliferation, cardiovascular disease

How do antioxidants reduce the risk of cancer?

How do antioxidants reduce the risk of cancer?

Can antioxidants prevent cancer or cur or stop? Strong and Considerable laboratory evidence from chemical, cell culture, and animal studies indicates that antioxidants may slow or possibly prevent the development of cancer. However, information from recent clinical trials is less clear. In recent years, large-scale, randomized clinical trials reached inconsistent conclusions. There is also some doubts on the fact that if the antioxidant supplements work the same as natural foods. But we should be clear. Cancer cells when they are out there and being increased antioxidants do play important role as slowing down but main thing that is associated with antioxidant is prevention and not letting it happen in the first place. which means a healthy diet should be considered by every one before cancer happens.

 

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What Foods have the highest antioxidants benefits?

What Foods have the highest antioxidants benefits?

  1. Goji berries25,000 ORAC score
  2. Wild blueberries14,000 ORAC score
  3. Dark chocolate21,000 ORAC score
  4. Pecans: 17,000 ORAC score
  5. Artichoke: 9,400 ORAC score
  6. Elderberries: 14,000 ORAC score
  7. Kidney beans8,400 ORAC score
  8. Cranberries9,500 ORAC score
  9. Blackberries5,300 ORAC score
  10. Cilantro: 5,100 ORAC score

Read the full list here : Strongest Antioxidant rank list

 

Related questions:

What Foods have the highest antioxidants benefits?

Green tea substance with antioxidant benefits?

What is the strongest antioxidant?

What is the highest antioxidant food?

The strongest tea in antioxidants?

What is the Strongest antioxidants in berries?

 

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Keywords: Green tea catechins, dyslipidemia, oxidative stress, inflammation, endothelial cells, platelets, proliferation, cardiovascular disease

How do antioxidants work?

How do antioxidants work?

Antioxidants are both produced by the body and obtained through foods. The are a critical part of the body’s powerful chemical defense system. To understand them, it’s important to know something about oxidation and why its bad for body. In cells, oxygen is constantly involved in chemical reactions in which electrons (charged atomic particles) are shifted around. This makes changes to chemical qualities of different substances in out body cells. It start destructing and making inflammations and making illnesses. The main thing that antioxidants do is to make free radicals that are unstable, stable. That make your bodies metabolism work very smoothly.

 

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What are antioxidants?

What are antioxidants?

Antioxidant
an·ti·ox·i·dant
an(t)ēˈäksədənt,ˌanˌtīˈäksədənt/

“a substance that inhibits oxidation, especially one used to counteract the deterioration of stored food products. a substance that removes potentially damaging oxidizing agents in a living organism.” Antioxidants may play a role in the management or prevention of some medical conditions, inflammations, illnesses, pains, such as some cancers, macular degeneration, Alzheimer’s disease, and some arthritis-related conditions.

 

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Cognitive decline and the best foods used to stop it!

Cognitive decline and the best foods used to stop it!

Antioxidant compounds, contained in fruit, vegetables and tea, have been postulated to have a protective effect against age-related cognitive decline by combating oxidative stress. However, recent research on this subject has been conflicting. here are some basic point about CD and Aging and the main focus of this Article is on foods that Helps us fight CD.

About Cognitive Decline (What is Cognitive Decline?):

If you have Cognitive Decline or cognitive impairment, you may be aware that your memory or mental function has “slipped.” Your family and close friends also may notice a change. But generally these changes aren’t severe enough to significantly interfere with your day-to-day life and usual activities.

When anyone makes some tea or use computer or even read a book, that person it utilizing the cognitive capacities. Cognitive capacities are the mental aptitudes that you have to carry from the easiest to the most perplexing task. These mental abilities incorporate mindfulness, memory, information handling and thinking. As our age increases, the cognitive abilities continuously break down. A specific sum of cognitive decrease is a typical thing in maturing. A few people may encounter an extreme crumbling in psychological abilities, prompting dementia. This can make it difficult to adapt to customary everyday tasks. In order to get rid or avoid such problems, below are some foods that can be utilized.

Mild cognitive impairment may increase your risk of later progressing to dementia, caused by Alzheimer’s disease or other neurological conditions. But some people with mild cognitive impairment never get worse, and a few eventually get better.

 

About Cognitive Decline (What is Cognitive Decline?):

 

Cognitive disorders like CD are a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium. While anxiety disorders, mood disorders, and psychotic disorders can also have an effect on cognitive and memory functions. Cognitive Decline is generally happening to all while aging but we dont really notice that. we get old and our abilities and awareness reduces but we dont understand maybe others do.

Cognitive decline is categorized under dementia in Mental disorders. For dementia cases, studies suggest that diets with high Omega 3 content, low in saturated fats and sugars, along with regular exercise can increase the level of brain plasticity and BDNF. Other studies have shown that mental exercise such a newly developed “computerized brain training programs” can also help build and maintain targeted specific areas of the brain.

Findings from some studies suggest that intakes of vitamin C and E that significantly exceed adequate or recommended intakes (over 130 and 15 mg/day for vitamin C and E, respectively) may be beneficial . This is in slight contrast to a very thorough review of vitamin C, cognitive decline and AD by Harrison , who concluded that a healthy, long-term diet in which adequate vitamin C levels are maintained and vitamin deficiency is avoided may protect against age-related cognitive decline and AD, and be more beneficial than taking supplements. (source & source & Source )

 

About Cognitive Decline (What is Cognitive Decline?):

 

 

Foods that are best to Slow down & stop Cognitive Decline caused by aging:

Green Tea:

Green Tea, Antioxidant effects and benefits

Green tea is on the top of the list in the skin friendly drinks due to its noteworthy storage facility of polyphenols that can cause aging. Having four glasses each day can give amazing results by fighting against aging elements in human body.

 

• GINGER ROOT:

Ginger (root) Unique health benefits & Antioxidant effects

Grated and ground ginger in two wooden spoons ginger root green leaves on the wooden board

Ginger and turmeric are from the same basic family of plants. Health benefits of turmeric is largely mentioned in many articles. But now ginger. Ginger is a Southeast Asian plant. The spice ginger is the underground rhizome of the ginger plant, known botanically as Zingiber officinale. Ginger is used as a spice and medicine.

•  TURMERIC:

Turmeric (Curcumin) Anti-inflammatory & Antioxidant Keeps you young

different types of turmeric barks

Health benefits of turmeric is largely mentioned in many articles. Turmeric is known for improving conditions for arthritis, heartburn (dyspepsia), joint pain, stomach pain, Crohn’s disease and ulcerative colitis, bypass surgery, hemorrhage, diarrhea, intestinal gas, stomach bloating, loss of appetite, stomach ulcers an so on.

•  Sage:

Sage, just a mint or strong antioxidants and Anti-Inflammatory

Sage is an herb, a mint. The leaf is used to make medicine. Sage contains rosmarinic acid, rosmarinic acid is a potent antioxidant and an anti-inflammatory agent. Rosmarinic acid reduces harmful inflammation.

Salmon:

Fish oil, DHA & EPA & OMEGA 3-6-9 Antioxidants and benefits

Raw red fish

Salmon contains astaxanthin which works amazingly on skin and enhances the elasticity of skin by decrease the number of fine lines and wrinkles.  astaxanthin is by some researches considered as the strongest antioxidant ever found.

• Fish and fish oil:

Fish oil, DHA & EPA & OMEGA 3-6-9 Antioxidants and benefits

According to the researchers after several researches, the phenomenal measure of fish they take keeps that away from dangerous heart diseases and cancer. Fish is a copious wellspring of omega-3 fats, which help avert cholesterol development in the arteries and secure against irregular heart rhythms.

•  Olive Oil & Olive extracts:

vitamin-e Unique health benefits & Antioxidant effects

Forty years back, analysts from the Seven Countries Study revealed that the monounsaturated fats found in the olive oil were to a great extent, reason of the low rates of coronary illness and cancer. Presently, the studies  indicated that olive oil additionally contains poly-phenols, effective cancer prevention agents that may help forestall age-related infections.

•  Berries:

Cranberry Strong Antioxidant Effects

All Berries, especially members of some important families, like Rosaceae (strawberry, raspberry, blackberry), and Ericaceae (blueberry, cranberry), belong to the best dietary sources of bioactive compounds (BAC). Because of the antioxidant properties of BAC, they are of great interest also for nutritionists and food technologists due to the opportunity to use BAC as functional foods ingredients. The bioactive compounds in berries contain mainly phenolic compounds (phenolic acids, flavonoids, such as anthocyanins and flavonols, and tannins) and ascorbic acid.

•  MATCHA:

Green Tea, Antioxidant effects and benefits

Matcha is basically green tea leaves that have been stone ground and processed into a powder. The powder is then filtered and raced with boiling water. Due to the difficult procedure required to deliver matcha, the tea is for the most part expensive than others.

OLIVE LEAF

branch of green olives antioxidant benefits

branch of green olives

If you are going to consider getting Olive leaf (extracts) you should know based on the studies these are the situations that it has been proven that Olive leaf (extracts) can improve.
Lowers Blood Pressure, Improves Cardiovascular Health, Diabetes, Reduces the Risk of Cancer and so on.

 

• Eggs:

Protein (amino acids) repairs all those cells that have endured the damage from free radical. Eggs, an amazing source of protein, likewise contain biotin which is an essential vitamin that protect the body from free radicals.

• Pomegranate:

The antioxidant rich fruit may help skin to make more collagen and can also help in speeding healing. The essential nutrients in it help making the skin look fresh and glower and it works amazingly as an anti aging food.

• Beans:

Beans are another protein source. They help repair cells that have endured the free radical damage. During digestion, protein separates into amino acids, the building squares of cells which further help to speed as well as repair and regenerate the skin cells along with collagen.

• Chocolate coco powder:

If dietary phenolics are active in-vivo antioxidants, chocolate can contribute a significant portion of dietary antioxidants, and the pleasant pairing of red wine and dark chocolate could have synergistic advantages beyond their complementary tastes. According to a study, the people who live in Kuna in the San Blas islands near panama, have a rate of heart illness that is a great percent less than those of Panamanians. The Kuna people, in order to stay away from heart diseases, drink a lot of a refreshments made with liberal extents of chocolate, which is bizarrely rich in flavanols that help protect the sound capacity of veins. Keeping up young veins and fights aging.

•  Watermelon:

The reviving and sweet treat contains a definitive cancer prevention agent, vitamin C, in addition to lycopene as well as potassium, which controls the adjust of water and supplements in cells and makes individuals look healthy and young.

• Dark Chocolate:

The sweet chocolate is rich in cocoa flavanols, plant compounds as well as the effective & strong antioxidant properties, which help hydrate skin and enhance circulation.

• Walnuts:

It’s the only kind of nut that contains a significant amount of unsaturated fats, which is particularly important for vegetarians who are not able to eat fish. Walnuts pack an omega-3 called alpha-linolenic corrosive. Deficiency in this fat can bring about dermatitis, which is related with dry, flaky skin. So, having walnuts will make the skin fresh, and young.

• Citrus fruits peel:

Analysts from the University of Arizona took a gander at individuals who stated that they ate citrus fruits, squeezes, and peels each week. Individuals, who ate peels such as orange peel or lemon juice, had a 33% diminished hazard for “squamous cell carcinoma”. Juices and fruit didn’t have any impact. Limonene is a compound found in the oil in the peels that offers the UV-defensive benefits and makes the skin look great.

• Walnuts:

Walnuts are stuffed with healthy as well as anti inflammatory supplements, and are the main great nut source of alpha linolenic corrosive. They help advance blood stream, which thusly takes into consideration a great delivery of oxygen to the cerebrum. What’s more, a study found that mice with the infection that were routinely nourished walnuts had enhanced memory, learning and function ability coordination.

• Coffee:

Caffeine, the gentle stimulant found in coffee actually enhances mental acuity. Beside caffeine’s mind boosting impacts, caffeine’s cell reinforcement lavishness keeps up the mental health. Also, some exploration recommends that drinking coffee can really fight with depression and anxiety in ladies and can stop cognitive decline.

• Blueberries:

Incredible things do come in little bundles, blueberries are a natural product few attempt to eat each and every. That is on the grounds that they have such a variety of extraordinary medical advantage ­while having an aftertaste like a great treat. It’s one of the most astounding cell reinforcement rich sustenance known to man, including vitamin C and vitamin K and fiber. As a result of their elevated amounts of Gallic acid, blueberries are particularly great at shielding our brains from degeneration, stress and cognitive decline.

• Broccoli:

It’s one of the best foods to improve brain health. On account of its elevated amounts of vitamin K and choline, it will help keep your memory sharp.

• Coconut oil:

It is a standout among the most flexible and bravo nourishments for brains out there. With 77 coconut oil uses and cures, there’s nothing that coconut oil can’t help. What’s more, with regards to your mental health it’s loaded with other advantages, as well. Coconut oil functions as a characteristic calming, stifling cells in charge of aggravation. It can help with memory misfortune as a person becomes older and kills terrible microbes that hang out in the guts. Hence, it’s great to stop cognitive decline in human.

• Egg Yolks:

Egg yolks contain a lot of choline, which helps in fetal mental health for pregnant ladies. It additionally separates bethane, a synthetic that produces hormones identified with bliss and fight against cognitive decline. The eggs can really make an individual happy and keep the mental health great.

• Spinach:

Spinach is rich in antioxidants, which is thought to fight against cognitive decline. What’s more, a study found that ladies who revealed eating the most verdant green and cruciferous vegetables had an especially decreased rate of cognitive decline as contrasted with the individuals who ate the minimum.

• Tomatoes:

A study found that lycopene-rich tomato helped participants prevent sunburn when they combined it with olive oil and use it for ten weeks without missing any day. Other than being an extraordinary source of strong antioxidant lycopene, tomatoes are considered a high carotenoid fruit. These nutrients may help to get rid from free radicals that can cause many diseases including aging.

 

 

 

Some good sources for cognition Decline:

http://www.mayoclinic.org/diseases-conditions/mild-cognitive-impairment/home/ovc-20206082

https://link.springer.com/article/10.1007%2Fs11130-013-0370-0

https://en.wikipedia.org/wiki/Cognitive_disorder

 

cranberry strong antioxidant effects, benefits and sideffects

Ginger (root) Unique health benefits & Antioxidant effects

Vitamin C, An antioxidant our body needs to stay healthy & prevent cancer

Olive leaf (extracts) One of the strongest antioxidants found

Olive leaf Extract One of the strongest antioxidants found, about Olive leaf Extract antioxidant benefits

Research in progress                        

Other Names of olive tree:
Acide Gras Insaturé, Acide Gras Mono-Insaturé, Acide Gras n-9, Acide Gras Oméga 9, Common Olive, Extra Virgin Olive Oil, Feuille d’Olivier, Green Olive, Huile d’Assaisonnement, Huile d’Olive

Introduction to Olive leaf extract benefits

Olive oil is has been known and used to prevent heart attack and stroke (cardiovascular disease), breast cancer, colorectal cancer, rheumatoid arthritis, and migraine headache. But Olive leaf extract comes from the leaves of olive tree, and is much different from Olive Oil. the olive leaf contains phenolics such as oleuropein, It has shown that it has protective effects against LDL oxidation also  benefits glucose metabolism for diabetes and skin health. Olive leaf is used as immune system boost for treating viral, bacterial, and other infections including influenza, swine flu, herpes, shingles, HIV/ARC/AIDS, and hepatitis B, pneumonia; chronic fatigue: tuberculosis (TB); gonorrhea; fever; malaria; dengue and infections in the teeth, ears, and urinary tract, and infections following surgery. Some Other also use it for high blood pressure, diabetes, hay fever, improving kidney and digestive function. Olive leaf kills and /or resists the multiplication of viruses, bacteria, yeasts, fungi, and other parasites in body. The olive leaf extract differ from immune boosters in that immune boosters tha stimulate your immune system to destroy disease which still requires your own energy. Olive leaf extract mainly does the work for you. it is not a supplementary for immune system it is like a parallel procedure.

vitamin-e Unique health benefits & Antioxidant effects

Proven Olive Leaf Benefits

I you are going to consider getting Olive leaf (extracts) you should know based on the studies these are the situations that it has been proven that Olive leaf (extracts) can improve.
  • Lowers Blood Pressure
  • Improves Cardiovascular Health
  • Diabetes
  • Reduces the Risk of Cancer
  • Improves Brain Function
  • Treats Arthritis
  • Kills Bacteria and Fungi
  • Improves Immune System
  • Protects Skin
  • More energy
  • Toothache relief
  • Diminished food cravings
  • Joint pain relief
  • Heartbeat regulation
  • Improved wound healing

 

branch of green olives antioxidant benefits

branch of green olives

Cancer and Olive leaf (extracts)

The Mediterranean diet which includes olive is renowned for its ability to reduce the risk of cancer as some researches say.  While numerous aspects of the diet contribute to this risk reduction, there’s growing evidence that olive oil and leaf extract contains phenolics such as oleuropein that are key components of the diet’s anti-cancer effects. Oleuropein and olive leaf extracts have numerous other mechanisms of action against cancer: They can prevent inflammation,  inflammation is another major promoter of tumor growth and olive leaf extracts are strong in fighting  inflammations.
In breast cancer cells specifically, oleuropein reduces malignant cells’ ability to respond to estrogen, the female hormone that many breast cancer cells depend on for their survival. Oleuropein stops production growth factor and the “protein-melting” enzymes that cancer cells need in order to invade healthy tissues.

Neuroprotection of Olive leaf (extracts)

Olive extracts help protect the brain neural system from the destruction brought on by age-related degenerative conditions such as Alzheimer’s and Parkinson’s diseases.  Olive extracts suppress the inflammations and reduce the damage done by oxidative stress in body cells, we did mention what oxidative stress is and how antioxidants tend to stop it from damaging our body, read more about that in our full article about Antioxidants.
Researchers found that if  the possible stroke patients be pre-treated by olive  extracts they can greatly reduce the damage after stroke. cause basically after a normal blood flow comes back after the stroke the damage gets worse. But olive extracts has shown that they change the atmosphere of the system so the come back is not that dangerous. Microscopic examination of brain tissue showed up to a 55% decrease in the volume of dying brain tissue after strokes that were pre-treated by olive extracts. Brain damages and inflammations in brain all lead to more dying neurons and cells that will lead to creating more tangles. tangles are one of the two main reasons and causes in brain aging. so Olive extracts generally work as a nice anti-age supplement.

branch of green olives antioxidant benefits

POLYPHENOLIC ANTIOXIDANTS & Olive leaf (extracts)

Polyphenolic antioxidants can help to slow down ageing by reducing cell degradation and assist in the prevention of a number of degenerative diseases. Polyphenolic antioxidants are best known in the scientific and medical communities for their ability to neutralize free radicals. The most studied polyphenolic antioxidants in Olive Leaf.
OLIVE EXTRACTS INTERACTIONS 
Moderate Interaction Be cautious with this combination
  • Medications for diabetes (Antidiabetes drugs) interacts with OLIVE
  • Medications for high blood pressure (Antihypertensive drugs) interacts with OLIVE
 

Useful Website sources and articles on Vitamin E and its benefits:


 
 
 
 
 
Phenolic compounds and antioxidant activity of olive leaf extracts.
 
 
 
 
 
 
 
 
Papers and articles for reading and references about Olive leaf (extracts):
 
 
Available at: http://www.tesisenred.net/bitstream/handle/10803/7208/tvk.pdf?sequence=1#page=30. Accessed March 8, 2013.
 
Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010;78(2):133-54.
 
Wahle KW, Caruso D, Ochoa JJ, Quiles JL. Olive oil and modulation of cell signaling in disease prevention. Lipids.2004 Dec;39(12):1223-31.
 
Waterman E, Lockwood B. Active components and clinical applications of olive oil. Altern Med Rev. 2007 Dec;12(4):331-42.
 
Hamdi HK, Castellon R. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Biophys Res Commun.2005 Sep 2;334(3):769-78.
 
Ribeiro Rde A, Fiuza de Melo MM, De Barros F, Gomes C, Trolin G. Acute antihypertensive effect in conscious rats produced by some medicinal plants used in the state of Sao Paulo. J Ethnopharmacol.1986 Mar;15(3):261-9.
 
Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. J Ethnopharmacol.2003 Feb;84(2-3):299-305.
 
Khayyal MT, el-Ghazaly MA, Abdallah DM, Nassar NN, Okpanyi SN, Kreuter MH. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung.2002;52(11):797-802.
 
Cherif S, Rahal N, Haouala M, et al. A clinical trial of a titrated Olea extract in the treatment of essential arterial hypertension. J Pharm Belg. 1996 Mar-Apr;51(2):69-71.
 
Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, Aydogan C. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res. 2008 Sep;22(9):1239-42.
 
Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine.2011 Feb 15;18(4):251-8.
 
Available at: http://www.rxlist.com/capoten-drug.htm. Accessed March 11, 2013.
 
Scheffler A, Rauwald HW, Kampa B, Mann U, Mohr FW, Dhein S. Olea europaea leaf extract exerts L-type Ca(2+) channel antagonistic effects. J Ethnopharmacol.2008 Nov 20;120(2):233-40.
 
Gilani AH, Khan AU, Shah AJ, Connor J, Jabeen Q. Blood pressure lowering effect of olive is mediated through calcium channel blockade. Int J Food Sci Nutr.2005 Dec;56(8):613-20.
 
Zare L, Esmaeili-Mahani S, Abbasnejad M, et al. Oleuropein, chief constituent of olive leaf extract, prevents the development of morphine antinociceptive tolerance through inhibition of morphine-induced L-type calcium channel overexpression. Phytother Res. 2012 Nov;26(11):1731-7.
 
Visioli F, Bellosta S, Galli C. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci. 1998;62(6):541-6.
 
Rocha BS, Gago B, Barbosa RM, Laranjinha J. Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology.2009 Nov 9;265(1-2):41-8.
 
Palmieri D, Aliakbarian B, Casazza AA, et al. Effects of polyphenol extract from olive pomace on anoxia-induced endothelial dysfunction. Microvasc Res. 2012 May;83(3):281-9.
 
Scoditti E, Calabriso N, Massaro M, et al. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys. 2012 Nov 15;527(2):81-9.
 
Dell’Agli M, Fagnani R, Galli GV, et al. Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling. J Agric Food Chem. 2010 Feb 24;58(4):2246-52.
 
Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem Biol Interact. 2008 Nov 25;176(2-3):88-98.
 
Visioli F, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sci. 1994;55(24):1965-71.
 
Masella R, Vari R, D’Archivio M, et al. Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J Nutr.2004 Apr;134(4):785-91.
 
Wang L, Geng C, Jiang L, et al. The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis. Eur J Nutr. 2008 Aug;47(5):235-43.
 
Impellizzeri D, Esposito E, Mazzon E, et al. The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. Clin Nutr. 2011 Aug;30(4):533-40.
 
Carluccio MA, Siculella L, Ancora MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):622-9.
 
Turner R, Etienne N, Alonso MG, et al. Antioxidant and anti-atherogenic activities of olive oil phenolics. Int J Vitam Nutr Res. 2005 Jan;75(1):61-70.
 
Dell’Agli M, Fagnani R, Mitro N, et al. Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation. J Agric Food Chem. 2006 May 3;54(9):3259-64.
 
Singh I, Mok M, Christensen AM, Turner AH, Hawley JA. The effects of polyphenols in olive leaves on platelet function. Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):127-32.
 
Zbidi H, Salido S, Altarejos J, et al. Olive tree wood phenolic compounds with human platelet antiaggregant properties. Blood Cells Mol Dis. 2009 May-Jun;42(3):279-85.
 
Wainstein J, Ganz T, Boaz M, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food. 2012 Jul;15(7):605-10.
 
Gonzalez M, Zarzuelo A, Gamez MJ, Utrilla MP, Jimenez J, Osuna I. Hypoglycemic activity of olive leaf. Planta Med. 1992 Dec;58(6):513-5.
 
Al-Azzawie HF, Alhamdani MS. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci. 2006 Feb 16;78(12):1371-7.
 
Jemai H, El Feki A, Sayadi S. Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats. J Agric Food Chem. 2009 Oct 14;57(19):8798-804.
 
Eidi A, Eidi M, Darzi R. Antidiabetic effect of Olea europaea L. in normal and diabetic rats. Phytother Res. 2009 Mar;23(3):347-50.
 
Poudyal H, Campbell F, Brown L. Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J Nutr. 2010 May;140(5):946-53.
 
Simon D, Balkau B. Diabetes mellitus, hyperglycaemia and cancer. Diabetes Metab. 2010 Jun;36(3):182-91.
 
Kontou N, Psaltopoulou T, Soupos N, et al. Metabolic syndrome and colorectal cancer: the protective role of Mediterranean diet–a case-control study. Angiology. 2012 Jul;63(5):390-6.
 
Verberne L, Bach-Faig A, Buckland G, Serra-Majem L. Association between the Mediterranean diet and cancer risk: a review of observational studies. Nutr Cancer. 2010;62(7):860-70.
 
Anter J, Fernandez-Bedmar Z, Villatoro-Pulido M, et al. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutat Res. 2011 Aug 16;723(2):165-70.
 
Corona G, Deiana M, Incani A, Vauzour D, Dessi MA, Spencer JP. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem Biophys Res Commun. 2007 Oct 26;362(3):606-11.
 
Kimura Y, Sumiyoshi M. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. J Nutr. 2009 Nov;139(11):2079-86.
 
Sirianni R, Chimento A, De Luca A, et al. Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation. Mol Nutr Food Res. 2010 Jun;54(6):833-40.
 
Menendez JA, Vazquez-Martin A, Oliveras-Ferraros C, et al. Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. Int J Mol Med. 2008 Oct;22(4):433-9.
 
Goulas V, Exarchou V, Troganis AN, et al. Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res. 2009 May;53(5):600-8.
 
Abdel-Hamid NM, El-Moselhy MA, El-Baz A. Hepatocyte lysosomal membrane stabilization by olive leaves against chemically induced hepatocellular neoplasia in rats. Int J Hepatol. 2011;2011:736581.
 
Fares R, Bazzi S, Baydoun SE, Abdel-Massih RM. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract. Plant Foods Hum Nutr. 2011 Mar;66(1):58-63.
 
Grawish ME, Zyada MM, Zaher AR. Inhibition of 4-NQO-induced F433 rat tongue carcinogenesis by oleuropein-rich extract. Med Oncol. 2011 Dec;28(4):1163-8.
 
Acquaviva R, Di Giacomo C, Sorrenti V, et al. Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol. 2012 Jul;41(1):31-8.
 
Mohagheghi F, Bigdeli MR, Rasoulian B, Hashemi P, Pour MR. The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia. Phytomedicine. 2011 Jan 15;18(2-3):170-5.
 
Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J. Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. 2007 Feb;49(2):93-102. Epub 2006 Dec 20.
 
Dekanski D, Selakovic V, Piperski V, Radulovic Z, Korenic A, Radenovic L. Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils. Phytomedicine.2011 Oct 15;18(13):1137-43.
 
Khalatbary AR, Ahmadvand H. Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurol Res. 2012 Jan;34(1):44-51.
 
Bazoti FN, Bergquist J, Markides KE, Tsarbopoulos A. Noncovalent interaction between amyloid-beta-peptide (1-40) and oleuropein studied by electrospray ionization mass spectrometry. J Am Soc Mass Spectrom. 2006 Apr;17(4):568-75.
 
Daccache A, Lion C, Sibille N, et al. Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem Int. 2011 May;58(6):700-7.
 
Rigacci S, Guidotti V, Bucciantini M, et al. Abeta(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon. Curr Alzheimer Res. 2011 Dec;8(8):841-52.
 
Flemmig J, Kuchta K, Arnhold J, Rauwald HW. Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. Phytomedicine.2011 May 15;18(7):561-6.
 
Impellizzeri D, Esposito E, Mazzon E, et al. Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in mice. J Pharmacol Exp Ther.2011 Dec;339(3):859-69.
 
Gong D, Geng C, Jiang L, Wang L, Yoshimura H, Zhong L. Mechanisms of olive leaf extract-ameliorated rat arthritis caused by kaolin and carrageenan. Phytother Res. 2012 Mar;26(3):397-402.
 
Olive leaf. Monograph. Altern Med Rev. 2009 Mar;14(1):62-6.

Matcha green-tea New trending tea that burns fat and kills cancer

What are Carotenoids antioxidant effects

What are Carotenoids antioxidant effects

essential_carotenoids benefits as an antioxidant

Research in progress                           

ALA, ALPHA – LIPOIC ACID, Antioxidant & anti-Inflammatory your body needs

ALA, ALPHA – LIPOIC ACID Antioxidant & anti-Inflammatory 



Other Names for ALPHA – LIPOIC ACID : 
Acetate Replacing Factor, A-Lipoic Acid, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque, Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque


 Introduction to ALPHA – LIPOIC ACID or ALA


Alpha-lipoic acid is a substance made by the body. It is found in every body cell, where it helps turn glucose into energy. Alpha-lipoic acid is a vitamin-like chemical and an antioxidant. ALPHA – LIPOIC ACID or ALA can be found in Yeast, liver, kidney, spinach, broccoli, and potatoes. It is also made in the laboratory for use as medicine.  
Alpha-lipoic acid is used to break down carbohydrates in body and use the energy for organs in the body. Alpha-Lipoic Acid (ALA) is a mitochondrial fatty acid that is highly involved in energy metabolism as mentioned mostly for carbohydrates. ALA has shown benefit against various forms of oxidation and inflammation some part of this is because ALA resets the cycle of vitamin E & C.


ALPHA - LIPOIC ACID

ALA, ALPHA – LIPOIC ACID is Known for:


Alpha-lipoic acid helps prevent certain kinds of cell damage in the body. It also restores vitamin levels such as vitamin E and vitamin C in their cycles so they would work again as an antioxidant in their cycles and this reduces body need of antioxidants. There are some evidence that alpha-lipoic acid can improve the function and conduction of neuron cells in diabetes. ALA antioxidant benefits might also be helpful in liver diseases. 

ALA is know to be used to improve these conditions:

  • Coronary artery bypass graft (CABG) surgery.
  • Diabetes. 
  • Prediabetes. 
  • Diabetic nerve pain. 
  • Vitiligo. 
  • Weight loss. 1800 mg of alpha-lipoic acid daily for 20 weeks.
  • Wound healing. 
  • Alcoholic liver disease. 300 mg of alpha-lipoic acid daily for up to 6 months
  • Alzheimer’s disease. 600-900 mg of alpha-lipoic acid daily for up to 2 years
  • Heart-related nerve problems 
  • Damage to the retina caused by diabetes
  • HIV-related brain problems.
  • Rheumatoid arthritis.  300 mg of alpha-lipoic acid by mouth daily for 12 weeks 



Get ALA for: 


ALA is known to improve the following :

  • Diabetes
  • Cancer
  • Anti-Aging
  • Weight Loss
  • Pain
  • EYE health
  • Nerve Repair
  • Blood Pressure
  • liver disease
  • Heart-related nerve problems
  • Weight loss
  • Cardiovascular 
  • Immune system
  • HIV
  • Inflammatory and pain
  • Neuro-degenerative diseases
  • Cognition decline
  • Autoimmune diseases (rheumatoid arthritis)
  • Joint health
  • Motion Sickness
  • Arthritis
  • Damaging nerves system 
  • Treatment of Dementia
  • Alzheimer’s disease
  • High cholesterol
  • Healthier Arteries




Get ALA naturally:


Main natural sources of ALA ALPHA – LIPOIC ACID

  • Broccoli
  • Spinach
  • Red meat
  • Organ meat (sch as liver, hearts, kidneys from beef or chicken)
  • Brussel sprouts
  • Tomatoes
  • Peas
  • Brewer’s yeast
  • Beets
  • Carrots


ALPHA - LIPOIC ACID



ALA ALPHA – LIPOIC ACID is Both water and fat soluble and found in many natural foods meats, and plants. It can be in a protein bound or in other forms. 
This list is for  lipoyllysinem, the protein-bound form.

Food Dry Weight (mg/g) Protein (ng/g)
1. spinach 3.15 92.51
2. bovine (cow) kidney 2.64 50.57
3. bovine (cow) heart 1.51 41.42
4. broccoli 0.94 41.01
5. tomato 0.56 48.61
6. green pea 0.39 17.13
7. brussel sprouts 0.39 18.39
8. bovine (cow) spleen 0.36 5.69
9. bovine (cow) brain 0.27 4.85
10. rice bran 0.16 4.44






Side Effects of ALA:


  • ALA, Alpha-lipoic acid is known as SAFE by mouth or when applied to the skin. the safe dosage is about the regular dose that can be found in natural sources like plants. 600 or 1200 mg daily.
  • Negative effects could occur with long term high-dosage supplementation. High-dose ALA supplementation is therefore not recommended.
  • People with diabetes should be careful to check their blood sugar levels because alpha-lipoic acid might lower blood sugar.
  • People taking alpha-lipoic acid by mouth might get some rash.
 


Interactions of ALA:

  • Medications for cancer (Chemotherapy) interacts with ALPHA-LIPOIC ACID.
  • Medications for diabetes (Antidiabetes drugs) interacts with ALPHA-LIPOIC ACID
  • Thyroid medications, Levothyroxine — Apha-lipoic acid may lower levels of thyroid hormone. 
  • Vitamin B1 (Thiamine) — Alpha lipoic acid can lower the level of vitamin B1 (Thiamine) in the body. This can be particularly dangerous in alcoholics.












Online sources for this article and good readings on ALA Alpha-lipoic acid:


draxe.com

webmd.com

examine.com

superfoodly.com

umm.edu


List of references and papers:

Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo. 2000;14(2):327-330.

Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149:841-9.

Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin. 1999;94 Suppl 3:84-89.

Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke. 2001;32(4):1000-1004.

Faust A, Burkart V, Ulrich H, et al. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice. Int J Immunopharmacol. 1994;16:61-66.

Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. 2001;6(2):141-166.

Hruby K, Csomos G, Fuhrmann M, Thaler H. Chemotherapy of Amanita phalloides poisoning with intravenous silibinin. Hum Exp Toxicol. 1983;2(2):183-195.

Ibrahimpasic K. Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med Arh. 2013; 67(1):7-9.

Lynch MA. Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue. Nutr Neurosci. 2001;4(6):419-438.

Melhem MF, Craven PA, Derubertis FR. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol. 2001;12:124-133.

Melhem MF, Craven PA, Liachenko J, et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol. 2002;13:108-116.

Melmed: Williams Textbook of Endocrinology, 12th ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2011.

Mitkov MD, Aleksandrova IY, Orbetzova MM. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv). 2013; 55(1):55-63.

Monograph:Alpha-Lipoic Acid. Altern Med Rev. 1998;3(4):308-311.

Nagamatsu M, Nickander KK, Schmelzer JD,et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.

Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17(10):888-895.

Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-linoic acis. Free Radic Biol Med. 1997;22:359-378.

Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Rad Bio Med. 1995;19(2):227-250.

Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V. Alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996;717(1-2):184-188.

Rakel D. Rakel Integrative Medicine, 3rd ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2012.

Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung. 1991;41:1294-1298.

Xu J, Gao H, Song L, et al. Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. Lipids Health Dis. 2013; 12:58.

Yoo TH, Lee JH, Chun HS, Chi SG. a-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kB induction of RPS6KA4. Anticancer Drugs. 2013; 24(6):555-65.

Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care. 2006;29:2365-70.

Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997;46 (suppl 2):S62-66.

Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999; 107:421-430.


Glutathione the mother of antioxidants, but how helpful can it really be as a supplement?

What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Introduction to Antioxidant

Antioxidant
an·ti·ox·i·dant
ˌan(t)ēˈäksədənt,ˌanˌtīˈäksədənt/

“a substance that inhibits oxidation, especially one used to counteract the deterioration of stored food products. a substance that removes potentially damaging oxidizing agents in a living organism.”
What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system
First thing that comes up in google search is what you see above. But what it really means that it removes potentially damaging oxidizing agents? what do the oxidizing agents do? what antioxidants do to them? how it helps our body with aging? how is it related to aging? Do antioxidants help your body in weight loss processes? How? Do they really keeps us young? are they same as anti-inflammatory substances? 



Lets take a closer look to the whole concept of Antioxidants.

It has been about 50 years only that even the word Antioxidant is being used. 

What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

The human body by its self naturally produces free radicals and the antioxidants to counteract their damaging effects, its something our body is aware of and has some solutions for it. However, in most cases, free radicals far outnumber the naturally occurring antioxidants and thats why we see that it could expedite aging and health issues. But what are free radicals? for a short answer: 

 What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Free Radicals and Oxidative Damage



Human body need oxygen for its chemical activities and in order to live. the simple act of breathing is the start of the formation of highly reactive molecules called free radicals. Free radicals interact with other molecules in the body as they are in blood and metabolism, they cause Oxidative Damage. 

What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system



Oxidative damage can result the development of a wide range of illnesses and diseases or increasing the possibility of illness by effecting the immune system. Oxidative stress occurs when the production of reactive oxygen is greater than the body’s ability to detoxify and clean the reactive intermediates. This imbalance as mentioned before leads to oxidative damage to proteins, molecules, and genes within the body. when proteins start being damaged means now all your body is in danger cause not only your muscles but all of cell’s functions even DNA functions are done by different kinds of protein. But the free radical intensity does not only depend on the body it self it depends a lot on many factor and behaviors that we  can control. Some external body causes could increase the free radicals and the damage they have on our body like:

  • Smoking (first or second hand)
  • Excessive exposure to UV rays
  • Pollution
  • Eating an unhealthy diet
  • Certain medications and/or treatments
  • Excessive exercise
  • Breathing deep and enough



What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system


How Free Radicals are Formed



Normally, in our body bonds dont lag, they dont split in a way that leaves a molecule with an odd (unstable condition or harmful situation), unpaired electron. But when weak bonds split, free radicals are formed. Free radicals are very unstable it means they can react and bond quickly with many potentialities and affect quickly the other compounds, trying to capture the needed electron to gain stability. 

Some internally generated sources of free radicals are:

  • Mitochondria
  • Xanthine oxidase
  • Peroxisomes
  • Inflammation
  • Phagocytosis
  • Arachidonate pathways
  • Exercise
  • Ischemia/reperfusion injury
  • Some externally generated sources of free radicals are:
  • Cigarette smoke
  • Environmental pollutants
  • Radiation
  • Certain drugs, pesticides
  • Industrial solvents
  • Ozone


Generally, free radicals attack (try to bond and become stable) the nearest stable molecule, “stealing” its electron. When the “attacked” molecule loses its electron, it becomes a free radical itself and causing this in a mass scale in body by beginning a chain reaction. Once the process is started, it can cascade, finally resulting in the disruption of a living cell. Cells are smallest stable and almost independent units in our body. every and each one of them are playing an important role in what an organ and bigger part does. It means they are independent but they also work as a team and they communicate, so if something goes wrong in one specially in RNA/DNA level it will spread. they communicate with substances and some other factors so many effects that free radicals have can be very local and at the same time in whole body.


What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Our body sometimes uses the free radicals. basically our body pretty much knows what they are and some free radicals arise normally during metabolism. Sometimes the body immune systems cells or white blood cells purposefully create them to neutralize viruses and bacteria, well that is as smart as it can get. However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also increase free radicals unnaturally. Usually The body handles free radicals, but if antioxidants are unavailable, or if the free-radical production becomes excessive, damage can occur. 


Of particular importance is that free radical damage accumulates with age. Yes aging can be expedited by free radicals. they make your body an unsafe place to live for cells. they interfere with metabolism and damage the immune system and their number one scary result can be cancer. 


Antioxidants Counteract Oxidative Stress and Free Radicals
The body is aware of its substances it naturally produces antioxidants like superoxide dismutase, catalase, or peroxidase enzymes, as a means of defending itself against free radicals. The antioxidants neutralize the free radicals, so makes them harmless to other cells. Antioxidants can repair damaged molecules in body by donating hydrogen atoms to them. Some antioxidants even have a chelating effect on free radical production that’s catalyzed by heavy metals. In this situation, the antioxidant contains the heavy metal molecules so strongly that the chemical reaction necessary to create a
free radical never occurs. When these kinds of antioxidants are water-soluble, it also causes the removal of the heavy metals from the body via the urine. for example Astaxanthin is in some cases considered nature’s most powerful antioxidant in foods and also available in pills and supplements now.



What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Different Types of Antioxidants

 

All the antioxidants are different and function different. Astaxanthin is actually a lipid-soluble antioxidant, while resveratrol is a water-soluble antioxidant And Each type of them function in its own way. antioxidants can be categorized in tow different ways, as a matter of fact three but molecular size is not an effective issue in terms of choosing what to take for you.


1. Antioxidants can be categorized basically in two categories:

 

Soluble in lipids/fat (hydrophobic) or water (hydrophilic). Both of them are neede in body in order to protect your cells. basically because body cells have both environments in them and as a matter of facts the interior of your cells and the fluid between them are composed of water, while the cell membranes themselves are mostly made of fat. The free radicals can strike both the watery cell contents or the fatty cellular membrane. Lipid-soluble antioxidants are the ones that protect your cell membranes from lipid peroxidation. Some examples of lipid-soluble antioxidants are vitamins A and E, carotenoids, and lipoic acid. Water-soluble antioxidants are found in aqueous fluids, like your blood and the fluids examples of water-soluble antioxidants are vitamin C, polyphenols, and glutathione.


2. They can also be categorized in another way as enzymatic and non-enzymatic antioxidants:


Enzymatic antioxidants benefit you by breaking down the structure of the free radicals and removing free radicals from your system. They can flush out dangerous oxidative products by converting them into hydrogen peroxide, then into water and gone you are free of free radicals.

Non-enzymatic antioxidants benefit you by interrupting free radical chain reactions that is another way to block them from damaging the whole environment. Some examples are carotenoids, vitamin C, vitamin E, plant polyphenols, and glutathione (GSH). Most antioxidants found in supplements and foods are non-enzymatic.



What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

 
What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune systemAstaxanthin has an especially high propensity for absorbing the excess energy from singlet oxygen, releasing it as heat, and returning the oxygen (and itself) back to its original state. This process is known as “quenching.”  Because of very different structures of all the molecules we call antioxidants the actual chemical procedure is different and the effectiveness and the way they can help the body is different. 

Why may Antioxidant Supplements do not work as well as foods Work?

Some Clinical and scientific studies of antioxidant supplements have not found them to be as effective as expected. Researchers have suggested several reasons:
 
> The Antioxidant beneficial health effects of a diet high in vegetables and fruits or other antioxidant-rich foods may actually be caused by other substances. that we dont know about them.
 
> Problem with doses. The effects of the large doses of antioxidants used in supplementation studies may be different from the smaller doses in natural foods.
 
> Differences in the chemical composition of antioxidants, For example, eight chemical forms of vitamin E are present in natural foods. but only two in Vitamin E supplements like alpha-tocopherol. Alpha-tocopherol also has been used in almost all research studies on vitamin E.


ALPHA - LIPOIC ACID What are Antioxidants & free-radicals? Antioxidants effects on aging, weight loss, Immune system

Good natural sources for Vitemin C, vitamin A and vitamin E as the most popular antioxidants:


Good Food Sources of Vitamin C (mg/serving)

Food
Amount
Vitamin C
Orange juice, fresh squeezed
1 cup
124
Grapefruit juice, fresh squeezed
1 cup
94
Papaya
1/2 medium
94
Cantaloupe
1/4 melon
86
Orange
1 medium
80
Green peppers, raw chopped
1/2 cup
67
Tomato juice
1 cup
44
Strawberries
1/2 cup
43
Broccoli, raw chopped
1/2 cup
41
Grapefruit
1/2 medium
40
Source: USDA Nutrient Database for Standard Reference Release 13
 

Good Food Sources of Vitamin E (mg/serving)

Food
Amount
Vitamin E
Almonds
1/4 cup
9.3 (13.9 IU)
Sunflower seeds
1/4 cup
5.8 (8.7 IU)
Safflower oil
1 tbsp
4.7 (7.0 IU)
Peanuts
1/4 cup
3.3 (4.9 IU)
Peanut butter
2 tbsp
3.2 (4.8 IU)
Corn oil
1 tbsp
2.8 (4.2 IU)

Good Food Sources of Vitamin A  


Food                                                      mcg RAE perserving    IU per serving   Percent DV*


Sweet potato, baked in skin, 1 whole        1,403               28,058         561

Beef liver, pan fried, 3 ounces                   6,5822             2,175          444
Spinach, frozen, boiled, ½ cup                  5731                1,458          229
Carrots, raw, ½ cup                                 459                  9,189          184
Pumpkin pie,  1 piece                              488                   3,743          249
Cantaloupe, raw, ½ cup                           135                   2,706          54
Peppers, sweet, red, raw, ½ cup               117                   2,332          47
Mangos, raw, 1 whole                              112                   2,240          45
Black-eyed peas (cowpeas),boiled, 1 cup   66                     1,305          26
Apricots, dried, sulfured, 10 halves            63                    1,261          25
Broccoli, boiled, ½ cup                              60                    1,208          24
Ice cream, French vanilla, soft serve, 1 cup 278                 1,014           20
Cheese, ricotta, part skim, 1 cup                263                  945             19
Tomato juice, canned, ¾ cup                     42                    821             16
Herring, Atlantic, pickled, 3 ounces            219                   731            15



Some important questions about antioxidants:

 


Where are antioxidants? 

 
They are naturally in foods and vegetables and fruits. some of them have more some less but still they are the best source comparing to supplements. Means eating fish regularly is better that fish oil supplements only. 
 

How can we get them? 

 
IN foods and vegetables and fruits. Also available in supplements. but in some cases it is better to take the natural option than just the pill.
 

Do natural sources work the same as supplements in terms of antioxidants? 

 
In some cases ye sand some no. 
 

What is the strongest antioxidant?

 
I n some cases they say its DHA fish oil and in some cases Astaxanthin in terms of effects in what part of cell or body. And in some cases olive extracts also has been mentioned. For example DHA in fish oils improve the brain plasticity/ BDNF and is the best in therms of brain aging. but it is different in all the body.
 

Is there a list of antioxidants?

 
Yes you can find a complete list of antioxidants in our website: antioxidants list
 

Antioxidants are effective more in natural forms like food or pills/ tablets/ supplements? 

 
The researches has shown that it depends on the issue and on the antioxidant substance. in some cases because of the different doses and absorbent quality the food id much better and in some cases it can be the same. 
 

What foods are high in antioxidants?

 
Fish, fish oils, vegetables, fruits and so on are the natural sources. there are also extracts in supplements that can do the job in some cases. 
 

What do antioxidants do? or what are the benefits of antioxidants ?

 
Just read the article please
 

Do antioxidants cure cancer? 

 
No, not exactly. but they can improve the symptoms and reduce the possibility of getting cancer.
 

Do antioxidants prevent cancer?

 
In many researches the free radicals are the ones causing cancer or increasing the chance to get cancer but if you get enough antioxidants for sure you are reducing the chance of cancer. it does apply to many cancer types but to all.
 

Are antioxidants the same as vitamins? 

 
Yes an some cases like vitamin E or C or A. but not all of them are considered as vitamins. 
 

 

Which diseases can be healed and/or cured by antioxidants?

It is not limited to these diseases or body conditions but these are the most associated ones with antioxidants

 

This can be a very small and useful list of them but in fact as mentioned antioxidants are substances fighting Degenerative Diseases effecting both immune system and DNA in many levels this list of Degenerative Diseases can also be considered.

Categorization of Degenerative Diseases

  • Neoplasms (divisions of mutated cells)

               – Examples:

                Cancer

                Tumor

  • Diseases of the Blood
  • Endocrine Diseases

                – Examples:

                 Thyroidism

  • Metabolic Syndrome (is a cluster of conditions – high blood pressure, high blood sugar, excess body fat (typically around the waist) and high level of bad cholesterol or low level of good cholesterol)

               – Examples:

                  Diabetes 

                  Hyperlipidemia (high level of fats in the blood)

                  Arteriosclerosis (thickening and hardening of artery walls)

                  Fatty Liver (build up of fats in the liver)

                  Hypertension (high blood pressure)

                  Obesity (being over weight)

  • Diseases of the Nervous System
  • Diseases of the Eye and Adnexa
  • Diseases of the Ear and Mastoid Process
  • Diseases of the Circulatory System
  • Diseases of the Respiratory System
  • Diseases of the Skin and Subcutaneous Tissue
  • Diseases of the Musculoskeletal System and Connective Tissue
  • Diseases of the Genitourinary System
  • Ischemia (restriction or cut-off of blood supply)/reperfusion (restoration of blood supply) injuries

                – Examples:

                   Cerebral Infraction (stroke caused by blockage)

                   Myocardial infraction (heart attack)

                   Organ transplant 

                   Post Cardiac Arrest (resuscitated heart after the heart stopped)

  • Mitochondrial Diseases
  • Aging

                – Examples:

                   Wrinkles,

                   Freckles

  • Hemodialysis

                – Examples:

                   Cystisis

  • Inflammation

                – Examples:

                  Rhematoid arthritis

                  Wound healing

                  Bowel disease

  • Neuroprotection

                – Examples:

                   Dementia

                   Parkinson Disease

                   Depression

  • Medication Induced

               – Examples:

                  Anesthetia

                  Radiatheraphy

                 Chemotheraphy

  • Stress Induced

               – Examples:

                 Exercise

                 Fatigue

Antioxidants Also Combat Infectious Diseases in basically two main ways:


1- Building or maintaining very healthy immune cells to fight the invasion
2- Countering the cell damages caused by the invasions/infections

 
And this is a good list of diseases caused by infections that can be improved by antioxidants and the most popular one whit fighting infections is vitamin C.


  • Bacteria Infections
               – Examples:
                 Strep throat
                 Tuberculosis
                 Urinary tract infections (UTI)
  • Virus Infections
               – Examples:   
                  AIDS
                 Common cold
                 Ebola hemorrhagic fever
                 Genital herpes
                 Influenza
                Measles
                Chickenpox and shingles
  • Fungi Infections
              – Examples:
                 Thrush
                 Athlete’s foot
                 Ringworm
  • Protozoa Infections
                – Examples:
                  Giardia
                  Malaria
                  Toxoplasmosis
  • Helminths Infections
                – Examples:
                   Tapeworm infection
                   Roundworms infection
                   Heartworms infection

Do antioxidants help in weight loss? or Do antioxidants help us lose weight?

 
Yes and NO. Well Not exactly, the antioxidants effectdoes not directly effect your body fat. But help a lot in body metabolism that can be said that it indirectly helps with losing weights by iproving body metabolism and blod stream.
but it is very important to know that many fruits and also extracts that are considered for their antioxidants effects has shown in researches that they also have benefits in loosing weight like Vitamin E or Green Tea and so on.











Sources in web and scientific articles on antioxidants, free radicals and oxidation:


nutrex-hawaii.com

news-medical.net
ncbi.nlm.nih.gov
cancer.gov
google.com
simplyantioxidant.com

……………………………………………………………………………………………………………………………………………………………………………………………………………………………….

 

Some handy articles on antioxidants, free radicals and oxidation:
 
 

 

list of articles:

1. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. 4th. Oxford, UK: Clarendon Press; 2007.

2. Bahorun T, Soobrattee MA, Luximon-Ramma V, Aruoma OI. Free radicals and antioxidants in cardiovascular health and disease. Internet J. Med. Update. 2006;1:1–17.

3. Valko M, Izakovic M, Mazur M, Rhodes CJ, et al. Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell Biochem. 2004;266:37–56. [PubMed]

4. Valko M, Leibfritz D, Moncola J, Cronin MD, et al. Free radicals and antioxidants in normal physiological functions and human disease. Review. Int. J. Biochem. Cell Biol. 2007;39:44–84. [PubMed]

5. Droge W. Free radicals in the physiological control of cell function. Review. Physiol. Rev. 2002;82:47–95.[PubMed]

6. Willcox JK, Ash SL, Catignani GL. Antioxidants and prevention of chronic disease. Review. Crit. Rev. Food. Sci. Nutr. 2004;44:275–295. [PubMed]

7. Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 2007;87:315–424. [PMC free article] [PubMed]

8. Genestra M. Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Review. Cell Signal. 2007;19:1807–1819. [PubMed]

9. Halliwell B. Biochemistry of oxidative stress. Biochem. Soc. Trans. 2007;35:1147–1150. [PubMed]

10. Young I, Woodside J. Antioxidants in health and disease. J. Clin. Pathol. 2001;54:176–186.[PMC free article] [PubMed]

11. Valko M, Rhodes CJ, Moncol J, Izakovic M, et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Mini-review. Chem. Biol. Interact. 2006;160:1–40. [PubMed]

12. Valko M, Morris H, Cronin MTD. Metals, toxicity and oxidative stress. Curr. Med. Chem. 2005;12:1161–1208. [PubMed]

13. Parthasarathy S, Santanam N, Ramachandran S, Meilhac O. Oxidants and antioxidants in atherogenesis: an appraisal. J. Lipid Res. 1999;40:2143–2157. [PubMed]

14. Frei B. Reactive oxygen species and antioxidant vitamins. Linus Pauling Institute. Oregon State University. 1997 http://lpi.oregonstate.edu/f-w97/reactive.html .

15. Chatterjee M, Saluja R, Kanneganti S, et al. Biochemical and molecular evaluation of neutrophil NOS in spontaneously hypertensive rats. Cell Mol. Biol. 2007;53:84–93. [PubMed]

16. Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Review. Diabetes Care. 2008;31(Suppl 2):S181–184. [PubMed]

17. Halliwell B. Role of free radicals in neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging. 2001;18:685–716. [PubMed]

18. Singh RP, Sharad S, Kapur S. Free radicals and oxidative stress in neurodegenerative diseases: Relevance of Dietary Antioxidants. JIACM. 2004;5:218–225.

19. Christen Y. Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 2000;71:621S–629S. [PubMed]

20. Butterfield DA. Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer’s disease brain. A review. Free Radic. Res. 2002;36:1307–1313. [PubMed]

21. Caramori G, Papi A. Oxidants and asthma. Review. Thorax. 2004;59:170–173. [PMC free article][PubMed]

22. Guo RF, Ward PA. Role of oxidants in lung injury during sepsis. Antioxid. Redox. Signal. 2007;9:1991–2002. [PubMed]

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